公开(公告)号：SK287607B6

公开(公告)日：2011-03-04

申请号：SK612003

申请日：2001-07-12

Applicant: SOLVAY PHARM GMBH

Inventor： HEBEBRAND JOHANNES ,  ANTEL JOCHEN ,  PREUSCHOFF ULF ,  DAVID SAMUEL ,  SANN HOLGER ,  WESKE MICHAEL

IPC: A61P1/00 ,  G01N33/50 ,  A61K45/00 ,  A61P3/04 ,  C12Q1/02 ,  C12Q1/527 ,  G01N33/15

Abstract: The method for locating compounds which are suitable for the treatment and/or prophylaxis of obesity, whereby the ability of the examined compounds to inhibit de novo lipogenase in mammals and/or humans is determined. Also disclosed is the use of compounds which are capable of inhibiting de novo lipogenase in mammals in the production of medicaments for the treatment and/or prophylaxis of obesity.

公开(公告)号：DE19805822B4

公开(公告)日：2009-02-05

申请号：DE19805822

申请日：1998-02-13

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  PREUSCHOFF ULF ,  EECKHOUT CHRISTIAN

IPC: C07H17/08 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/06 ,  A61P1/14 ,  A61P43/00 ,  C07H1/00

Abstract: (2R,3S,4S,5R,6R,10R,11R)-2,4,6,8,10-Pentamethyl-11-acetyl-12,13- dioxabicyclo(8.2.1)tridec-8-en-1-one compounds are new. (2R,3S,4S,5R,6R,10R,11R)-2,4,6,8,10-pentamethyl-11-acetyl-12,13- dioxabicyclo(8.2.1)tridec-8-en-1-one compounds of formula (I) and their acid addition salts are new R1 = H or Me; R2 = H or lower alkanoyl.

公开(公告)号：AU2007211475A1

公开(公告)日：2007-08-09

申请号：AU2007211475

申请日：2007-02-01

Applicant: SOLVAY PHARM GMBH

Inventor： BRUCKNER REINHARD ,  PREUSCHOFF ULF ,  JAUNZEMS JANIS ,  BENSON WERNER ,  ATTALI AMOS ,  SANN HOLGER ,  MENTZEL MATTHIAS ,  ADOLFS MARTINUS ,  FIRNGES MICHAEL ,  JASSERAND DANIEL

IPC: C07D211/66 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/445 ,  C07D211/58 ,  C07D211/62 ,  C07D295/14 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

公开(公告)号：BRPI0417161A

公开(公告)日：2007-03-06

申请号：BRPI0417161

申请日：2004-12-09

Applicant: SOLVAY PHARM GMBH

Inventor： MENTZEL MATTHIAS ,  REICHE DANIA B ,  BRUECKNER REINHARD ,  DAVID SAMUEL ,  STEEN BARTHOLOMEUS J VAN ,  UWE SCHOEN ,  JASSERAND DANIEL ,  PREUSCHOFF ULF

IPC: A61K31/438 ,  A61K31/4747 ,  A61P9/06 ,  A61P9/12 ,  A61P29/00 ,  C07D221/00 ,  C07D233/00 ,  C07D471/10 ,  C07D487/08

Abstract: The invention relates to a group of hydronopol derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these novel hydronopol derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1) wherein the symbols have the meanings as given in the description.

公开(公告)号：SK285313B6

公开(公告)日：2006-10-05

申请号：SK15099

申请日：1999-02-05

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  PREUSCHOFF ULF ,  EECKHOUT CHRISTIAN

IPC: C07H17/00 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/06 ,  A61P1/14 ,  A61P43/00 ,  C07H17/08

Abstract: Ring-contracted N-desmethyl-N-isopropyl-erythromycin-A derivatives having a modified side chain and gastrointestinally effective motilin-agonistic properties, the preparation thereof and pharmaceutical compositions containing them are described.

公开(公告)号：NO20063138L

公开(公告)日：2006-09-06

申请号：NO20063138

申请日：2006-07-06

Applicant: SOLVAY PHARM GMBH

Inventor： MENTZEL MATTHIAS ,  REICHE DANIA B ,  BRUCKNER REINHARD ,  DAVID SAMUEL ,  STEEN BARTHOLOMEUS J VAN ,  SCHON UWE ,  JASSERAND DANIEL ,  PREUSCHOFF ULF

IPC: C07D471/10 ,  A61K31/4747 ,  C07D487/08

Abstract: The invention relates to a group of hydronopol derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these novel hydronopol derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1) wherein the symbols have the meanings as given in the description.

公开(公告)号：AU2001277534B9

公开(公告)日：2006-02-23

申请号：AU2001277534

申请日：2001-07-12

Applicant: SOLVAY PHARM GMBH

Inventor： PREUSCHOFF ULF ,  WESKE MICHAEL ,  SANN HOLGER ,  HEBEBRAND JOHANNES ,  ANTEL JOCHEN ,  DAVID SAMUEL

IPC: A61P1/00 ,  G01N33/50 ,  A61K45/00 ,  A61P3/04 ,  C12Q1/02 ,  C12Q1/527 ,  G01N33/15

Abstract: Compounds for the treatment and/or prevention of obesity are selected on the basis of their capability to inhibit de novo lipogenesis in mammals. An independent claim is also included for the use of compounds which are capable of inhibiting de novo lipogenesis in mammals and which have no anticonvulsant activity for the production of a medicament for the treatment and/or prevention of obesity. - ACTIVITY : Anorectic. - MECHANISM OF ACTION : Lipogenesis inhibitor; Carboanhydrase inhibitor. No biological data given.

公开(公告)号：SI1293506T1

公开(公告)日：2005-12-31

申请号：SI200230195

申请日：2002-09-07

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  PREUSCHOFF ULF ,  ANTEL JOCHEN ,  DAVID SAMUEL ,  SANN HOLGER ,  BRUECKNER REINHARD ,  REICHE DANIA ,  EECKHOUT CHRISTIAN

IPC: C07D295/12 ,  C07D333/00 ,  A61K31/00 ,  A61K31/341 ,  A61K31/381 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/00 ,  C07D209/08 ,  C07D295/00 ,  C07D295/08 ,  C07D295/084 ,  C07D295/092 ,  C07D307/00 ,  C07D307/52 ,  C07D333/20 ,  C07D407/00 ,  C07D407/04 ,  C07D407/06 ,  C07D409/06

公开(公告)号：AT308537T

公开(公告)日：2005-11-15

申请号：AT02754561

申请日：2002-05-04

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  ANTEL JOCHEN ,  PREUSCHOFF ULF ,  BRUECKNER REINHARD ,  SANN HOLGER ,  WURL MICHAEL ,  EICKELMANN PETER

IPC: C07D401/12 ,  A61K31/454 ,  A61P1/04 ,  A61P1/06 ,  A61P1/14 ,  C07D211/32 ,  C07D401/06 ,  C07D405/14

Abstract: 4-substituted 1-amidomethylcarbonyl-piperidine compounds having motilin-agonistic properties and their acid addition salts, pharmaceutical compositions containing these compounds, processes and intermediate products for the preparation of these compounds, and methods of treatment utilizing these compounds.

公开(公告)号：AT305464T

公开(公告)日：2005-10-15

申请号：AT02020115

申请日：2002-09-07

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  PREUSCHOFF ULF ,  ANTEL JOCHEN ,  DAVID SAMUEL ,  SANN HOLGER ,  BRUECKNER REINHARD ,  REICHE DANIA ,  EECKHOUT CHRISTIAN

IPC: C07D295/12 ,  A61K31/341 ,  A61K31/381 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/08 ,  C07D295/08 ,  C07D295/084 ,  C07D295/092 ,  C07D307/52 ,  C07D333/20 ,  C07D407/04 ,  C07D407/06 ,  C07D409/06

Abstract: 1-(1-(Hetero)aryl)-1-(polyhydroxyalkyl)-methyl)-4-(4-(N-methylbenzamid o)-3-phenylbutyl)-piperazine derivatives (I) are new. Also new are 1-unsubstituted analog intermediates (II). 1-(1-(Hetero)aryl)-1-(polyhydroxyalkyl)-methyl)-4-(4-(N-methylbenzamid o)-3-phenylbutyl)-piperazine derivatives of formula (I) and their acid addition salts are new. A = naphthyl, phenyl (optionally substituted by OH), mono- or bi-cyclic heteroaryl or 3-6C alkenyl (optionally substituted by phenyl); Q = (CHOR1)k-(CHOR2)l-(CHOR3)m-(CHOR4)n-CH2OR5 ; R1-R5 = H or lower alkanoyl, or two of R1-R5 = CO, CS or CH2 (optionally substituted by lower alkyl or 4-5C alkylene), completing a 5- or 6-membered ring; k, l, m, n = 0 or 1, and R6, R7 = H or halo. Independent claims are also included for: (1) the preparation of (I), and (2) new piperazine derivative intermediates of formula (II).