公开(公告)号：US20230355636A1

公开(公告)日：2023-11-09

申请号：US18144065

申请日：2023-05-05

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Sanford Markowitz ,  Won Jin Ho ,  Stephen P. Fink ,  Vinay Varadan

IPC: A61K31/5377 ,  A61P1/00 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/573 ,  A61K31/56

CPC classification number: A61K31/5377 ,  A61P1/00 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/573 ,  A61K31/56

Abstract: A method of treating intestinal, gastrointestinal, or bowel disorders in a subject in need thereof includes administering to the subject a therapeutically effective amount of 15-PGDH inhibitor alone or in combination with a corticosteroid and/or TNF alpha antagonist.

公开(公告)号：US20180064694A1

公开(公告)日：2018-03-08

申请号：US15556972

申请日：2016-03-08

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Sanford Markowitz ,  Stanton Gerson ,  Amar Desai ,  Won Jin Ho

IPC: A61K31/4365 ,  A61K31/426 ,  C07D277/02

CPC classification number: A61K31/4365 ,  A61K31/426 ,  C07D277/00 ,  C07D277/02 ,  Y02A50/423

Abstract: A method of treating or preventing a fibrotic disease, disorder or condition includes administering to a subject in need of treatment a 15-PGDH inhibitor.

公开(公告)号：US11690847B2

公开(公告)日：2023-07-04

申请号：US16465500

申请日：2017-11-30

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Sanford Markowitz ,  Won Jin Ho ,  Stephen P. Fink ,  Vinay Varadan

IPC: A61K31/5377 ,  A61P1/00 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/573 ,  A61K31/56

CPC classification number: A61K31/5377 ,  A61K31/421 ,  A61K31/426 ,  A61K31/437 ,  A61K31/4365 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/56 ,  A61K31/573 ,  A61P1/00

Abstract: A method of treating intestinal gastrointestinal, or bowel disorders in a subject in need thereof includes administering to the subject a therapeutically effective amount of 15-PGDH inhibitor alone or in combination with a corticosteroid and/or TNF alpha antagonist.

公开(公告)号：US10945998B2

公开(公告)日：2021-03-16

申请号：US15556972

申请日：2016-03-08

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Sanford Markowitz ,  Stanton Gerson ,  Amar Desai ,  Won Jin Ho

IPC: A61K31/44 ,  A61K31/4365 ,  C07D277/00 ,  A61K31/426 ,  C07D277/02

Abstract: A method of treating or preventing a fibrotic disease, disorder or condition includes administering to a subject in need of treatment a 15-PGDH inhibitor.

公开(公告)号：US20230165883A1

公开(公告)日：2023-06-01

申请号：US17893777

申请日：2022-08-23

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  Board of Regents of the University of Texas System

Inventor： Sanford Markowitz ,  Won Jin Ho ,  Yiyuan Yuan ,  Mukesh Jain ,  Mohamad Sabeh ,  Joseph Ready ,  Noelle Williams

IPC: A61K31/704 ,  A61P9/00 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/7048 ,  C07K16/32

CPC classification number: A61K31/704 ,  A61P9/00 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/7048 ,  C07K16/32

Abstract: A method of treating preventing, minimizing, and/or reversing congestive heart failure, cardiomyopathy, and/or reduction of cardiac ejection fraction in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.

公开(公告)号：US20210283113A1

公开(公告)日：2021-09-16

申请号：US17131911

申请日：2020-12-23

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Sanford Markowitz ,  Stanton Gerson ,  Amar Desai ,  Won Jin Ho

IPC: A61K31/4365 ,  C07D277/00 ,  A61K31/426 ,  C07D277/02

Abstract: A method of treating or preventing a fibrotic disease, disorder or condition includes administering to a subject in need of treatment a 15-PGDH inhibitor.

公开(公告)号：US11426420B2

公开(公告)日：2022-08-30

申请号：US16603544

申请日：2018-04-09

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  Board of Regents of the University of Texas System

Inventor： Sanford Markowitz ,  Won Jin Ho ,  Yiyuan Yuan ,  Mukesh Jain ,  Mohamed Sabeh ,  Joseph Ready ,  Noelle Williams

IPC: A61K31/704 ,  A61P9/00 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/7048 ,  C07K16/32

Abstract: A method of treating preventing, minimizing, and/or reversing congestive heart failure, cardiomyopathy, and/or reduction of cardiac ejection fraction in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.

公开(公告)号：US20200061073A1

公开(公告)日：2020-02-27

申请号：US16465500

申请日：2017-11-30

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Sanford Markowitz ,  Won Jin Ho ,  Stephen P. Fink ,  Vinay Varadan

IPC: A61K31/5377 ,  A61K31/4439 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4985 ,  A61K31/4365 ,  A61K31/519 ,  A61K31/437 ,  A61K31/573 ,  A61P1/00

Abstract: A method of treating intestinal gastrointestinal, or bowel disorders in a subject in need thereof includes administering to the subject a therapeutically effective amount of 15-PGDH inhibitor alone or in combination with a corticosteroid and/or TNF alpha antagonist.