公开(公告)号：WO2008112863A1

公开(公告)日：2008-09-18

申请号：PCT/US2008/056807

申请日：2008-03-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  HEWAWASAM, Piyasena ,  TU, Yong

Inventor： HEWAWASAM, Piyasena ,  TU, Yong

IPC: C07D487/04 ,  A61K31/55 ,  A61P31/12

CPC classification number: C07D487/04

Abstract: The invention encompasses compounds of formula (I) as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

Abstract translation: 本发明包括式（I）的化合物以及使用该化合物的组合物和方法。 这些化合物对丙型肝炎病毒（HCV）具有活性，可用于治疗感染HCV的患者。

公开(公告)号：WO2008112848A1

公开(公告)日：2008-09-18

申请号：PCT/US2008/056778

申请日：2008-03-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  GENTLES, Robert G. ,  ZHENG, Xiaofan ,  DING, Min ,  TU, Yong ,  HAN, Ying ,  HEWAWASAM, Piyasena ,  KADOW, John F. ,  BENDER, John A. ,  YEUNG, Kap-Sun ,  GRANT-YOUNG, Katharine A. ,  HUDYMA, Thomas W.

Inventor： GENTLES, Robert G. ,  ZHENG, Xiaofan ,  DING, Min ,  TU, Yong ,  HAN, Ying ,  HEWAWASAM, Piyasena ,  KADOW, John F. ,  BENDER, John A. ,  YEUNG, Kap-Sun ,  GRANT-YOUNG, Katharine A. ,  HUDYMA, Thomas W.

IPC: C07D487/04 ,  A61P31/12 ,  A61K31/55

CPC classification number: C07D487/04

Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

公开(公告)号：WO2007092000A1

公开(公告)日：2007-08-16

申请号：PCT/US2006/004156

申请日：2006-02-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  HUDYMA, Thomas, W. ,  ZHENG, Xiaofan ,  HE, Feng ,  DING, Min ,  BERGSTROM, Carl, P. ,  HEWAWASAM, Piyasena ,  MARTIN, Scott, W. ,  GENTLES, Robert, G.

Inventor： HUDYMA, Thomas, W. ,  ZHENG, Xiaofan ,  HE, Feng ,  DING, Min ,  BERGSTROM, Carl, P. ,  HEWAWASAM, Piyasena ,  MARTIN, Scott, W. ,  GENTLES, Robert, G.

IPC: C07D487/04 ,  C07D471/04 ,  C07D491/14 ,  C07D403/04 ,  A61K31/55 ,  A61P31/14

CPC classification number: C07D471/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/14 ,  C07D491/14 ,  C07D513/14

Abstract: Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds. (I)

Abstract translation: 描述式I的吲哚化合物。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。 还描述了包含化合物的不同形式和组合物以及制备化合物的方法。 （一世）

公开(公告)号：WO2007033032A1

公开(公告)日：2007-03-22

申请号：PCT/US2006/035133

申请日：2006-09-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  MEANWELL, Nicholas A. ,  GENTLES, Robert G. ,  DING, Min ,  BENDER, John A. ,  KADOW, John F. ,  HEWAWASAM, Piyasena ,  HUDYMA, Thomas W. ,  ZHENG, Xiaofan

Inventor： MEANWELL, Nicholas A. ,  GENTLES, Robert G. ,  DING, Min ,  BENDER, John A. ,  KADOW, John F. ,  HEWAWASAM, Piyasena ,  HUDYMA, Thomas W. ,  ZHENG, Xiaofan

IPC: C07D487/04 ,  A61K31/55 ,  A61P31/12

CPC classification number: C07D487/04

Abstract: The invention encompasses compounds of formula (I), pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

Abstract translation: 本发明包括式（I）的化合物，其药学上可接受的盐，组合物和使用该化合物的方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：WO2005046712A1

公开(公告)日：2005-05-26

申请号：PCT/US2004/038165

申请日：2004-11-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  SCOLA, Paul, Michael ,  MCPHEE, Fiona ,  MEANWELL, Nicholas, A. ,  HEWAWASAM, Piyasena ,  CAMPBELL, Jeffrey, Allen

Inventor： SCOLA, Paul, Michael ,  MCPHEE, Fiona ,  MEANWELL, Nicholas, A. ,  HEWAWASAM, Piyasena ,  CAMPBELL, Jeffrey, Allen

IPC: A61K38/06

CPC classification number: C07K5/0808 ,  A61K38/00 ,  C07K5/0802

Abstract: Compounds are disclosed having general formula (I), wherein R 1 , R 2 , R 3 , R 4 , R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Abstract translation: 公开了具有通式（I）的化合物，其中在说明书中描述了R1，R2，R3，R4，R'，B，Y和X. 还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。

公开(公告)号：WO2003080047A1

公开(公告)日：2003-10-02

申请号：PCT/US2003/008613

申请日：2003-03-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： GILLMAN, Kevin, W. ,  HEWAWASAM, Piyasena ,  SCHMITZ, William, D. ,  LOPEZ, Omar, D. ,  STARRETT, John, E. ,  PROVENCAL, David, P.

IPC: A61K31/40

CPC classification number: C07F9/5728

Abstract: The present invention provides novel phosphate derivatives having the general Formula (I) wherein the wavy bond (b) represents the racemate, the (R)-enantiomer or the (S)-enantiomer and A, B, R 1 , R 2 , R 3 , R 4 , m and n are as defined herein, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are useful in the treatment of disorders which are responsive to the opening of potassium channels.

Abstract translation: 本发明提供具有通式（I）的新型磷酸酯衍生物，其中波状键（b）表示外消旋物，（R） - 对映异构体或（S） - 对映异构体，A，B，R 1， R 3，R 4，m和n如本文所定义，或其无毒的药学上可接受的盐或溶剂化物，并且可用于治疗对钾通道开放有反应的病症。

公开(公告)号：WO2002096858A1

公开(公告)日：2002-12-05

申请号：PCT/US2002/017049

申请日：2002-05-31

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： WU, Yong-Jin ,  SUN, Li-Qiang ,  CHEN, Jie ,  HE, Huan ,  L'HEUREUX, Alexandre ,  DEXTRAZE, Pierre ,  DARIS, Jean-Paul ,  KINNEY, Gene, G. ,  DWORETZKY, Steven, I. ,  HEWAWASAM, Piyasena

IPC: C07C237/20

CPC classification number: C07D213/40 ,  C07C233/11 ,  C07C235/34 ,  C07D209/08 ,  C07D213/56 ,  C07D215/04 ,  C07D215/12 ,  C07D217/06 ,  C07D239/26 ,  C07D241/12 ,  C07D265/30 ,  C07D265/36 ,  C07D295/135 ,  C07D307/79 ,  C07D311/58 ,  C07D317/58 ,  C07D317/60 ,  C07D319/18 ,  C07D333/24 ,  C07D407/12 ,  C07D491/08

Abstract: There is provided novel cinnamide derivatives of Formula I wherein R is C 1-4 alkyl or trifluoromethyl, R 1 is selected from the group consisting of pyridinyl, quinolinyl, thienyl, furanyl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, chromanyl, indanyl, biphenylyl, phenyl and substituted phenyl which are openers of the KCNQ potassium channels and are useful in the treatment of disorders which are responsive to the opening of the KCNQ potassium channels.

Abstract translation: 提供式I的新颖的肉桂酰胺衍生物，其中R是C 1-4烷基或三氟甲基，R 1选自吡啶基，喹啉基，噻吩基，呋喃基，1,4-苯并二恶烷基，1,3-苯并二恶唑基， 苯并二氢吡喃基，茚满基，联苯基，苯基和取代的苯基，其是KCNQ钾通道的开放剂，并且可用于治疗对开放KCNQ钾通道有响应的病症。

公开(公告)号：WO2002072088A3

公开(公告)日：2002-09-19

申请号：PCT/US2002/004374

申请日：2002-02-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： DWORETZKY, Steven ,  GRIBKOFF, Valentin, K. ,  KINNEY, Gene, G. ,  HEWAWASAM, Piyasena

IPC: A61K31/404

Abstract: Compounds which function as modulators, particularly, openers, of human KCNQ potassium channel proteins or polypeptides, particularly, central nervous system(CNS)-located KCNQ potassium channels, and heteromultimers thereof, and their use in the treatment of migraine are provided by the present invention. One novel type of potassium channel polypeptide openers provided by the present invention is the fluorooxindole compounds, described for the first time as therapeutics for the treatment of migraine by preventing the asynchronous firing of neurons. Other KCNQ potassium channel opener compounds that are also useful in the treatments of the invention include 2,4-disubstituted pyrimidine-5-carboxamide derivatives. One or more of the compounds according to the present invention may be utilized alone, in combination, or in conjunction with other treatment modalities for reducing, ameliorating and/or alleviating migraine or diseases similar to, or mechanistically related to, migraine, e.g., cluster headache.

公开(公告)号：WO2002066426A2

公开(公告)日：2002-08-29

申请号：PCT/US2002/004304

申请日：2002-02-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： HEWAWASAM, Piyasena ,  DEXTRAZE, Pierre ,  GRIBKOFF, Valentin, K. ,  KINNEY, Gene, G. ,  DWORETZKY, Steven, I.

IPC: C07D209/00

CPC classification number: C07D209/34

Abstract: There is provided novel 3-fluoro-3-phenyl oxindole derivatives of Formula I wherein R 1 , R 2 , R 3 and R 4 each are independently hydrogen, C 1-4 alkyl, halogen, fluoromethyl, trifluoromethyl, phenyl, 4-methylphenyl or 4-trifluoromethylphenyl; R 5 is C 1-6 alkyl optionally substituted with one to three same or different groups selected from fluoro and chloro, provided R 5 is not C 1-6 alkyl when Y is O; Y is O or S; and R 6 and R 7 each are independently hydrogen, chloro, bromo or trifluoromethy; which are openers of the KCNQ potassium channels and are useful in the treatment of disorders which are responsive to the opening of the KCNQ potassium channels.

Abstract translation: 提供式I的新的3-氟-3-苯基羟吲哚衍生物，其中R 1，R 2，R 3和R 4各自独立地为氢，C 1-4烷基，卤素，氟甲基， 三氟甲基，苯基，4-甲基苯基或4-三氟甲基苯基; R 5是任选被一至三个选自氟和氯的相同或不同的基团取代的C 1-6烷基，当Y是O时，R 5不是C 1-6烷基; Y为O或S; 和R 6和R 7各自独立地是氢，氯，溴或三氟甲基; 其是KCNQ钾通道的开放剂，并且可用于治疗响应于KCNQ钾通道开放的疾病。

公开(公告)号：EP2499127B1

公开(公告)日：2018-09-05

申请号：EP10779605.4

申请日：2010-11-05

Applicant: Bristol-Myers Squibb Company

Inventor： LAVOIE, Rico ,  BENDER, John A. ,  YANG, Zhong ,  BELEMA, Makonen ,  LOPEZ, Omar D. ,  CHEN, Qi ,  WANG, Gan ,  HEWAWASAM, Piyasena

IPC: C07D405/14 ,  C07D401/14 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  C07D413/14 ,  A61K45/06 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/5377 ,  C07D403/10 ,  C07D309/06 ,  A61K31/4375

CPC classification number: C07D309/06 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.