公开(公告)号：DK375875A

公开(公告)日：1976-02-22

申请号：DK375875

申请日：1975-08-20

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER A ,  QUITT P

IPC: A61K31/14 ,  A61K31/13 ,  C07D499/00 ,  C07D499/24 ,  C07D499/64 ,  C07D499/68 ,  C07D

Abstract: Choline and N-methyl-D-glucamine salts of amoxicillin, processes for their preparation and pharmaceutical compositions containing the salts as the active antibacterial component are disclosed.

公开(公告)号：BR6681938D0

公开(公告)日：1973-12-26

申请号：BR18193866

申请日：1966-08-08

Applicant: HOFFMANN LA ROCHE

Inventor： FURST A ,  FURLENMEIER A ,  LANGEMANN A ,  WALDVOGEL G ,  HOCKS P ,  KERB U ,  WIECHERT R

IPC: C07J1/00 ,  C07J5/00 ,  C07J9/00 ,  C07J31/00 ,  C07J75/00

公开(公告)号：BR7200305D0

公开(公告)日：1973-12-18

申请号：BR30572

申请日：1972-01-19

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER A ,  QUITT P ,  VOGLER K ,  LANZ P

IPC: C07D499/12 ,  A61K31/431 ,  A61P31/04 ,  C07D207/28 ,  C07D207/34 ,  C07D213/78 ,  C07D213/79 ,  C07D213/89 ,  C07D215/48 ,  C07D215/50 ,  C07D217/26 ,  C07D231/14 ,  C07D233/90 ,  C07D239/54 ,  C07D239/557 ,  C07D261/18 ,  C07D263/34 ,  C07D277/56 ,  C07D285/06 ,  C07D307/68 ,  C07D309/12 ,  C07D333/38 ,  C07D499/00 ,  C07D499/56 ,  C07D499/60

Abstract: Compounds represented by the following formula WHEREIN A is a substituted or unsubstituted heterocyclic radical and T is a C2-C5 alkyl, alkenyl, cycloproplymethyl, cyclobutylmethyl or cyclopentyl group A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES THEREFOR ARE DISCLOSED. These compounds are useful antibiotics.

公开(公告)号：ZA7208924B

公开(公告)日：1973-09-26

申请号：ZA7208924

申请日：1972-12-18

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER A ,  VOGLER K ,  LANZ P ,  QUITT P

IPC: C07D207/32 ,  C07D207/327 ,  C07D209/18 ,  C07D213/55 ,  C07D257/04 ,  C07D307/54 ,  C07D333/24 ,  C07D499/00 ,  C07D499/60 ,  C07D

CPC classification number: C07D207/327 ,  C07D209/18 ,  C07D213/55 ,  C07D257/04 ,  C07D307/54 ,  C07D333/24 ,  C07D499/00 ,  Y02P20/55

公开(公告)号：ZA7208771B

公开(公告)日：1973-08-29

申请号：ZA7208771

申请日：1972-12-12

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER A ,  VOGLER K ,  LANZ P ,  ZANETTI G

IPC: C07D499/60 ,  B25C5/02 ,  B25C5/06 ,  C07C51/60 ,  C07D499/00 ,  C07D

CPC classification number: C07D499/00 ,  B25C5/0257 ,  B25C5/06 ,  C07C51/60 ,  C07C59/70

公开(公告)号：ZA718537B

公开(公告)日：1972-09-27

申请号：ZA718537

申请日：1971-12-21

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER A ,  QUITT P ,  VOGLER K ,  LANZ P

IPC: C07D499/12 ,  A61K31/431 ,  A61P31/04 ,  C07D207/28 ,  C07D207/34 ,  C07D213/78 ,  C07D213/79 ,  C07D213/89 ,  C07D215/48 ,  C07D215/50 ,  C07D217/26 ,  C07D231/14 ,  C07D233/90 ,  C07D239/54 ,  C07D239/557 ,  C07D261/18 ,  C07D263/34 ,  C07D277/56 ,  C07D285/06 ,  C07D307/68 ,  C07D309/12 ,  C07D333/38 ,  C07D499/00 ,  C07D499/56 ,  C07D499/60 ,  C07D

Abstract: Compounds represented by the following formula WHEREIN A is a substituted or unsubstituted heterocyclic radical and T is a C2-C5 alkyl, alkenyl, cycloproplymethyl, cyclobutylmethyl or cyclopentyl group A PROCESS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES THEREFOR ARE DISCLOSED. These compounds are useful antibiotics.

公开(公告)号：ZA7103845B

公开(公告)日：1972-03-29

申请号：ZA7103845

申请日：1971-06-14

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER A ,  VOGLER K ,  ZANETTI G ,  LANZ P

IPC: C07C229/38 ,  C07D207/32 ,  C07D207/327 ,  C07D207/46 ,  C07D309/12 ,  C07D499/00 ,  C07D499/60 ,  C07C

CPC classification number: C07D207/327 ,  C07C229/38 ,  C07C317/00 ,  C07C323/00 ,  C07D207/46 ,  C07D309/12 ,  C07D499/00 ,  Y02P20/55

公开(公告)号：FI43596B

公开(公告)日：1971-02-01

申请号：FI212066

申请日：1966-08-12

Applicant: HOFFMANN LA ROCHE

Inventor： FUERST A ,  FURLENMEIER A ,  LANGEMANN A ,  KERB U ,  WIECHERT R ,  WALDVOGEL G ,  HOCKS P

IPC: C07J1/00 ,  C07J5/00 ,  C07J9/00 ,  C07J31/00 ,  C07J75/00 ,  C07C167/16 ,  C07C169/60

公开(公告)号：SE305873B

公开(公告)日：1968-11-11

申请号：SE1011667

申请日：1967-06-30

Applicant: HOFFMANN LA ROCHE

Inventor： BATCHO A ,  BERGER J ,  SPIEGELBERG H ,  VATERLAUS B ,  PECHERER B ,  SCHOCHER A ,  FURLENMEIER A ,  KELLER O

IPC: C07D27/22

公开(公告)号：YU216188A

公开(公告)日：1990-04-30

申请号：YU216188

申请日：1988-11-24

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER A ,  HUBSCHWERLEN C ,  MONTAVON M

IPC: C07D499/897 ,  A61K31/397 ,  A61K31/40 ,  A61K31/435 ,  A61K31/47 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D463/00 ,  C07D477/00 ,  C07D477/08 ,  C07D499/00 ,  C07D499/32 ,  C07D499/893 ,  C07D501/04 ,  C07D501/06 ,  C07D501/16 ,  C07D501/18 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D505/00 ,  C07D513/04 ,  A61K31/43

Abstract: Novel esters of pharmacologically active carboxylic acids, which can be cleaved under physiological conditions, in particular of antibiotically active carboxylic acids from the beta -lactam antibiotic field, are described, which are characterised in that the alcohol component of the ester is a group of the general formula in which R denotes hydrogen or lower alkyl, R denotes hydrogen, lower alkyl, lower haloalkyl, lower alkenyl, lower alkoxycarbonyl, aryl or heteroaryl or, together with R denotes lower alkylene, R denotes hydrogen, lower alkyl or lower alkoxycarbonyl, R denotes the group -COOR , -COR , -SO2-R , -CONR R or -PO(OR )2, R denotes a saturated or unsaturated hydrocarbon radical having up to 12 carbon atoms, in which up to two methylene groups can be replaced by oxygen atoms, or denotes aryl or aryl-lower alkyl, R denotes lower alkyl or aryl, R and R each denotes hydrogen or lower alkyl or together denotes lower alkylene in which a methylene group can be replaced by an oxygen or sulphur atom or by an imino or lower alkylimino group, and R denotes lower alkyl. If a basic substituent is present, these esters can also be present in the form of pharmaceutically acceptable acid addition salts.