公开(公告)号：US3792054A

公开(公告)日：1974-02-12

申请号：US3792054D

申请日：1972-05-31

Applicant: HOECHST AG

Inventor： RUSHIG H ,  DUWEL D ,  KONIG J

IPC: A61K31/165 ,  A23K1/16 ,  A61K31/22 ,  A61K31/245 ,  A61P33/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C235/56 ,  C07C235/64 ,  C07D307/68 ,  F23Q7/02 ,  F24C5/14 ,  C07D29/30

CPC classification number: A61K31/245 ,  C07D307/68 ,  Y10S514/893

Abstract: DIACYLOXY-BENZOIC ACID ANILIDES OF THE GENERAL FORMULA

1-((R1-PHENYL)-NH-CO-),2,6-DI(R2-COO-),3-X,5-(O2N-)BENZENE

IN WHICH X REPRESENTS HYDROGEN OR HALOGEN, R1 REPRESENTS 1 TO 3 NITRO GROUPS, TRIFLUOROMETHYL GROUPS AND/OR HYDROGEN; LOWER ALKYL WHICH MAY BE SUBR2 REPRESENTS HYDROGEN; LOWER ALKYL WHICH MAE SUBSTITUTED BY HALOGEN, LOWER ALKOXY OR PHENYL; ALKENYL HAVING 3 TO 6 CARBON ATOMS; CYCLOALKYL HAVING 4 TO 6 CARBON ATOMS; PHENYL; AN UNSATURATED HETEROCYCLIC 5OR 6-MEMBERED RING; ALKYL-AMINO OR DIALKYL-AMINO IN WHICH THE ALKYL GROUPS EACH CONTAIN 1 TO 4 CARBON ATOMS OR MAY FORM TOGETHER WITH THE NITROGEN ATOM A PYRROLIDINE, PIPERIDINE, MORPHOLINE OR N-METHYL-PIPERAZINE RING.

公开(公告)号：JPS4820540B1

公开(公告)日：1973-06-21

申请号：JP4839070

申请日：1970-06-04

Applicant: HOECHST AG

Inventor： RUSCHIG H ,  DUWEL D ,  KONIG J

IPC: A61K31/165 ,  A23K1/16 ,  A61K31/22 ,  A61K31/245 ,  A61P33/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C235/56 ,  C07C235/64 ,  C07D307/68 ,  F23Q7/02 ,  F24C5/14 ,  C07C103/74

公开(公告)号：SE373125B

公开(公告)日：1975-01-27

申请号：SE780870

申请日：1970-06-05

Applicant: HOECHST AG

Inventor： RUSCHIG H ,  DUWEL D ,  KONIG J

IPC: A23K1/16 ,  A61K31/165 ,  A61K31/22 ,  A61K31/245 ,  A61P33/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C235/56 ,  C07C235/64 ,  C07D307/68 ,  F23Q7/02 ,  F24C5/14 ,  C07C103/76

Abstract: 1280407 Diacyloxy-benzoic acid anilides FARBWERKE HOECHST AG 9 June 1970 [9 June 1969] 27829/70 Heading C2C Novel compounds of Formula I (in which X is H or halogen; R 1 is 1 to 3 substituents selected from NO 2 , CF 3 and halogen; and R 2 is H; C 1-6 alkyl which may be substituted by one or more halogen atoms or a C 1-6 alkoxy or phenyl group; C 2-5 alkenyl; C 4-6 cycloalkyl; phenyl; an unsaturated 5- or 6- membered heterocyclic ring; C 1-4 alkylamino; di - (C 1-4 alkyl)amino ; pyrrolidino; piperidino ; morpholino; or 4-methylpiperazino) are prepared by acylating compounds of Formula II 5 - Iodo - 3 - nitro - 2,6 - dihydroxy - benzoic acid 4 1 -chloroanilide is prepared by reacting 3- nitro - 2,6 - dihydroxy - benzoic acid 4 1 - chloroanilide with iodine monochloride. Anthelmintic compositions for oral or parenteral administration, comprise a compound of Formula I together with a pharmaceutical carrier.

公开(公告)号：BG17763A3

公开(公告)日：1973-12-25

申请号：BG1485570

申请日：1970-06-04

Applicant: HOECHST AG

Inventor： RUSCHIG H ,  DUWEL D ,  KONIG J

IPC: A61K31/165 ,  A23K1/16 ,  A61K31/22 ,  A61K31/245 ,  A61P33/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C235/56 ,  C07C235/64 ,  C07D307/68 ,  F23Q7/02 ,  F24C5/14 ,  C07C103/30

Abstract: 1280407 Diacyloxy-benzoic acid anilides FARBWERKE HOECHST AG 9 June 1970 [9 June 1969] 27829/70 Heading C2C Novel compounds of Formula I (in which X is H or halogen; R 1 is 1 to 3 substituents selected from NO 2 , CF 3 and halogen; and R 2 is H; C 1-6 alkyl which may be substituted by one or more halogen atoms or a C 1-6 alkoxy or phenyl group; C 2-5 alkenyl; C 4-6 cycloalkyl; phenyl; an unsaturated 5- or 6- membered heterocyclic ring; C 1-4 alkylamino; di - (C 1-4 alkyl)amino ; pyrrolidino; piperidino ; morpholino; or 4-methylpiperazino) are prepared by acylating compounds of Formula II 5 - Iodo - 3 - nitro - 2,6 - dihydroxy - benzoic acid 4 1 -chloroanilide is prepared by reacting 3- nitro - 2,6 - dihydroxy - benzoic acid 4 1 - chloroanilide with iodine monochloride. Anthelmintic compositions for oral or parenteral administration, comprise a compound of Formula I together with a pharmaceutical carrier.

公开(公告)号：GB1280407A

公开(公告)日：1972-07-05

申请号：GB2782970

申请日：1970-06-09

Applicant: HOECHST AG

Inventor： RUSCHIG H ,  DUWEL D ,  KONIG J

IPC: A61K31/165 ,  A23K1/16 ,  A61K31/22 ,  A61K31/245 ,  A61P33/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C235/56 ,  C07C235/64 ,  C07D307/68 ,  F23Q7/02 ,  F24C5/14

Abstract: 1280407 Diacyloxy-benzoic acid anilides FARBWERKE HOECHST AG 9 June 1970 [9 June 1969] 27829/70 Heading C2C Novel compounds of Formula I (in which X is H or halogen; R 1 is 1 to 3 substituents selected from NO 2 , CF 3 and halogen; and R 2 is H; C 1-6 alkyl which may be substituted by one or more halogen atoms or a C 1-6 alkoxy or phenyl group; C 2-5 alkenyl; C 4-6 cycloalkyl; phenyl; an unsaturated 5- or 6- membered heterocyclic ring; C 1-4 alkylamino; di - (C 1-4 alkyl)amino ; pyrrolidino; piperidino ; morpholino; or 4-methylpiperazino) are prepared by acylating compounds of Formula II 5 - Iodo - 3 - nitro - 2,6 - dihydroxy - benzoic acid 4 1 -chloroanilide is prepared by reacting 3- nitro - 2,6 - dihydroxy - benzoic acid 4 1 - chloroanilide with iodine monochloride. Anthelmintic compositions for oral or parenteral administration, comprise a compound of Formula I together with a pharmaceutical carrier.

公开(公告)号：DK133148B

公开(公告)日：1976-03-29

申请号：DK295870

申请日：1970-06-08

Applicant: HOECHST AG

Inventor： RUSCHIG H ,  DYWEL D ,  KONIG J

IPC: A61K31/165 ,  A23K1/16 ,  A61K31/22 ,  A61K31/245 ,  A61P33/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C235/56 ,  C07C235/64 ,  C07D307/68 ,  F23Q7/02 ,  F24C5/14 ,  C07C103/76 ,  C07D295/14

Abstract: 1280407 Diacyloxy-benzoic acid anilides FARBWERKE HOECHST AG 9 June 1970 [9 June 1969] 27829/70 Heading C2C Novel compounds of Formula I (in which X is H or halogen; R 1 is 1 to 3 substituents selected from NO 2 , CF 3 and halogen; and R 2 is H; C 1-6 alkyl which may be substituted by one or more halogen atoms or a C 1-6 alkoxy or phenyl group; C 2-5 alkenyl; C 4-6 cycloalkyl; phenyl; an unsaturated 5- or 6- membered heterocyclic ring; C 1-4 alkylamino; di - (C 1-4 alkyl)amino ; pyrrolidino; piperidino ; morpholino; or 4-methylpiperazino) are prepared by acylating compounds of Formula II 5 - Iodo - 3 - nitro - 2,6 - dihydroxy - benzoic acid 4 1 -chloroanilide is prepared by reacting 3- nitro - 2,6 - dihydroxy - benzoic acid 4 1 - chloroanilide with iodine monochloride. Anthelmintic compositions for oral or parenteral administration, comprise a compound of Formula I together with a pharmaceutical carrier.

公开(公告)号：CS163765B2

公开(公告)日：1975-11-07

申请号：CS402870

申请日：1970-06-09

Applicant: HOECHST AG

Inventor： RUSCHIG H ,  DUWEL D ,  KONIG J

IPC: A61K31/165 ,  A23K1/16 ,  A61K31/22 ,  A61K31/245 ,  A61P33/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C235/56 ,  C07C235/64 ,  C07D307/68 ,  F23Q7/02 ,  F24C5/14 ,  C07C103/26

Abstract: 1280407 Diacyloxy-benzoic acid anilides FARBWERKE HOECHST AG 9 June 1970 [9 June 1969] 27829/70 Heading C2C Novel compounds of Formula I (in which X is H or halogen; R 1 is 1 to 3 substituents selected from NO 2 , CF 3 and halogen; and R 2 is H; C 1-6 alkyl which may be substituted by one or more halogen atoms or a C 1-6 alkoxy or phenyl group; C 2-5 alkenyl; C 4-6 cycloalkyl; phenyl; an unsaturated 5- or 6- membered heterocyclic ring; C 1-4 alkylamino; di - (C 1-4 alkyl)amino ; pyrrolidino; piperidino ; morpholino; or 4-methylpiperazino) are prepared by acylating compounds of Formula II 5 - Iodo - 3 - nitro - 2,6 - dihydroxy - benzoic acid 4 1 -chloroanilide is prepared by reacting 3- nitro - 2,6 - dihydroxy - benzoic acid 4 1 - chloroanilide with iodine monochloride. Anthelmintic compositions for oral or parenteral administration, comprise a compound of Formula I together with a pharmaceutical carrier.

公开(公告)号：IE34263B1

公开(公告)日：1975-03-19

申请号：IE72570

申请日：1970-06-04

Applicant: HOECHST AG

Inventor： RUSCHIG H ,  DUWEL D ,  KONIG J

IPC: A61K31/165 ,  A23K1/16 ,  A61K31/22 ,  A61K31/245 ,  A61P33/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C235/56 ,  C07C235/64 ,  C07D307/68 ,  F23Q7/02 ,  F24C5/14 ,  C07C103/74 ,  C07D5/16 ,  C07D27/04 ,  C07D29/12 ,  C07D63/12

Abstract: 1280407 Diacyloxy-benzoic acid anilides FARBWERKE HOECHST AG 9 June 1970 [9 June 1969] 27829/70 Heading C2C Novel compounds of Formula I (in which X is H or halogen; R 1 is 1 to 3 substituents selected from NO 2 , CF 3 and halogen; and R 2 is H; C 1-6 alkyl which may be substituted by one or more halogen atoms or a C 1-6 alkoxy or phenyl group; C 2-5 alkenyl; C 4-6 cycloalkyl; phenyl; an unsaturated 5- or 6- membered heterocyclic ring; C 1-4 alkylamino; di - (C 1-4 alkyl)amino ; pyrrolidino; piperidino ; morpholino; or 4-methylpiperazino) are prepared by acylating compounds of Formula II 5 - Iodo - 3 - nitro - 2,6 - dihydroxy - benzoic acid 4 1 -chloroanilide is prepared by reacting 3- nitro - 2,6 - dihydroxy - benzoic acid 4 1 - chloroanilide with iodine monochloride. Anthelmintic compositions for oral or parenteral administration, comprise a compound of Formula I together with a pharmaceutical carrier.

公开(公告)号：SE386666B

公开(公告)日：1976-08-16

申请号：SE1008471

申请日：1971-08-06

Applicant: HOECHST AG

Inventor： RUSCHIG H ,  KONIG J ,  DITTMAR W ,  KLATT P ,  DUWEL D

IPC: C07C235/84 ,  A61K20060101 ,  A61K31/00 ,  A61K31/16 ,  A61K31/165 ,  A61K31/18 ,  C07C20060101 ,  C07C233/00 ,  C07C233/12 ,  C07C327/38 ,  A01N9/12 ,  A01N9/20 ,  C07C103/737 ,  C07C155/03

公开(公告)号：AT305254B

公开(公告)日：1973-01-15

申请号：AT518370

申请日：1970-06-09

Applicant: HOECHST AG

Inventor： RUSCHIG H ,  DUWEL D ,  KONIG J

IPC: A61K31/165 ,  A23K1/16 ,  A61K31/22 ,  A61K31/245 ,  A61P33/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C235/56 ,  C07C235/64 ,  C07D307/68 ,  F23Q7/02 ,  F24C5/14 ,  C07C103/74

Abstract: 1280407 Diacyloxy-benzoic acid anilides FARBWERKE HOECHST AG 9 June 1970 [9 June 1969] 27829/70 Heading C2C Novel compounds of Formula I (in which X is H or halogen; R 1 is 1 to 3 substituents selected from NO 2 , CF 3 and halogen; and R 2 is H; C 1-6 alkyl which may be substituted by one or more halogen atoms or a C 1-6 alkoxy or phenyl group; C 2-5 alkenyl; C 4-6 cycloalkyl; phenyl; an unsaturated 5- or 6- membered heterocyclic ring; C 1-4 alkylamino; di - (C 1-4 alkyl)amino ; pyrrolidino; piperidino ; morpholino; or 4-methylpiperazino) are prepared by acylating compounds of Formula II 5 - Iodo - 3 - nitro - 2,6 - dihydroxy - benzoic acid 4 1 -chloroanilide is prepared by reacting 3- nitro - 2,6 - dihydroxy - benzoic acid 4 1 - chloroanilide with iodine monochloride. Anthelmintic compositions for oral or parenteral administration, comprise a compound of Formula I together with a pharmaceutical carrier.