公开(公告)号：DE3278160D1

公开(公告)日：1988-04-07

申请号：DE3278160

申请日：1982-12-10

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07D295/08 ,  A61K31/40 ,  A61P9/08 ,  A61P9/10 ,  C07D20060101 ,  C07D207/00 ,  C07D295/088 ,  C07D295/12 ,  C07D295/13

Abstract: A novel, efficient, economical procedure for the synthesis of ethers of n-propanoldiamine having the formula: wherein R is a straight or branched chain lower alkyl group or an aralkyl group, Ar is an aromatic group, Ar1 is an aromatic or heterocyclic group, A is a tertiary aliphatic, cycloaliphatic or heterocyclic amino group and addition salts thereof with pharmacologically acceptable acids.

公开(公告)号：IT1157249B

公开(公告)日：1987-02-11

申请号：IT4976082

申请日：1982-12-28

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: A61K31/40 ,  C07D295/08 ,  A61P9/08 ,  A61P9/10 ,  C07D20060101 ,  C07D207/00 ,  C07D295/088 ,  C07D295/12 ,  C07D295/13 ,  A61K

Abstract: A novel, efficient, economical procedure for the synthesis of ethers of n-propanoldiamine having the formula: wherein R is a straight or branched chain lower alkyl group or an aralkyl group, Ar is an aromatic group, Ar1 is an aromatic or heterocyclic group, A is a tertiary aliphatic, cycloaliphatic or heterocyclic amino group and addition salts thereof with pharmacologically acceptable acids.

公开(公告)号：DK391983D0

公开(公告)日：1983-08-26

申请号：DK391983

申请日：1983-08-26

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: A61K31/40 ,  C07D295/08 ,  A61P9/08 ,  A61P9/10 ,  C07D20060101 ,  C07D207/00 ,  C07D295/088 ,  C07D295/12 ,  C07D295/13 ,  C07D295

Abstract: A novel, efficient, economical procedure for the synthesis of ethers of n-propanoldiamine having the formula: wherein R is a straight or branched chain lower alkyl group or an aralkyl group, Ar is an aromatic group, Ar1 is an aromatic or heterocyclic group, A is a tertiary aliphatic, cycloaliphatic or heterocyclic amino group and addition salts thereof with pharmacologically acceptable acids.

公开(公告)号：DK391983A

公开(公告)日：1983-08-26

申请号：DK391983

申请日：1983-08-26

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: A61K31/40 ,  C07D295/08 ,  A61P9/08 ,  A61P9/10 ,  C07D20060101 ,  C07D207/00 ,  C07D295/088 ,  C07D295/12 ,  C07D295/13 ,  C07D

Abstract: Process for synthesizing 1-[3-isobutoxy-2- phenyl(benzylamino)propylpyrrolidine hydrochloride by preparing 1-(3-isobutoxy-2-chloro)propylpyrrolidine followed by condensing this with N-benzylaniline in the presence of an equimolar quantity of sodium hydride condensing agent.

公开(公告)号：CA1138866A

公开(公告)日：1983-01-04

申请号：CA342002

申请日：1979-12-14

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07D498/04 ,  C07D498/02

Abstract: The compound 7-chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo (3,2-b) (1,3)-benzoxazin-9-one is produced by reacting a mixture of tetrahydrofuran and crotonaldehyde with 5-chloro-salicylhydroxamic acid. The compound has demonstrated utility as a uricosuric agent.

公开(公告)号：DE2952385A1

公开(公告)日：1980-07-10

申请号：DE2952385

申请日：1979-12-24

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07D498/04

Abstract: The compound 7-chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo(3,2-b)(1,3)-benzoxazin- 9-one is produced by reacting a mixture of tetrahydrofuran and crotonaldehyde with 5-chlorosalicylhydroxamic acid. The compound has demonstrated utility as a uricosuric agent.

公开(公告)号：IT8067054D0

公开(公告)日：1980-01-16

申请号：IT6705480

申请日：1980-01-16

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: A61K20060101 ,  A61K

公开(公告)号：ES2058540T3

公开(公告)日：1994-11-01

申请号：ES89308266

申请日：1989-08-15

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07C33/26 ,  C07C271/16 ,  C07C271/10 ,  C07C29/00 ,  C07C205/04 ,  C07C201/12

Abstract: A method for the preparation of 2-phenyl-1, 3-propanediol dicarbamate which comprises: a) reacting benzaldehyde with a compound selected from hydroxylamine sulphate and hydroxyalmine hydrochloride to form benzaldehyde oxime; b) oxidizing the benzaldehyde oxime of step (a) to obtain nitromethylbenzene; c) reacting the nitromethylbenzene obtained in step (b) with formaldehyde to form 2-nitro-2-phenyl-1,3-propanediol; d) reducing 2-nitro-2-phenyl-1, 3-propanediol with hydrogen to form 2-phenyl-1, 3-propanediol; e) converting 2-phenyl-1, 3-propanediol to the desired dicarbamate.

公开(公告)号：NO940113D0

公开(公告)日：1994-01-12

申请号：NO940113

申请日：1994-01-12

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: B01J23/44 ,  B01J27/232 ,  C07B61/00 ,  C07C20060101 ,  C07C29/00 ,  C07C29/132 ,  C07C33/26 ,  C07C201/10 ,  C07C201/12 ,  C07C205/04 ,  C07C205/16 ,  C07C

公开(公告)号：NO158059C

公开(公告)日：1988-07-06

申请号：NO833071

申请日：1983-08-26

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: A61K31/40 ,  C07D295/08 ,  A61P9/08 ,  A61P9/10 ,  C07D20060101 ,  C07D207/00 ,  C07D295/088 ,  C07D295/12 ,  C07D295/13

Abstract: A novel, efficient, economical procedure for the synthesis of ethers of n-propanoldiamine having the formula: wherein R is a straight or branched chain lower alkyl group or an aralkyl group, Ar is an aromatic group, Ar1 is an aromatic or heterocyclic group, A is a tertiary aliphatic, cycloaliphatic or heterocyclic amino group and addition salts thereof with pharmacologically acceptable acids.