公开(公告)号：ES2062130T3

公开(公告)日：1994-12-16

申请号：ES90103814

申请日：1990-02-27

Applicant: KAO CORP

Inventor： OMATSU SHINICHIRO ,  MASUDA MITSUHARU ,  ITO HIROSHI ,  IMAMURA TAKASHI ,  KUROSAKI TOMIHIRO

IPC: A61K8/27 ,  A61K8/55 ,  A61Q1/10 ,  A61Q1/12 ,  C07F9/11 ,  C07F9/113 ,  A61K7/035

公开(公告)号：DE3506973A1

公开(公告)日：1985-09-05

申请号：DE3506973

申请日：1985-02-27

Applicant: KAO CORP

Inventor： KUROSAKI TOMIHIRO ,  MASUDA MITSUHARU

IPC: C11D1/88 ,  A61K8/06 ,  A61K8/55 ,  A61Q19/00 ,  A61Q19/10 ,  C07F9/09 ,  C09K23/00 ,  C09K23/14 ,  C11D3/36 ,  A61K7/50 ,  B01F17/14

Abstract: A phosphoric ester of the following formula (I): (I) in which R1 represents a saturated or unsaturated, linear or branched and substituted or unsubstituted hydrocarbon group having from 8 to 32 carbon atoms, R2, R3 and R4 are the same or different and represent a saturated or unsaturated hydrocarbon group having from 1 to 4 carbon atoms, R5 represents a hydrogen atom, a saturated or unsaturated hydrocarbon group having from 1 to 4 carbon atoms, and n is an integer of from 0 to 50. The above novel phosphoric acid ester has excellent detergent performance with very low irritations to living body. A manufacturing method of the ester is also disclosed. According to the method, the ester can be prepared from inexpensive, readily available starting materials by a simple procedure in high purity and high yield.

公开(公告)号：DE68922278T2

公开(公告)日：1995-12-21

申请号：DE68922278

申请日：1989-11-21

Applicant: KAO CORP ,  MEITO SANGYO CO

Inventor： CHIKAWA YOSHIKO ,  KITA KATSUMI ,  MASUDA MITSUHARU ,  KUROSAKI TOMIHIRO ,  ITOH TAKASHI ,  INOUE NORIKO ,  KATO HARUYA ,  IMAMURA TAKASHI ,  ISHII YASUO ,  KOKUSHO YOSHITAKA ,  TSUNODA AKIRA ,  KATO SHIGEAKI

IPC: A61K8/14 ,  A61K8/55 ,  A61K9/127 ,  A61Q19/00 ,  C07F9/10 ,  C07H11/04 ,  A61K7/00 ,  C08G65/32

公开(公告)号：AT121292T

公开(公告)日：1995-05-15

申请号：AT89121567

申请日：1989-11-21

Applicant: KAO CORP ,  MEITO SANGYO KK

Inventor： CHIKAWA YOSHIKO ,  KITA KATSUMI ,  MASUDA MITSUHARU ,  KUROSAKI TOMIHIRO ,  ITOH TAKASHI ,  INOUE NORIKO ,  KATO HARUYA ,  IMAMURA TAKASHI ,  ISHII YASUO ,  KOKUSHO YOSHITAKA ,  TSUNODA AKIRA ,  KATO SHIGEAKI

IPC: A61K8/14 ,  A61K8/55 ,  A61K9/127 ,  A61Q19/00 ,  C07F9/10 ,  C07H11/04 ,  A61K7/00 ,  C08G65/32

公开(公告)号：DE69011360T2

公开(公告)日：1995-01-19

申请号：DE69011360

申请日：1990-02-27

Applicant: KAO CORP

Inventor： OMATSU SHINICHIRO ,  MASUDA MITSUHARU ,  ITO HIROSHI ,  IMAMURA TAKASHI ,  KUROSAKI TOMIHIRO

IPC: A61K8/27 ,  A61K8/55 ,  A61Q1/10 ,  A61Q1/12 ,  C07F9/11 ,  C07F9/113 ,  A61K7/035

公开(公告)号：DE68918924D1

公开(公告)日：1994-11-24

申请号：DE68918924

申请日：1989-12-19

Applicant: KAO CORP

Inventor： TAKEDA MOTORU ,  MASUDA MITSUHARU ,  IMAMURA TAKASHI ,  KUROSAKI TOMIHIRO

IPC: C07F9/09 ,  C07F9/10 ,  C07F9/655

公开(公告)号：FR2560599B1

公开(公告)日：1986-12-26

申请号：FR8502841

申请日：1985-02-27

Applicant: KAO CORP

Inventor： KUROSAKI TOMIHIRO ,  MASUDA MITSUHARU

IPC: A61K8/06 ,  A61K8/55 ,  A61Q19/00 ,  C11D1/88 ,  A61Q19/10 ,  C07F9/09 ,  C09K23/00 ,  C09K23/14

Abstract: A phosphoric ester of the following formula (I): (I) in which R1 represents a saturated or unsaturated, linear or branched and substituted or unsubstituted hydrocarbon group having from 8 to 32 carbon atoms, R2, R3 and R4 are the same or different and represent a saturated or unsaturated hydrocarbon group having from 1 to 4 carbon atoms, R5 represents a hydrogen atom, a saturated or unsaturated hydrocarbon group having from 1 to 4 carbon atoms, and n is an integer of from 0 to 50. The above novel phosphoric acid ester has excellent detergent performance with very low irritations to living body. A manufacturing method of the ester is also disclosed. According to the method, the ester can be prepared from inexpensive, readily available starting materials by a simple procedure in high purity and high yield.

公开(公告)号：DE68922278D1

公开(公告)日：1995-05-24

申请号：DE68922278

申请日：1989-11-21

Applicant: KAO CORP ,  MEITO SANGYO CO

Inventor： CHIKAWA YOSHIKO ,  KITA KATSUMI ,  MASUDA MITSUHARU ,  KUROSAKI TOMIHIRO ,  ITOH TAKASHI ,  INOUE NORIKO ,  KATO HARUYA ,  IMAMURA TAKASHI ,  ISHII YASUO ,  KOKUSHO YOSHITAKA ,  TSUNODA AKIRA ,  KATO SHIGEAKI

IPC: A61K8/14 ,  A61K8/55 ,  A61K9/127 ,  A61Q19/00 ,  C07F9/10 ,  C07H11/04 ,  A61K7/00 ,  C08G65/32

公开(公告)号：DE69011360D1

公开(公告)日：1994-09-15

申请号：DE69011360

申请日：1990-02-27

Applicant: KAO CORP

Inventor： OMATSU SHINICHIRO ,  MASUDA MITSUHARU ,  ITO HIROSHI ,  IMAMURA TAKASHI ,  KUROSAKI TOMIHIRO

IPC: A61K8/27 ,  A61K8/55 ,  A61Q1/10 ,  A61Q1/12 ,  C07F9/11 ,  C07F9/113 ,  A61K7/035

公开(公告)号：GB2183653A

公开(公告)日：1987-06-10

申请号：GB8627271

申请日：1986-11-14

Applicant: KAO CORP

Inventor： MASUDA MITSUHARU ,  KUROSAKI TOMIHIRO

IPC: A61K8/55 ,  A61Q19/00 ,  C07F9/09 ,  C09K23/14

Abstract: A novel phosphoric ester represented by the following formula (I): (I) is produced by halogenating the hydroxyl group of a monoalkyl phosphoric acid, reacting the halogenated product with N-benzoyloxycarbonyl serine ester and then removing protecting groups for the carboxyl group and amino group. According to the present production process, the phosphoric ester can be obtained inexpensively at a high yield and high purity. Further, the phosphoric ester has a structure similar to that of the phospholipid and has nitrogen-containing polar groups such as amino group in one molecule, so that it has excellent emulsification ability and moisture keeping function. It is thus useful as emulsifiers, humectants and the like.