公开(公告)号：EP1263480A1

公开(公告)日：2002-12-11

申请号：EP01905092.1

申请日：2001-01-26

Applicant: BAXTER INTERNATIONAL INC.

Inventor： WOO, Lecon ,  BOGGS, Daniel, R. ,  STERNBERG, Shmuel ,  SANDFORD, Craig ,  KHARE, Atul ,  BREILLATT, Julian

IPC: A61L2/10 ,  A61L2/02 ,  A61M1/36

CPC classification number: A61L2/10 ,  A61L2/0011 ,  A61M1/0281 ,  A61M1/3681 ,  A61M2202/0415 ,  A61M2205/053

Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device (10) comprises a radiation permeable cylindrical tube (12) having a concentric cylindrical rotor (14) disposed therein, thereby providing a thin gap (16) therebetween. A top plate (18) having a fluid outlet (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication with the thin gap (16). A rotor shaft (36) is diposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides fluid flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows, the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow, which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).

Abstract translation: 一种装置和方法，用于以连续流动布置灭菌辐射灭活治疗流体中的病原体，同时表现出流体在装置内的辐射剂量均匀性和狭窄的停留时间分布。 装置（10）包括具有设置在其中的同心圆柱形转子（14）的辐射可透过圆柱形管（12），从而在其间提供薄间隙（16）。 具有流体出口（26）的顶板（18）和具有流体入口（24）的底板（20）密封圆柱形管（12）。 入口（24）和出口（26）均与薄间隙（16）流体连通。 转子轴（36）轴向穿过圆柱形转子（14）并与马达（30）连接。 泵提供通过装置（10）的流体流动。 辐射源通过圆柱形管（12）向流体提供消毒辐射。 当流体流动时，马达（30）驱动转子（14）以向流体流施加泰勒涡旋，这使流体更靠近圆柱形管（12），流体更接近转子（14）。

公开(公告)号：EP0684866B1

公开(公告)日：1999-03-31

申请号：EP95906088.0

申请日：1994-12-20

Applicant: BAXTER INTERNATIONAL INC.

Inventor： STERNBERG, Shmuel ,  LYNN, Daniel, R.

IPC: B01D25/00 ,  B01D29/50 ,  B01D35/00 ,  B01D35/30

CPC classification number: B01D39/2017 ,  A61M1/0222 ,  A61M1/3636 ,  A61M1/3652 ,  A61M2202/0439 ,  B01D29/012 ,  B01D29/58 ,  B01D29/908 ,  B01D39/083 ,  B01D39/1623 ,  B01D39/18 ,  B01D2239/0471 ,  B01D2239/0618 ,  B01D2239/065 ,  B01D2239/0654 ,  B01D2239/1233 ,  Y10S264/26 ,  Y10S264/48 ,  A61M2202/0057

Abstract: A method correlates average fiber diameter with performance for a complex filtration media comprising a matrix of fibers having a fibrillated component with a diameter so small (e.g., less than 0.01 microns), that cannot be physically measured with accuracy. The method manufactures a selected matrix, derives the number average diameter of the fibers according to prescribed steps, some of which do not require actual physical measurements, and observes a performance characteristic. The method repeats the foregoing steps for different matrixes, yielding different number average diameters. The method expresses change in the selected performance characteristic as a function of change in number average diameter of the matrices.

公开(公告)号：EP0684864A1

公开(公告)日：1995-12-06

申请号：EP95906087.0

申请日：1994-12-20

Applicant: BAXTER INTERNATIONAL INC.

Inventor： STERNBERG, Shmuel

IPC: G01B21 ,  A61K35 ,  A61M1 ,  B01D17 ,  B01D29 ,  G01N15 ,  G01N33

CPC classification number: G01N15/08 ,  B29C65/04 ,  B29C65/08 ,  B29C66/1122 ,  B29C66/1312 ,  B29C66/24221 ,  B29C66/53261 ,  B29C66/53262 ,  B29C66/54 ,  B29C66/71 ,  B29C66/73921 ,  B29C66/81423 ,  B29C66/81431 ,  B29C66/8322 ,  B29C66/83221 ,  B29C66/9513 ,  B29K2027/06

Abstract: A methodology quantifies the average fiber diameter in complex multiple fiber matrixes in media region (28, 30 and 32) of a filter and assembly (20), even when the diameter of one or more of the fibers cannot be physically ascertained by conventional measurement methods.