公开(公告)号：WO2006056779A3

公开(公告)日：2007-07-05

申请号：PCT/GB2005004511

申请日：2005-11-24

Applicant: UCB PHARMA SA ,  BROWN DEREK THOMAS ,  KIRBY HISHANI ,  FINNEY HELENE MARGARET ,  LAWSON ALASTAIR DAVID GRIFFITH

Inventor： BROWN DEREK THOMAS ,  KIRBY HISHANI ,  FINNEY HELENE MARGARET ,  LAWSON ALASTAIR DAVID GRIFFITH

IPC: C07K16/24 ,  A61K39/395 ,  A61P37/06

CPC classification number: C07K16/241 ,  C07K2317/56 ,  C07K2317/76

Abstract: Anti-TNFa antibodies which selectively inhibit TNFa signalling through the p55R. In particular anti-TNFa antibodies which selectively inhibit TNFa signalling through the p55R relative to the p75R.

Abstract translation: 通过p55R选择性抑制TNFa信号传导的抗TNFα抗体。 特别是抗TNFa抗体，其通过p55R相对于p75R选择性地抑制TNFa信号转导。

公开(公告)号：AU2006318950A1

公开(公告)日：2007-05-31

申请号：AU2006318950

申请日：2006-11-21

Applicant: UCB PHARMA SA

Inventor： FINNEY HELENE MARGARET ,  LAWSON ALASTAIR DAVID GRIFFITH

IPC: C12N15/63 ,  C07K14/705 ,  C12N5/16 ,  G01N33/566

公开(公告)号：AU2004242823A1

公开(公告)日：2004-12-09

申请号：AU2004242823

申请日：2004-05-24

Applicant: UCB PHARMA SA

Inventor： LIGHTWOOD DANIEL JOHN ,  LAWSON ALASTAIR DAVID GRIFFITH

IPC: C07K16/24 ,  C07K16/00 ,  C12N5/06

公开(公告)号：AU2003278354A1

公开(公告)日：2004-05-25

申请号：AU2003278354

申请日：2003-10-28

Applicant: UCB PHARMA SA

Inventor： FINNEY HELENE MARGARET ,  LAWSON ALASTAIR DAVID GRIFFITH

IPC: C07K14/705 ,  C07K16/28 ,  C12N15/62 ,  A61K38/17 ,  C12N5/10

Abstract: Nucleic acids are described which code for chimeric cytoplasmic signalling molecules containing at least one cytoplasmic signalling sequence derived from CD134 or ICOS. The nucleic acids may be expressed in cells to produce chimeric receptors and other proteins which are able to regulate cell activation processes. Such regulated cells are of use in medicine, for example in the treatment of infectious, inflammatory and autoimmune diseases.

公开(公告)号：AU2005252863A1

公开(公告)日：2005-12-22

申请号：AU2005252863

申请日：2005-06-10

Applicant: UCB PHARMA SA

Inventor： LAWSON ALASTAIR DAVID GRIFFITH ,  TICKLE SIMON PETER

IPC: C07K16/00 ,  G01N33/531 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58 ,  G01N33/68

Abstract: The present invention provides an automated homogeneous assay for identifying an antibody-producing cell producing an antibody which binds to a selected antigen, especially a high yielding antibody-producing cell.