公开(公告)号：ES2247668T3

公开(公告)日：2006-03-01

申请号：ES98402963

申请日：1998-11-27

Applicant: SERVIER LAB

Inventor： LEFOULON FRANCOIS ,  DEMUYNCK LUC ,  LESIEUR DANIEL ,  DEPREUX PATRICK ,  BENNEJEAN CAROLINE ,  RENARD PIERRE

IPC: A61K31/00 ,  A61K31/10 ,  A61K31/16 ,  A61K31/165 ,  A61K31/17 ,  A61K31/18 ,  A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61P25/20 ,  A61P43/00 ,  C07C233/05 ,  C07C233/17 ,  C07C233/18 ,  C07C233/22 ,  C07C233/31 ,  C07C233/36 ,  C07C233/47 ,  C07C233/58 ,  C07C233/60 ,  C07C255/66 ,  C07C275/24 ,  C07C309/65 ,  C07C317/14 ,  C07C317/22 ,  C07C317/32 ,  C07C327/42 ,  C07C335/06 ,  C07D213/56 ,  C07D233/60 ,  C07D307/12 ,  C07D307/52 ,  C07D307/54 ,  C07D333/16 ,  C07D333/20

Abstract: COMPUESTO DE FORMULA (I): EN LA QUE: - T REPRESENTA UNA CADENA ALQUILENO, . A Y B FORMAN JUNTOS UN GRUPO NAFTALENO, DIHIDRONAFTALENO O TETRAHIDRONAFTALENO, . R REPRESENTA UN HIDROGENO, UN GRUPO HIDROXI, R'' O OR'', ESTANDO R'' DEFINIDO COMO EN LA DESCRIPCION, . G 1 REPRESENTA UN HALOGENO, UN RADICAL R SUB,1 UN GRUPO - O - CO - R 1 , ESTANDO R 1 DEFINIDO COMO EN LA DESCRIPCION, . G 2 REPRESENTA UN GRUPO ELEGIDO ENTRE: ESTANDO X, R 2 Y R 21 DEFINIDOS COMO EN LA DESCRIPCION. MEDICAMENTOS.

公开(公告)号：ES2197062T3

公开(公告)日：2004-01-01

申请号：ES00610050

申请日：2000-05-22

Applicant: SERVIER LAB

Inventor： DEPREUX PATRICK ,  YOUS SAID ,  CHEVE GWENAEL ,  GUILLAUMET GERALD ,  VIAUD MARIE-CLAUDE ,  LARRAYA CARLOS

IPC: C07D319/20 ,  A61K31/24 ,  A61K31/34 ,  A61K31/343 ,  A61K31/352 ,  A61K31/357 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4355 ,  A61K31/44 ,  A61P1/14 ,  A61P3/00 ,  A61P9/00 ,  A61P9/02 ,  A61P25/00 ,  A61P25/20 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07C233/22 ,  C07D209/16 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D311/58 ,  C07D333/58 ,  C07D333/60 ,  C07D333/66 ,  C07D339/08 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D471/04

Abstract: The invention relates to compound of formula (I):wherein:A represents a grouping NR1C(Q)R2, C(Q)NR2R3 or NR1C(Q)NR2R3,B represents a grouping NR1C(Q)R2, NR1C(Q)NR2R3, C(Q)NR2R3, C(Q)OR1, NR1C(Q)OR2 or NR2R3,G1 and G3 represent an optionally substituted alkylene chain,Cy and Cy', which are different, represent a ring structureorG2 represents a chainand medicinal products containing the same are useful in treating or in preventing melatoninergic disorders.

公开(公告)号：AT237610T

公开(公告)日：2003-05-15

申请号：AT00610050

申请日：2000-05-22

Applicant: SERVIER LAB

Inventor： DEPREUX PATRICK ,  YOUS SAID ,  CHEVE GWENAEL ,  GUILLAUMET GERALD ,  VIAUD MARIE-CLAUDE ,  LARRAYA CARLOS ,  BENNEJEAN CAROLINE ,  DELAGRANGE PHILIPPE ,  REGARD PIERRE ,  DESCAMPS-FRANCOIS CAROLE

IPC: C07D319/20 ,  A61K31/24 ,  A61K31/34 ,  A61K31/343 ,  A61K31/352 ,  A61K31/357 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4355 ,  A61K31/44 ,  A61P1/14 ,  A61P3/00 ,  A61P9/00 ,  A61P9/02 ,  A61P25/00 ,  A61P25/20 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07C233/22 ,  C07D209/16 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D311/58 ,  C07D333/58 ,  C07D333/60 ,  C07D333/66 ,  C07D339/08 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D471/04

Abstract: The invention relates to compound of formula (I):wherein:A represents a grouping NR1C(Q)R2, C(Q)NR2R3 or NR1C(Q)NR2R3,B represents a grouping NR1C(Q)R2, NR1C(Q)NR2R3, C(Q)NR2R3, C(Q)OR1, NR1C(Q)OR2 or NR2R3,G1 and G3 represent an optionally substituted alkylene chain,Cy and Cy', which are different, represent a ring structureorG2 represents a chainand medicinal products containing the same are useful in treating or in preventing melatoninergic disorders.

公开(公告)号：NO312897B1

公开(公告)日：2002-07-15

申请号：NO960109

申请日：1996-01-10

Applicant: SERVIER LAB

Inventor： LESIEUR DANIEL ,  FOURMAINTRAUX ERIC ,  DEPREUX PATRICK ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE ,  GUARDIOLA-LEMAITRE BEATRICE

IPC: A61K31/165 ,  A61K31/17 ,  A61K31/18 ,  A61K31/34 ,  A61K31/343 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61P3/00 ,  A61P3/04 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  A61P43/00 ,  C07C231/02 ,  C07C233/02 ,  C07C233/05 ,  C07C233/08 ,  C07C233/09 ,  C07C233/58 ,  C07C273/02 ,  C07C275/24 ,  C07C275/26 ,  C07C303/38 ,  C07C311/03 ,  C07C311/10 ,  C07C311/11 ,  C07C327/38 ,  C07C335/12 ,  C07C335/14 ,  C07D209/14 ,  C07D307/81 ,  C07D333/58 ,  C07D307/80

Abstract: Hetero-cycloalkyl derivs. of formula (I) and their enantiomers and diastereoisomers are new. R1 = alkyl opt. substd. by Q; or cycloalkyl or cycloalkylalkyl, both opt. substd. by Q'; A together with the benzene gp. = tetrahydronaphthalene, dihydronaphthalene, naphthalene, benzothiophene, 2,3-dihydrobenzothiophene; or indoline or indole both opt. N-substd. by Ra, CORa or CO2Ra; Ra = alkyl, Ph or phenylalkyl; R2 = H or alkyl; R3 = C(=X)R4 or C(=X')NHR5; X, X' = S or O; R4 = H, alkenyl, alkynyl, alkyl opt. substd. by Q, or cycloalkyl or cycloalkylalkyl both opt. substd. by Q'; R5 = H, alkyl opt. substd. by Q, or cycloalkyl or cycloalkylalkyl both opt. substd. by Q'; alkyl, alkoxy = 1-6C; alkenyl, alkynyl = 2-6C; cycloalkyl = 3-8C; Q = halo, OH, alkyl or alkoxy; Q' = halo, alkyl or oxo.

公开(公告)号：PT708099E

公开(公告)日：2002-05-31

申请号：PT95402331

申请日：1995-10-19

Applicant: SERVIER LAB

Inventor： LESIEUR DANIEL ,  RENARD PIERRE ,  DELAGRANGE PHILIPPE ,  DEPREUX PATRICK ,  MANSOUR HAMID AIT ,  LECLERK VERONIQUE

IPC: A61K31/34 ,  A61K31/343 ,  A61K31/35 ,  A61K31/352 ,  A61K31/38 ,  A61K31/41 ,  A61P3/04 ,  A61P25/00 ,  A61P25/04 ,  A61P25/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/28 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07C233/13 ,  C07C233/20 ,  C07C233/60 ,  C07D307/92 ,  C07D311/92 ,  C07D491/04 ,  C07D491/044 ,  C07D491/052 ,  C07D493/04 ,  C07D495/04 ,  C07C233/18 ,  C07C275/22

Abstract: Tricyclic amides of formula (I), their enantiomers, diastereoisomers, and salts are new. R = 1-4C alkylene, opt. substd. by alkyl, OH, alkoxycarbonyl, or COOH; R = H or alkyl; R = a group R which is -C(=X')-(CH2)n-R or a group R which is -C(=X)-NH-(CH2)m -R ; m and n = 0-3; R5, R6 = H, alkyl, alkenyl, alkynyl, cycloalkyl, or di-cycloalkyl-alkyl (all opt. substd.); X, X' = O or S; A = -O-A -; A = 2-5C alkylene, alkenylene, or alkynylene which may be substd. by alkyl, alkoxy, OH and oxo gps.; Y forms, with the benzene ring to which it is attached, a group Y which is naphthalene, benzofuran, or benzothiophene, all of which may be partially hydrogenated, or indole; provided that the substitutions on alkyl, alkenyl, and alkynyl groups are halogen, alkyl, or alkoxy, while the substitution on cycloalkyl and di-cycloalkyl-alkyl groups are alkyl, alkoxy, hydroxy, or oxo. Alkyl, alkoxy, alkenyl and alkynyl groups have up to 6C, and cycloalkyl groups have up to 8C, and may be satd. or unsatd. Intermediates of formula (II) and (VI) are new. Z = a reactive gp.; A = 2-5C alkenyl opt. substd. by 1-6C alkyl.

公开(公告)号：HK1030937A1

公开(公告)日：2001-05-25

申请号：HK01101746

申请日：2001-03-12

Applicant: SERVIER LAB

Inventor： DEPREUX PATRICK ,  YOUS SAID ,  CHEVE GWENAEL ,  GUILLAUMET GERALD ,  VIAUD MARIE-CLAUDE ,  LARRAYA CARLOS ,  BENNEJEAN CAROLINE ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE ,  DESCAMPS-FRANCOIS CAROLE

IPC: C07D319/20 ,  A61K31/24 ,  A61K31/34 ,  A61K31/343 ,  A61K31/352 ,  A61K31/357 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4355 ,  A61K31/44 ,  A61P1/14 ,  A61P3/00 ,  A61P9/00 ,  A61P9/02 ,  A61P25/00 ,  A61P25/20 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07C233/22 ,  C07D209/16 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D311/58 ,  C07D333/58 ,  C07D333/60 ,  C07D333/66 ,  C07D339/08 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D471/04 ,  C07D ,  A61K ,  A61P

Abstract: The invention relates to compound of formula (I):wherein:A represents a grouping NR1C(Q)R2, C(Q)NR2R3 or NR1C(Q)NR2R3,B represents a grouping NR1C(Q)R2, NR1C(Q)NR2R3, C(Q)NR2R3, C(Q)OR1, NR1C(Q)OR2 or NR2R3,G1 and G3 represent an optionally substituted alkylene chain,Cy and Cy', which are different, represent a ring structureorG2 represents a chainand medicinal products containing the same are useful in treating or in preventing melatoninergic disorders.

公开(公告)号：AU4089496A

公开(公告)日：1996-07-18

申请号：AU4089496

申请日：1996-01-09

Applicant: SERVIER LAB

Inventor： LESIEUR DANIEL ,  FOURMAINTRAUX ERIC ,  DEPREUX PATRICK ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE ,  GUARDIOLA-LEMAITRE BEATRICE

IPC: A61K31/165 ,  A61K31/17 ,  A61K31/18 ,  A61K31/34 ,  A61K31/343 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61P3/00 ,  A61P3/04 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  A61P43/00 ,  C07C231/02 ,  C07C233/02 ,  C07C233/05 ,  C07C233/08 ,  C07C233/09 ,  C07C233/58 ,  C07C273/02 ,  C07C275/24 ,  C07C275/26 ,  C07C303/38 ,  C07C311/03 ,  C07C311/10 ,  C07C311/11 ,  C07C327/38 ,  C07C335/12 ,  C07C335/14 ,  C07D209/14 ,  C07D307/81 ,  C07D333/58

Abstract: Hetero-cycloalkyl derivs. of formula (I) and their enantiomers and diastereoisomers are new. R1 = alkyl opt. substd. by Q; or cycloalkyl or cycloalkylalkyl, both opt. substd. by Q'; A together with the benzene gp. = tetrahydronaphthalene, dihydronaphthalene, naphthalene, benzothiophene, 2,3-dihydrobenzothiophene; or indoline or indole both opt. N-substd. by Ra, CORa or CO2Ra; Ra = alkyl, Ph or phenylalkyl; R2 = H or alkyl; R3 = C(=X)R4 or C(=X')NHR5; X, X' = S or O; R4 = H, alkenyl, alkynyl, alkyl opt. substd. by Q, or cycloalkyl or cycloalkylalkyl both opt. substd. by Q'; R5 = H, alkyl opt. substd. by Q, or cycloalkyl or cycloalkylalkyl both opt. substd. by Q'; alkyl, alkoxy = 1-6C; alkenyl, alkynyl = 2-6C; cycloalkyl = 3-8C; Q = halo, OH, alkyl or alkoxy; Q' = halo, alkyl or oxo.

公开(公告)号：DE69831121T2

公开(公告)日：2006-06-14

申请号：DE69831121

申请日：1998-11-27

Applicant: SERVIER LAB

Inventor： LEFOULON FRANCOIS ,  DEMUYNCK LUC ,  LESIEUR DANIEL ,  DEPREUX PATRICK ,  BENNEJEAN CAROLINE ,  RENARD PIERRE ,  DELAGRANGE PHILIPPE

IPC: C07C233/22 ,  A61K31/00 ,  A61K31/10 ,  A61K31/16 ,  A61K31/165 ,  A61K31/17 ,  A61K31/18 ,  A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61P25/20 ,  A61P43/00 ,  C07C233/05 ,  C07C233/17 ,  C07C233/18 ,  C07C233/31 ,  C07C233/36 ,  C07C233/47 ,  C07C233/58 ,  C07C233/60 ,  C07C255/66 ,  C07C275/24 ,  C07C309/65 ,  C07C317/14 ,  C07C317/22 ,  C07C317/32 ,  C07C327/42 ,  C07C335/06 ,  C07D213/56 ,  C07D233/60 ,  C07D307/12 ,  C07D307/52 ,  C07D307/54 ,  C07D333/16 ,  C07D333/20

Abstract: Naphthalenic compounds (I), their enantiomers, diastereoisomers, and salts with acids and bases. The naphthalenic compounds are of formula (I) A and B' rings = naphthalene, 1,2-dihydronaphthalene, 2,3- dihydronaphthalene, 1,4- dihydronaphthalene, or tetrahydronaphthalene; T = 1-6C alkylene which may be substituted by one or more 1-6C alkyl, alkoxy, alkoxycarbonyl, OH, or COOH groups; R = H, OH, R', or OR'; R' = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, 4-7C cycloalkenyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted), or 1-6C trihaloalkyl sulfonyl; R may further link with two atoms of ring A and = a 5-7 membered saturated or unsaturated O-containing ring, which may be substituted by 1-6C alkyl, alkoxy, alkoxy-carbonyl, OH, or oxo; G1 = halo (in which case it is linked to ring B'), 1-6C trihalo alkyl sulfonyloxy, COOH, formyl, CN, R1 or -O-CO-R1; R1 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted); G2 = a group G20, G21, or G22; X = O or S; R2 = H or 1-6C alkyl; R21 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted) with various provisos listed in the Definitions section.

公开(公告)号：DK0919541T3

公开(公告)日：2005-10-17

申请号：DK98402963

申请日：1998-11-27

Applicant: SERVIER LAB

Inventor： RENARD PIERRE ,  LEFOULON FRANCOIS ,  DEMUYNCK LUC ,  LESIEUR DANIEL ,  DEPREUX PATRICK ,  BENNEJEAN CAROLINE ,  DELAGRANGE PHILIPPE

IPC: A61K31/00 ,  A61K31/10 ,  A61K31/16 ,  A61K31/165 ,  A61K31/17 ,  A61K31/18 ,  A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61P25/20 ,  A61P43/00 ,  C07C233/05 ,  C07C233/17 ,  C07C233/18 ,  C07C233/22 ,  C07C233/31 ,  C07C233/36 ,  C07C233/47 ,  C07C233/58 ,  C07C233/60 ,  C07C255/66 ,  C07C275/24 ,  C07C309/65 ,  C07C317/14 ,  C07C317/22 ,  C07C317/32 ,  C07C327/42 ,  C07C335/06 ,  C07D213/56 ,  C07D233/60 ,  C07D307/12 ,  C07D307/52 ,  C07D307/54 ,  C07D333/16 ,  C07D333/20

Abstract: Naphthalenic compounds (I), their enantiomers, diastereoisomers, and salts with acids and bases. The naphthalenic compounds are of formula (I) A and B' rings = naphthalene, 1,2-dihydronaphthalene, 2,3- dihydronaphthalene, 1,4- dihydronaphthalene, or tetrahydronaphthalene; T = 1-6C alkylene which may be substituted by one or more 1-6C alkyl, alkoxy, alkoxycarbonyl, OH, or COOH groups; R = H, OH, R', or OR'; R' = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, 4-7C cycloalkenyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted), or 1-6C trihaloalkyl sulfonyl; R may further link with two atoms of ring A and = a 5-7 membered saturated or unsaturated O-containing ring, which may be substituted by 1-6C alkyl, alkoxy, alkoxy-carbonyl, OH, or oxo; G1 = halo (in which case it is linked to ring B'), 1-6C trihalo alkyl sulfonyloxy, COOH, formyl, CN, R1 or -O-CO-R1; R1 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted); G2 = a group G20, G21, or G22; X = O or S; R2 = H or 1-6C alkyl; R21 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted) with various provisos listed in the Definitions section.

公开(公告)号：DE69831121D1

公开(公告)日：2005-09-15

申请号：DE69831121

申请日：1998-11-27

Applicant: SERVIER LAB

Inventor： LEFOULON FRANCOIS ,  DEMUYNCK LUC ,  LESIEUR DANIEL ,  DEPREUX PATRICK ,  BENNEJEAN CAROLINE ,  RENARD PIERRE ,  DELAGRANGE PHILIPPE

IPC: A61K31/00 ,  A61K31/10 ,  A61K31/16 ,  A61K31/165 ,  A61K31/17 ,  A61K31/18 ,  A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61P25/20 ,  A61P43/00 ,  C07C233/05 ,  C07C233/17 ,  C07C233/18 ,  C07C233/22 ,  C07C233/31 ,  C07C233/36 ,  C07C233/47 ,  C07C233/58 ,  C07C233/60 ,  C07C255/66 ,  C07C275/24 ,  C07C309/65 ,  C07C317/14 ,  C07C317/22 ,  C07C317/32 ,  C07C327/42 ,  C07C335/06 ,  C07D213/56 ,  C07D233/60 ,  C07D307/12 ,  C07D307/52 ,  C07D307/54 ,  C07D333/16 ,  C07D333/20

Abstract: Naphthalenic compounds (I), their enantiomers, diastereoisomers, and salts with acids and bases. The naphthalenic compounds are of formula (I) A and B' rings = naphthalene, 1,2-dihydronaphthalene, 2,3- dihydronaphthalene, 1,4- dihydronaphthalene, or tetrahydronaphthalene; T = 1-6C alkylene which may be substituted by one or more 1-6C alkyl, alkoxy, alkoxycarbonyl, OH, or COOH groups; R = H, OH, R', or OR'; R' = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, 4-7C cycloalkenyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted), or 1-6C trihaloalkyl sulfonyl; R may further link with two atoms of ring A and = a 5-7 membered saturated or unsaturated O-containing ring, which may be substituted by 1-6C alkyl, alkoxy, alkoxy-carbonyl, OH, or oxo; G1 = halo (in which case it is linked to ring B'), 1-6C trihalo alkyl sulfonyloxy, COOH, formyl, CN, R1 or -O-CO-R1; R1 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted); G2 = a group G20, G21, or G22; X = O or S; R2 = H or 1-6C alkyl; R21 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted) with various provisos listed in the Definitions section.