公开(公告)号：ZA772950B

公开(公告)日：1978-04-26

申请号：ZA772950

申请日：1977-05-17

Applicant: HOECHST AG

Inventor： HITZEL V ,  PFAFF W ,  WEYER R ,  GEISEN K

IPC: A61K31/44 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/47 ,  A61P25/04 ,  C07D213/82 ,  C07D215/54 ,  C07D ,  A61K

公开(公告)号：DK214577A

公开(公告)日：1977-11-19

申请号：DK214577

申请日：1977-05-17

Applicant: HOECHST AG

Inventor： HITZEL V ,  WEYER R ,  PFAFF W ,  GEISEN K

IPC: A61K31/44 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/47 ,  A61P25/04 ,  C07D213/82 ,  C07D215/54 ,  C07D

公开(公告)号：ZA7600007B

公开(公告)日：1976-12-29

申请号：ZA7600007

申请日：1976-01-02

Applicant: HOECHST AG

Inventor： PFAFF W ,  HITZEL V ,  GEISEN K ,  WEYER R

IPC: C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/10 ,  C07C231/12 ,  C07C233/81 ,  C07C235/52 ,  C07C237/36 ,  C07D213/82 ,  C07D215/44 ,  C07D215/48 ,  C07D307/79 ,  C07D311/58 ,  C07D333/38 ,  C07D ,  A61K

CPC classification number: C07D213/82 ,  C07D215/48 ,  C07D307/79 ,  C07D311/58 ,  C07D333/38 ,  Y10S514/866

公开(公告)号：SE7503193L

公开(公告)日：1975-09-22

申请号：SE7503193

申请日：1975-03-20

Applicant: HOECHST AG

Inventor： HITZEL V ,  PFAFF W ,  WEYER R ,  WEBER H

IPC: C07C311/58 ,  A61K20060101 ,  A61K31/00 ,  A61K31/17 ,  A61K31/18 ,  A61K31/64 ,  C07C20060101 ,  C07C67/00 ,  C07C301/00 ,  C07C303/36 ,  C07C303/38 ,  C07C303/40 ,  C07C143/83

Abstract: N-acylaminoalkyl-benzenesulfonyl-N'-methyl ureas, especially those of the general formula in which R is C1- C4-alkyl or a phenyl radical substituted in 2-position by alkoxy of 1 to 4 carbon atoms, phenoxy or dimethylamino and in 5-position by H, CH3, Cl or Br, their manufacture and their use as oral antidiabetics.

公开(公告)号：SE362872B

公开(公告)日：1973-12-27

申请号：SE1324769

申请日：1969-09-26

Applicant: HOECHST AG

Inventor： GEIGER R ,  PFAFF W ,  SCHOENE H H ,  MAGER A

IPC: A61K38/00 ,  C07K14/62 ,  C07C103/52

Abstract: N (A1), N (B29)-di-tert. butyloxycarbonyl insulin, useful as a hypoglycemic agent. A method for its preparation by reacting insulin, in a mixture of an N,N'-dialkylcarboxylic acid amide having a total of from three to six carbon atoms and an aqueous buffer solution having a pH between 8.0 and 9.0, with a 20 to 75 fold molar excess of tert. butyloxycarbonyl azide at 20 DEG to 50 DEG C.

公开(公告)号：EG12586A

公开(公告)日：1981-06-30

申请号：EG29077

申请日：1977-05-14

Applicant: HOECHST AG

Inventor： HITZEL V ,  PFAFF W ,  WEYER R ,  GEISEN K

IPC: A61K31/44 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/47 ,  A61P25/04 ,  C07D213/82 ,  C07D215/54 ,  A61K33/04

公开(公告)号：NZ187195A

公开(公告)日：1980-09-12

申请号：NZ18719578

申请日：1978-05-08

Applicant: HOECHST AG

Inventor： HITZEL V ,  PFAFF W ,  WEYER R ,  GEISEN K

IPC: C07D213/81 ,  A61K31/63 ,  A61P3/08 ,  A61P3/10 ,  C07D213/82

公开(公告)号：ZA782064B

公开(公告)日：1979-03-28

申请号：ZA782064

申请日：1978-04-11

Applicant: HOECHST AG

Inventor： VERTESY L ,  OEDING V ,  PFAFF W ,  WEIDENMUELLER H

IPC: C12D13/00

公开(公告)号：ZA7802064B

公开(公告)日：1979-03-28

申请号：ZA7802064

申请日：1978-04-11

Applicant: HOECHST AG

Inventor： VERTESY L ,  OEDING V ,  PFAFF W ,  WEIDENMUELLER H

IPC: C12D13/00

公开(公告)号：ZA78946B

公开(公告)日：1979-01-31

申请号：ZA78946

申请日：1978-02-17

Applicant: HOECHST AG

Inventor： PFAFF W ,  WEYER R ,  HITZEL V ,  GEISEN K

IPC: C07D213/80 ,  C07D213/82 ,  C07D213/81 ,  C07D213/63 ,  C07C103/84

Abstract: Benzoic acid derivatives of the formula wherein T is hydrogen or halogen, W is a carboxyl group, an ester or salt thereof; X is wherein R1 is alkyl having from 2 to 8 carbon atoms, aralkyl or phenyl, cycloalkyl, cycloalkylalkyl or alkylcycloalkyl; R2 is hydrogen or halogen, R3 is alkyl having from 5 to 8 carbon atoms, aralkyl or phenyl, or cycloalkyl having from 5 to 8 carbon atoms; R4 is hydrogen or alkyl; Y is a single chemical bond or a hydrocarbon chain having from 1 to 3 carbon atoms; and Z is hydrogen, halogen, alkyl, alkoxy, alkoxyalkoxy or alkenyloxy, have a blood sugar lowering effect and can be used for the treatment of Diabetes mellitus.