公开(公告)号：AU704649B2

公开(公告)日：1999-04-29

申请号：AU6056396

申请日：1996-07-17

Applicant: HOECHST AG

Inventor： WEICHERT ANDREAS ,  BRENDEL JOACHIM ,  KLEEMANN HEINZ-WERNER ,  LANG HANS JOCHEN ,  SCHWARK JAN-ROBERT ,  SCHOLZ WOLFGANG ,  ALBUS UDO

IPC: A61K49/00 ,  A01N1/02 ,  A61K31/155 ,  A61K31/165 ,  A61K31/18 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P41/00 ,  C07C303/40 ,  C07C311/16 ,  C07C315/04 ,  C07C317/44 ,  C07C317/50 ,  A61K31/195

Abstract: Benzoyl-guanidine derivs. of formula (I) and their salts are new: R1 = R4-SOm, R5R6N-SO2-, -Op-(CH2)q-(CF2)r-CF3, -SR10, -OR10 or -CR10R11R12; m = 1-2; R4, R5 = 1-8C alkyl, 3-6C alkenyl, CF3 or -CnH2n-R7; n = 0-4; R6 = H or 1-4C alkyl; R7 = 3-8C cycloalkyl or Ph (opt. substd. with 1-3 substits. from F, Cl, CF3, Me, OMe and NR8R9; R8, R9 = H or 1-4C alkyl; R5 = H; or R5 + R6 = 4-5C methylene group (with opt. replacement of a CH2 by O, S, NH, NMe or N-benzyl; ; p = 0-1; q = 0-2; r = 0-3;R10, R11, R12 = H, 1-8C alkyl, CsH2s-(3-8C cycloalkyl) or an aromatic gp. chosen from pyridyl, pyrrolyl, quinolyl, isoquinolyl, imidazolyl or Ph (in which the aromatic system may be opt. 1-3 times substd. by F, Cl, CF3, Me, OMe, OH, NH2, NHMe or N(Me)2; s = 0-2; R2 = -(CH2)u-(CF2)t-CF3; t = 0-3; u = 0-1; R3 = H or as for R1.

公开(公告)号：AU704461B2

公开(公告)日：1999-04-22

申请号：AU6066896

申请日：1996-07-24

Applicant: HOECHST AG

Inventor： SCHWARK JAN-ROBERT ,  BRENDEL JOACHIM ,  KLEEMANN HEINZ-WERNER ,  LANG HANS JOCHEN ,  WEICHERT ANDREAS ,  ALBUS UDO ,  SCHOLZ WOLFGANG

IPC: C07C279/20 ,  A01N1/02 ,  A61K31/155 ,  A61K31/16 ,  A61K31/275 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4418 ,  A61P3/08 ,  A61P3/10 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  C07C277/08 ,  C07C279/22 ,  C07C323/62 ,  C07D213/65 ,  C07D213/70 ,  C07D213/63

Abstract: Substd. cinnamic acid guanidides of formula (I) and their salts are new: at least one of R1-R5 = XaYbLnU; X = CR16R17, O, S or NR18; a = 0-1; Y = 1-8C alkenyl, 1-8C alkenyl-T, 1-8C alkenyl-T2; T = NR20, O, S or phenyl (opt. substd. by 1-3 F, Cl, CF3, CH3, OCH3 or NR21R22); b = 0-1; L = O, S, NR23 or CkH2k; k = 1-8; n = 0-1; U = NR24R25 or 1-9C N-heterocycle with a N- or C- bridge and opt. substd. by 1-3 F, Cl, CF3, CH3, OCH3 or NR27R28; R24, R 25 = H, 1-8C alkyl or 1-8C perfluoroalkyl; or R24+R25 = (CH2)x with one CH2 opt. replaced by O, S, NH, NMe or N-benzyl; the remaining R1-R5 = H, F, Cl, Br, I, CN, OnCmH2m+1, Op(CH2)sCqF2q+1 or CrH2rR10; m = 0-8; p = 0-1; q = 1-8; s, r = 0-4; R10 = 3-8C cycloalkyl or phenyl opt. substd. by 1-3 F, Cl, CF3, CH3, OCH3 or NR11R12; R6, R7 = H, F, Cl, Br, I, CN, 1-8C alkyl, 1-8C perfluoroalkyl, 3-8C cycloalkyl, phenyl substd. by 1-3 F, Cl, CF3, CH3, OCH3 or NR14R15; and R11, R12, R14-R18, R20-R23, R27 and R28 = H, 1-4C alkyl or 1-4C perfluoroalkyl.

公开(公告)号：AU703352B2

公开(公告)日：1999-03-25

申请号：AU7180496

申请日：1996-11-18

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER ,  BRENDEL JOACHIM ,  SCHWARK JAN-ROBERT ,  WEICHERT ANDREAS ,  LANG HANS JOCHEN ,  ALBUS UDO ,  SCHOLZ WOLFGANG

IPC: A61K31/165 ,  A61P1/16 ,  A61P3/08 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00 ,  C07C279/20 ,  C07C279/22 ,  A01N1/02 ,  A61K31/135

Abstract: Benzenedicarboxylic acid diguanidide compounds of formula (I) and their salts are new. One of R1-R4 = -CO-N=C(NH2)2; and the others are as follows; R1 = H, 1-4C alkyl, F, Cl, OR32, NR33R34 or CF3; R2, R4 = H, halo, OH, CN, CF3, 1-8C alkyl, 2-8C alkenyl, (CH2)mR14, 1-, 2- or 3-pyrrolyl (optionally substituted by 1-4 of halo, CN, 2-8C alkanoyl, 2-8C alkoxycarbonyl, CHO, COOH, CF3, Me and OMe), SO2R22, CONH2, CONHMe, CONMe2, COR28, SO2NH2, SO2NHMe, SO2NMe2, OR35 or NR35R36; R3 = H, SR25, OR25, NR25R26 or CR25R26R27; R5 =1-4C alkyl, halo, (CH2)yCF3, O(CH2)yCF3, or phenyl (optionally substituted by 1-3 of F, Cl, CF3, Me, OMe, NH2, NHMe and NMe2); R32-R34 = H or 1-4C alkyl; m, y = 0-2; R14 = phenyl (optionally substituted by 1-3 of F, Cl, CF3, Me, OMe, NH2, NHMe or NMe2) or 3-8C cycloalkyl; R22, R28 = Me or CF3; R23, R24, R29, R30 = H or Me; R35, R36 = H or 1-6C alkyl; or R35+R36 = 4-7 (CH2)(4-7) optionally with one CH2 replaced by O, S, NH, NMe or N-benzyl; R25 = H, 1- 8C alkyl, phenyl (optionally substituted by 1-3 of F, Cl, CF3, Me, OMe, OH, NH2, NHMe and NMe2) or 1-9C heteroaryl (optionally substituted by 1-3 of F, Cl, CF3, Me, OMe, OH, NH2, NHMe and NMe2); R26, R27 = groups as defined for R25, or H, 1-8C alkyl (sic).

公开(公告)号：HU9800745A2

公开(公告)日：1998-12-28

申请号：HU9800745

申请日：1998-04-01

Applicant: HOECHST AG

Inventor： ALBUS UDO ,  BRENDEL JOACHIM ,  KLEEMANN HEINZ-WERNER ,  LANG HANS JOCHEN ,  SCHOLZ WOLFGANG ,  SCHWARK JAN-ROBERT ,  WEICHERT ANDREAS

IPC: A61K31/155 ,  A61K31/165 ,  A61P3/06 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00 ,  C07C279/10 ,  C07C279/20 ,  C07C279/22

Abstract: Benzoyl-guanidines of formula (I) and their salts are new. One of R2,R3 = H; and the other = -C(OH)MeCH2OH, -CHMeCH2OH or -C(OH)(Me)2; and R4 = Me, OMe, Cl or CF3 (preferably Me).

公开(公告)号：HU9700903A2

公开(公告)日：1998-12-28

申请号：HU9700903

申请日：1997-05-15

Applicant: HOECHST AG

Inventor： BOHN HELMUT ,  BRENDEL JOACHIM ,  BUSCH ANDREAS ,  ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  GREGER RAINER ,  GOEGELEIN HEINZ ,  HERLING ANDREAS ,  HROPOT MAX ,  LANG HANS JOCHEN

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/44 ,  A61K31/443 ,  A61P1/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/06 ,  C07D311/68 ,  C07D311/70 ,  C07D311/72 ,  C07D311/96 ,  C07D405/12 ,  A61K31/40

公开(公告)号：PL327693A1

公开(公告)日：1998-12-21

申请号：PL32769396

申请日：1996-12-13

Applicant: HOECHST AG

Inventor： WIRTH KLAUS ,  SCHOLZ WOLFGANG ,  JANSEN HANS-WILLI ,  LANG HANS JOCHEN ,  BRENDEL JOACHIM ,  KLEEMANN HEINZ-WERNER ,  SCHWARK JAN-ROBERT ,  WEICHERT ANDREAS

IPC: A61K31/00 ,  A61K31/155 ,  A61K31/165 ,  A61K31/166 ,  A61K31/425

Abstract: The active ingredients identified as NHE inhibitors are particularly suitable for the preparation of a drug for respiratory stimulation. They are particularly good for treating sleep apnea or other respiratory disorders.

公开(公告)号：MX9801516A

公开(公告)日：1998-11-30

申请号：MX9801516

申请日：1998-02-25

Applicant: HOECHST AG

Inventor： BRENDEL JOACHIM ,  LANG HANS JOCHEN ,  GERLACH UWE

IPC: C07D239/24 ,  A61K31/18 ,  A61K31/335 ,  A61K31/38 ,  A61K31/39 ,  A61K31/495 ,  A61P1/00 ,  A61P9/00 ,  C07C311/07 ,  C07D239/70 ,  C07D313/08 ,  C07D321/02 ,  C07D321/06 ,  C07C309/19

Abstract: La presente invencion se refiere a compuestos de la formula I en donde X1, X2, X3, X4, Y1, Y2, Y3, Y4, R(3), R(4), y R(5) tienen los significados indicados en las reivindicaciones, a su preparacion y a su empleo, en particular en medicamentos. Los compuestos influyen sobre el canal de potasio o el canal de Iks abierto por adenosina monofosfato cíclico (AMPc) y se adecuan de manera extraordinaria como principios activos medicamentosos, por ejemplo para la profilaxis y terapia de enfermedades circulatorias del corazon, en particular de arritmias, para el tratamiento de ulceras del tramo gastrointestinal o para el tratamiento de enfermedades diarreícas.

公开(公告)号：MX9805141A

公开(公告)日：1998-10-31

申请号：MX9805141

申请日：1998-06-24

Applicant: HOECHST AG

Inventor： WIRTH KLAUS ,  SCHOLZ WOLFGANG ,  JANSEN HANZ-WILLI ,  LANG HANS JOCHEN ,  BRENDEL JOACHIM ,  KLEEMANN HEINZ-WERNER ,  SCHWARK JAN-ROBERT ,  WIECHERT ANDREAS

IPC: A61K31/00 ,  A61K31/155 ,  A61K31/165 ,  A61K31/166 ,  A61K31/425 ,  A61K31/455 ,  A61K45/00 ,  A61K45/06

Abstract: Los compuestos activos identificadores como inhibidores de NHE son especialmente adecuados para la preparacion de un fármaco para estimular la respiracion. Son esencialmente adecuados para el tratamiento de la apnea del sueño o bien otros trastornos respiratorios.

公开(公告)号：ZA9802688B

公开(公告)日：1998-10-01

申请号：ZA9802688

申请日：1998-03-31

Applicant: HOECHST AG

Inventor： WEICHERT ANDREAS ,  BRENDEL JOACHIM ,  KLEEMANN HEINZ-WERNER ,  LANG HANS JOCHEN ,  SCHWARK JAN-ROBERT ,  ALBUS UDO ,  SCHOLZ WOLFGANG

IPC: A61K31/155 ,  A61K31/165 ,  A61P3/06 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00 ,  C07C279/10 ,  C07C279/20 ,  C07C279/22 ,  C07C ,  A01N ,  A61K

CPC classification number: C07C279/22

公开(公告)号：TR9800301A2

公开(公告)日：1998-09-21

申请号：TR9800301

申请日：1998-02-24

Applicant: HOECHST AG

Inventor： BRENDEL JOACHIM ,  LANG HANS JOCHEN ,  GERLACH UWE

IPC: C07D239/24 ,  A61K31/18 ,  A61K31/335 ,  A61K31/38 ,  A61K31/39 ,  A61K31/495 ,  A61P1/00 ,  A61P9/00 ,  C07C311/07 ,  C07D239/70 ,  C07D313/08 ,  C07D321/02 ,  C07D321/06 ,  C07D

CPC classification number: C07C311/07 ,  C07C2602/12 ,  C07D313/08