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公开(公告)号：CY1107158T1
公开(公告)日：2012-10-24
申请号：CY081100097
申请日：2008-01-28
Applicant: SERVIER LAB
Inventor： POISSONNIER-DURIEUX SOPHIE , WALLEZ VALERIE , GASNEREAU ANNE , YOUS SAID , LESIEUR DANIEL , DELAGRANGE PHILIPPE , RENARD PIERRE , BENNEJEAN CAROLINE , BOUTIN JEAN ALBERT , AUDINOT VALERIE
IPC: A61K31/472 , C07D217/14 , A61P1/00 , A61P3/02 , A61P3/04 , A61P3/10 , A61P9/00 , A61P15/00 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P37/02 , A61P43/00 , C07D217/16 , C07D217/24
Abstract: Ενώσειςτουτύπου (Ι) καιη χρήσητουςγιατηθεραπείατωνδιαταραχώντουμελατονινεργικούσυστήματος.
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32.发明专利
公开(公告)号：ES2059069T4
公开(公告)日：2012-03-13
申请号：ES91400526
申请日：1991-02-27
Applicant: SERVIER LAB , ADIR
Inventor： ANDRIEUX JEAN , HOUSSIN RAYMOND , YOUS SAID , GUARDIOLA BEATRICE , LESIEUR DANIEL
IPC: A61K31/165 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/4409 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P17/00 , A61P25/00 , A61P25/18 , A61P25/28 , A61P35/00 , C07C217/60 , C07C233/17 , C07C233/22 , C07C233/60 , C07C233/73 , C07C237/08 , C07D207/12 , C07D207/27 , C07D209/42 , C07D213/81 , C07D233/60 , C07D241/44 , C07D295/14 , C07D295/15 , C07D333/38
Abstract: COMPUESTOS DE FORMULA GENERAL: EN LA QUE R, R SUB 1 Y R SUB 2 ESTAN DEFINIDOS EN LA DESCRIPCION. LOS COMPUESTOS DE FORMULA (I) SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL.
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公开(公告)号：CA2462939C
公开(公告)日：2010-04-27
申请号：CA2462939
申请日：2004-04-06
Applicant: SERVIER LAB
Inventor： POISSONNIER-DURIEUX SOPHIE , WALLEZ VALERIE , GASNEREAU ANNE , YOUS SAID , LESIEUR DANIEL , DELAGRANGE PHILIPPE , RENARD PIERRE , BENNEJEAN CAROLINE , BOUTIN JEAN ALBERT , AUDINOT VALERIE
IPC: C07D217/14 , A61K31/472 , A61P1/00 , A61P3/02 , A61P3/04 , A61P3/10 , A61P9/00 , A61P15/00 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P37/02 , A61P43/00 , C07D217/16 , C07D217/24
Abstract: La présente invention concerne des composés de formule (I): (voir formule I) dans laquelle : ~ n vaut 1, 2 ou 3, ~ A représente un groupement (voir formule II), (voir formule III) ou un groupement (voir formule IV) ~ X représente N ou NR1 ~ R2 représente un groupement alkoxy, cycloalkyloxy ou cycloalkylalkyloxy et la représentation ~ signifie que la liaison est simple ou double étant entendu que la valence des atomes est respectée, la présente invention concerne également leur procédé de préparation, leur utilisation et les compositions pharmaceutiques qui les contiennent.
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公开(公告)号：DE602004009849T2
公开(公告)日：2008-09-04
申请号：DE602004009849
申请日：2004-04-07
Applicant: SERVIER LAB
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公开(公告)号：HRP20070549T3
公开(公告)日：2008-07-31
申请号：HRP20070549
申请日：2007-12-04
Applicant: SERVIER LAB
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Patent Agency Ranking
公开(公告)号：SI1466604T1
公开(公告)日：2008-02-29
申请号：SI200430535
申请日：2004-04-07
Applicant: SERVIER LAB
Inventor： POISSONNIER-DURIEUX SOPHIE , WALLEZ VALERIE , GASNEREAU ANNE , YOUS SAID , LESIEUR DANIEL , DELAGRANGE PHILIPPE , RENARD PIERRE , BENNEJEAN CAROLINE , BOUTIN JEAN ALBERT , AUDINOT VALERIE
IPC: A61K31/00 , C07D217/14 , A61K31/472 , A61P1/00 , A61P3/00 , A61P3/02 , A61P3/04 , A61P3/10 , A61P9/00 , A61P15/00 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P37/02 , A61P43/00 , C07D217/00 , C07D217/16 , C07D217/24
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37.发明专利
公开(公告)号：UA81610C2
公开(公告)日：2008-01-25
申请号：UA2004042636
申请日：2004-04-07
Applicant: SERVIER LAB
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公开(公告)号：FI118565B
公开(公告)日：2007-12-31
申请号：FI955023
申请日：1995-10-20
Applicant: SERVIER LAB
Inventor： LESIEUR DANIEL , DEPREUX PATRICK , LECLERC VERONIQUE , AIT MANSOUR HAMIT , DELAGRANGE PHILIPPE , RENARD PIERRE
IPC: C07D307/92 , A61K31/34 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/38 , A61K31/41 , A61P3/04 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/28 , A61P35/00 , A61P37/06 , A61P43/00 , C07C233/13 , C07C233/20 , C07C233/60 , C07D311/92 , C07D491/04 , C07D491/044 , C07D491/052 , C07D493/04 , C07D495/04
Abstract: Tricyclic amides of formula (I), their enantiomers, diastereoisomers, and salts are new. R = 1-4C alkylene, opt. substd. by alkyl, OH, alkoxycarbonyl, or COOH; R = H or alkyl; R = a group R which is -C(=X')-(CH2)n-R or a group R which is -C(=X)-NH-(CH2)m -R ; m and n = 0-3; R5, R6 = H, alkyl, alkenyl, alkynyl, cycloalkyl, or di-cycloalkyl-alkyl (all opt. substd.); X, X' = O or S; A = -O-A -; A = 2-5C alkylene, alkenylene, or alkynylene which may be substd. by alkyl, alkoxy, OH and oxo gps.; Y forms, with the benzene ring to which it is attached, a group Y which is naphthalene, benzofuran, or benzothiophene, all of which may be partially hydrogenated, or indole; provided that the substitutions on alkyl, alkenyl, and alkynyl groups are halogen, alkyl, or alkoxy, while the substitution on cycloalkyl and di-cycloalkyl-alkyl groups are alkyl, alkoxy, hydroxy, or oxo. Alkyl, alkoxy, alkenyl and alkynyl groups have up to 6C, and cycloalkyl groups have up to 8C, and may be satd. or unsatd. Intermediates of formula (II) and (VI) are new. Z = a reactive gp.; A = 2-5C alkenyl opt. substd. by 1-6C alkyl.
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公开(公告)号：DE69933149T2
公开(公告)日：2006-12-21
申请号：DE69933149
申请日：1999-05-10
Applicant: SERVIER LAB
Inventor： LESIEUR DANIEL , KLUPSCH FREDERIQUE , GUILLAUMET GERALD , VIAUD MARIE-CLAUDE , LANGLOIS MICHEL , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: C07C233/36 , C07D295/12 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/19 , A61K31/27 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/382 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4402 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/4453 , A61K31/453 , A61K31/454 , A61K31/473 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P1/00 , A61P3/06 , A61P3/10 , A61P5/02 , A61P9/00 , A61P15/08 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/40 , C07C233/43 , C07C233/62 , C07C233/65 , C07C237/48 , C07C271/20 , C07C271/30 , C07C275/24 , C07C275/40 , C07C311/46 , C07C317/32 , C07C323/40 , C07C323/41 , C07C323/44 , C07C323/62 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/20 , C07D209/60 , C07D209/90 , C07D213/70 , C07D221/08 , C07D221/10 , C07D233/42 , C07D233/84 , C07D235/06 , C07D235/14 , C07D261/20 , C07D295/18 , C07D307/68 , C07D307/77 , C07D307/81 , C07D307/92 , C07D311/58 , C07D311/60 , C07D311/92 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/40 , C07D333/50 , C07D333/56 , C07D333/58 , C07D333/74 , C07D335/06 , C07D335/08 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/06 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/048 , C07D491/052 , C07D493/04 , C07D495/04 , C07D495/14 , C07D521/00
Abstract: The invention concerns compounds of formula (I): R-A-R' wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R 1 , R 2 , R 3 , v and R 4 are as defined in the description; R' represents a -(CH 2 )t-R 5 group wherein t and R 5 are as defined in the description.
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公开(公告)号：ZA200503232B
公开(公告)日：2006-06-28
申请号：ZA200503232
申请日：2005-04-21
Applicant: SERVIER LAB
Inventor： POISSONNIER-DURIEUX SOPHIE , YOUS SAID , LESIEUR DANIEL , BENNEJEAN CAROLINE , DELAGRANGE PHILIPPE , RENARD PIERRE
IPC: A61K20060101 , A61P20060101 , A61P1/00 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/10 , A61P15/18 , A61P25/00 , A61P35/00 , A61P37/02 , C07C20060101 , C07C233/18 , C07C233/36 , C07C233/60 , C07D20060101 , C07D207/26 , C07D207/27
Abstract: 1-(Amido-, ureido- or carbamoyl-alkyl)-3-(substituted methyl-phenyl)-naphthalene derivatives (I) are new. Phenyl-naphthalene derivatives of formula (I) and their enantiomers, diastereomers and acid or base addition salts are new. A = -NR2-CO-R1, -NR2-CO-NR1R'1 or -CO-NR1R'1; R1, R'1 = 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 3-8C cycloalkyl, (3-8C) cycloalkyl-(1-6C) alkyl, aryl, aryl-(1-6C) alkyl, heteroaryl or heteroaryl-(1-6C) alkyl; R2 = H or alkyl; or R1 + R2 = 3-6C linear or branched alkylene; R3 = 1-6C alkoxy; R4 = halo, OH, 1-6C alkoxy, NH2 or mono- or di-(1-6C alkyl)-amino; aryl moieties = phenyl, naphthyl or biphenylyl (all optionally substituted by 1-3 of 1-6C alkyl, 1-6C alkoxy, OH, COOH, CHO, NO2, CN, 1-6C polyhaloalkyl, alkoxycarbonyl or halo); p = 1-3; heteroaryl moieties = mono- or bicyclic aromatic group containing 1-3 of O, S and N as heteroatom(s) (optionally substituted as for aryl). Independent claims are included for: (a) the preparation of (I); and (b) new alkoxycarbonylphenyl-naphthalene derivative intermediates of formula (V) and their enantiomers, diastereomers and acid or base addition salts. R'5 = (1-6C) alkoxycarbonyl.
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