公开(公告)号：US20250134868A1

公开(公告)日：2025-05-01

申请号：US18905874

申请日：2024-10-03

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Sanford Markowitz ,  Amar Desai ,  Joseph Ready

IPC: A61K31/4365 ,  A61K31/444 ,  A61K31/495 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K38/19 ,  A61K45/06

Abstract: A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.

公开(公告)号：US20240024297A1

公开(公告)日：2024-01-25

申请号：US18128075

申请日：2023-03-29

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  INJE INDUSTRY ACEDEMIC COOPERATION FOUNDATION

Inventor： Sanford Markowitz ,  Ki Beom Bae ,  Hye Jung Kim ,  Sun-Hee Kim

IPC: A61K31/4365

CPC classification number: A61K31/4365

Abstract: A method for preventing or treating renal ischemia reperfusion injury or acute kidney injury associated with renal ischemia reperfusion injury in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.

公开(公告)号：US20230310390A1

公开(公告)日：2023-10-05

申请号：US18020202

申请日：2021-08-09

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  The United States Government as represented by the Department of Veterans Affairs ,  UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER

Inventor： Sanford Markowitz ,  Andrew Pieper ,  Hongyun Li ,  Edwin Vazquez Rosa ,  Min-Kyoo Shin ,  Yeojung Koh ,  Joseph Ready

IPC: A61K31/4365 ,  A61P25/28

CPC classification number: A61K31/4365 ,  A61P25/28

Abstract: A method of treating neurodegeneration and/or neurodegenerative condition, disease, or disorder caused by and/or associated with elevated or aberrant 15-PGDH activity in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.

公开(公告)号：US20230165883A1

公开(公告)日：2023-06-01

申请号：US17893777

申请日：2022-08-23

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  Board of Regents of the University of Texas System

Inventor： Sanford Markowitz ,  Won Jin Ho ,  Yiyuan Yuan ,  Mukesh Jain ,  Mohamad Sabeh ,  Joseph Ready ,  Noelle Williams

IPC: A61K31/704 ,  A61P9/00 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/7048 ,  C07K16/32

CPC classification number: A61K31/704 ,  A61P9/00 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/7048 ,  C07K16/32

Abstract: A method of treating preventing, minimizing, and/or reversing congestive heart failure, cardiomyopathy, and/or reduction of cardiac ejection fraction in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.

公开(公告)号：US20230136730A1

公开(公告)日：2023-05-04

申请号：US17879379

申请日：2022-08-02

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  CASE WESTERN RESERVE UNIVERSITY

Inventor： Sanford Markowitz ,  James K.V. Willson ,  Bruce Posner ,  Joseph Ready ,  Monika Antczak ,  Yongyou Zhang ,  Amar Desai ,  Stanton Gerson ,  William Greenlee ,  Sung Yeun Yang ,  KiBeom Bae

IPC: A61K31/5377 ,  C07D495/04 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/444 ,  A61K31/496 ,  A61K31/519

Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

公开(公告)号：US20220096064A1

公开(公告)日：2022-03-31

申请号：US17643341

申请日：2021-12-08

Applicant: Case Western Reserve University

Inventor： Sanford Markowitz ,  Amitabh Chak ,  Joseph Willis ,  Jeffrey Silver Taggart ,  Rebecca Blice ,  Dean Secrest ,  Dennis Siedlak

IPC: A61B10/02

Abstract: A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.

公开(公告)号：US20220096062A1

公开(公告)日：2022-03-31

申请号：US17643329

申请日：2021-12-08

Applicant: Case Western Reserve University

Inventor： Sanford Markowitz ,  Amitabh Chak ,  Joseph Willis ,  Jeffrey Silver Taggart ,  Rebecca Blice ,  Dean Secrest ,  Dennis Siedlak

IPC: A61B10/02

Abstract: A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.

公开(公告)号：US20210283113A1

公开(公告)日：2021-09-16

申请号：US17131911

申请日：2020-12-23

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Sanford Markowitz ,  Stanton Gerson ,  Amar Desai ,  Won Jin Ho

IPC: A61K31/4365 ,  C07D277/00 ,  A61K31/426 ,  C07D277/02

Abstract: A method of treating or preventing a fibrotic disease, disorder or condition includes administering to a subject in need of treatment a 15-PGDH inhibitor.

公开(公告)号：US20210032265A1

公开(公告)日：2021-02-04

申请号：US16943932

申请日：2020-07-30

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION

Inventor： Sanford Markowitz ,  James K.V. Willson ,  Bruce Posner ,  Joseph Ready ,  Yongyou Zhang ,  Hsin-Hsiung Tai ,  Monika Antczak ,  Stanton Gerson ,  KiBeom Bae ,  Sung Yeun Yang ,  Amar Desai

IPC: C07D495/04 ,  C07C311/21 ,  C07D213/71 ,  C07D213/73 ,  C07D213/75 ,  C07D213/76 ,  C07D215/08 ,  C07D237/20 ,  C07D405/12 ,  C07D239/42 ,  C07D241/20 ,  C07D261/14 ,  C07D207/263 ,  C07D275/03 ,  C07D209/08 ,  C07D277/46 ,  C07D295/185 ,  A61K31/4365 ,  A61K31/519

Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.

公开(公告)号：US09801863B2

公开(公告)日：2017-10-31

申请号：US15347587

申请日：2016-11-09

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  Board of Regents of the University of Texas System

Inventor： Sanford Markowitz ,  Amar Desai ,  Stanton Gerson ,  Joseph Ready

IPC: A61K31/4365 ,  A61K38/19 ,  A61K31/495

CPC classification number: A61K31/4365 ,  A61K31/495 ,  A61K38/193

Abstract: A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.