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公开(公告)号：DE112018002121B4
公开(公告)日：2021-09-30
申请号：DE112018002121
申请日：2018-06-20
Applicant: IBM
Inventor： GOECKE ONUR , DELAMARCHE EMMANUEL
IPC: G01N21/78 , G01D7/00 , G01D13/00 , G01N27/22 , G01R27/26 , G02B1/06 , G06F21/00 , G09F9/00 , G09F9/30 , H04W12/00
Abstract: Verfahren zum optischen Auslesen von Informationen, die in einer Mikrofluidik-Einheit codiert sind, wobei das Verfahren aufweist:Bereitstellen der Mikrofluidik-Einheit, aufweisend:einen Eingabe-Mikrokanal;mindestens zwei Mikrofluidik-Module; undzwei Sätze von Knoten von jeweils mindestens zwei Knoten, umfassend einen ersten Satz und einen zweiten Satz, wobei:jeder Knoten des ersten Satzes den Eingabe-Mikrokanal mit einem entsprechenden der mindestens zwei Mikrofluidik-Module verbindet,jeder Knoten des zweiten Satzes ein entsprechendes geordnetes Paar von zwei der mindestens zwei Mikrofluidik-Module verbindet, unddie Knoten sowohl in dem ersten Satz als auch in dem zweiten Satz von Knoten unterschiedliche Flüssigkeits-Festhaltefähigkeiten aufweisen;Laden von Flüssigkeit in den Eingabe-Mikrokanal, wodurch diese Flüssigkeit durch jedes der mindestens zwei Mikrofluidik-Module gelangt, in einer Reihenfolge, die durch die unterschiedlichen Flüssigkeits-Festhaltefähigkeiten der Knoten bestimmt wird; undoptisches Auslesen eines dynamischen Musters, das durch die Flüssigkeit bewirkt wird, wobei das Muster dynamisch gemäß der Reihenfolge entsteht, in welcher die Flüssigkeit durch jedes der mindestens zwei Mikrofluidik-Module gelangt.
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公开(公告)号：CA2755298C
公开(公告)日：2018-03-13
申请号：CA2755298
申请日：2010-05-07
Applicant: IBM
Inventor： DELAMARCHE EMMANUEL , DRECHSLER UTE , LOVCHIK ROBERT
Abstract: The invention is directed to a multilayer microfluidic probe (MFP) head (100). The head typically comprises a first (110) and second (120) layers facing each others, and at least one tubing port (182), extending from the first layer (110). The first layer comprises one or more via (112), whereby fluid communication is enabled through the first layer towards the second layer. The second layer comprises at least one microchannel (124), relaying fluid communication to an aperture (122). Such a multilayered MFP head is easier to fabricate than heads made with unitary construction. In particular, a microchannel can advantageously be engraved a groove (124) at the level of the interface between the two layers. The MFP head can further be interfaced with tubing using e.g. a standard fitting for tubing port. The invention has substantial potential for e.g. patterning continuous and discontinuous patterns of biomolecules on surfaces as well as for direct processing of resist materials in a non- contact mode.
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公开(公告)号：GB2531452A
公开(公告)日：2016-04-20
申请号：GB201600188
申请日：2014-06-18
Applicant: IBM
Inventor： DELAMARCHE EMMANUEL , TEMIZ YUKSEL
IPC: B01L3/00
Abstract: The present invention is notably directed to methods of fabrication of a microfluidic chip package or assembly (1), comprising: providing (S1) a substrate (10, 30) having at least one block (14, 14a) comprising one or more microfluidic structures on a face (F) of the substrate; partially cutting (S2) into the substrate to obtain partial cuts (10c), such that a residual 6 thickness of the substrate at the level of the partial cuts (10c) enables singulation of said at least one block (14, 14a); cleaning (S4) said at least one block; and applying (S5 S7) a cover-film (62) to cover said at least one block (14, 14a), whereby at least one covered block is obtained, the applied cover film still enabling singulation of each covered block, wherein each covered block corresponds to a microfluidic chip after singulation. The present invention is further directed to microfluidic chips, packing or assembly, obtainable with such 12 methods.
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公开(公告)号：GB2499933A
公开(公告)日：2013-09-04
申请号：GB201308835
申请日：2011-10-18
Applicant: IBM
Inventor： DELAMARCHE EMMANUEL , KAIGALA GOVIND , LOVCHIK ROBERT
IPC: B01L3/00
Abstract: The invention is directed to a microfluidic probe head (100) with a base layer (120) comprising: at least two processing liquid microchannel (123, 124) in fluid communication with a processing liquid aperture (121, 122) on a face of the base 10 layer; and an immersion liquid microchannel (223, 224) in fluid communication with a immersion liquid aperture (221, 222) on a face of the base layer, wherein the microfluidic probe head is configured to allow, in operation, processing liquid provided through the processing liquid aperture to merge into immersion liquid provided through the immersion liquid aperture. An additional layer can be provided 15 to close the microchannels. Such a multilayered head is compact and easier to fabricate than heads made with unitary construction. The head can further be interfaced with tubing using e.g. a standard fitting for tubing port.
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公开(公告)号：DE112011103579T5
公开(公告)日：2013-08-08
申请号：DE112011103579
申请日：2011-10-18
Applicant: IBM
Inventor： KAIGALA GOVIND , DELAMARCHE EMMANUEL , LOVCHIK ROBERT
Abstract: Die Erfindung betrifft einen Mikrofluidik-Sondenkopf (100) mit einer Basisschicht (120) aufweisend: wenigstens zwei Arbeitsflüssigkeit-Mikrokanäle (123, 124) in Fluidverbindung mit einer Arbeitsflüssigkeit-Öffnung (121, 122) an einer Seite der Basisschicht; und einen Immersionsflüssigkeit-Mikrokanal (223, 224) in Fluidverbindung mit einer Immersionsflüssigkeit-Öffnung (221, 222) an einer Seite der Basisschicht, wobei der Mikrofluidik-Sondenkopf dafür gestaltet ist, in Verwendung ein Mischen von Arbeitsflüssigkeit, die durch die Arbeitsflüssigkeit-Öffnung bereitgestellt wird, mit Immersionsflüssigkeit, die durch die Immersionsflüssigkeit-Öffnung bereitgestellt wird, zu erlauben. Eine zusätzliche Schicht kann bereitgestellt werden, um die Mikrokanäle abzuschließen. Ein derartiger mehrschichtiger Kopf ist kompakt und leichter herzustellen als mit unitärem Aufbau hergestellte Köpfe. Der Kopf kann ferner mit Schläuchen verbunden werden, beispielsweise unter Verwendung von Standardkupplungen für Schlauchanschlüsse.
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Patent Agency Ranking
公开(公告)号：GB2499147A
公开(公告)日：2013-08-07
申请号：GB201308641
申请日：2011-08-03
Applicant: IBM
Inventor： DELAMARCHE EMMANUEL , GERVAIS LUC , HITZBLECK MARTINA
Abstract: The invention is directed to a microfluidic device having a flow inlet and outlet, generally defining a flow direction. A bypass channel (11) and an auxiliary channel (21) are provided which respectively defines a first and a second flow path toward the same outlet (102). The auxiliary channel connects to a reagent area (215), i.e., designed to receive a reagent (e.g., chemical or biological, such as detection antibodies). It further joins the bypass channel at the level of a junction (J1) downstream the reagent area, with respect to the second flow path, e.g., like a T- junction. Such a solution provides a simple way of adapting the dissolution rate of the reagent.
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公开(公告)号：CA2755298A1
公开(公告)日：2010-11-11
申请号：CA2755298
申请日：2010-05-07
Applicant: IBM
Inventor： DELAMARCHE EMMANUEL , DRECHSLER UTE , LOVCHIK ROBERT
Abstract: The invention is directed to a multilayer microfluidic probe (MFP) head (100). The head typically comprises a first (110) and second (120) layers facing each others, and at least one tubing port (182), extending from the first layer (110). The first layer comprises one or more via (112), whereby fluid communication is enabled through the first layer towards the second layer. The second layer comprises at least one microchannel (124), relaying fluid communication to an aperture (122). Such a multilayered MFP head is easier to fabricate than heads made with unitary construction. In particular, a microchannel can advantageously be engraved a groove (124) at the level of the interface between the two layers. The MFP head can further be interfaced with tubing using e.g. a standard fitting for tubing port. The invention has substantial potential for e.g. patterning continuous and discontinuous patterns of biomolecules on surfaces as well as for direct processing of resist materials in a non- contact mode.
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公开(公告)号：CA2701069A1
公开(公告)日：2009-06-04
申请号：CA2701069
申请日：2008-10-30
Applicant: IBM
Inventor： DELAMARCHE EMMANUEL , SOLIS DANIEL J
Abstract: There is provided an apparatus for the detection of an analyte in a sample. The apparatus comprises at least a first measurement channel (2a) comprising a detection reactant (3) corresponding to the analyte (4) to be detected, and at least a microstructure (5) associated with the first measurement channel (2a). When the apparatus (1 ) is in use, the sample is introduced into the first measurement channel (2a) and propagated by way of the first measurement channel (2a) towards the microstructure (5) such that the analyte (4), if it is present in the sample, interacts with the detection reactant (3) to form a networked product (6), and the microstructure (5) is configured to filter the networked product (6).
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公开(公告)号：DE69817329D1
公开(公告)日：2003-09-25
申请号：DE69817329
申请日：1998-06-02
Applicant: IBM
Inventor： BERNARD ANDRE , MICHEL BRUNO , BIEBUYCK HANS , SCHMID HEINZ , DELAMARCHE EMMANUEL
IPC: G01N13/02 , G01N33/483
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公开(公告)号：DE69624934T2
公开(公告)日：2003-07-31
申请号：DE69624934
申请日：1996-09-06
Applicant: IBM
Inventor： BIEBUYCK HANS , DELAMARCHE EMMANUEL , MICHEL BRUNO
Abstract: PCT No. PCT/IB96/00908 Sec. 371 Date Apr. 29, 1998 Sec. 102(e) Date Apr. 29, 1998 PCT Filed Sep. 6, 1996 PCT Pub. No. WO98/09735 PCT Pub. Date Mar. 12, 1998A method is proposed with which chemically defined bodies can be deposited on a substrate. Therefor, the bodies are fixed with a predetermined orientation on a stamping means which is then approached to the substrate whereby the bodies are deposited. While releasing the stamping means the bodies remain on the substrate keeping their orientation.
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