公开(公告)号：JPH10194919A

公开(公告)日：1998-07-28

申请号：JP1777897

申请日：1997-01-16

Applicant: KAO CORP

Inventor： HORI TAKASHI ,  NISHIZAWA YOSHINORI ,  MASUDA MITSUHARU ,  KAWAKAMI KYOKO

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/41 ,  A61K8/49 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain a skin lotion, excellent in skin-aging-preventing effect and improving effect of skin trouble caused by abnormality of keratinization and having good safety and stability by combinedly using a specific chromone derivative with specific amine derivatives. SOLUTION: This skin lotion is obtained by formulating (A) one or two or more kinds of compound selected from a chromone derivative of formula I (R is a 1-15C straight-chain or branched chain alkyl; R is H, OH or a lower alkoxy) with (B) an amine derivative of formula II (R is a 1-40C alkyl or a 1-40C cycloalkyl; R is H or an alkyl) or its acid additive salt. 2-(1- Ethylpenthyl)-7-methoxychromone, etc., is preferably used as the component A. 1-(2-Hydroxyehylamino)-3-isostearyloxy-2-propanol, etc., is preferably used as the component B. The components A and B are each preferably formulated in a ratio of 0.01-50wt.% and 0.005-10wt.% based on total amount of skin lotion.