公开(公告)号：US3711543A

公开(公告)日：1973-01-16

申请号：US3711543D

申请日：1970-06-04

Applicant: HOFFMANN LA ROCHE

Inventor： BOLLAG W ,  GUTMANN H ,  LANGEMANN A ,  MULLER M ,  HEGEDUS B ,  KAISER A ,  ZELLER P

IPC: C07C51/60 ,  C07C233/00 ,  C07C243/38 ,  C07D213/81 ,  C07D213/82 ,  C07D261/18 ,  C07D307/14 ,  C07D307/52 ,  C07D317/58 ,  C07C127/16

CPC classification number: C07D213/81 ,  C07C51/60 ,  C07C233/00 ,  C07C243/00 ,  C07C243/38 ,  C07D213/82 ,  C07D261/18 ,  C07D307/14 ,  C07D307/52 ,  C07D317/58 ,  Y02P20/55 ,  C07C63/10

Abstract: Benzene-ring substituted (2-methylhydrazino)-methyl-benzene compounds and intermediates therefore are described. The former compounds are useful as cytostatic agents and, particularly, inhibit the growth of transplantable tumors in both mice and rats. Thus, they are active, for example, against Walker tumors, Ehrlich carcinoma and Ehrlich ascites carcinoma.

公开(公告)号：US3795678A

公开(公告)日：1974-03-05

申请号：US3795678D

申请日：1972-11-21

Applicant: HOFFMANN LA ROCHE

Inventor： BOLLAG W ,  GUTMANN H ,  HEGEDUS B ,  MULLER M ,  ZELLER P ,  KAISER A ,  LANGEMANN A

IPC: C07C51/60 ,  C07C233/00 ,  C07C243/38 ,  C07D213/81 ,  C07D213/82 ,  C07D261/18 ,  C07D307/14 ,  C07D307/52 ,  C07D317/58 ,  C07D31/44

CPC classification number: C07D213/81 ,  C07C51/60 ,  C07C233/00 ,  C07C243/00 ,  C07C243/38 ,  C07D213/82 ,  C07D261/18 ,  C07D307/14 ,  C07D307/52 ,  C07D317/58 ,  Y02P20/55 ,  C07C63/10

Abstract: BENZENE-RING SUBSTITUTED (2-METHYLHYDRAZINO)-METHYLBENZENE COMPOUNDS AND INTERMEDIATES THEREFOR ARE DESCRIBED. THE FORMER COMPOUNDS ARE USEFUL AS CYTOSTATIC AGENTS AND, PARTICUARLY, INHIBIT THE GROWTH OF TRANSPLANTABLE TUMORS IN BOTH MICE AND RATS. THUS, THEY ARE ACTIVE, FOR EXAMPLE, AGAINST WALKER TUMORS, EHRLICH CARCINOMA AND EHRLICH ASCITES CARCINOMA.

公开(公告)号：US3835127A

公开(公告)日：1974-09-10

申请号：US70923968

申请日：1968-02-29

Applicant: HOFFMANN LA ROCHE

Inventor： FURST A ,  FURLENMEIER A ,  WIECHERT R ,  HOCKS P ,  KERB U ,  LANGEMANN A ,  WALDVOGEL G

IPC: C07J9/00 ,  C07C173/00

CPC classification number: C07J9/00

Abstract: This invention is directed to 2,3-substituted-20-hydrocarbyl 6keto-steroids which are useful as metamorphosis hormones and are additionally useful as intermediates for the production of other insect hormones. Accordingly, the compounds may be employed in the control of insect population.

Abstract translation: 本发明涉及可用作变态激素的2,3-取代的20-烃基6-酮类固醇，并且还可用作生产其它昆虫激素的中间体。 因此，这些化合物可用于防治昆虫群体。

公开(公告)号：US3830840A

公开(公告)日：1974-08-20

申请号：US30862872

申请日：1972-11-21

Applicant: HOFFMANN LA ROCHE

Inventor： ZELLER P ,  LANGEMANN A ,  MULLER M ,  HEGEDUS B ,  KAISER A ,  BOLLAG W ,  GUTMANN H

IPC: C07C311/02 ,  C07C143/74

CPC classification number: C07C243/00

Abstract: BEBZENE-RING SUBSTITUTED (2-METHYLHYDRAZINO)-METHYLBENZENE COMPOUNDS AND INTERMEIATES THEREOF ARE DESCRIBED. THE FORMED COMPOUNDS ARE USEFUL AS CYTOSTATIC AGENTS AND, PARTICULARLY, INIBIT THE ROOWTH OF TRANSPLANTALE TUMORS IN BOTH MICE AND RATS. THUS, THENY ARE ACTIVE FOR EXAMPLE, AGAINST WALKER TUMORS, ERLICH CARCINMA AND ERILICH ASCITES CARINOMA.

公开(公告)号：US3824288A

公开(公告)日：1974-07-16

申请号：US30862772

申请日：1972-11-21

Applicant: HOFFMANN LA ROCHE

Inventor： ZELLER P ,  LANGEMANN A ,  MULLER M ,  HEGEDUS B ,  KAISER A ,  BOLLAG W ,  GUTMANN H

IPC: C07C233/00 ,  C07C243/38 ,  C07C129/08

CPC classification number: C07C243/38 ,  C07C233/00 ,  C07C243/00

Abstract: BENZENE-RING SUBSTITUTED (2-METHYLHYDRAZINO)-METHYLBENZENE COMPOUNDS AND INTERMEDIATES THEREFOR ARE DESCRIBED. THE FORMER COMPOUNDS ARE USEFUL AS CYTOSTATIC AGENTS AND, PARTICULARLY, IN HIBIT THE GROWTH OF TRANSPLANTABLE TOUMORS IN BOTH MICE AND RATS. THUS, THEY ARE ACTIVE, FOR EXAMPLE,AGAINST WALKER TUMORS, EHRILICH CARCINOMA AND EHRILICH ASCITES CARCINOMA.

公开(公告)号：SE354654B

公开(公告)日：1973-03-19

申请号：SE1262266

申请日：1962-06-08

Applicant: HOFFMANN LA ROCHE

Inventor： BOLLAG W ,  GUTMANN H ,  HEGEDUES B ,  KAISER A ,  LANGEMANN A ,  MUELLER M ,  ZELLER P

IPC: C07C51/60 ,  C07C233/00 ,  C07C243/38 ,  C07D213/81 ,  C07D213/82 ,  C07D261/18 ,  C07D307/14 ,  C07D307/52 ,  C07D317/58 ,  C07C109/00 ,  C07C127/12

Abstract: Benzene-ring substituted (2-methylhydrazino)-methyl-benzene compounds and intermediates therefore are described. The former compounds are useful as cytostatic agents and, particularly, inhibit the growth of transplantable tumors in both mice and rats. Thus, they are active, for example, against Walker tumors, Ehrlich carcinoma and Ehrlich ascites carcinoma.

公开(公告)号：BR6681938D0

公开(公告)日：1973-12-26

申请号：BR18193866

申请日：1966-08-08

Applicant: HOFFMANN LA ROCHE

Inventor： FURST A ,  FURLENMEIER A ,  LANGEMANN A ,  WALDVOGEL G ,  HOCKS P ,  KERB U ,  WIECHERT R

IPC: C07J1/00 ,  C07J5/00 ,  C07J9/00 ,  C07J31/00 ,  C07J75/00

公开(公告)号：FI43596B

公开(公告)日：1971-02-01

申请号：FI212066

申请日：1966-08-12

Applicant: HOFFMANN LA ROCHE

Inventor： FUERST A ,  FURLENMEIER A ,  LANGEMANN A ,  KERB U ,  WIECHERT R ,  WALDVOGEL G ,  HOCKS P

IPC: C07J1/00 ,  C07J5/00 ,  C07J9/00 ,  C07J31/00 ,  C07J75/00 ,  C07C167/16 ,  C07C169/60

公开(公告)号：SE375536B

公开(公告)日：1975-04-21

申请号：SE22372

申请日：1966-07-29

Applicant: HOFFMANN LA ROCHE

Inventor： FURST A ,  FURLENMEIER A ,  LANGEMANN A ,  WALDVOGEL G ,  HOCKS P ,  KERB U ,  WIECHERT R

IPC: C07J1/00 ,  C07J5/00 ,  C07J9/00 ,  C07J31/00 ,  C07J75/00 ,  C07J7/00

公开(公告)号：DK122664B

公开(公告)日：1972-03-27

申请号：DK414166

申请日：1966-08-12

Applicant: HOFFMANN LA ROCHE

Inventor： FURST A ,  FURLENMEIER A ,  LANGEMANN A ,  WALDVOGEL G ,  HOCKS P ,  KERB U ,  WIECHERT R

IPC: C07J1/00 ,  C07J5/00 ,  C07J9/00 ,  C07J31/00 ,  C07J75/00 ,  C07C167/16 ,  C07C169/00