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公开(公告)号：CA1316171C
公开(公告)日：1993-04-13
申请号：CA280699
申请日：1977-06-16
Applicant: TAKEDA CHEMICAL INDUSTRIES LTD
Inventor： NUMATA MITSUO , MINAMIDA ISAO , TSUSHIMA SUSUMU
IPC: A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D257/04 , C07D277/38 , C07D277/40 , C07D277/46 , C07D499/00 , C07D501/00 , C07D501/20 , C07D501/22 , C07D501/24 , C07D501/28 , C07D501/34 , C07D501/36 , C07D501/38 , C07D501/46 , C07D501/56 , C07D501/60
Abstract: NOVEL CEPHALOSPORIN DERIVATIVES of the disclosure A 2-(syn)-hydroxyimino-acetamide derivative of the formula; wherein Y is hydrogen, hydroxyl, an acyloxy, carbamoyloxy, a quaternary ammonium or a nitrogen-containing heterocyclic ring-substituted thio group; or pharmaceutieally acceptable salts or esters thereof are useful as antibacterial agent.
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公开(公告)号：NO167734C
公开(公告)日：1991-12-04
申请号：NO880511
申请日：1988-02-05
Applicant: TAKEDA CHEMICAL INDUSTRIES LTD
Inventor： TSUSHIMA SUSUMU , TAKATANI MUNEO , HIRATA MINORU
IPC: C07C271/10 , A61K20060101 , A61K31/27 , A61K31/325 , A61K31/335 , A61K31/395 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61P9/06 , C07C20060101 , C07C269/02 , C07C271/06 , C07C271/12 , C07C271/24 , C07C271/28 , C07C275/00 , C07C275/14 , C07C275/28 , C07C323/25 , C07C333/04 , C07C333/06 , C07C333/10 , C07D209/48 , C07D211/04 , C07D211/34 , C07D211/58 , C07D213/24 , C07D213/36 , C07D213/38 , C07D213/53 , C07D295/10 , C07D295/12 , C07D295/125 , C07D295/13 , C07D521/00
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公开(公告)号：DK161081B
公开(公告)日：1991-05-27
申请号：DK621189
申请日：1989-12-08
Applicant: TAKEDA CHEMICAL INDUSTRIES LTD
Inventor： NUMATA MITSUO , MINAMIDA ISAO , TSUSHIMA SUSUMU
IPC: A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D257/04 , C07D277/38 , C07D277/40 , C07D277/46 , C07D499/00 , C07D501/00 , C07D501/20 , C07D501/22 , C07D501/24 , C07D501/28 , C07D501/34 , C07D501/36 , C07D501/38 , C07D501/46 , C07D501/56 , C07D501/60
Abstract: Disclosed are 2-(syn)-hydroxyimino-acetamide derivatives of the formula: wherein Y is hydrogen, hydroxyl, an acyloxy, carbamoyloxy, a quaternary ammonium or a nitrogen-containing heterocyclic ring-substituted thio group; or pharmaceutically acceptable salts or esters thereof are useful as antibacterial agents. Also disclosed are processes for producing them.
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公开(公告)号：AU607180B2
公开(公告)日：1991-02-28
申请号：AU1136088
申请日：1988-02-05
Applicant: TAKEDA CHEMICAL INDUSTRIES LTD
Inventor： TSUSHIMA SUSUMU , TAKATANI MUNEO , HIRATA MINORU
IPC: C07C271/10 , A61K20060101 , A61K31/27 , A61K31/325 , A61K31/335 , A61K31/395 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61P9/06 , C07C20060101 , C07C269/02 , C07C271/06 , C07C271/12 , C07C271/24 , C07C271/28 , C07C275/00 , C07C275/14 , C07C275/28 , C07C323/25 , C07C333/04 , C07C333/06 , C07C333/10 , C07D209/48 , C07D211/04 , C07D211/34 , C07D211/58 , C07D213/24 , C07D213/36 , C07D213/38 , C07D213/53 , C07D295/10 , C07D295/12 , C07D295/125 , C07D295/13 , C07D521/00 , A61K31/535 , C07C269/04 , C07C269/06 , C07C271/20 , C07C333/20 , C07D211/26
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公开(公告)号：CA2003210A1
公开(公告)日：1990-05-18
申请号：CA2003210
申请日：1989-11-17
Applicant: TAKEDA CHEMICAL INDUSTRIES LTD
Inventor： TSUSHIMA SUSUMU , KONDO KOICHI , NISHIKAWA KOHEI
IPC: A61K31/34 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/495 , A61K31/55
Abstract: Platelet activating factor antagonists inhibit the activities of endothelin and are useful as drugs for prevention or treatment of various endothelin-related diseases, hyperendothelinemia.
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Patent Agency Ranking
公开(公告)号：DK621189D0
公开(公告)日：1989-12-08
申请号：DK621189
申请日：1989-12-08
Applicant: TAKEDA CHEMICAL INDUSTRIES LTD
Inventor： NUMATA MITSUO , MINAMIDA ISAO , TSUSHIMA SUSUMU
IPC: A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D257/04 , C07D277/38 , C07D277/40 , C07D277/46 , C07D499/00 , C07D501/00 , C07D501/20 , C07D501/22 , C07D501/24 , C07D501/28 , C07D501/34 , C07D501/36 , C07D501/38 , C07D501/46 , C07D501/56 , C07D501/60
Abstract: Disclosed are 2-(syn)-hydroxyimino-acetamide derivatives of the formula: wherein Y is hydrogen, hydroxyl, an acyloxy, carbamoyloxy, a quaternary ammonium or a nitrogen-containing heterocyclic ring-substituted thio group; or pharmaceutically acceptable salts or esters thereof are useful as antibacterial agents. Also disclosed are processes for producing them.
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公开(公告)号：CA1261844A
公开(公告)日：1989-09-26
申请号：CA461429
申请日：1984-08-21
Applicant: TAKEDA CHEMICAL INDUSTRIES LTD
Inventor： NISHIKAWA KOHEI , TSUSHIMA SUSUMU , NOMURA HIROAKI
IPC: A61K31/685 , A61P9/00 , C07F9/10 , C07F9/58 , C07F9/62 , C07F9/6539 , C07F9/65
Abstract: 24205-566 A pharmaceutical composition which contains a compound of the formula wherein R1 is a C10-24 alkyl group, R2 is a C1-4 alkyl group or a phenyl-C1-3 alkyl grcup and A+ is a heterocyclic group containing a quaternized nitrogen, or a physiologically acceptable salt thereof is useful for inhibiting activities of platelet activating factor.
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公开(公告)号：DK421488A
公开(公告)日：1989-02-01
申请号：DK421488
申请日：1988-07-28
Applicant: TAKEDA CHEMICAL INDUSTRIES LTD
Inventor： TSUSHIMA SUSUMU , TAKATANI MUNEO , NISHIKAWA KOHEI
IPC: C07D215/36 , A61K31/44 , A61K31/4425 , A61K31/4427 , A61K31/47 , A61K31/495 , A61P7/02 , A61P9/02 , A61P11/08 , A61P43/00 , C07D213/71 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D213/83 , C07D215/48 , C07D215/54 , C07D401/12 , C07D405/12
Abstract: Novel pyridinium derivatives represented by the forumula (I): defined as in claim 1. The compounds are useful as antagonists of the platelet activating factor (PAF).
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公开(公告)号：DE3563968D1
公开(公告)日：1988-09-01
申请号：DE3563968
申请日：1985-01-09
Applicant: TAKEDA CHEMICAL INDUSTRIES LTD
Inventor： NOMURA HIROAKI , NISHIKAWA KOHEI , TSUSHIMA SUSUMU
IPC: A61K31/685 , C07D207/40 , C07D207/404 , C07D207/44 , C07D207/448 , C07D209/48 , C07F9/10 , C07F9/553 , C07F9/572 , C07F9/6558 , C07D207/452 , C07F9/65
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公开(公告)号：AT35993T
公开(公告)日：1988-08-15
申请号：AT85300133
申请日：1985-01-09
Applicant: TAKEDA CHEMICAL INDUSTRIES LTD
Inventor： NOMURA HIROAKI , NISHIKAWA KOHEI , TSUSHIMA SUSUMU
IPC: A61K31/685 , C07D207/404 , C07D207/452 , C07D209/48 , C07F9/10 , C07F9/65
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