公开(公告)号：EP2801611B1

公开(公告)日：2020-04-01

申请号：EP13733718.4

申请日：2013-01-07

Applicant: CJ Cheiljedang Corporation

Inventor： CHEONG, Ki Yong ,  LEE, Seok Myung ,  HWANG, Young Bin ,  LEE, Keun Cheol ,  LEE, Kwang Ho

IPC: C12N1/21 ,  C12P13/22 ,  C12N15/70

公开(公告)号：EP3119875B1

公开(公告)日：2019-02-27

申请号：EP15765883.2

申请日：2015-03-17

Applicant: CJ Cheiljedang Corporation

Inventor： LEE, Ji Sun ,  SEO, Chang Il ,  CHEONG, Ki Yong ,  KOH, Eun Sung ,  KWON, Do Hyun ,  LEE, Kwang Ho

IPC: C12N15/70 ,  C07K14/245 ,  C12P13/08 ,  C12P13/22

公开(公告)号：EP3404101A2

公开(公告)日：2018-11-21

申请号：EP18182250.3

申请日：2012-12-21

Applicant: Cj Cheiljedang Corporation

Inventor： LEE, Kwang Ho ,  LIM, Sang Jo ,  MOON, Jun Ok ,  JANG, Jae Woo ,  PARK, Su Jin ,  PARK, Sang Hee

IPC: C12N15/52 ,  C12N15/63 ,  C12N15/74 ,  C12P13/08

CPC classification number: C12P13/08 ,  C12N9/1022 ,  C12N9/1217 ,  C12N9/93 ,  C12N15/52 ,  C12N15/63 ,  C12N15/74 ,  C12Y202/01001 ,  C12Y207/02004 ,  C12Y604/01001 ,  Y02P20/52

Abstract: The present invention relates to a modified polynucleotide encoding aspartate kinase (EC:2.7.2.4; hereinafter, referred to as LysC), transketolase (EC:2.2.1.1; hereinafter, referred to as Tkt) or pyruvate carboxylase (EC:6.4.1.1; hereinafter, referred to as Pyc), in which the initiation codon is substituted with ATG, a vector including the same, a microorganism transformed with the vector, and a method for producing L-lysine using the same.

公开(公告)号：EP3296400A1

公开(公告)日：2018-03-21

申请号：EP16792967.8

申请日：2016-05-10

Applicant: CJ Cheiljedang Corporation

Inventor： LEE, Seok Myung ,  LEE, Baek Seok ,  KIM, Kyungrim ,  LEE, Kwang Ho ,  LEE, Keun Cheol ,  HONG, Hyeongpyo

IPC: C12N15/70 ,  C12P13/14

CPC classification number: C12P13/227 ,  C12N1/20 ,  C12N15/70 ,  C12P13/14

Abstract: The present invention relates to a microorganism of the genus Escherichia in which L-tryptophan productivity is improved by inactivating phosphatase activity. Further, the present invention relates to a method for producing L-tryptophan using the microorganism of the genus Escherichia.

Abstract translation: 本发明涉及埃希氏菌属微生物，其中通过失活磷酸酶活性来提高L-色氨酸生产力。 此外，本发明涉及使用埃希氏菌属微生物生产L-色氨酸的方法。

公开(公告)号：EP2665809B1

公开(公告)日：2018-01-10

申请号：EP12736463.6

申请日：2012-01-18

Applicant: CJ Cheiljedang Corporation

Inventor： LEE, Kwang Ho ,  LEE, Keun Chul ,  LEE, Seok Myung ,  HWANG, Young Bin

IPC: C12N1/21 ,  C12N9/10 ,  C12N9/12 ,  C12P13/08 ,  C12P13/04 ,  C12P13/22

CPC classification number: C12N15/70 ,  C07K14/245 ,  C12N9/1007 ,  C12N9/1205 ,  C12P13/04 ,  C12P13/08 ,  C12P13/227 ,  C12Y201/01 ,  C12Y207/01023

Abstract: A microorganism of the genus Escherichia having enhanced L-amino acid productivity, wherein the microorganism is transformed to have an enhanced NAD kinase activity and an inactivated activity of an enzyme having an amino acid sequence of SEQ ID NO: 2 encoded by tehB gene and a method for producing L-amino acids using the microorganism of the genus Escherichia.

公开(公告)号：EP2803722B1

公开(公告)日：2017-09-27

申请号：EP13736186.1

申请日：2013-01-10

Applicant: Cj Cheiljedang Corporation

Inventor： RAH, So Yeon ,  HUH, Lan ,  KIM, Chang Gyeom ,  LEE, Kwang Ho ,  MOON, Jun Ok ,  LEE, Kyung Han ,  SUNG, Jin Seok ,  KIM, Hyung Joon

IPC: C12N1/21 ,  C12N15/52 ,  C12N15/74 ,  C12P13/08

CPC classification number: C12P13/08 ,  C12N9/1205 ,  C12N9/92 ,  C12Y207/01017 ,  C12Y503/01005 ,  Y02P20/52

公开(公告)号：EP3159401A1

公开(公告)日：2017-04-26

申请号：EP15811391.0

申请日：2015-06-23

Applicant: CJ Cheiljedang Corporation

Inventor： CHEONG, Ki Yong ,  KIM, Kyung Rim ,  LEE, Seok Myung ,  LEE, Kwang Ho ,  LEE, Keun Cheol ,  HONG, Hyeong Pyo

IPC: C12N1/21 ,  C12N15/52 ,  C12P13/22

CPC classification number: C12P13/227 ,  C12N9/88 ,  C12N15/52 ,  C12P13/22 ,  C12Y401/02014 ,  C12Y402/01012

Abstract: The present application relates to a microorganism of the genus Escherichia producing L-tryptophan and, more specifically, to a microorganism of the genus Escherichia with improved activity of producing L-tryptophan by weakening or inactivating the activity of endogenous 6-phosphogluconate dehydratase and 2-keto-3-deoxy-6-phosphogluconate aldolase.
Additionally, the present application relates to a method for producing L-tryptophan using the microorganism of the genus Escherichia.

Abstract translation: 本申请涉及到属微生物大肠杆菌生产L-色氨酸，更具体地说，埃希氏杆菌属的具有改进的产生L-色氨酸通过弱化或失活内源性6-磷酸葡糖酸脱水和2-的活性的酶活性的微生物 酮-3-脱氧-6-磷酸葡糖酸醛缩酶。 此外，本申请涉及一种用于制造使用埃希氏菌属的微生物的L-色氨酸的方法。

公开(公告)号：EP2405006A2

公开(公告)日：2012-01-11

申请号：EP10748904.9

申请日：2010-02-16

Applicant: CJ CheilJedang Corporation

Inventor： JU, Jae Yeong ,  LEE, Kwang Ho ,  BAE, Hyun Ae

IPC: C12N15/52 ,  C12N1/21 ,  C12P13/04 ,  C12R1/19

CPC classification number: C12Y302/01048 ,  C12N9/2402 ,  C12P13/04

Abstract: The present invention relates to a microorganism belonging to the genus Escherichia sp. and a method for producing L-amino acid using the same. The microorganism belonging to the genus Escherichia sp. with sucrose assimilability and L-amino acid producing ability is obtained by introducing a gene encoding a sucrose assimilative microorganism-derived sucrose metabolic enzyme to the sucrose non-assimilative microorganism belonging to the genus Escherichia sp. having an L-amino acid producing ability.

Abstract translation: 本发明涉及属于埃希氏杆菌属菌的微生物。 和用于生产使用相同的L-氨基酸的方法。 属埃希氏菌属的微生物。 与蔗糖同化性和L-氨基酸产生能力通过引入编码蔗糖同化微生物来源蔗糖代谢酶属于埃希氏菌属菌的蔗糖非同化微生物的基因来获得。 具有L-氨基酸产生能力。

公开(公告)号：EP2233570A1

公开(公告)日：2010-09-29

申请号：EP09700769.4

申请日：2009-01-07

Applicant: CJ CheilJedang Corporation

Inventor： LEE, Kwang Ho ,  JU, Jae Yeong ,  LEE, Ji Sun ,  HWANG, Young Bin ,  JHON, Sung Hoo ,  KOH, Eun Sung ,  KIM, Chul Ha ,  SHIN, Soo An

IPC: C12N15/04

CPC classification number: C12P13/08 ,  C12N9/1085 ,  C12N9/88

Abstract: An L-threonine-producing Escherichia coli in which a promoter of a phosphoenolpyruvate carboxylase (ppc) gene on the chromosome is substituted with a promoter of a cysteine synthase ( cysk ) gene and a method of producing L-threonine by using the same are disclosed. The recombinant Escherichia coli may produce L-threonine in a high yield, and thus may be widely used in medical, pharmaceutical, and feed industries, particularly for an animal feed.

Abstract translation: 公开了其中染色体上的磷酸烯醇丙酮酸羧化酶（ppc）基因的启动子被半胱氨酸合成酶（cysk）基因的启动子取代的产生L-苏氨酸的大肠杆菌和使用该L-赖氨酸的L-苏氨酸的生产方法 。 重组大肠杆菌可以以高产率生产L-苏氨酸，因此可广泛用于医药，制药和饲料工业，尤其用于动物饲料。