公开(公告)号：SG11201400466TA

公开(公告)日：2014-04-28

申请号：SG11201400466T

申请日：2012-09-07

Applicant: GENOMATICA INC

Inventor： BURGARD ANTHONY P ,  BURK MARK J ,  OSTERHOUT ROBIN E ,  PHARKYA PRITI ,  LI JINGYI

IPC: C12P7/04 ,  C12P1/00

公开(公告)号：MX2013001071A

公开(公告)日：2013-06-28

申请号：MX2013001071

申请日：2011-07-26

Applicant: GENOMATICA INC

Inventor： OSTERHOUT ROBIN E ,  BURGARD ANTHONY P ,  PHARKYA PRITI ,  BURK MARK J

IPC: C12P5/00 ,  C12P5/02 ,  C12P7/40

Abstract: La invención proporciona organismos microbianos que no ocurren de manera natural teniendo una ruta de tolueno, benceno, p-toluato, tereftalato, (2-hidroxi-3-metil-4-oxobutoxi)fosfonato, (2-hidroxi-4-oxobutoxi)fosfonato, benzoato, estireno, 2, 4-pentadienoato, 3-buten-lol o 1, 3-butadieno. La invención proporciona adicionalmente métodos para usar tales organismos para producir tolueno, benceno, p-toluato, ter e ft a lato, (2-hidroxi-3-metil-4-oxobutoxi)fosfonato, (2-hidroxi-4-oxobutoxi)f osfonato, benzoato, estireno, 2, 4-pentadienoato, 3-buten-lol o 1, 3-butadieno.

公开(公告)号：AU2012321079A1

公开(公告)日：2013-05-30

申请号：AU2012321079

申请日：2012-11-12

Applicant: GENOMATICA INC

Inventor： BURGARD ANTHONY P ,  BURK MARK J ,  OSTERHOUT ROBIN E ,  PHARKYA PRITI ,  LI JINGYL

IPC: C12N15/00

Abstract: Provided herein are non-naturally occurring eukaryotic organisms that can be engineered to produce and increase the availability of cytosolic acetyl-CoA. Also provided herein are non naturally occurring eukaryotic organisms having a 1,3-butanediol (1,3-BDO) pathway. and methods of using such organisms to produce 1,3-BDO. -415 12956-227-228/871943 -22 8227

公开(公告)号：AU2012273005A1

公开(公告)日：2013-05-09

申请号：AU2012273005

申请日：2012-06-20

Applicant: GENOMATICA INC

Inventor： BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  SUN JUN ,  PHARKYA PRITI

IPC: C12P5/02 ,  C12N1/00 ,  C12N15/74

Abstract: The invention provides a non-naturally occurring microbial organism having a microbial organism having at least one exogenous gene insertion and/or one or more gene disruptions that confer production of primary alcohols and at least one exogenous nucleic acid that encodes an enzyme that increases the yields of the primary alcohol by (i) enhancing carbon fixation via the reductive TCA cycle, and/or (ii) accessing additional reducing equivalents from gaseous carbon sources and/or syngas components such as CO, C02, and/or H2. A method for producing long chain alcohols includes culturing these non-naturally occurring microbial organisms.

公开(公告)号：AU2013203175A1

公开(公告)日：2013-05-02

申请号：AU2013203175

申请日：2013-04-09

Applicant: GENOMATICA INC

Inventor： BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  SUN JUN ,  PHARKYA PRITI

公开(公告)号：AU2012304428A1

公开(公告)日：2013-05-02

申请号：AU2012304428

申请日：2012-09-07

Applicant: GENOMATICA INC

Inventor： BURGARD ANTHONY P ,  BURK MARK J ,  OSTERHOUT ROBIN E ,  PHARKYA PRITI ,  LI JINGYI

IPC: C12P7/04 ,  C12P1/00

Abstract: Provided herein are non-naturally occurring eukaryotic organisms that can be engineered to produce and increase the availability of cytosolic acetyl-CoA. Also provided herein are non-naturally occurring eukaryotic organisms having a 1,3-butanediol (1,3-BDO) pathway, and methods of using such organisms to produce 1,3-BDO.

公开(公告)号：AU2012273093A1

公开(公告)日：2013-05-02

申请号：AU2012273093

申请日：2012-06-20

Applicant: GENOMATICA INC

Inventor： BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  SUN JUN ,  PHARKYA PRITI

IPC: C12P7/04 ,  C12N1/21

Abstract: The invention provides a non-naturally occurring microbial organism having an adipate, a 6-aminocaproic acid, caprolactam, or hexametheylenediamine pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid, caprolactam or hexametheylenediamine pathway and at least one exogenous nucleic acid that encodes an enzyme that increases the yields of adipate, 6-aminocaproic acid, caprolactam or hexametheylenediamine by (i) enhancing carbon fixation via the reductive TCA cycle, and/or (ii) accessing additional reducing equivalents from gaseous carbon sources and/or syngas components such as CO, C02, and/or H2. The invention additionally provides a method for producing adipate, 6-aminocaproic acid, caprolactam or hexametheylenediamine. The method can include culturing an adipate, 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism described herein under conditions and for a sufficient period of time to produce adipate, 6-aminocaproic acid, caprolactam or hexametheylenediamine.

公开(公告)号：AU2012273082A1

公开(公告)日：2013-05-02

申请号：AU2012273082

申请日：2012-06-20

Applicant: GENOMATICA INC

Inventor： BURK MARK J ,  BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  SUN JUN ,  PHARKYA PRITI

IPC: C07C29/00 ,  C12N1/00 ,  C12N1/20 ,  C12P7/16

Abstract: The invention provides non-naturally occurring microbial organisms having a butadiene or crotyl alcohol pathway. The invention additionally provides methods of using such organisms to produce butadiene or crotyl alcohol.

公开(公告)号：AU2011286199A1

公开(公告)日：2013-02-14

申请号：AU2011286199

申请日：2011-07-26

Applicant: GENOMATICA INC

Inventor： OSTERHOUT ROBIN E ,  BURGARD ANTHONY P ,  PHARKYA PRITI ,  BURK MARK J

IPC: C12P5/00 ,  C12P5/02 ,  C12P7/40

Abstract: The invention provides non-naturally occurring microbial organisms having a toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-lol or 1,3-butadiene pathway. The invention additionally provides methods of using such organisms to produce toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4- oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4- pentadienoate, 3-butene-lol or 1,3-butadiene.

公开(公告)号：CA2831885A1

公开(公告)日：2012-10-04

申请号：CA2831885

申请日：2012-03-30

Applicant: GENOMATICA INC

Inventor： BURK MARK J ,  BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  SUN JUN ,  PHARKYA PRITI

IPC: C12P7/40 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N15/52 ,  C12N15/53 ,  C12N15/54 ,  C12N15/60 ,  C12N15/61 ,  C12P7/62

Abstract: The invention provides a non-naturally occurring microbial organism having a methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a methacrylic acid pathway. The invention additionally provides a method for producing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2- hydroxyisobutyrate. The method can include culturing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a methacrylic acid pathway enzyme in a sufficient amount to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate, under conditions and for a sufficient period of time to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate.