公开(公告)号：CZ9703258A3

公开(公告)日：1998-03-18

申请号：CZ325897

申请日：1996-04-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61K9/12 ,  A61K31/56 ,  A61K31/569 ,  A61M15/00 ,  A61M15/08 ,  A61M16/00 ,  A61P11/00 ,  B05D5/00 ,  B05D5/08 ,  B65D83/14

CPC classification number: B65D83/54 ,  A61M15/009 ,  A61M2205/0222

公开(公告)号：TR9701170T1

公开(公告)日：1998-02-21

申请号：TR9701170

申请日：1996-04-11

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL THOMAS

IPC: B65D83/38 ,  A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/00 ,  B05D5/08 ,  B65D83/14

CPC classification number: A61K9/008 ,  A61K31/573 ,  A61M15/009 ,  A61M2205/0222 ,  B65D83/54 ,  B65D83/752

公开(公告)号：NO974738L

公开(公告)日：1997-12-11

申请号：NO974738

申请日：1997-10-13

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: B65D83/38 ,  A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/00 ,  B05D5/08 ,  B65D83/14

Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone dipropionate or a physiologically acceptable solvate thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients.

公开(公告)号：NO974735A

公开(公告)日：1997-12-11

申请号：NO974735

申请日：1997-10-13

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61K9/12 ,  A61M15/00 ,  A61K31/56 ,  A61K31/569 ,  A61M15/08 ,  A61M16/00 ,  A61P11/00 ,  B05D5/00 ,  B05D5/08 ,  B65D83/14

CPC classification number: B65D83/54 ,  A61M15/009 ,  A61M2205/0222

公开(公告)号：NO974736D0

公开(公告)日：1997-10-13

申请号：NO974736

申请日：1997-10-13

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61M15/00 ,  B05D5/08 ,  B65D83/00 ,  B65D83/14 ,  A61M

Abstract: A metered dose inhaler characterised in that part or all of its internal surfaces are coated with a polymer blend of one or more fluorocarbon polymers in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising salmeterol, or a physiologically acceptable salt thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients, wherein a) the fluorocarbon polymer is selected from the group consisting of PTFE, PFA, FEP and mixtures thereof, b) the non-fluorocarbon polymer is selected from the group consisting of polyamideimides, polyimides, polyethersulfones, polyphenylene sulfides and amine-formaldehyde thermosetting resins, (c) the inhaler comprises a can made of metal whose interior surfaces are coated with the polymer blend.

公开(公告)号：NO974735D0

公开(公告)日：1997-10-13

申请号：NO974735

申请日：1997-10-13

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61K9/12 ,  A61K31/56 ,  A61K31/569 ,  A61M15/00 ,  A61M15/08 ,  A61M16/00 ,  A61P11/00 ,  B05D5/00 ,  B05D5/08 ,  B65D83/14 ,  A61M

Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising fluticasone propionate, or a physiologically acceptable solvate thereof, and a fluorocarbon propellant optionally in combination with one or more other pharmacologically active agents or one or more excipients.

公开(公告)号：SK39397A3

公开(公告)日：1997-10-08

申请号：SK39397

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH A

IPC: A61K9/00 ,  A61K9/72 ,  A61K9/12 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group. Said aerosol formulation is suitable for administration into the lungs or nasal cavity of a patient.

公开(公告)号：CZ9700936A3

公开(公告)日：1997-08-13

申请号：CZ93697

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/12 ,  A61K9/00 ,  A61K9/72 ,  A61K47/06 ,  B01F17/20 ,  C07F9/09 ,  C07F9/10

CPC classification number: A61K9/008 ,  C07F9/10 ,  Y10S514/975

公开(公告)号：IS4438A

公开(公告)日：1997-03-10

申请号：IS4438

申请日：1997-03-10

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/00 ,  A61K9/72 ,  A61K9/12 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

公开(公告)号：AU3532195A

公开(公告)日：1996-04-19

申请号：AU3532195

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/12 ,  A61K9/00 ,  A61K9/72 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10

Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.