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    CARDIAC VULNERABILITY TRACKING BY T-WAVE ALTERONS ANALYSIS
    31.
    发明申请
    CARDIAC VULNERABILITY TRACKING BY T-WAVE ALTERONS ANALYSIS 审中-公开
    通过T波形异常分析的心脏易感性跟踪

    公开(公告)号：WO1992014401A1

    公开(公告)日：1992-09-03

    申请号：PCT/US1992001053

    申请日：1992-02-12

    Applicant: GEORGETOWN UNIVERSITY

    Inventor： GEORGETOWN UNIVERSITY ,  VERRIER, Richard, L. ,  NEARING, Bruce, D.

    IPC: A61B05/0452

    CPC classification number: A61B5/4035 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/046

    Abstract: A method for dynamic tracking of cardiac vulnerability to ventricular fibrillation is disclosed. A heart is monitored to sense an ECG signal (202) which is amplified (206) and low-pass filtered (208) before it is digitally sampled (210) and stored (212). The location of the T-wave in each R-R interval of the ECG is estimated and each T-wave is partitioned into a plurality of time divisions. The sampled ECG signal in each of the time divisions is summed together and a time series is formed for each of the time divisions such that each time series includes corresponding sums from corresponding time divisions from successive T-waves. Each time series is detrended in order to eliminate the effects of drift and DC bias, and then a method of dynamic estimation is performed on each time series to estimate the amplitude of alternation for each time division (214).

    Abstract translation: 公开了一种用于动态跟踪心脏纤维颤动的易感性的方法。 监测心脏以感测在其被数字采样（210）并存储（212）之前被放大（206）和低通滤波（208）的ECG信号（202）。 在ECG的每个R-R间隔中估计T波的位置，并将每个T波分割成多个时分。 每个时分的采样ECG信号被加在一起，并且为每个时分形成时间序列，使得每个时间序列包括来自相继T波的相应时间分段的对应和。 为了消除漂移和直流偏压的影响，每个时间序列被去激活，然后对每个时间序列执行动态估计的方法以估计每个时间分割的交替幅度（214）。

    A PEPTIDE WHICH REGULATES WEIGHT GAIN IN MAMMALS
    32.
    发明申请
    A PEPTIDE WHICH REGULATES WEIGHT GAIN IN MAMMALS 审中-公开
    一种调节肥胖体重的蛋白质

    公开(公告)号：WO1992009296A1

    公开(公告)日：1992-06-11

    申请号：PCT/US1991008497

    申请日：1991-11-20

    Applicant: GEORGETOWN UNIVERSITY

    Inventor： GEORGETOWN UNIVERSITY ,  FLEMING, Patrick, J. ,  KENT, Ute, M.

    IPC: A61K37/00

    CPC classification number: C07K16/18 ,  A61K38/00 ,  C07K7/08 ,  C07K14/80 ,  Y10S514/909 ,  Y10S514/91

    Abstract: A peptide for regulating weight gain in mammals having formula: alpha beta gamma delta epsilon eta theta lambda mu pi rho sigma , wherein at least six of the amino acid residues are as defined and in the sequential positions specified in the sequence: CHHRKKGYADLY, wherein C is cysteine, H is histidine, R is arginine, K is lysine, G is glycine, Y is tyrosine, A is alanine, D is aspartic acid, and L is leucine; and the remaining amino acids are each independently glycine, alanine, valine, leucine, isoleucine, serine, threonine, cysteine, methionine, aspartic acid, glutamic acid, asparagine, glutamine, lysine, hydroxy lysine, histidine, arginine, phenylalanine, tyrosine, tryptophan, proline or hydroxyproline.

    Abstract translation: 一种用于调节哺乳动物体重增加的肽，其具有式：αβγδεδλλλlambda ho igma igma，其中至少六个氨基酸残基如下定义并且在序列中指定的顺序位置：CHHRKKGYADLY，其中C 是半胱氨酸，H是组氨酸，R是精氨酸，K是赖氨酸，G是甘氨酸，Y是酪氨酸，A是丙氨酸，D是天冬氨酸，L是亮氨酸; 剩余的氨基酸各自独立地为甘氨酸，丙氨酸，缬氨酸，亮氨酸，异亮氨酸，丝氨酸，苏氨酸，半胱氨酸，甲硫氨酸，天冬氨酸，谷氨酸，天冬酰胺，谷氨酰胺，赖氨酸，羟基赖氨酸，组氨酸，精氨酸，苯丙氨酸，酪氨酸，色氨酸 ，脯氨酸或羟脯氨酸。

    PLATINUM PHARMACEUTICALS
    34.
    发明申请
    PLATINUM PHARMACEUTICALS 审中-公开
    白蛋白药物

    公开(公告)号：WO1989000574A1

    公开(公告)日：1989-01-26

    申请号：PCT/US1988002353

    申请日：1988-07-18

    Applicant: GEORGETOWN UNIVERSITY

    Inventor： GEORGETOWN UNIVERSITY ,  TALEBIAN, Abdolhossen ,  GREEN, Diana, C. ,  HAMMER, Charles, F. ,  SCHEIN, Philip, S.

    IPC: C07H11/00

    CPC classification number: C07H23/00 ,  C07F15/0093

    Abstract: Platinum compounds useful in the treatment of cancer are disclosed. Compositions containing these compounds and methods of using the same are also discussed. Platinum compounds of formula (I) and (II) and (III) are disclosed. Compositions containing these compounds and methods of using the same are also discussed.

    Abstract translation: 公开了可用于治疗癌症的铂化合物。 还讨论了含有这些化合物的组合物及其使用方法。 公开了式（I）和（II）和（III）的铂化合物。 还讨论了含有这些化合物的组合物及其使用方法。

    1a-7-SUBSTITUTED DERIVATIVES OF MITOMYCIN AND USES THEREOF
    35.
    发明申请
    1a-7-SUBSTITUTED DERIVATIVES OF MITOMYCIN AND USES THEREOF 审中-公开
    咪唑啉的1a-7-取代衍生物及其用途

    公开(公告)号：WO1986007260A1

    公开(公告)日：1986-12-18

    申请号：PCT/US1986001203

    申请日：1986-06-02

    Applicant: GEORGETOWN UNIVERSITY

    Inventor： GEORGETOWN UNIVERSITY ,  McPHERSON, Eugene ,  SCHEIN, Philip, S.

    IPC: A61K31/70

    CPC classification number: C07H15/26 ,  Y10S514/908

    Abstract: 1a- and 7-substituted derivatives of mitosanes containing thiocarbamoyl and glycosyl residues. The compounds possess antibacterial and antitumor activity, with a concomitant reduction in bone marrow toxicity as compared to the parent compounds.

    Abstract translation: 含有硫代氨基甲酰基和糖基残基的线粒体的1a-和7-取代衍生物。 与母体化合物相比，该化合物具有抗细菌和抗肿瘤活性，伴随着骨髓毒性的降低。

    TYPE-SPECIFIC PAPILLOMAVIRUS DNA SEQUENCES AND PEPTIDES
    36.
    发明申请
    TYPE-SPECIFIC PAPILLOMAVIRUS DNA SEQUENCES AND PEPTIDES 审中-公开

    公开(公告)号：WO1986005816A1

    公开(公告)日：1986-10-09

    申请号：PCT/US1986000629

    申请日：1986-03-28

    Applicant: GEORGETOWN UNIVERSITY

    Inventor： GEORGETOWN UNIVERSITY ,  LANCASTER, Wayne, D. ,  JENSON, Bennett, A.

    IPC: C12Q01/68

    CPC classification number: C07K14/005 ,  A61K39/00 ,  C12N2710/20022 ,  C12Q1/708 ,  Y10S436/811

    Abstract: The polynucleotide sequence fragment conferring immunologic specificity to papillomavirus (PV) has been located and isolated. From this information, assays for type-specific PV, including DNA probes, RNA probes, immunoassays and the like are produced. The vaccines against specific PVs may be produced also. Further, the genus-specific amino acid sequence of the L1 capsid protein has been identified.

    Abstract translation: 赋予乳头瘤病毒（PV）免疫特异性的多核苷酸序列片段已被定位和分离。 根据该信息，产生类型特异性PV的测定，包括DNA探针，RNA探针，免疫测定等。 针对特定PV的疫苗也可以生产。 此外，已经鉴定了L1衣壳蛋白的属特异性氨基酸序列。

    TUMOR- OR CELL-SPECIFIC HERPES SIMPLEX VIRUS REPLICATION
    38.
    发明申请
    TUMOR- OR CELL-SPECIFIC HERPES SIMPLEX VIRUS REPLICATION 审中-公开
    肿瘤或细胞特异性纯化复制病毒复制

    公开(公告)号：WO1996039841A1

    公开(公告)日：1996-12-19

    申请号：PCT/US1996008621

    申请日：1996-06-06

    Applicant: GEORGETOWN UNIVERSITY

    Inventor： GEORGETOWN UNIVERSITY ,  MARTUZA, Robert, L. ,  RABKIN, Samuel, D. ,  MIYATAKE, Shin-ichi

    IPC: A01N63/00

    CPC classification number: C12N15/86 ,  A01K67/0271 ,  A01K2217/05 ,  A01K2217/30 ,  A01K2227/10 ,  A01K2267/03 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/525 ,  A61K2121/00 ,  C07K14/005 ,  C12N15/8509 ,  C12N2710/16622 ,  C12N2710/16643 ,  C12N2830/008

    Abstract: A method for killing tumor cells in vivo entails providing replication competent herpes simplex virus vectors to tumor cells. A replication competent herpes simplex virus vector, with an essential herpes simplex virus gene which is driven by a tumor-specific or cell-specific promoter that specifically destroys tumor cells and is not neurovirulent. Also, a method for producing an animal model, by ablating a specific cell type in vivo, entails providing replication competent herpes simplex virus vectors to the animal. Such a vector, with an essential herpes simplex virus gene driven by a cell- or tissue-specific promoter, specifically destroys the target cell type. This method of viral-mediated gene therapy employs cell-specific viral replication, where viral replication and associated cytotoxicity are limited to a specific cell-type by the regulated expression of an essential immediate-early (IE) viral gene product.

    Abstract translation: 在体内杀死肿瘤细胞的方法需要向肿瘤细胞提供可复制的单纯疱疹病毒载体。 具有复制能力的单纯疱疹病毒载体，其具有由特异性破坏肿瘤细胞而不是神经毒性的肿瘤特异性启动子驱动的必需单纯疱疹病毒基因。 此外，通过在体内烧蚀特定细胞类型来产生动物模型的方法需要向动物提供可复制的单纯疱疹病毒载体。 具有由细胞或组织特异性启动子驱动的必需单纯疱疹病毒基因的这种载体特异性地破坏靶细胞类型。 这种病毒介导的基因治疗方法采用细胞特异性病毒复制，其中病毒复制和相关的细胞毒性通过必需的立即早期（IE）病毒基因产物的调节表达而限于特定的细胞类型。

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