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    PREPARATION OF VINYLSILANE HAVING PERFLUORO GROUP
    31.
    发明专利
    PREPARATION OF VINYLSILANE HAVING PERFLUORO GROUP 失效

    公开(公告)号：JPS57140788A

    公开(公告)日：1982-08-31

    申请号：JP2554081

    申请日：1981-02-25

    Applicant: SAGAMI CHEM RES

    Inventor： OSHIMA IWAO ,  FUCHIGAMI TAKAMASA ,  YATABE MOMOKO

    IPC: C07F7/12 ,  B01J27/00 ,  B01J31/16 ,  C07F7/18

    Abstract: PURPOSE:To prepare the titled compound useful as a synthetic intermediate of pharmaceuticals, pesticides, etc., from easily available raw materials, in high yield, by reacting an olefin having perfluoro group with hydrosilane in the presence of an Ru complex or an Rh complex. CONSTITUTION:The olefin of formulaI(Rf is 1-20C perfluoroalkyl or perfluoroaryl) is made to react with the hydrosilane of formula II (R is alkyl, aryl, halogen or alkoxy) to obtain the vinylsilane of formula III. The reaction is carried out in the presence of an Ru complex or an Rh complex, e.g. Ru3(CO)12, Ru(PPh3)3Cl2, Rh(PPh3)3Cl, etc., preferably in a solvent such as benzene at 50-150 deg.C. The compound of formula III is useful as a synthetic intermediate of various fluorine-containing compounds.

    Preparation of olefin derivative containing perfluoro group
    32.
    发明专利
    Preparation of olefin derivative containing perfluoro group 失效
    空值

    公开(公告)号：JPS5754124A

    公开(公告)日：1982-03-31

    申请号：JP12913680

    申请日：1980-09-19

    Applicant: Sagami Chem Res Center

    Inventor： OSHIMA IWAO ,  FUCHIGAMI TAKAMASA

    IPC: C07D333/12 ,  B01J23/00 ,  B01J23/44 ,  B01J27/00 ,  B01J27/10 ,  B01J27/13 ,  B01J31/00 ,  B01J31/04 ,  B01J31/24 ,  B01J31/28 ,  C07B31/00 ,  C07B37/04 ,  C07B61/00 ,  C07C17/00 ,  C07C17/25 ,  C07C17/269 ,  C07C22/02 ,  C07C22/08 ,  C07C25/24 ,  C07C41/00 ,  C07C43/225 ,  C07C51/00 ,  C07C51/363 ,  C07C63/74 ,  C07C67/00 ,  C07C67/307 ,  C07C69/76 ,  C07C201/00 ,  C07C205/12 ,  C07D213/26 ,  C07D333/10

    CPC classification number: Y02P20/52

    Abstract: PURPOSE: To obtain the titled compound useful as a raw material for preparing fluorine-containing silicone rubber by one process in high yield using a readily obtainable raw material, by reacting a halide with an ethylene derivative containing a perfluoro group using a Pd catalyst and a base.
    CONSTITUTION: A halide, e.g., iodobenzene, etc. shown by the formula RX (R is aromatic group, vinyl group, hetero aromatic group; X is Br of I) is reacted with an ethylene derivative, e.g., 3,3,3-tri-fluoropropene, etc., having a perfluoro group shown by the formula CH
    2 =CH-R
    f (R
    f is perfluoro group) in the presence of a palladium catalyst, e.g., palladium chloride, palladium acetate, etc. and a base, e.g., potassium acetate, triethylamine, etc., sometimes in a solvent, at 60W200°C, to give an olefin derivative, e.g., trans-β-trifluoro-methylstyrene, etc., having a perfluoro group shown by the formula R-CH=CH-R
    f .
    COPYRIGHT: (C)1982,JPO&Japio

    Abstract translation: 目的：使用容易获得的原料，通过一次高收率制备含氟硅橡胶的原料，通过使用Pd催化剂使卤化物与含有全氟基团的乙烯衍生物反应，得到标题化合物，得到 基础。 构成：通式RX（R为芳基，乙烯基，杂芳基; X为I的Br）所示的卤化物，如碘苯等与乙烯衍生物反应， 三氟丙烯等，在钯催化剂例如氯化钯，乙酸钯等存在下，具有通式CH 2 = CH-Rf（Rf是全氟基团）所示的全氟基团， 乙酸钾，三乙胺等，有时在溶剂中，在60-200℃下，得到具有式R-所示全氟基团的烯烃衍生物，例如反式-β-三氟甲基苯乙烯等， CH = CH-Rf。

    PREPARATION OF 4-PERFLUOROALKYLNORVALINE
    33.
    发明专利
    PREPARATION OF 4-PERFLUOROALKYLNORVALINE 失效

    公开(公告)号：JPS56164151A

    公开(公告)日：1981-12-17

    申请号：JP6592980

    申请日：1980-05-20

    Applicant: SAGAMI CHEM RES

    Inventor： OSHIMA IWAO ,  FUCHIGAMI TAKAMASA

    IPC: C07C227/20 ,  C07C67/00 ,  C07C227/00 ,  C07C229/20

    Abstract: PURPOSE:To obtain the titled compound useful as an antimicrobial agent without passing through troublesome steps, by hydrogenating a specific N-acyldehydroamino acid or an ester thereof in the presence of a metallic or a metallic complex catalyst selected from Group VIII, and hydrolyzing the resultant hydrogenation product. CONSTITUTION:An N-acyldehydroamino acid of formula III (Rf is perfluoroalkyl; R is H, etc.; R is alkyl, etc.) or an ester thereof is hydrogenated in the presence of a metallic catalyst, e.g. Pt, selected from Group VIII or a metallic complex catalyst selected from Group VIII, e.g. (Ph3P)3RhCl, to give an N-acylamino acid of formula IV or an ester thereof, which is then hydrolyzed in the presence of an acid, e.g. hydrochloric acid, to afford the titled compound. EFFECT:The reaction can be started from a readily available raw material.

    PRODUCTION OF FLUORINE-CONTAINING ACETYLENE COMPOUND
    37.
    发明专利
    PRODUCTION OF FLUORINE-CONTAINING ACETYLENE COMPOUND 失效

    公开(公告)号：JPH11246448A

    公开(公告)日：1999-09-14

    申请号：JP5302498

    申请日：1998-03-05

    Applicant: SAGAMI CHEM RES

    Inventor： FUCHIGAMI TAKAMASA ,  SHIMIZU RIE

    IPC: B01J31/24 ,  C07B61/00 ,  C07C17/26 ,  C07C17/263 ,  C07C21/22

    Abstract: PROBLEM TO BE SOLVED: To produce the subject compound according to a simple method without any disadvantage such as carrying out of a reaction under strong basic conditions by reacting a specific organotin compound with a specified halide in the presence of a transition metal catalyst. SOLUTION: An organotin compound represented by formula I (R is hydrogen, an alkyl or the like; R is a lower alkyl) [e.g. (phenylethyl)tributyltin] is reacted with a halide represented by formula II [X is bromine or iodine; R is R ; R is hydrogen, fluorine or the like; R is hydrogen, chlorine or the like; (n) is 1 or 2] (e.g. 3-fluoro-1-iododecane) in the presence of a transition metal catalyst [preferably tetrakis(triphenylphosphine)palladium] to afford the objective compound represented by formula III. The reaction is carried out in the presence of a solvent without participating in the reaction such as benzene at 60-150 deg.C by using the compound represented by formula I in an amount of preferably 0.7-5.0 equiv. based on the compound represented by formula II and the transition metal catalyst in an amount of preferably 0.005-0.5 equiv. based on the compound represented by formula II.

    PRODUCTION OF BETA-HYDROXYSULFOXIDE
    38.
    发明专利
    PRODUCTION OF BETA-HYDROXYSULFOXIDE 失效

    公开(公告)号：JPH11130784A

    公开(公告)日：1999-05-18

    申请号：JP29436797

    申请日：1997-10-27

    Applicant: SAGAMI CHEM RES

    Inventor： FUCHIGAMI TAKAMASA ,  SAITO YASUKO ,  HIROZAWA TOMOTARI

    IPC: B01J27/12 ,  B01J31/02 ,  C07B61/00 ,  C07C315/04 ,  C07C317/18 ,  C07F7/18

    Abstract: PROBLEM TO BE SOLVED: To provide a simple process for the production of a β-hydroxysulfoxide useful as a synthetic intermediate for pharmaceuticals and amino acids. SOLUTION: The objective β-hydroxysulfoxide derivative expressed by the general formula R (S=O)CH2 -CH(OSiR R R )-R (R , R , R and R are each independently an alkyl or an aromatic group; R is a (substituted)aromatic group or vinyl group) and/or β-hydroxysulfoxide expressed by the general formula R (S=O)CH2 -CH(OH)-R can be produced by reacting an aldehyde expressed by the general formula RHC=O with a sulfinylmethylsilane expressed by the general formula R (S=O)CH2 -SiR R R in the presence of fluorine ion.

    PRODUCTION OF ALKINYLSILANE COMPOUNDS
    39.
    发明专利
    PRODUCTION OF ALKINYLSILANE COMPOUNDS 失效

    公开(公告)号：JPH09295986A

    公开(公告)日：1997-11-18

    申请号：JP34078296

    申请日：1996-12-20

    Applicant: SAGAMI CHEM RES

    Inventor： FUCHIGAMI TAKAMASA ,  SHIMIZU RIE

    IPC: B01J31/20 ,  B01J31/24 ,  C07B61/00 ,  C07F7/08 ,  C07F7/12 ,  C07F7/18

    Abstract: PROBLEM TO BE SOLVED: To provide a method for producing an alkinylsilane, capable of simply and efficiently producing the 1-alkinylsilane and high in generality. SOLUTION: A hydroxysilane of the formula: HSiR3 (R groups are each independently an alkyl group, an alkenyl group, an aryl group, an alkoxy group, an aryloxy group, a silyloxy group or a halogen atom, or two of the R groups may together form a ring) is reacted with a 1-alkine of the formula: R'-C≡CH (R' is hydrogen, an alkyl group, an alkenyl group, an aryl group or a silly group) to produce a 1-alkinylsilane of the formula: R'-C≡C-SiR3 (R and R' are each the same as above).

    PRODUCTION OF AMINE
    40.
    发明专利
    PRODUCTION OF AMINE 失效

    公开(公告)号：JPH09241222A

    公开(公告)日：1997-09-16

    申请号：JP5135296

    申请日：1996-03-08

    Applicant: SAGAMI CHEM RES

    Inventor： FUCHIGAMI TAKAMASA ,  HIROZAWA TOMOTARI ,  WAKASA NORIKO

    IPC: B01J23/652 ,  B01J23/656 ,  C07B61/00 ,  C07C209/50 ,  C07C211/17

    Abstract: PROBLEM TO BE SOLVED: To obtain an amine widely usable as e.g. a raw material for medicines, solvent, catalyst, ligand, under mild conditions in high yield and selectivity, by hydrogenating reduction of an amide in a hydrocarbon solvent in the presence of a specific catalyst. SOLUTION: This amine is obtained by hydrogenating reduction of an amide in the presence of a catalyst composed of at least one element selected from among group VIII elements (pref. rhodium, ruthenium, palladium) and at least one element selected from among group VIb elements (pref. molybdenum, tungsten) or group VIIb elements (pref. rhenium) [pref. Ru/Al2 O3 -Mo(CO)6 , Rh/Al2 O3 - Re2 (CO)10 ]. Using the above reaction, for example, (S)-N-(1-phenylethyl)acetamide is converted into (S)-N-(1-cyclohexylethyl)ethylamine.

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