公开(公告)号：ZA7006474B

公开(公告)日：1971-05-27

申请号：ZA7006474

申请日：1970-09-22

Applicant: HOECHST AG

Inventor： SCHORR M ,  SCHRINNER E ,  SCHUETZ E

IPC: C07D499/00 ,  C07D499/60 ,  C07D

CPC classification number: C07D499/00

公开(公告)号：SE8306994D0

公开(公告)日：1983-12-16

申请号：SE8306994

申请日：1983-12-16

Applicant: HOECHST AG

Inventor： DURCKHEIMER W ,  BORMANN D ,  EHLERS E ,  SCHRINNER E ,  HAYMES R

IPC: A61K31/397 ,  A61K31/435 ,  A61K31/505 ,  A61K31/535 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B25J15/08 ,  C07D205/08 ,  C07D277/20 ,  C07D277/40 ,  C07D277/42 ,  C07D277/50 ,  C07D463/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D501/20 ,  C07D501/24 ,  C07D501/36 ,  C07D505/00 ,  C07D519/06 ,  C07F9/6561

Abstract: Cephem derivatives of the general formula in which the R2O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against bacterial infections and contain these compounds.

公开(公告)号：YU87378A

公开(公告)日：1983-01-21

申请号：YU87378

申请日：1978-04-12

Applicant: HOECHST AG

Inventor： DUERCKHEIMER W ,  EHLERS E ,  SELIGER H G ,  SCHRINNER E

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61K31/675 ,  A61K31/695 ,  A61P31/04 ,  B23K1/18 ,  B23Q5/033 ,  C07D20060101 ,  C07D277/20 ,  C07D277/40 ,  C07D501/00 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D501/60 ,  C07D519/06

Abstract: What are disclosed are cephem compounds of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.

公开(公告)号：NZ186968A

公开(公告)日：1981-04-24

申请号：NZ18696878

申请日：1978-04-13

Applicant: HOECHST AG

Inventor： SELIGER H ,  DUERCKHEIMER W ,  SCHRINNER E ,  EHLERS E

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61K31/675 ,  A61K31/695 ,  A61P31/04 ,  B23K1/18 ,  B23Q5/033 ,  C07D20060101 ,  C07D277/20 ,  C07D277/40 ,  C07D501/00 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D501/60 ,  C07D519/06

Abstract: What are disclosed are cephem compounds of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.

公开(公告)号：ZA792571B

公开(公告)日：1980-06-25

申请号：ZA792571

申请日：1979-05-25

Applicant: HOECHST AG

Inventor： SCHRINNER E ,  DUERCHHEIMER W ,  BORMANN D

IPC: C07D501/22 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/32 ,  C07D501/20 ,  C07D501/34 ,  C07D

公开(公告)号：ZA787209B

公开(公告)日：1979-12-27

申请号：ZA787209

申请日：1978-12-21

Applicant: HOECHST AG

Inventor： BLUMBACH J ,  SCHRINNER E ,  DUEREKHEIMER W

IPC: C07D501/06 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D277/46 ,  C07D501/34 ,  C07D ,  A61K

Abstract: Cephalosporin derivatives of the formula I processes for their manufacture and their use for combating bacterial infections.

公开(公告)号：ZA781433B

公开(公告)日：1979-02-28

申请号：ZA781433

申请日：1978-03-10

Applicant: HOECHST AG

Inventor： SCHRINNER E ,  BORMANN D ,  KNABE B ,  WORM M

IPC: A61K31/44 ,  A61K31/535 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D277/38 ,  C07D277/40 ,  C07D463/00 ,  C07D501/20 ,  C07D505/00 ,  A61K31/00

Abstract: Cephem derivatives of the formula in which R1 denotes hydrogen or low-molecular alkoxy, R2 denotes hydrogen, optionally substituted alkyl, phthalide or a cation, X denotes sulfur, oxygen or CH2 and A denotes hydrogen, alkoxy, halogen or a group -CH2Y, in which Y represents hydrogen, acyloxy, alkoxy, optionally substituted carbamoyloxy or a group -SR3, in which R3 can represent acyl, alkyl or an optionally substituted 5-membered or 6-membered heterocyclic structure are disclosed as valuable antibiotics which are well suited for combating Gram-positive and in particular Gram-negative infections and also have an unexpectedly good action against penicillinase-forming staphylococci.

公开(公告)号：LU79350A1

公开(公告)日：1978-11-27

申请号：LU79350

申请日：1978-03-31

Applicant: HOECHST AG

Inventor： DUERCKHEIMER W ,  SCHRINNER E ,  HEYMES R ,  EHLERS E ,  BORMANN D

IPC: A61K31/397 ,  A61K31/435 ,  A61K31/505 ,  A61K31/535 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B25J15/08 ,  C07D205/08 ,  C07D277/20 ,  C07D277/40 ,  C07D277/42 ,  C07D277/50 ,  C07D463/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D501/20 ,  C07D501/24 ,  C07D501/36 ,  C07D505/00 ,  C07D519/06 ,  C07F9/6561 ,  C07D ,  A61K

公开(公告)号：SE7803660L

公开(公告)日：1978-10-03

申请号：SE7803660

申请日：1978-03-31

Applicant: HOECHST AG

Inventor： DURCKHEIMER W ,  BORMANN D ,  EHLERS E ,  SCHRINNER E ,  HAYMES R

IPC: A61K31/397 ,  A61K31/435 ,  A61K31/505 ,  A61K31/535 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B25J15/08 ,  C07D205/08 ,  C07D277/20 ,  C07D277/40 ,  C07D277/42 ,  C07D277/50 ,  C07D463/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D501/20 ,  C07D501/24 ,  C07D501/36 ,  C07D505/00 ,  C07D519/06 ,  C07F9/6561 ,  C07D501/34 ,  C07D487/02

Abstract: Cephem derivatives of the general formula in which the R2O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against bacterial infections and contain these compounds.

公开(公告)号：SE7514094L

公开(公告)日：1976-06-14

申请号：SE7514094

申请日：1975-12-12

Applicant: HOECHST AG

Inventor： SCHORR M ,  SCHRINNER E ,  SCHMITT W

IPC: C07D499/66 ,  C07D499/00 ,  C07D499/64 ,  C07D499/68 ,  C07D499/70

Abstract: Acylaminopenicillanic acids of the general formula in which R1, R2 and R3 represent hydrogen or lower alkyl which may be substituted, and in which the radicals R1 and R2 or R2 and R3 may form together an alkylene radical which may be substituted, R4 and R5 represent hydrogen or lower alkyl, R6 represents phenyl which may be substituted, a monocyclic aromatic heterocycle which may be substituted, or dihydrophenyl, A represents a benzene or thiophene ring which may be substituted, and X represents oxygen or a single bond, a process for preparing them and pharmaceutical compositions active against bacterial infections containing these compounds.