公开(公告)号：SE401090B

公开(公告)日：1978-04-24

申请号：SE7310961

申请日：1973-08-10

Applicant: HOECHST AG

Inventor： DUWEL D ,  DIERY H ,  CUNTZE U

IPC: A01N57/12 ,  C07F9/08 ,  C07F9/141 ,  A01N9/36 ,  A61L13/00

Abstract: 1446003 Phosphorous acid esters HOECHST AG 10 Aug 1973 [12 Aug 1972 14 April 1973] 37992/73 Heading C2P [Also in Division A5] Phosphorous acid esters having application as disinfectants or anthelmintics are of formula wherein R 1 is H or methyl; R 2 is H; R 3 , R 4 , R 5 , R 6 and R 8 are H or C 1 to C 4 alkyl; R, is C 8 to C 18 alkyl or alkenyl; n is 2 or 3; and m is 1 to 4; or of formula wherein R 1 and R 2 are methyl; R 3 and R 4 are H; and R 5 , R 6 and R 7 are as above. The phosphorous acid esters may be prepared by reacting a cyclic phosphite of formula with an amine of formula wherein R 1 and R 8 are as above and m is 0 to 4.

公开(公告)号：BR7601238A

公开(公告)日：1977-09-06

申请号：BR7601238

申请日：1976-02-26

Applicant: HOECHST AG

Inventor： LOEWE H ,  URBANIETZ J ,  DUWEL D ,  KIRSCH R

IPC: A61K31/415 ,  C07D235/30

公开(公告)号：SE7610311L

公开(公告)日：1977-03-20

申请号：SE7610311

申请日：1976-09-16

Applicant: HOECHST AG

Inventor： LOEWE H ,  URBANIETZ J ,  DUWEL D ,  KIRSCH R

IPC: C07D235/32 ,  C07D285/16

公开(公告)号：EG10942A

公开(公告)日：1976-11-30

申请号：EG10073

申请日：1973-03-15

Applicant: HOECHST AG

Inventor： FRANZ R ,  DUWEL D

IPC: A23K1/16 ,  A61K31/60 ,  C07C67/00 ,  C07C201/16 ,  C07C205/60 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/65 ,  C07C233/66 ,  C07C235/64 ,  A61K31/135

Abstract: Anthelminthically active salicylanilides of the formula IN WHICH X1 and X2 each represent hydrogen, chlorine, methyl or trifluoromethyl, Y1 and Y2 each represent hydrogen, chlorine or the nitrogroup, at least one of the substituents Y1 and Y2 not being hydrogen, and Z stands for -OH, -O-CO-alkyl or -O H3N -, are described as well as their preparation by reacting a correspondingly substituted salicylic acid chloride or salicylic acid phenyl ester with an aniline derivative carrying the appropriate substituents or by nitrating a corresponding salicylanilide. The salicylanilides of the above formula are used as active ingredients in pharmaceutical preparations having anthelmintic activity.

公开(公告)号：SE7510045A

公开(公告)日：1976-03-11

申请号：SE7510045

申请日：1975-09-09

Applicant: HOECHST AG

Inventor： LOEWE H ,  URBANIETZ J ,  DUWEL D ,  KIRSCH R

IPC: A61K31/4184 ,  C07D235/32 ,  C07D295/092

CPC classification number: C07D295/088 ,  C07D235/32

公开(公告)号：SE7509442L

公开(公告)日：1976-03-01

申请号：SE7509442

申请日：1975-08-25

Applicant: HOECHST AG

Inventor： LOEWE H ,  URBANIETZ J ,  DUWEL D ,  KIRSCH R

IPC: A61K31/415 ,  A61K31/4184 ,  A61P33/10 ,  C07D235/32

Abstract: 2-Carbalkoxyamino-5(6)-phenyl sulfonyloxy benzimidazoles are disclosed as well as a process for their manufacture. The new compounds are valuable chemotherapeutic agents and are suitable for combating diseases caused by parasites in humans and animals, such as helminths and liver flukes.

公开(公告)号：SE7412041L

公开(公告)日：1975-03-26

申请号：SE7412041

申请日：1974-09-25

Applicant: HOECHST AG

Inventor： DUWEL D ,  KIRSCH R ,  LOEWE H ,  URBANIETZ J

IPC: C07D235/32 ,  C07D49/38

Abstract: The invention describes novel 2-carbalkoxy-amino-benzimidazolyl-5(6)-amino-phenyl ether of the formula (I) wherein R1 is alkyl having 1 to 4 carbon atoms, R2, in each case independently from one another, represents hydrogen, alkyl having 1 to 4 carbon atoms, hydroxyl, alkoxy having 1 to 4 carbon atoms, halogen or trifluoromethyl, n represents the integers 0, 1 or 2 and X represents oxygen or sulfur, the salts of such compounds with physiologically tolerable salts and their preparation. These compounds are chemotherapeutics and act particularly against helminths in humans and animals.

公开(公告)号：SE373125B

公开(公告)日：1975-01-27

申请号：SE780870

申请日：1970-06-05

Applicant: HOECHST AG

Inventor： RUSCHIG H ,  DUWEL D ,  KONIG J

IPC: A23K1/16 ,  A61K31/165 ,  A61K31/22 ,  A61K31/245 ,  A61P33/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C235/56 ,  C07C235/64 ,  C07D307/68 ,  F23Q7/02 ,  F24C5/14 ,  C07C103/76

Abstract: 1280407 Diacyloxy-benzoic acid anilides FARBWERKE HOECHST AG 9 June 1970 [9 June 1969] 27829/70 Heading C2C Novel compounds of Formula I (in which X is H or halogen; R 1 is 1 to 3 substituents selected from NO 2 , CF 3 and halogen; and R 2 is H; C 1-6 alkyl which may be substituted by one or more halogen atoms or a C 1-6 alkoxy or phenyl group; C 2-5 alkenyl; C 4-6 cycloalkyl; phenyl; an unsaturated 5- or 6- membered heterocyclic ring; C 1-4 alkylamino; di - (C 1-4 alkyl)amino ; pyrrolidino; piperidino ; morpholino; or 4-methylpiperazino) are prepared by acylating compounds of Formula II 5 - Iodo - 3 - nitro - 2,6 - dihydroxy - benzoic acid 4 1 -chloroanilide is prepared by reacting 3- nitro - 2,6 - dihydroxy - benzoic acid 4 1 - chloroanilide with iodine monochloride. Anthelmintic compositions for oral or parenteral administration, comprise a compound of Formula I together with a pharmaceutical carrier.

公开(公告)号：BG17763A3

公开(公告)日：1973-12-25

申请号：BG1485570

申请日：1970-06-04

Applicant: HOECHST AG

Inventor： RUSCHIG H ,  DUWEL D ,  KONIG J

IPC: A61K31/165 ,  A23K1/16 ,  A61K31/22 ,  A61K31/245 ,  A61P33/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C235/56 ,  C07C235/64 ,  C07D307/68 ,  F23Q7/02 ,  F24C5/14 ,  C07C103/30

Abstract: 1280407 Diacyloxy-benzoic acid anilides FARBWERKE HOECHST AG 9 June 1970 [9 June 1969] 27829/70 Heading C2C Novel compounds of Formula I (in which X is H or halogen; R 1 is 1 to 3 substituents selected from NO 2 , CF 3 and halogen; and R 2 is H; C 1-6 alkyl which may be substituted by one or more halogen atoms or a C 1-6 alkoxy or phenyl group; C 2-5 alkenyl; C 4-6 cycloalkyl; phenyl; an unsaturated 5- or 6- membered heterocyclic ring; C 1-4 alkylamino; di - (C 1-4 alkyl)amino ; pyrrolidino; piperidino ; morpholino; or 4-methylpiperazino) are prepared by acylating compounds of Formula II 5 - Iodo - 3 - nitro - 2,6 - dihydroxy - benzoic acid 4 1 -chloroanilide is prepared by reacting 3- nitro - 2,6 - dihydroxy - benzoic acid 4 1 - chloroanilide with iodine monochloride. Anthelmintic compositions for oral or parenteral administration, comprise a compound of Formula I together with a pharmaceutical carrier.

公开(公告)号：GB1280407A

公开(公告)日：1972-07-05

申请号：GB2782970

申请日：1970-06-09

Applicant: HOECHST AG

Inventor： RUSCHIG H ,  DUWEL D ,  KONIG J

IPC: A61K31/165 ,  A23K1/16 ,  A61K31/22 ,  A61K31/245 ,  A61P33/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C235/56 ,  C07C235/64 ,  C07D307/68 ,  F23Q7/02 ,  F24C5/14

Abstract: 1280407 Diacyloxy-benzoic acid anilides FARBWERKE HOECHST AG 9 June 1970 [9 June 1969] 27829/70 Heading C2C Novel compounds of Formula I (in which X is H or halogen; R 1 is 1 to 3 substituents selected from NO 2 , CF 3 and halogen; and R 2 is H; C 1-6 alkyl which may be substituted by one or more halogen atoms or a C 1-6 alkoxy or phenyl group; C 2-5 alkenyl; C 4-6 cycloalkyl; phenyl; an unsaturated 5- or 6- membered heterocyclic ring; C 1-4 alkylamino; di - (C 1-4 alkyl)amino ; pyrrolidino; piperidino ; morpholino; or 4-methylpiperazino) are prepared by acylating compounds of Formula II 5 - Iodo - 3 - nitro - 2,6 - dihydroxy - benzoic acid 4 1 -chloroanilide is prepared by reacting 3- nitro - 2,6 - dihydroxy - benzoic acid 4 1 - chloroanilide with iodine monochloride. Anthelmintic compositions for oral or parenteral administration, comprise a compound of Formula I together with a pharmaceutical carrier.