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公开(公告)号：JPH10182551A
公开(公告)日：1998-07-07
申请号：JP17517097
申请日：1997-06-17
Applicant: HOECHST AG
Inventor： HEMMERLE HORST DR , HENKE STEPHAN , BELOW PETER , BURGER HANS-JOERG , HERLING ANDREAS , JAEHNE GERHARD
IPC: C07D317/60 , A61K31/19 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/38 , A61K31/381 , A61K31/60 , A61P3/08 , A61P3/10 , C07C65/105 , C07C65/24 , C07C65/28 , C07C65/40 , C07C205/57 , C07C217/76 , C07C233/46 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/87 , C07C235/16 , C07C235/24 , C07C235/38 , C07C235/56 , C07C235/64 , C07C237/40 , C07C255/56 , C07C255/57 , C07C275/42 , C07C311/21 , C07C323/50 , C07D213/55 , C07D213/81 , C07D213/82 , C07D241/44 , C07D307/54 , C07D307/66 , C07D307/68 , C07D317/50 , C07D317/68 , C07D333/24 , C07D333/28 , C07D333/36 , C07D333/38 , C07D405/12 , C07D407/12 , C07D409/12
Abstract: PROBLEM TO BE SOLVED: To obtain the subject new compound especially useful for treating II type diabetes as a glucose-6-phosphatase system inhibitor. SOLUTION: A compound of formula I (R is a 1-10C alkyl, a 2-10C alkenul, an alkinyl, a 6-12C aryl, a 1-10C alkyl-(6-12C) aryl, etc.; R is a 1-10C alkyl, a 2-10C alkenyl, an alkinyl, a 1-9C heteroaryl, a 1-10C alkanoyl, etc.; R is H, a 1-10C alkyl, etc.,). The compound of formula I is obtained by producing a compound of formula III (R is phenyl, tolyl, alkyl, pyridyl) from 5-nitro-2- iodobenzoic acid of formula II as a starting substance through four processes and subsequently subjecting the compound of formula III to an alkaline hydrolysis reaction. The compound of formula I is contained as an active ingredient in a pharmaceutical preparation in an amount of 0.1-95wt.%, and administered at a daily dose of 10-500mg per 75kg of a body.
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公开(公告)号：CA2149007C
公开(公告)日：2005-07-26
申请号：CA2149007
申请日：1995-05-09
Applicant: HOECHST AG
Inventor： HEMMERLE HORST , SCHUBERT GERRIT , BURGER HANS-JORG , HERLING ANDREAS , EFENDIC SUAD
IPC: A61K31/435 , A61K31/4353 , A61K31/52 , A61P1/16 , A61P3/08 , A61P3/10 , A61P43/00 , C07D221/00 , C07D235/00 , C07D239/00 , C07D471/04
Abstract: Cyclohexane derivatives of the formula I (see formula I) wherein R2, R4 and R5 have the given meanings and a process for their preparation are described. The compounds have useful pharmacological properties and can therefore be used as pharmaceuticals.
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公开(公告)号：FI110097B
公开(公告)日：2002-11-29
申请号：FI952203
申请日：1995-05-08
Applicant: HOECHST AG
Inventor： HEMMERLE HORST , SCHUBERT GERRIT , BURGER HANS-JOERG , HERLING ANDREAS , EFENDIC SUAD
IPC: A61K31/435 , A61K31/4353 , A61K31/52 , A61P1/16 , A61P3/08 , A61P3/10 , A61P43/00 , C07D221/00 , C07D235/00 , C07D239/00 , C07D471/04 , A61K31/495
Abstract: Cyclohexane derivs. of formula (I), and their salts, are new. R = O-(3-5C)alkyl-R , in which the alkyl component is straight, branched or cyclic; R = phenyl (opt. 4-substd. by F, Cl or Me); and R , R = H or OH.
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公开(公告)号：HK1006708A1
公开(公告)日：1999-03-12
申请号：HK98105877
申请日：1998-06-22
Applicant: HOECHST AG
Inventor： HEMMERLE HORST , SCHINDLER PETER , HERLING ANDREAS
IPC: A61K31/185 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/28 , A61K31/357 , A61K31/37 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/433 , A61K31/435 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/47 , A61P3/08 , A61P3/10 , C07C59/205 , C07C59/80 , C07C62/10 , C07C69/65 , C07C69/708 , C07C69/732 , C07C69/734 , C07C69/738 , C07C69/74 , C07C69/75 , C07C69/753 , C07C69/757 , C07C69/76 , C07C235/40 , C07C235/54 , C07C255/31 , C07C309/02 , C07C309/64 , C07C311/02 , C07D207/16 , C07D209/18 , C07D209/42 , C07D213/02 , C07D213/55 , C07D213/79 , C07D215/48 , C07D215/54 , C07D233/54 , C07D235/06 , C07D235/08 , C07D239/26 , C07D239/34 , C07D257/04 , C07D285/06 , C07D307/85 , C07D311/06 , C07D317/72 , C07D333/02 , C07D333/16 , C07D333/24 , C07D333/28 , C07D333/38 , C07D333/68 , C07D493/04 , C07D493/10 , C07D495/00 , C07D495/04 , C07D495/14 , C07D521/00 , C07C , A61K , C07D
Abstract: Cyclohexane derivatives of the formula I in which the radicals R to R , X, Y and Z have the meanings indicated, and a process for the preparation of these compounds are described. The compounds have useful pharmacological properties and can therefore be used as medicaments.
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公开(公告)号：HK1006640A1
公开(公告)日：1999-03-12
申请号：HK98106052
申请日：1998-06-23
Applicant: HOECHST AG
Inventor： LANG HANS JOCHEN , GERLACH UWE U , BRENDEL JOACHIM , ENGLERT HEINRICH CHRISTIAN , GOEGELEIN HEINZ , HROPOT MAX , BOHN HELMUT , HERLING ANDREAS , BUSCH ANDREAS , GREGER RAINER
IPC: A61K31/35 , A61K31/352 , A61K31/353 , A61K31/44 , A61K31/443 , A61P1/00 , A61P1/04 , A61P9/00 , A61P9/06 , C07D311/68 , C07D311/70 , C07D311/72 , C07D311/96 , C07D405/12 , C07D , A61K , A61P
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Patent Agency Ranking
公开(公告)号：BR9703161A
公开(公告)日：1998-09-29
申请号：BR9703161
申请日：1997-05-14
Applicant: HOECHST AG
Inventor： GOEGELEIN HEINZ , ENGLERT HEINRICH CHRISTIAN , BRENDEL JOACHIM , BOHN HELMUT , HERLING ANDREAS , LANG HANS JOCHEN , BUSCH ANDREAS , GERLACH UWE , GREGER RAINER , HROPOT MAX
IPC: A61K31/35 , A61K31/352 , A61K31/353 , A61K31/44 , A61K31/443 , A61P1/00 , A61P1/04 , A61P9/00 , A61P9/06 , C07D311/68 , C07D311/70 , C07D311/72 , C07D311/96 , C07D405/12 , C07D311/02 , A61K31/63
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公开(公告)号：PL319995A1
公开(公告)日：1997-11-24
申请号：PL31999597
申请日：1997-05-15
Applicant: HOECHST AG
Inventor： LANG HANS JOCHEN , GERLACH UWE , BRENDEL JOACHIM , ENGLERT HEINRICH CHRISTIAN , GOEGELEIN HEINZ , HROPOT MAX , BOHN HELMUT , HERLING ANDREAS , BUSCH ANDREAS , GREGER RAINER
IPC: A61K31/35 , A61K31/352 , A61K31/353 , A61K31/44 , A61K31/443 , A61P1/00 , A61P1/04 , A61P9/00 , A61P9/06 , C07D311/68 , C07D311/70 , C07D311/72 , C07D311/96 , C07D405/12 , C07D311/22
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公开(公告)号：FI952203A
公开(公告)日：1995-11-11
申请号：FI952203
申请日：1995-05-08
Applicant: HOECHST AG
Inventor： HEMMERLE HORST , SCHUBERT GERRIT , BURGER HANS-JOERG , HERLING ANDREAS , EFENDIC SUAD
IPC: A61K31/435 , A61K31/4353 , A61K31/52 , A61P1/16 , A61P3/08 , A61P3/10 , A61P43/00 , C07D221/00 , C07D235/00 , C07D239/00 , C07D471/04
Abstract: Cyclohexane derivs. of formula (I), and their salts, are new. R = O-(3-5C)alkyl-R , in which the alkyl component is straight, branched or cyclic; R = phenyl (opt. 4-substd. by F, Cl or Me); and R , R = H or OH.
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9.发明专利
公开(公告)号：ZA951220B
公开(公告)日：1995-10-11
申请号：ZA951220
申请日：1995-02-15
Applicant: HOECHST AG
Inventor： HEMMERLE HORST , SCHUBERT GERRIT , BELOW PETER , HERLING ANDREAS , BURGER HANS-JOERG
IPC: C07D235/08 , A61K31/215 , A61K31/33 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61P3/08 , A61P3/10 , C07C65/36 , C07C69/02 , C07C233/08 , C07C233/90 , C07C255/50 , C07C311/01 , C07C311/02 , C07C311/50 , C07C327/20 , C07C327/38 , C07C327/56 , C07C329/04 , C07C329/14 , C07C333/02 , C07D233/02 , C07D235/04 , C07D235/06 , C07D277/22 , C07D403/08 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/12 , C07D491/10 , C07D491/113 , C07D493/10 , C07D , A61K , C07C
Abstract: Cyclohexanol esters of formula (I) and their salts are new: R = CONHCOR ; CSNHR ; CONHSO2R ;etc.; or a gp. of formula (i)-(viii): V, W = N or CH; U = O or S; E = NR ; O; S; or NH;with aromatic rings in R being opt. substd. by 1 or more F, Cl, Br, I, OH,etc.; and R = 1-10C alkyl, 1-10C alkoxy, 2-10C alkenyl,etc.; or R +R form a ring of formula (xxvi): R = 1-10C alkyl, 3-8C cycloalkyl, Ph,etc.;R , R = H; OH opt. protected by usual alcohol protecting gp.; F; Cl; Br; or R ;R = H; 1-10C alkyl,R ,etc.; R = Ph, naphthyl, phenanthryl, pyridyl,etc.; R = 3-10C alkenoyl opt. substd. by R ; R -substd. 1-10C alkanoyl; or R ; X = (CH2)m; -CH=CH-; -C IDENTICAL CH-;etc.;Y = (CH2)m; O,etc.; Z = (CH2)m; S; O; 1-10C alkylthio; 1-10C alkoxy; CH=CH;etc.; or, when Y = O, -C(O)-Z-R - can be Ala, Arg, Asn,etc., or Tyr opt. protected with usual protecting gps.; m = 0-4; and n = 0-2.
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10.发明专利
公开(公告)号：IL112655D0
公开(公告)日：1995-05-26
申请号：IL11265595
申请日：1995-02-15
Applicant: HOECHST AG
Inventor： HEMMERLE HORST , SCHUBERT GERRIT , BELOW PETER , HERLING ANDREAS , BURGER HANS-JOERG
IPC: C07D235/08 , A61K31/215 , A61K31/33 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61P3/08 , A61P3/10 , C07C65/36 , C07C69/02 , C07C233/08 , C07C233/90 , C07C255/50 , C07C311/01 , C07C311/02 , C07C311/50 , C07C327/20 , C07C327/38 , C07C327/56 , C07C329/04 , C07C329/14 , C07C333/02 , C07D233/02 , C07D235/04 , C07D235/06 , C07D277/22 , C07D403/08 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/12 , C07D491/10 , C07D491/113 , C07D493/10 , C07D
Abstract: Cyclohexanol esters of formula (I) and their salts are new: R = CONHCOR ; CSNHR ; CONHSO2R ;etc.; or a gp. of formula (i)-(viii): V, W = N or CH; U = O or S; E = NR ; O; S; or NH;with aromatic rings in R being opt. substd. by 1 or more F, Cl, Br, I, OH,etc.; and R = 1-10C alkyl, 1-10C alkoxy, 2-10C alkenyl,etc.; or R +R form a ring of formula (xxvi): R = 1-10C alkyl, 3-8C cycloalkyl, Ph,etc.;R , R = H; OH opt. protected by usual alcohol protecting gp.; F; Cl; Br; or R ;R = H; 1-10C alkyl,R ,etc.; R = Ph, naphthyl, phenanthryl, pyridyl,etc.; R = 3-10C alkenoyl opt. substd. by R ; R -substd. 1-10C alkanoyl; or R ; X = (CH2)m; -CH=CH-; -C IDENTICAL CH-;etc.;Y = (CH2)m; O,etc.; Z = (CH2)m; S; O; 1-10C alkylthio; 1-10C alkoxy; CH=CH;etc.; or, when Y = O, -C(O)-Z-R - can be Ala, Arg, Asn,etc., or Tyr opt. protected with usual protecting gps.; m = 0-4; and n = 0-2.
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