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    PROCESS FOR PREPARING CEPHEM DERIVATIVES
    1.
    发明授权
    PROCESS FOR PREPARING CEPHEM DERIVATIVES 失效

    公开(公告)号：KR810000981B1

    公开(公告)日：1981-08-25

    申请号：KR780000611

    申请日：1978-03-09

    Applicant: HOECHST AG

    Inventor： BORMANN D ,  WORM M ,  SCHRINNER E ,  KNABE B

    IPC: A61K31/545 ,  C07D501/36

    Abstract: Title compds. [I; R1 = H, lower alkoxy; R2=H, alkyl, phthalide; X = O, S, Me; A = H, alkoxy, halogen, CH2Y(Y = H, acyloxy, alkoxy, carbamoyloxy, or acyl, alkyl, 5-6membered heterocyclic compd. -substituted thionyl group) were prepd. by reaction of II and III, and removing protected-group of amino from IV. Thus, III(R = 2-triphenylmethyl) in MeCl, Et3N and pivaloylchloride were mixed and reacted with II(R1,R2,A = H) and Et3N to give IV(R = 2-triphenylmethyl; R1,R2,A = H). IV was reacted with formic acid to give yellow crystal-form I.

    Process for preparing cephem-4-carboxylic acid esters
    2.
    发明授权
    Process for preparing cephem-4-carboxylic acid esters 失效
    制备CEPHEM-4-羧酸酯的方法

    公开(公告)号：US3781283A

    公开(公告)日：1973-12-25

    申请号：US3781283D

    申请日：1971-12-28

    Applicant: HOECHST AG

    Inventor： BORMANN D ,  WORM M

    IPC: C07D205/08 ,  C07D501/10 ,  C07F9/54 ,  C07F9/568 ,  C07D99/24

    CPC classification number: C07F9/5683 ,  C07D205/08 ,  C07F9/5407

    Abstract: PROCESS FOR PREPARING A CEPHEM-CARBOXYLIC ACID ESTER OF THE FORMULA

    7-(R-NH-),2-(R''-OOC-),3-CH3-2-CEPHEM

    BY HEATING A PENICILLIN OXIDE OF THE FORMULA

    6-(R-NH-),2-(R''-OOC-),3,3-DI(CH3-)PENAM

    IN A SOLVENT WITH A PHOSPHONIUM SALT OF THE FORMULA

    R1-P(+)(-R2)(-R3)-R4 X(-)

    IN THE FORMULAS; R IS ACYL; R'' IS ALKYL, SUBSTITUTED ALKYL, CYCLOALKYL, OR ARYL; R1, R2 ARE EACH SUBSTITUTED OR UNSUBSTITUTED HYDROCARBON; R4 IS METHYL SUBSTITUTED BY AN ELECTRON-ATTRACTING GROUP, AND MAY CONTAIN A FURTHER SUBSTITUENT; AND ? IS AN ANION.

    PREPARATION OF CEFODIZIME
    3.
    发明专利
    PREPARATION OF CEFODIZIME 未知

    公开(公告)号：NZ218452A

    公开(公告)日：1989-01-06

    申请号：NZ21845286

    申请日：1986-12-01

    Applicant: HOECHST AG

    Inventor： JAENICKE O ,  WAGNER H ,  WORM M

    IPC: C07D501/06 ,  A61K20060101 ,  A61K31/545 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/36 ,  C07D501/46 ,  C07D501/56

    Abstract: A process for the preparation of cefodizime of the formula +TR wherein (a) a compound of the formula II (ATS) wherein R1 represents hydrogen or an aminoprotective group and A represents a hydrogen atom or one equivalent of an alkali metal or alkaline earth metal, of ammonium or of an organic nitrogen base, is first reacted with a compound of the formula III R-SO2Hal wherein R represents an optionally substituted alkyl, aryl or aralkyl radical and Hal represents a halogen atom, in an organic solvent and, if appropriate, in the presence of a base, (b) a compound of the formula I (TACS) in which A has the above meaning, is reacted with a silylating agent in an organic solvent and, if appropriate, in the presence of a base, and (c) the two products formed in (a) and (b) are reacted in their reaction solutions, and any protective group R1 present in the end product of the formula I is eliminated.

    POSTOPEK ZA PRIPRAVO CEFODIZIMA
    6.
    发明专利
    POSTOPEK ZA PRIPRAVO CEFODIZIMA 未知

    公开(公告)号：YU45807B

    公开(公告)日：1992-07-20

    申请号：YU206186

    申请日：1986-12-02

    Applicant: HOECHST AG

    Inventor： JAENICKE O ,  WAGNER H ,  WORM M

    IPC: C07D501/06 ,  A61K20060101 ,  A61K31/545 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/36 ,  C07D501/46 ,  C07D501/56

    Abstract: POSTOPEK ZA PRIPRAVO CEFODIZIMA, s formulo označen s tem, da najprej v organskem topilu in v danem primeru v prisotnosti baze spojino s formulo II (ATS) v kateri R1 predstavlja vodik ali amino zaščitno skupino in A atom vodika ali ekvivalent alkalijske ali zemeljskoalkalijske kovine, amonija ali organske dušikove baze, presnovimo s spojino s formulo III R-SO2-Hal v kateri stoji R za p-tozilni ali fenilni ostanek in Hal predstavlja atom klora, v drugi stopnji v organskem topilu in v danem primeru v prisotnosti baze s spojino s formulo I (TACS) v kateri ima A zgornji pomen, presnovimo s sililirnim sredstvom in oba po prvi in drugi stopnji nastala proizvoda presnovimo v njihovih reakcijskih raztopinah in v končnem proizvodu odcepimo v danem primeru prisotno zaščitno skupino R1. Prijava vsebuje še 10 patentnih zahtevkov.

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