公开(公告)号：AU2002334135B8

公开(公告)日：2009-01-29

申请号：AU2002334135

申请日：2002-10-10

Applicant: UCB PHARMA SA

Inventor： ZINKEWICH-PEOTTI KAREN ,  POPPLEWELL ANDREW GEORGE ,  TICKLE SIMON PETER ,  MORRISON ROBERT KENDALL

IPC: C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08

Abstract: There are disclosed antibody molecules containing at least on CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.

公开(公告)号：NZ532758A

公开(公告)日：2008-04-30

申请号：NZ53275802

申请日：2002-10-10

Applicant: UCB PHARMA SA

Inventor： POPPLEWELL ANDREW GEORGE ,  TICKLE SIMON PETER ,  ZINKEWICH-PEOTTI KAREN ,  MORRISON ROBERT KENDALL

IPC: C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08 ,  C12N15/70

Abstract: Disclosed are antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.

公开(公告)号：AU2005252863A1

公开(公告)日：2005-12-22

申请号：AU2005252863

申请日：2005-06-10

Applicant: UCB PHARMA SA

Inventor： LAWSON ALASTAIR DAVID GRIFFITH ,  TICKLE SIMON PETER

IPC: C07K16/00 ,  G01N33/531 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58 ,  G01N33/68

Abstract: The present invention provides an automated homogeneous assay for identifying an antibody-producing cell producing an antibody which binds to a selected antigen, especially a high yielding antibody-producing cell.

公开(公告)号：DK1504035T6

公开(公告)日：2018-03-12

申请号：DK03718974

申请日：2003-05-02

Applicant: UCB PHARMA SA

Inventor： POPPLEWELL ANDREW GEORGE ,  TICKLE SIMON PETER ,  LADYMAN HEATHER MARGARET

IPC: C07K16/18 ,  C07K16/28 ,  A61K31/7088 ,  A61K38/16 ,  A61K39/395 ,  A61P35/00 ,  C12N5/10 ,  C12N15/13 ,  C12N15/63 ,  C12N15/85 ,  C12P21/00

公开(公告)号：CY1115147T1

公开(公告)日：2016-12-14

申请号：CY141100263

申请日：2014-04-08

Applicant: UCB PHARMA SA

Inventor： ADAMS RALPH ,  POPPLEWELL ANDREW GEORGE ,  RAPECKI STEPHEN EDWARD ,  TICKLE SIMON PETER

IPC: C07K16/24 ,  A61K39/395 ,  A61K47/48 ,  A61P43/00 ,  C07K14/54 ,  C12N5/16 ,  C12N15/13 ,  C12N15/63

Abstract: Ηεφεύρεσησχετίζεταιμεέναμόριοαντισώματοςπουέχειειδικότηταγιααντιγονικούςκαθοριστέςτης IL-17, τιςθεραπευτικέςχρήσειςτουμορίουαντισώματοςκαιτιςμεθόδουςπαραγωγήςτουενλόγωμορίουαντισώματος.

公开(公告)号：DK1814915T3

公开(公告)日：2014-11-17

申请号：DK05803526

申请日：2005-11-16

Applicant: UCB PHARMA SA

Inventor： ADAMS RALPH ,  POPPLEWELL ANDREW GEORGE ,  RAPECKI STEPHEN EDWARD ,  TICKLE SIMON PETER

IPC: C07K16/24 ,  A61K39/395 ,  A61K47/48 ,  A61P43/00 ,  C07K14/54 ,  C12N5/16 ,  C12N15/13 ,  C12N15/63

公开(公告)号：HRP20140237T1

公开(公告)日：2014-05-09

申请号：HRP20140237

申请日：2014-03-13

Applicant: UCB PHARMA SA

Inventor： ADAMS RALPH ,  POPPLEWELL ANDREW GEORGE ,  RAPECKI STEPHEN EDWARD ,  TICKLE SIMON PETER

IPC: C07K16/24 ,  A61K39/395 ,  A61K47/48 ,  A61P43/00 ,  C07K14/54 ,  C12N5/16 ,  C12N15/13 ,  C12N15/63

公开(公告)号：SI1814915T1

公开(公告)日：2014-04-30

申请号：SI200531833

申请日：2005-11-16

Applicant: UCB PHARMA SA

Inventor： ADAMS RALPH ,  POPPLEWELL ANDREW GEORGE ,  RAPECKI STEPHEN EDWARD ,  TICKLE SIMON PETER

IPC: C07K16/00 ,  A61K39/00 ,  A61K47/00 ,  A61K47/48 ,  A61P43/00 ,  C07K14/00 ,  C07K16/24 ,  C12N5/00 ,  C12N15/00

公开(公告)号：UA92580C2

公开(公告)日：2010-11-25

申请号：UA20041209866

申请日：2003-05-02

Applicant: UCB PHARMA SA

Inventor： POPPLEWELL ANDREW GEORGE ,  TICKLE SIMON PETER ,  LADYMAN HEATHER MARGARET

IPC: C07K16/18 ,  C07K16/28 ,  A61K38/16 ,  A61K39/395 ,  A61P35/00 ,  C07K16/30 ,  C07K19/00 ,  C12N15/13 ,  C12N15/63 ,  C12P21/00

Abstract: Изобретениеотноситсяк антителу, котороеспецифическисвязываетсяс СD22. Раскрытыехимерическиеи гуманизированныеантитела, полученныеизисходногомышиногоантитела 5/44. Изобретениетакжеотноситсяк последовательностиДНК, которыйкодируеттяжелуюи легкуюцепьантитела, вектора, клетки-хозяина, способаполученияантитела, способаполученияфармацевтическойи диагностическойкомпозиции, применениеданногоантителадлялеченияпатологии, опосредованнойклетками, которыеэкспрессируют CD22.

公开(公告)号：DK1438340T3

公开(公告)日：2010-11-22

申请号：DK02800666

申请日：2002-10-10

Applicant: UCB PHARMA SA

Inventor： POPPLEWELL ANDREW GEORGE ,  TICKLE SIMON PETER ,  ZINKEWICH-PEOTTI KAREN ,  MORRISON ROBERT KENDALL

IPC: C07K16/28 ,  C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08