公开(公告)号：US10409047B2

公开(公告)日：2019-09-10

申请号：US15724738

申请日：2017-10-04

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Garth Jason Simpson ,  Charles Addison Bouman ,  Ryan Douglas Muir ,  Shane Sullivan ,  Justin Allen Newman ,  Mark Carlsen ,  Suhas Sreehari

IPC: G02B21/00 ,  G02B26/10

Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.

公开(公告)号：US10309902B2

公开(公告)日：2019-06-04

申请号：US15514893

申请日：2015-09-28

Applicant: Purdue Research Foundation

Inventor： Garth Jason Simpson ,  Paul David Schmitt

IPC: G01N21/00 ,  G01N21/65 ,  G01N23/207 ,  G01N21/63

Abstract: A method for quantifying crystallinity within a sample using second harmonic generation microscopy is described herein. In one aspect, a method for reducing the timeframe for accelerated stability testing of amorphous solid dispersions of active pharmaceutical ingredients though identifying regions of interest to quantify crystallinity and composition is presented herein.

公开(公告)号：US20170212053A1

公开(公告)日：2017-07-27

申请号：US15514893

申请日：2015-09-28

Applicant: Purdue Research Foundation

Inventor： Garth Jason Simpson ,  Paul David Schmitt

IPC: G01N21/65 ,  G01N23/207

CPC classification number: G01N21/65 ,  G01N21/636 ,  G01N23/207 ,  G01N2223/606 ,  G01N2223/612

Abstract: A method for quantifying crystallinity within a sample using second harmonic generation microscopy is described herein. In one aspect, a method for reducing the timeframe for accelerated stability testing of amorphous solid dispersions of active pharmaceutical ingredients though identifying regions of interest to quantify crystallinity and composition is presented herein.

公开(公告)号：US20150323687A1

公开(公告)日：2015-11-12

申请号：US14708335

申请日：2015-05-11

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Garth Jason Simpson ,  Ryan Douglas Muir ,  Nicholas Roman Pogranichniy

IPC: G01T1/36 ,  G01T1/17

CPC classification number: G01T1/24 ,  G01T1/17 ,  G01T1/36

Abstract: The present disclosure provides a system and method for efficiently mining multi-threshold measurements acquired using photon counting pixel-array detectors for spectral imaging and diffraction analyses. Images of X-ray intensity as a function of X-ray energy were recorded on a 6 megapixel X-ray photon counting array detector through linear fitting of the measured counts recorded as a function of counting threshold. An analytical model is disclosed for describing the probability density of detected voltage, utilizing fractional photon counting to account for edge/corner effects from voltage plumes that spread across multiple pixels. Three-parameter fits to the model were independently performed for each pixel in the array for X-ray scattering images acquired for 13.5 keV and 15.0 keV X-ray energies. From the established pixel responses, multi-threshold composite images produced from the sum of 13.5 keV and 15.0 keV data can be analytically separated to recover the monochromatic images through simple linear fitting.

Abstract translation: 本公开提供了一种用于有效挖掘使用光子计数像素阵列检测器获得的用于光谱成像和衍射分析的多阈值测量的系统和方法。 作为X射线能量的函数的X射线强度的图像通过线性拟合作为计数阈值的函数记录的测量计数记录在6百万像素的X射线光子计数阵列检测器上。 公开了一种用于描述检测电压的概率密度的分析模型，利用分数光子计数来解释跨越多个像素的电压羽流的边缘/角落效应。 针对13.5 keV和15.0 keV X射线能量获得的X射线散射图像，阵列中的每个像素独立地执行与模型的三参数拟合。 从建立的像素响应中，可以分析地从13.5 keV和15.0 keV数据的总和产生的多阈值合成图像通过简单的线性拟合来恢复单色图像。