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    Benzenesulfonyl ureas
    3.
    发明授权
    Benzenesulfonyl ureas 失效
    苯并呋喃酸

    公开(公告)号：US3812185A

    公开(公告)日：1974-05-21

    申请号：US4116170

    申请日：1970-05-25

    Applicant: HOECHST AG

    Inventor： WEBER H ,  WEYER R ,  AUMUELLER W ,  MUTH K

    IPC: C07C311/59 ,  C07D333/38 ,  C07D333/70 ,  C07C127/00

    CPC classification number: C07D333/38 ,  C07C311/59 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/50 ,  C07C2603/66 ,  C07D333/70 ,  Y10S514/866

    Abstract: BENZENESULFONYL-UREAS HAVING HYPOGLYCEMIC ACTIVITIES CORRESPONDING TO THE FORMULA

    1-(R1-NH-CO-NH-SO2-),4-(X-CO-NH-Y-)BENZENE

    WHEREIN R1 IS (A) NOCRARAN-7-YL, BICYCLO- 3,1,0!-HEXYL, BICYCLO- 5, 1,0!-OCTYL, OR BICYCLO- 6,1,0!-NONYL; (B) 4,7-ENDOMETHYLENE - PERHYDROINDAN-5-YL; 4,7ENDOMETHYLENE-6-CHLORO-PERHYROINDAN-5-YL; 4,7ENDOMETHYLENE-PERHYDROINDAN - 2 YL; 2,6-ENDOMETHYLENECYCLOHEPTYL; 2,5-ENDOCYCLOBUTYLENE-1,2CYCLOHEXYL; EXO-TRICYCLO-(3,2,1,02,4)-OCTANYL; (C) SPIRO-(2-CYCLOPROPANE) - CYCLOPETYL; SPIRO-(2CYCLOBUTANE)-CYCLOPENTYL; SPIRO-(2-CYCLOPETANE)CYCLOPENTYL; SPIRO-(2-CYLOHEXANE)-CYCLOPENTYL; OR SPIRO-(5,5)-UNDECYL-3; X IS

    A,A1-PHENYL OR 3-B,5-A1-THIEN-2-YL

    IN WHICH A STANDS FOR HYDROGEN, HALOGEN, RIFLUOROMETHYL, PHENOXY, LOWER ALKYL OR LOWER ALKOXY BOTH HAVING 1-4 CARBON ATOMS, A1 STANDS FOR HYDROGEN, HALOGEN OR LOWER ALKYL OF 1-4 CARBON ATOMS AND B STANDS FOR HYDROGEN OR LOWER ALKOXY HOF 1-4 CARBON ATOMS Y IS A HYDROCARBON CHAIN OF 1-3 CARBON ATOMS OR A PHYSIOLOGICALLY TOLERABLE SALT THEREOF.

    Benzenesulfonyl ureas having hypoglycemic activity
    6.
    发明授权
    Benzenesulfonyl ureas having hypoglycemic activity 失效
    具有高血压活性的苯二甲酸尿素

    公开(公告)号：US3709908A

    公开(公告)日：1973-01-09

    申请号：US3709908D

    申请日：1970-10-07

    Applicant: HOECHST AG

    Inventor： WEBER H ,  MUTH K ,  STACH K ,  WEYER R ,  AUMULLER W

    IPC: C07D209/08 ,  C07D215/08 ,  C07D317/66 ,  C07D27/38 ,  C07D33/10

    CPC classification number: C07D317/66 ,  C07D209/08 ,  C07D215/08

    Abstract: BENZENESULFONYL UREA COMPOUNDS THAT ARE EFFECTIVE AS ORAL ANTIDIABETIC AGENTS ARE DISCLOSED TO HAVE THE FORMULA

    (4-(X-N(-X1)-CO-NH-Y-)PHENYL)-SO2-NH-CO-NH-R

    WHEREIN R IS (A) ALKYL OR ALKENYL OF 3-6 CARBON ATOMS, (B) ENDOALKYLENE-CYCLOHEXYL, ENDOALKYLENE-CYCLOHEXENYL, ENDOALKYLENE-CYCLOHEXYLMETHYL OR ENDOALKYLENE-CYCLOHEXENYLMETHYL OF 1-2 ENDOALKYLENE CARBON ATOMS, (C) BENZYL, PHENYLETHYL, (D) CYCLOHEXYL METHYL, (E) LOWER ALKYL CYCLOHEXYL OR DIALKYL CYCLOHEXYL, METHYL CYCLOPENTYL, (F) CYCLOALKYL OF 5-8 CARBON ATOMS IN THE RING (G) CYCLOHEXENYL, CYCLOHEXENYL-METHYL, METHYLCYCLOHEXENYL, OR (H) NORTRICYCLYL,

    X-N(-X1)-

    IS INDOLINO OR TETRAHYDROQUINOLINO, AND Y IS ALKYLENE OF 1 TO 3 CARBON ATOMS.

    Benzenesulfonamidopyrimidines
    7.
    发明授权
    Benzenesulfonamidopyrimidines 失效
    苯并呋喃二恶嗪

    公开(公告)号：US3816424A

    公开(公告)日：1974-06-11

    申请号：US22653072

    申请日：1972-02-15

    Applicant: HOECHST AG

    Inventor： WEYER R ,  WEBER H ,  HUBNER M ,  AUMULLER W ,  SCHWEITZER R

    IPC: A61K31/18 ,  A61K31/47 ,  A61K31/505 ,  C07D215/14 ,  C07D215/48 ,  C07D239/42 ,  C07D239/69 ,  C07D401/12 ,  C07D57/00

    CPC classification number: C07D239/69 ,  C07D215/48 ,  Y10S514/866

    Abstract: NEW SULFONAMIDOPYRIMIDINES WITH HYPOGLYCEMIC PROPERTIES HAVING THE FORMULA

    1-((X-QUINOL-8-YL)-CO-NH-Y-),2-R,4-((4-R",5-R''-PYRIMIDIN-

    2-YL)-NH-SO2-)BENZENE

    IN WHICH X REPRESENTS HYDROGEN, CHLORINE, BROMINE, METHYL, METHOXY Y REPRESENTS -CH(CH3)-CH2-, OR, PREFERABLY,

    -CH2-CH2-

    R REPRESENTS HYDROGEN OR, TOGETHER WITH Y, A BRIDGE OF 3 OR 4 CARBON ATOMS, R'' REPRESENTS ALKYL, CYCLOALKYL, CYCLOALKYLALKYL, ARYL, ARALKYL, ALKOXY, CYCLOALKOXY, ALKOXYALKYL, ALKOXYALKOXY, ALKYLMERCAPTO, ALKYLMERCAPTOALKYL, THE ALKLY CONTAINING, IN ANY CASE FROM 1 TO 4 CARBON ATOMS AND THE CYCLOALKYL, IN ANY CASE, 5 TO 8 CARBON ATOMS, R" REPRESENTS HYDROGEN, LOWER ALKYL, R" AND R'' TOGETHER BEING ABLE TO FORM A RING OF FROM 3 TO 5 METHYL GROUPS, AND PHYSIOLOGICALLY TOLERABLE SALTS THEREOF AND PROCESSES FOR THEIR PREPARATION.

    Benzenesulfonyl-ureas and process for their manufacture
    9.
    发明授权
    Benzenesulfonyl-ureas and process for their manufacture 失效
    苯并呋喃及其制备方法

    公开(公告)号：US3751418A

    公开(公告)日：1973-08-07

    申请号：US3751418D

    申请日：1971-06-03

    Applicant: HOECHST AG

    Inventor： WEYER R ,  AUMULLER W ,  HEERDT R ,  WEBER H ,  SCHWEITZER R

    IPC: C07D215/48 ,  C07D33/56

    CPC classification number: C07D215/48 ,  Y10S514/866

    Abstract: HYPOGLYCEMICALLY ACTIVE BENZENESULFONYL-UREAS OF THE FORMULA

    (X-QUINOLIN-8-YL)-CO-NH-Y-(2-Z-1,4-PHENYLENE)-SO2-NH-CO-

    NH-R

    WHEREIN X IS HYDROGEN, CHLORINE, BROMINE, METHOXY OR METHYL, Y IS -CH(CH3)-CH2-, -CH2-CH(CH3)OR -CH2CH2-, R IS ALKYL OF 3 TO 6 CARBON ATOMS, CYCLOALKYL OF 5 TO 8 CARBON ATOMS, WHICH MAY BE SUBSTITUTED BY 1 OR 2 ALKYL OF UP TO 3 CARBON ATOMS OR BY CHLORINE, CYCLOALKENYL OF 5 TO 8 CARBON ATOMS, WHICH MAY BE SUBSTITUTED BY 1 TO 2 ALKYL OF UP TO 3 CARBON ATOMS, BICYCLOALKYL OR BICYCLOALKENYL OF 7 OR 8 CARBON ATOMS, NORTRICYCLYL, SPIRO(2,4)-HEPTYL, Z IS HYDROGEN OR A HYDROCARBON RADICAL OF 1 OR 2 CARBON ATOMS WHICH FORMS WITH Y A 5- OR 6-MEMBERED RING, OR THE SALTS THEREOF AS WELL AS A PROCESS FOR THEIR MANUFACTURE.

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