公开(公告)号：JPH10139775A

公开(公告)日：1998-05-26

申请号：JP31186597

申请日：1997-11-13

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  MANIA DIETER ,  LINZ WOLFGANG ,  GOEGELEIN HEINZ ,  KLAUS ERIK

IPC: C07D311/04 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/40 ,  A61K31/4025 ,  A61P9/00 ,  A61P9/06 ,  C07D207/26 ,  C07D209/34 ,  C07D211/76 ,  C07D217/24 ,  C07D227/02 ,  C07D311/16 ,  C07D311/18 ,  C07D311/42 ,  C07D311/58 ,  C07D311/70 ,  C07D405/12

Abstract: PROBLEM TO BE SOLVED: To produce the subject new compound, having amide group at the 3-position of the chroman system and useful for treatment of especially arrhythmia, prevention of sudden cardiac death and treatment and prevention, etc., of weakened cardiac forces in order to treat disorders in the cardiovascular system. SOLUTION: This is represented by formula I [R(3) is H or a 1-4C alkyl; R(1) is R(3), a 1-4C alkoxy, a halogen, etc.; R(2a) to R(2c) are each H or a 1-2C alkyl; Z is O or S; A is phenyl (substituted with 1 to 3 halogens, 1-2C alkyl groups or alkoxy groups), etc.] or its salt, e.g. 3-(5-chloro-2- methoxybenzamido)-6-(methylaminocarbonylaminosulfonyl)-7methoxychroman. The compound represented by formula I in which Z is O is obtained by reacting a compound represented by formula II with a compound represented by formula III in the presence of a base.

公开(公告)号：RU2195459C2

公开(公告)日：2002-12-27

申请号：RU97118653

申请日：1997-11-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  MANIA DIETER ,  LINZ WOLFGANG ,  GOEGELEIN HEINZ ,  KLAUS ERIK

IPC: C07D311/04 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/40 ,  A61K31/4025 ,  A61P9/00 ,  A61P9/06 ,  C07D207/26 ,  C07D209/34 ,  C07D211/76 ,  C07D217/24 ,  C07D227/02 ,  C07D311/16 ,  C07D311/18 ,  C07D311/42 ,  C07D311/58 ,  C07D311/70 ,  C07D405/12

Abstract: FIELD: organic chemistry, chemical technology, medicine, pharmacy. SUBSTANCE: invention relates to novel organic compounds, namely, to 3-amido-chromanylsulfonyl(thio)-ureas of the formula (I): where R(1) means hydrogen atom, alkyl with 1, 2, 3 or 4 carbon atoms, alkoxyl with 1, 2, 3 or 4 carbon atoms; R(2a), R(2b) and R(2c) are similar or distinct and mean hydrogen atom or alkyl with 1 or 2 carbon atoms; R(3) means hydrogen atom or alkyl with 1, 2, 3 or 4 carbon atoms; Z means sulfur or oxygen atom; A means unsubstituted phenyl or phenyl substituted with up to three similar or distinct substituted taken among group consisting of halogen atom, alkyl with 1 or 2 carbon atoms and alkoxyl with 1 or 2 carbon atoms; or A means residue of saturated or unsaturated lactam of the formula: where B means alkenylene or alkylene with 3, 4, 5 or 6 carbon atoms that is unsubstituted or substituted up to three similar or distinct alkyl groups with 1, 2, 3 or 4 carbon atoms; in all their stereoisomeric forms and as their mixtures taken in any ratios; and also their physiologically acceptable salts that are valuable medicinal active substances used for treatment of cardiovascular system disorders, especially for treatment of arrhythmia, for prevention of sudden heart stopping or for effect on decreased heart contractibility and also to method of their synthesis and pharmaceutical compositions containing thereof. EFFECT: synthesis of novel useful compounds, improved method of synthesis, valuable medicinal properties of compounds. 13 cl, 2 tbl, 23 ex

公开(公告)号：FI105182B

公开(公告)日：2000-06-30

申请号：FI904362

申请日：1990-09-04

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  LANG HANS-JOCHEN ,  LINZ WOLFGANG ,  SCHOELKENS BERNWARD ,  SCHOLZ WOLFGANG

IPC: C07C279/22 ,  A61K31/155 ,  A61K31/18 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/445 ,  A61K31/455 ,  A61K31/535 ,  A61K31/5375 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  C07C277/00 ,  C07C279/10 ,  C07C311/15 ,  C07C311/47 ,  C07C317/42 ,  C07C317/44 ,  C07C323/60 ,  C07C323/62 ,  C07C323/65 ,  C07C323/67 ,  C07D209/08 ,  C07D211/28 ,  C07D295/14 ,  C07D295/155 ,  C07D295/195 ,  C07D295/22 ,  C07D295/26 ,  C07C311/29 ,  C07C323/64

Abstract: Benzoylguanidines of the formula I (* CHEMICAL STRUCTURE *) (I) where R(1) or R(2) is equal to R(6)-S(O)n- or R(7)R(8)N-O2S- and the other substituent R(1) or R(2) is in each case equal to H, F, Cl, Br, I, alkyl, alkoxy or phenoxy, R(6)-S(O)n or R(7)R(8)N- and R(6) is equal to alkyl, cycloalkyl, cyclopentylmethyl, cyclohexylmethyl or phenyl, R(7) and R(8) are equal to alkyl or phenylalkyl or phenyl, and in which R(7) and R(8) may also together be a C4-C7 chain, and in which R(7) and R(8), together with the nitrogen atom to which they are bonded, may be a dihydroindole, tetrahydroquinoline or tetrahydroisoquinoline system, and where R(3), R(4) and R(5) are equal to hydrogen or alkyl, or R(3) and R(4) are together an alkylene chain or R(4) and R(4) are together an alkylene chain, and where n is equal to zero, 1 or 2 and their pharmaceutically tolerable salts are outstanding antiarrhythmics.

公开(公告)号：HK1011965A1

公开(公告)日：1999-07-23

申请号：HK98113240

申请日：1998-12-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  MANIA DIETER ,  GOGELEIN HEINZ ,  KAISER JOACHIM

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C311/59 ,  C07C327/40 ,  C07C335/42 ,  C07C ,  A61K

Abstract: Substd. benzene sulphonyl urea and thiourea derivs. of formula (I) and their salts are new. R1 = H, Me or CF3; R2 = 4-10C alkoxy with 1-6C replaced by O, S or NH; Q = O or S; Y = ÄC(R3)2Üm; R3 = H, Me or Et; R' = H, halo or 1-6C alkyl; R" = halo, 1-4C alkoxy or 1-4C alkyl; and m = 1-4.

公开(公告)号：HK1006640A1

公开(公告)日：1999-03-12

申请号：HK98106052

申请日：1998-06-23

Applicant: HOECHST AG

Inventor： LANG HANS JOCHEN ,  GERLACH UWE U ,  BRENDEL JOACHIM ,  ENGLERT HEINRICH CHRISTIAN ,  GOEGELEIN HEINZ ,  HROPOT MAX ,  BOHN HELMUT ,  HERLING ANDREAS ,  BUSCH ANDREAS ,  GREGER RAINER

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/44 ,  A61K31/443 ,  A61P1/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/06 ,  C07D311/68 ,  C07D311/70 ,  C07D311/72 ,  C07D311/96 ,  C07D405/12 ,  C07D ,  A61K ,  A61P

公开(公告)号：NZ329160A

公开(公告)日：1998-10-28

申请号：NZ32916097

申请日：1997-11-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  MANIA DIETER ,  LINZ WOLFGANG ,  GOEGELEIN HEINZ ,  KLAUS ERIK

IPC: C07D311/04 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/40 ,  A61K31/4025 ,  A61P9/00 ,  A61P9/06 ,  C07D207/26 ,  C07D209/34 ,  C07D211/76 ,  C07D217/24 ,  C07D227/02 ,  C07D311/16 ,  C07D311/18 ,  C07D311/42 ,  C07D311/58 ,  C07D311/70 ,  C07D405/12 ,  C07D311/68

Abstract: 3-Amido-chromanylsulphonyl-urea or -thiourea derivatives of formula (I), in all stereoisomer (or mixture) forms, and their salts are new. R1 = H, alkyl, alkoxy, alkoxyalkoxy, alkylthio, F, Cl, Br, I or CF3; R2 = H, Me or Et; R3 = H or alkyl; Z = O or S; A = phenyl (optionally substituted by 1-3 halo, Me, Et, OMe or OEt), lactam residue of formula (i), 1-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl, 1-oxo-perhydroisoquinolin-2-yl, 1-oxo-2,3-isoindolin-2-yl or 1-oxo-perhydroisoindolin-2-yl; B = 3-6C alkylene or 3-6C alkenylene (both optionally substituted by 1-3 alkyl); all alkyl moieties have 1-4C.

公开(公告)号：BR9703161A

公开(公告)日：1998-09-29

申请号：BR9703161

申请日：1997-05-14

Applicant: HOECHST AG

Inventor： GOEGELEIN HEINZ ,  ENGLERT HEINRICH CHRISTIAN ,  BRENDEL JOACHIM ,  BOHN HELMUT ,  HERLING ANDREAS ,  LANG HANS JOCHEN ,  BUSCH ANDREAS ,  GERLACH UWE ,  GREGER RAINER ,  HROPOT MAX

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/44 ,  A61K31/443 ,  A61P1/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/06 ,  C07D311/68 ,  C07D311/70 ,  C07D311/72 ,  C07D311/96 ,  C07D405/12 ,  C07D311/02 ,  A61K31/63

公开(公告)号：MX9708783A

公开(公告)日：1998-05-31

申请号：MX9708783

申请日：1997-11-14

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  MANIA DIETER ,  LINZ WOLFGANG ,  GOGELEIN HEINZ ,  KLAUS ERIK

IPC: C07D311/04 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/40 ,  A61K31/4025 ,  A61P9/00 ,  A61P9/06 ,  C07D207/26 ,  C07D209/34 ,  C07D211/76 ,  C07D217/24 ,  C07D227/02 ,  C07D311/16 ,  C07D311/18 ,  C07D311/42 ,  C07D311/58 ,  C07D311/70 ,  C07D405/12

Abstract: La presente invencion se refiere a 3-amido-cromanilsulfonil(tio) ureas de la formula I: que son valiosos principios activos medicamentos para el tratamiento de trastornos del sistema circulatorio del corazon, en particular para el tratamiento de arritmias, para evitar la muerte repentina por parálisis cardíaca o para influir en una contractilidad reducida del corazon, así como a procedimientos para su preparacion, a su empleo y a preparados farmacéuticos que las contienen.

公开(公告)号：PL322943A1

公开(公告)日：1998-05-25

申请号：PL32294397

申请日：1997-10-31

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  MANIA DIETER ,  LINZ WOLFGANG ,  GOEGELEIN HEINZ ,  KLAUS ERIK

IPC: C07D311/04 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/40 ,  A61K31/4025 ,  A61P9/00 ,  A61P9/06 ,  C07D207/26 ,  C07D209/34 ,  C07D211/76 ,  C07D217/24 ,  C07D227/02 ,  C07D311/16 ,  C07D311/18 ,  C07D311/42 ,  C07D311/58 ,  C07D311/70 ,  C07D405/12 ,  C07D407/12

Abstract: 3-Amido-chromanylsulphonyl-urea or -thiourea derivatives of formula (I), in all stereoisomer (or mixture) forms, and their salts are new. R1 = H, alkyl, alkoxy, alkoxyalkoxy, alkylthio, F, Cl, Br, I or CF3; R2 = H, Me or Et; R3 = H or alkyl; Z = O or S; A = phenyl (optionally substituted by 1-3 halo, Me, Et, OMe or OEt), lactam residue of formula (i), 1-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl, 1-oxo-perhydroisoquinolin-2-yl, 1-oxo-2,3-isoindolin-2-yl or 1-oxo-perhydroisoindolin-2-yl; B = 3-6C alkylene or 3-6C alkenylene (both optionally substituted by 1-3 alkyl); all alkyl moieties have 1-4C.

公开(公告)号：NO975214A

公开(公告)日：1998-05-15

申请号：NO975214

申请日：1997-11-13

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  MANIA DIETER ,  LINZ WOLFGANG ,  GAEGELEIN HEINZ ,  KLAUS ERIK

IPC: C07D311/04 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/40 ,  A61K31/4025 ,  A61P9/00 ,  A61P9/06 ,  C07D207/26 ,  C07D209/34 ,  C07D211/76 ,  C07D217/24 ,  C07D227/02 ,  C07D311/16 ,  C07D311/18 ,  C07D311/42 ,  C07D311/58 ,  C07D311/70 ,  C07D405/12 ,  C07D311/20

CPC classification number: C07D405/12 ,  C07D311/58 ,  C07D311/70