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公开(公告)号：WO2016100285A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/065723
申请日：2015-12-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： MAPELLI, Claudio , GILLIS, Eric P. , SUN, Li-Qiang , ZHAO, Qian , ALLEN, Martin Patrick , MULL, Eric , SCOLA, Paul Michael
CPC classification number: A61K38/12 , A61K45/06 , C07K7/52 , C07K7/54 , Y02A50/463
Abstract: The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
Abstract translation: 本公开提供了抑制PD-1 / PD-L1和PD-L1 / CD80蛋白/蛋白相互作用的新型大环肽，因此可用于改善各种疾病，包括癌症和感染性疾病。
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公开(公告)号：WO2016077518A1
公开(公告)日：2016-05-19
申请号：PCT/US2015/060265
申请日：2015-11-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： GILLMAN, Kevin W. , GOODRICH, Jason , BOY, Kenneth M. , ZHANG, Yunhui , MAPELLI, Claudio , POSS, Michael A. , SUN, Li-Qiang , ZHAO, Qian , MULL, Eric , GILLIS, Eric P. , SCOLA, Paul Michael , LANGLEY, David, R.
CPC classification number: C07K7/08 , A61K38/00 , A61K38/10 , A61K45/06 , A61K51/088 , C07K7/56 , Y02A50/463
Abstract: The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
Abstract translation: 本公开提供了作为免疫调节剂的化合物，因此可用于改善各种疾病，包括癌症和感染性疾病。
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3.发明申请MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80(B7-1)/PD-L1 PROTEIN/PROTEIN INTERACTIONS 审中-公开PD-1 / PD-L1和CD80（B7-1）/ PD-L1蛋白/蛋白质相互作用的MACROCYCLIC抑制剂
公开(公告)号：WO2014151634A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/026138
申请日：2014-03-13
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： MILLER, Michael Matthew , MAPELLI, Claudio , ALLEN, Martin Patrick , BOWSHER, Michael S. , BOY, Kenneth M. , GILLIS, Eric P. , LANGLEY, David R. , MULL, Eric , POIRIER, Maude A. , SANGHVI, Nishith , SUN, Li-Qiang , TENNEY, Daniel J. , YEUNG, Kap-Sun , ZHU, Juliang , REID, Patrick C. , SCOLA, Paul Michael
CPC classification number: C07K7/56 , A61K38/00 , A61K38/10 , A61K39/39 , A61K45/06 , C07K7/08 , G01N33/574 , G01N2333/70532 , G01N2500/02 , G01N2800/26 , Y02A50/463
Abstract: The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
Abstract translation: 本公开提供了抑制PD-1 / PD-L1和PD-L1 / CD80蛋白/蛋白相互作用的新型大环肽，因此可用于改善各种疾病，包括癌症和感染性疾病。
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公开(公告)号：WO2012141704A1
公开(公告)日：2012-10-18
申请号：PCT/US2011/032391
申请日：2011-04-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY , WANG, Tao , PENDRI, Annapurna , ZHANG, Zhongxing , ZHAI, Weixu , LI, Guo , GERRITZ, Samuel , SCOLA, Paul, Michael , SUN, Li-Qiang , ZHAO, Qian , MULL, Eric
Inventor： WANG, Tao , PENDRI, Annapurna , ZHANG, Zhongxing , ZHAI, Weixu , LI, Guo , GERRITZ, Samuel , SCOLA, Paul, Michael , SUN, Li-Qiang , ZHAO, Qian , MULL, Eric
IPC: C07D487/08 , C07D498/08 , A61K31/53 , A61P31/14
CPC classification number: C07D498/08 , C07D487/08
Abstract: The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
Abstract translation: 本公开提供式I化合物，包括药学上可接受的盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：WO2008060927A3
公开(公告)日：2008-05-22
申请号：PCT/US2007/084012
申请日：2007-11-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY , SIN, Ny , VENABLES, Brian Lee , SUN, Li-Qiang , SIT, Sing-Yuen , CHEN, Yan , SCOLA, Paul Michael
Inventor： SIN, Ny , VENABLES, Brian Lee , SUN, Li-Qiang , SIT, Sing-Yuen , CHEN, Yan , SCOLA, Paul Michael
IPC: C07D401/12 , C07D401/14 , C07D417/14 , A61K31/4709 , A61P31/14 , C07K5/00
Abstract: Hepatitis C virus inhibitors having the general formula, (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
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Patent Agency Ranking
公开(公告)号：WO2020237081A1
公开(公告)日：2020-11-26
申请号：PCT/US2020/034053
申请日：2020-05-21
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： WANG, Tao , SUN, Li-Qiang , MENG, Zhaoxing , SCOLA, Paul
IPC: A61P31/12 , C07K7/08 , C07K7/56 , G01N33/574
Abstract: In accordance with the present disclosure, macrocyclic compounds have been discovered that bind to PD-L1 and are capable of inhibiting the interaction of PD-L1 with PD-1 and CD80. These macrocyclic compounds exhibit in vitro immunomodulatory efficacy thus making them therapeutic candidates for the treatment of various diseases including cancer and infectious diseases.
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公开(公告)号：WO2017066227A1
公开(公告)日：2017-04-20
申请号：PCT/US2016/056504
申请日：2016-10-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： YEUNG, Kap-Sun , CONNOLLY, Timothy P. , FRENNESSON, David B. , GRANT-YOUNG, Katharine A. , HEWAWASAM, Piyasena , LANGLEY, David R. , MENG, Zhaoxing , MULL, Eric , PARCELLA, Kyle E. , SAULNIER, Mark George , SUN, Li-Qiang , WANG, Alan Xiangdong , XU, Ningning , ZHU, Juliang , SCOLA, Paul Michael
IPC: C07D403/12 , C07D401/14 , C07D213/71 , C07D213/85 , C07D401/12 , C07D455/02 , C07D207/12 , A61K31/4427 , A61P35/00 , A61P37/00
CPC classification number: C07D401/14 , A61K31/135 , A61K31/138 , A61K31/166 , A61K31/397 , A61K31/40 , A61K31/4025 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4453 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/541 , A61K45/06 , C07C215/20 , C07C235/46 , C07D205/04 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/22 , C07D213/71 , C07D213/80 , C07D213/82 , C07D213/85 , C07D265/30 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D455/02 , C07D471/04 , C07D471/08 , C07D491/08
Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases. The compounds have formula (I), wherein R2 is selected from (II) and (III).
Abstract translation: 本公开一般涉及可用作免疫调节剂的化合物。 本文提供化合物，包含此类化合物的组合物及其使用方法。 本公开还涉及包含至少一种根据本公开内容的化合物的药物组合物，其可用于治疗各种疾病，包括癌症和感染性疾病。 该化合物具有式（I），其中R2选自（II）和（III）。
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公开(公告)号：WO2014123894A1
公开(公告)日：2014-08-14
申请号：PCT/US2014/014654
申请日：2014-02-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： WANG, Tao , ZHANG, Zhongxing , YIN, Zhiwei , SUN, Li-Qiang , MULL, Eric , ZHAO, Qian , SCOLA, Paul, Michael
IPC: C07D498/08 , C07D498/18 , C07D498/22 , A61K31/53 , A61P31/12
CPC classification number: C07D498/22 , A61K31/53 , A61K31/551 , A61K45/06 , C07D498/08 , C07D498/18 , C07D498/20
Abstract: Compounds of Formula I, including pharmaceutically acceptable salts thereof, are set forth, in addition to compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
Abstract translation: 除了使用这些化合物的组合物和方法之外，还列举了式I化合物，包括其药学上可接受的盐。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：WO2013055563A1
公开(公告)日：2013-04-18
申请号：PCT/US2012/058654
申请日：2012-10-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： SUN, Li-Qiang , ZHAO, Qian , SCOLA, Paul, Michael
IPC: A61K31/505 , C07D498/04 , A61P31/12
CPC classification number: C07D498/08
Abstract: The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
Abstract translation: 本公开提供式I化合物，包括药学上可接受的盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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10.发明申请
公开(公告)号：WO2012166459A1
公开(公告)日：2012-12-06
申请号：PCT/US2012/039090
申请日：2012-05-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY , SUN, Li-Qiang , SCOLA, Paul Michael
Inventor： SUN, Li-Qiang , SCOLA, Paul Michael
IPC: C07D401/12 , A61K31/4725 , A61P31/14
CPC classification number: A61K38/06 , A61K38/005 , A61K38/204 , A61K38/208 , A61K38/21 , A61K45/00 , A61K45/06 , C07D401/12 , C07K5/0808
Abstract: Hepatitis C virus inhibitors having the general formula (I) [INSERT CHEMICAL STRUCTURE HERE] are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
Abstract translation: 公开了具有通式（I）[此处的INSERT CHEMICAL STRUCTURE HERE]的丙型肝炎病毒抑制剂。 还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。
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