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    PROCESS FOR THE PREPARATION OF D-HOMOSTEROID
    1.
    发明授权
    PROCESS FOR THE PREPARATION OF D-HOMOSTEROID 失效

    公开(公告)号：KR800000810B1

    公开(公告)日：1980-08-21

    申请号：KR750002257

    申请日：1975-10-17

    Applicant: HOFFMANN LA ROCHE

    Inventor： MULLER M ,  WEICHERT R ,  KERB U ,  ALIG L

    IPC: C07J63/00

    Abstract: Title compds. (I;R3=oxo;R13=lower alkyl, R17β=H,acyl, lower alkyl;R17aα=H, lower alkyl, ethinyl, vinyl, l, propinyl, chloroethinyl, butadienyl, propadienyl;The dotted line in ring A means additive C-C bond at 4,5-or 5(10)-position) are prepd. by hydrolysing compd. II(R13=group changed to 3-keto-Δ3 or 3-keto-Δ5(10) group by hydrolysis) with inoraganic acid or carboxylic acid in alcohol-H2O mixt. The final products exhibit hormanal action such as suppression of pregnancy or ovulation.

    PROCESS FOR THE PREPARATION OF D-HOMOSTEROID
    2.
    发明授权
    PROCESS FOR THE PREPARATION OF D-HOMOSTEROID 失效

    公开(公告)号：KR800000809B1

    公开(公告)日：1980-08-21

    申请号：KR750002179

    申请日：1975-10-07

    Applicant: HOFFMANN LA ROCHE

    Inventor： MULLER M ,  WEICHERT R ,  KERB U ,  ALIG L

    IPC: C07J63/00

    Abstract: D-homosteroid(I;R6=H, F, Cl, methyl;R17a=hydroxy, acyloxy, alkoxy, lower alkyl; R21=H, F, Cl), having progestational activity, was prepd, by oxidation of compd. II. Thus, 1.15 g 3β-hydroxy-17aα-methyl-D-homo-5, 16-pregnadiene-20-one and a mixt. of 1.1 ml cyclohexano and 22 m1 toluene were boiled, and added 550 mg aluminium isopropylate and 2 ml toluene, destillated for 45 min to give 17aα-methyl-D-homo-4, 16-pregnadiene-3, 20-dione(m.p.181.5- ! 185.5≦̸C).

    PROCESS FOR THE PREPARATION OF D-HOMOSTEROID
    3.
    发明授权
    PROCESS FOR THE PREPARATION OF D-HOMOSTEROID 失效

    公开(公告)号：KR800000811B1

    公开(公告)日：1980-08-21

    申请号：KR790003614

    申请日：1979-10-19

    Applicant: HOFFMANN LA ROCHE

    Inventor： MULLER M ,  WEICHERT R ,  KERB U ,  ALIG L

    IPC: C07J63/00

    Abstract: The title compds. (I; R17a=hydroxy, acyloxy, lower alkyl; R21=H, F, Cl) with hormonal action were prepd. by multistep synthesis. Key steps include the hydrolysing of compd. II(X=alkoxy, alkylthio, sec-amino, alkylenedioxy, alkylenedithio) and fluorinating or chlorinating at C6 position, if necessary, and methylating at C6 position or acylating hydroxyl group.

    PROCESS FOR THE PREPARATION OF D-HOMOSTEROID
    4.
    发明授权
    PROCESS FOR THE PREPARATION OF D-HOMOSTEROID 失效

    公开(公告)号：KR800000812B1

    公开(公告)日：1980-08-21

    申请号：KR790003615

    申请日：1979-10-19

    Applicant: HOFFMANN LA ROCHE

    Inventor： MULLER M ,  WEICHERT R ,  KERB U ,  ALIG L

    IPC: C07J63/00

    Abstract: D-Homosteroids [R1, R2=H or 1α, 2α-methylene, C-C; R6=H, F, Cl, Me; R17a=OH, acyloxy, alkoxy, lower alkyl; R10=Me or H when R1, R2 is H; R21=F, Cl) having hormonal activity esp. on topmarked anti-inflammatory effect were prepd. by reacting compd. II with CClO4 or triphenyl phosphin in the dimethyl formamide.

    20-hydrocarbyl-6-keto-steroids
    5.
    发明授权
    20-hydrocarbyl-6-keto-steroids 失效
    20-油酰六-KETO-STEROIDS

    公开(公告)号：US3835127A

    公开(公告)日：1974-09-10

    申请号：US70923968

    申请日：1968-02-29

    Applicant: HOFFMANN LA ROCHE

    Inventor： FURST A ,  FURLENMEIER A ,  WIECHERT R ,  HOCKS P ,  KERB U ,  LANGEMANN A ,  WALDVOGEL G

    IPC: C07J9/00 ,  C07C173/00

    CPC classification number: C07J9/00

    Abstract: This invention is directed to 2,3-substituted-20-hydrocarbyl 6keto-steroids which are useful as metamorphosis hormones and are additionally useful as intermediates for the production of other insect hormones. Accordingly, the compounds may be employed in the control of insect population.

    Abstract translation: 本发明涉及可用作变态激素的2,3-取代的20-烃基6-酮类固醇，并且还可用作生产其它昆虫激素的中间体。 因此，这些化合物可用于防治昆虫群体。

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