公开(公告)号：CA2892045C

公开(公告)日：2022-05-31

申请号：CA2892045

申请日：2013-11-21

Applicant: PTC THERAPEUTICS INC

Inventor： LEE CHANG-SUN ,  BAIAZITOV RAMIL ,  CAO LIANGXIAN ,  DAVIS THOMAS W ,  DU WU ,  LIU RONGGANG ,  MOON YOUNG-CHOON ,  PAGET STEVEN D ,  REN HONGYU ,  SYDORENKO NADIYA ,  WILDE RICHARD GERALD

IPC: C07D403/04 ,  A61K31/506 ,  A61P35/00 ,  C07D471/04

Abstract: There is provided amine substituted reverse pyrimidine compounds of Formula (I): or a form thereof. The compounds inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and provide methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.

公开(公告)号：PL2434891T3

公开(公告)日：2020-12-28

申请号：PL10781238

申请日：2010-05-27

Applicant: PTC THERAPEUTICS INC

Inventor： ALMSTEAD NEIL ,  ARASU TAMIL ,  CHOI SOONGYU ,  CAO LIANGXIAN ,  CAMPBELL JEFF ,  CORSON DON ,  DAVIS THOMAS W ,  GRACI JASON D ,  GU ZHENGXIAN ,  HWANG PETER SEONGWOO ,  LENNOX WILLIAM ,  MIAO HARRY H ,  MILLER LANGDON ,  MOON YOUNG-CHOON ,  QI HONGYAN ,  TROTTA CHRISTOPHER ,  WEETALL MARLA L

IPC: A01N43/42 ,  A61K31/44 ,  C07D471/04

公开(公告)号：CU24387B1

公开(公告)日：2019-03-04

申请号：CU20150053

申请日：2013-11-21

Applicant: PTC THERAPEUTICS INC

Inventor： BAIAZITOV RAMIL ,  CAO LIANGXIAN ,  DAVIS THOMAS W ,  DU WU ,  LEE CHANG-SUN ,  LIU RONNGGANG ,  MOON YOUNG-CHOON ,  PAGET STEVEN D ,  REN HONGYU ,  SYDORENKO NADIYA ,  WILDE RICHARD GERALD

IPC: C07D239/48

Abstract: Compuestos inversos de pirimidina sustituidos con amina de fórmula I (ESPACIO PARA LA FÓRMULA) y formas de la misma que inhiben la función y reducen el nivel de la proteína del sitio de integración 1 (Bmi-1) del virus de la leucemia de Moloney específico de células B para su uso para inhibir la función de Bmi-1 y reducir el nivel de Bmi-1 para el tratamiento de un cáncer mediado por Bmi-1 se describen en el presente documento.

公开(公告)号：AU2013348009B2

公开(公告)日：2018-05-17

申请号：AU2013348009

申请日：2013-11-21

Applicant: PTC THERAPEUTICS INC

Inventor： LEE CHANG-SUN ,  BAIAZITOV RAMIL ,  CAO LIANGXIAN ,  DAVIS THOMAS W ,  DU WU ,  LIU RONGGANG ,  MOON YOUNG-CHOON ,  PAGET STEVEN D ,  REN HONGYU ,  SYDORENKO NADIYA ,  WILDE RICHARD GERALD

IPC: C07D239/48 ,  C07D471/04

Abstract: Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.

公开(公告)号：AU2013348009A1

公开(公告)日：2015-06-04

申请号：AU2013348009

申请日：2013-11-21

Applicant: PTC THERAPEUTICS INC

Inventor： LEE CHANG-SUN ,  BAIAZITOV RAMIL ,  CAO LIANGXIAN ,  DAVIS THOMAS W ,  DU WU ,  LIU RONGGANG ,  MOON YOUNG-CHOON ,  PAGET STEVEN D ,  REN HONGYU ,  SYDORENKO NADIYA ,  WILDE RICHARD GERALD

IPC: C07D239/48 ,  C07D471/04

Abstract: Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.

公开(公告)号：AU2010253852A1

公开(公告)日：2012-01-12

申请号：AU2010253852

申请日：2010-05-27

Applicant: PTC THERAPEUTICS INC

Inventor： NEIL ALMSTEAD ,  TAMIL ARASU ,  SOONGYU CHOI ,  LIANGXIAN CAO ,  JEFF CAMPBELL ,  DON CORSON ,  DAVIS THOMAS W ,  GRACI JASON D ,  ZHENGXIAN GU ,  SEONGWOO HWANG PETER ,  WILLIAM LENNOX ,  MIAO HARRY H ,  LANGDON MILLER ,  YOUNG-CHOON MOON ,  HONGYAN QI ,  CHRISTOPHER TROTTA ,  WEETALL MARLA L

IPC: A01N43/42 ,  A61K31/44

Abstract: Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.

公开(公告)号：EP2922828A4

公开(公告)日：2016-07-27

申请号：EP13857326

申请日：2013-11-21

Applicant: PTC THERAPEUTICS INC

Inventor： LEE CHANG-SUN ,  BAIAZITOV RAMIL ,  CAO LIANGXIAN ,  DAVIS THOMAS W ,  DU WU ,  LIU RONGGANG ,  MOON YOUNG-CHOON ,  PAGET STEVEN D ,  REN HONGYU ,  SYDORENKO NADIYA ,  WILDE RICHARD GERALD

IPC: C07D403/04 ,  A61K31/506 ,  A61P35/00 ,  C07D405/14 ,  C07D471/04

CPC classification number: C07D403/12 ,  A61K31/506 ,  A61K45/06 ,  A61N5/10 ,  C07D403/04 ,  C07D471/04 ,  C07D487/04

Abstract: Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.