公开(公告)号：WO2005058890A3

公开(公告)日：2005-08-18

申请号：PCT/EP2004053373

申请日：2004-12-09

Applicant: SOLVAY PHARM GMBH ,  MENTZEL MATTHIAS ,  REICHE DANIA B ,  BRUCKNER REINHARD ,  DAVID SAMUEL ,  VAN STEEN BARTHOLOMEUS J ,  SCHON UWE ,  JASSERAND DANIEL ,  PREUSCHOFF ULF

Inventor： MENTZEL MATTHIAS ,  REICHE DANIA B ,  BRUCKNER REINHARD ,  DAVID SAMUEL ,  VAN STEEN BARTHOLOMEUS J ,  SCHON UWE ,  JASSERAND DANIEL ,  PREUSCHOFF ULF

IPC: A61K31/438 ,  A61K31/4747 ,  A61P9/06 ,  A61P9/12 ,  A61P29/00 ,  C07D221/00 ,  C07D233/00 ,  C07D471/10 ,  C07D487/08

CPC classification number: C07D471/10

Abstract: The invention relates to a group of hydronopol derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these novel hydronopol derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1) wherein the symbols have the meanings as given in the description.

Abstract translation: 本发明涉及作为人ORL1（伤害感受肽）受体激动剂的一组水溶角质醇衍生物。 本发明还涉及这些化合物的制备，含有药理学活性量的至少一种这些新型水溶黄酚醇衍生物作为活性成分的药物组合物，以及这些药物组合物用于治疗其中 ORL1受体参与。 本发明涉及通式（1）的化合物，其中符号具有在说明书中给出的含义。

公开(公告)号：CA2403139C

公开(公告)日：2011-02-22

申请号：CA2403139

申请日：2002-09-13

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  PREUSCHOFF ULF ,  ANTEL JOCHEN ,  DAVID SAMUEL ,  SANN HOLGER ,  BRUECKNER REINHARD ,  REICHE DANIA ,  EECKOUT CHRISTIAN

IPC: C07D295/12 ,  C07D409/06 ,  A61K31/341 ,  A61K31/381 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/08 ,  C07D241/04 ,  C07D295/08 ,  C07D295/084 ,  C07D295/092 ,  C07D307/52 ,  C07D333/20 ,  C07D407/02 ,  C07D407/04 ,  C07D407/06 ,  C07D409/02

Abstract: Novel 1-[1-(hetero)aryl-1-perhydroxyalkylmethyl]--piperazine compounds which are antagonistic to tachykinin receptors, of the general formula I, (see formula I) wherein R6, R7, A and Z have the meanings given in the description, and medicaments containing these compounds are described. Furthermore, a process for the preparation of the novel compounds and intermediate products of this process are described.

公开(公告)号：CZ301695B6

公开(公告)日：2010-05-26

申请号：CZ20011813

申请日：2001-05-23

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  SCHOEN UWE ,  SANN HOLGER ,  BRUECKNER REINHARD ,  EECKHOUT CHRISTIAN

IPC: C07D403/14 ,  C07D491/10 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61P1/00 ,  A61P1/04 ,  A61P25/00 ,  A61P29/00 ,  A61P43/00 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D413/14

Abstract: Deriváty N-triazomethyl-piperazinu obecného vzorce I, kde substituenty mají specifický význam, které úcinne antagonisticky pusobí na neurokininové receptory. Jsou popsány zpusoby výroby derivátu N-triazolylmethylpiperazinu a meziprodukty techto výrob a také léciva s obsahem slouceniny obecného vzorce I.

公开(公告)号：PL193724B1

公开(公告)日：2007-03-30

申请号：PL32822198

申请日：1998-08-26

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUECKNER REINHARD ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM

IPC: C07D403/06 ,  A61K31/495 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/00 ,  C07D209/14 ,  C07D241/00

公开(公告)号：PL192281B1

公开(公告)日：2006-09-29

申请号：PL33144499

申请日：1999-02-12

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  PREUSCHOFF ULF ,  EECKHOUT CHRISTIAN

IPC: C07H17/04 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/06 ,  A61P1/14 ,  A61P43/00 ,  C07H17/08

公开(公告)号：NO20063138A

公开(公告)日：2006-09-06

申请号：NO20063138

申请日：2006-07-06

Applicant: SOLVAY PHARM GMBH

Inventor： MENTZEL MATTHIAS ,  REICHE DANIA B ,  BRUCKNER REINHARD ,  DAVID SAMUEL ,  STEEN BARTHOLOMEUS J VAN ,  SCHON UWE ,  JASSERAND DANIEL ,  PREUSCHOFF ULF

IPC: C07D471/10 ,  A61K31/4747 ,  C07D487/08

CPC classification number: C07D471/10

公开(公告)号：DE50204789D1

公开(公告)日：2005-12-08

申请号：DE50204789

申请日：2002-05-04

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  ANTEL JOCHEN ,  PREUSCHOFF ULF ,  BRUECKNER REINHARD ,  SANN HOLGER ,  WURL MICHAEL ,  EICKELMANN PETER

IPC: C07D401/12 ,  A61K31/454 ,  A61P1/04 ,  A61P1/06 ,  A61P1/14 ,  C07D211/32 ,  C07D401/06 ,  C07D405/14

Abstract: 4-substituted 1-amidomethylcarbonyl-piperidine compounds having motilin-agonistic properties and their acid addition salts, pharmaceutical compositions containing these compounds, processes and intermediate products for the preparation of these compounds, and methods of treatment utilizing these compounds.

公开(公告)号：PT1293506E

公开(公告)日：2005-11-30

申请号：PT02020115

申请日：2002-09-07

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  EECKHOUT CHRISTIAN ,  BRUCKNER REINHARD ,  ANTEL JOCHEN ,  SANN HOLGER ,  PREUSCHOFF ULF ,  DAVID SAMUEL ,  REICHE DANIA

IPC: C07D295/12 ,  A61K31/341 ,  A61K31/381 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/08 ,  C07D295/08 ,  C07D295/084 ,  C07D295/092 ,  C07D307/52 ,  C07D333/20 ,  C07D407/04 ,  C07D407/06 ,  C07D409/06 ,  C07D295/92

公开(公告)号：SK284802B6

公开(公告)日：2005-11-03

申请号：SK7572001

申请日：2001-06-01

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  SCHON UWE ,  SANN HOLGER ,  BRUCKNER REINHARD ,  EECKHOUT CHRISTIAN

IPC: A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61P1/00 ,  C07D491/10 ,  A61P1/04 ,  A61P25/00 ,  A61P29/00 ,  A61P43/00 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

Abstract: N-triazolylmethyl-piperazine derivatives which exhibit neurokinin receptor antagonistic activity corresponding to the formula (I), wherein R1, R2 and R3 have the meanings given in the specification, pharmaceutical compositions containing these compounds. A process for preparing these compounds and intermediate products of this processes.

公开(公告)号：DK175286B1

公开(公告)日：2004-08-09

申请号：DK256689

申请日：1989-05-26

Applicant: SOLVAY PHARM GMBH

Inventor： BIARD DOMINIQUE ,  CHRISTEN MARIE-ODILE ,  DANSETTE PATRICK ,  JASSERAND DANIEL ,  MANSUY DANIEL ,  SASSI AMOR

IPC: A61K31/36 ,  A61K31/365 ,  A61K31/385 ,  A61P1/16 ,  C07D339/04 ,  C07D409/04

Abstract: The use of 5-phenyl-3H-1,2-dithiole-3-thione S-oxides which are optionally substituted in the phenyl ring as active compounds in liver-protective medicines and 5-phenyl-3H-1,2-dithiole-3-thione S-oxides substituted in the phenyl ring are described.