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公开(公告)号：KR101808066B1
公开(公告)日：2017-12-14
申请号：KR1020160088235
申请日：2016-07-12
Applicant: 주식회사 주빅
CPC classification number: A61K8/0204 , A61K8/498 , A61K8/676 , A61K8/735 , A61Q19/02 , B81B1/008 , B81B2201/055 , B81C1/00111
Abstract: 본발명은 (a) 기판상에고형물을제조하는단계; (b) 상기고형물상에용매를첨가하여유동화시키는단계; 및 (c) 상기유동화된고형물을성형하는단계를포함하는마이크로구조체및 이의제조방법에관한것이다.
Abstract translation: （A）在基底上制备固体; （b）向固体中加入溶剂以引起流化; 并且（c）使流化的固体材料成形，以及制造该微结构的方法。
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公开(公告)号：KR1020040065848A
公开(公告)日：2004-07-23
申请号：KR1020030003041
申请日：2003-01-16
Applicant: 포스트마이크로 주식회사
IPC: B29D99/00
CPC classification number: B81C99/0085 , A61B5/14514 , A61M37/0015 , A61M2037/0053 , B81B2201/055 , B81C2201/032 , G03F7/00 , G03F7/0035
Abstract: PURPOSE: A preparation method of a microneedle array of polymer material using a LIGA(LIthographie, Galvanoformung, Abformung) process is provided to enhance a production efficiency and to use a polymer harmless to a human body. CONSTITUTION: The preparation method of a microneedle array(15) of a polymer material comprises the steps of: preparing an X-ray mask by forming an absorber having a microneedle array structure on a silicon substrate; preparing a microneedle array PMMA frame by exposing X-ray vertically or slantwise on the PMMA using the X-ray mask; preparing a flexible PDMS die by pouring PDMS on the PMMA frame; charging a gel type polymer on the die and forming in a determined thickness; irradiating the polymer with UV and shape-etching a whole in a determined shape; and completing a microneedle array of a polymer material by detaching the die.
Abstract translation: 目的：提供使用LIGA（LIthographie，Galvanoformung，Abformung）工艺的聚合物材料的微针阵列的制备方法，以提高生产效率并使用对人体无害的聚合物。 构成：聚合物材料的微针阵列（15）的制备方法包括以下步骤：通过在硅衬底上形成具有微针阵列结构的吸收体来制备X射线掩模; 通过使用X射线掩模在PMMA上垂直或倾斜X射线来制备微针阵列PMMA框架; 通过在PMMA框架上浇注PDMS来制备柔性PDMS模具; 在模具上加入凝胶型聚合物并以确定的厚度进行成型; 用UV照射聚合物并以确定的形状整体形状蚀刻; 并通过分离模具来完成聚合物材料的微针阵列。
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公开(公告)号：KR1020170008183A
公开(公告)日：2017-01-23
申请号：KR1020160088235
申请日：2016-07-12
Applicant: 주식회사 주빅
CPC classification number: A61K8/0204 , A61K8/498 , A61K8/676 , A61K8/735 , A61Q19/02 , B81B1/008 , B81B2201/055 , B81C1/00111
Abstract: 본발명은 (a) 기판상에고형물을제조하는단계; (b) 상기고형물상에용매를첨가하여유동화시키는단계; 및 (c) 상기유동화된고형물을성형하는단계를포함하는마이크로구조체및 이의제조방법에관한것이다.
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公开(公告)号：KR1020180031321A
公开(公告)日：2018-03-28
申请号：KR1020160119783
申请日：2016-09-20
Applicant: 한국기계연구원
CPC classification number: A61M37/0015 , A61M2037/0053 , A61M2207/10 , B81B2201/055 , B81C99/009
Abstract: 본발명은마이크로니들용몰드의제조방법에관한것으로, 본발명에따른제조방법은투광영역에액체렌즈가형성된광 마스크를이용하고감광층을포함하는기재를노광및 현상하여, 노광시렌즈에의한광의집속경로에따른마이크로니들형상또는마이크로니들의역상의패턴을갖는몰드를제조하는몰드제조단계;를포함한다.
Abstract translation: 本发明是一个在于，在所述制造方法中使用的光掩模时是形成在透射区域和通过曝光和显影含有感光性层的基板的液体透镜本发明，曝光透镜涉及一种用于制备模具的微针 以及模具制造步骤，根据微针的聚焦路径或微针的反相图案来制造具有微针形状的模具。
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公开(公告)号：KR101180032B1
公开(公告)日：2012-09-05
申请号：KR1020100066940
申请日：2010-07-12
Applicant: 인싸이토(주)
CPC classification number: A61M5/00 , A61B5/14532 , A61B5/14865 , A61B5/685 , A61F9/00781 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , B29C41/08 , B29C41/36 , B29C41/38 , B29D23/00 , B29L2031/7544 , B81B2201/055 , B81C1/00111 , G01N33/49
Abstract: The present invention relates to a method for fabricating a hollow microneedle having a variable appearance. The method makes it possible to vary the length of the microneedle, the outer and inner diameters of the upper and lower parts thereof, the aspect ratio, the sharpness, and the structural bending rate thereof, in accordance with the purposes of the same. Accordingly, the appearance of the hollow microneedles according to the present invention can be varied with flexibility according to various purposes, such as the transferring of medication and the taking of a blood sample, and to various factors, such as the target part for the medication transfer, the depth of the medication transfer, and the amount and viscosity of the medication. Thus, the microneedle can be used as a multi-purpose device for transferring medication.
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Patent Agency Ranking
公开(公告)号：US12098069B2
公开(公告)日：2024-09-24
申请号：US17540750
申请日：2021-12-02
Applicant: Sangwoo Lee
Inventor： Sangwoo Lee
CPC classification number: B81C1/00111 , A61B5/293 , B81B1/008 , A61B2562/125 , A61N1/0529 , B81B2201/055 , B81B2203/0361 , B81B2203/04 , B81C2201/0133
Abstract: A method of manufacturing a plurality of neural probes from a silicon wafer in which after neural probes are formed on one side of a silicon wafer, the other side of the silicon wafter is subject to a dicing process that separates and adjusts the thickness of the neural probes.
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公开(公告)号：US20240108817A1
公开(公告)日：2024-04-04
申请号：US18529219
申请日：2023-12-05
Applicant: SNVIA CO., LTD.
Inventor： Seung Yun YANG , Sang-Gu YIM , Young Jun HWANG
CPC classification number: A61M5/3286 , B81B1/008 , B81C1/00111 , A61M2207/00 , B81B2201/055 , B81B2203/0361 , B81C2201/0197
Abstract: An implantable microneedle and a manufacturing method therefor is disclosed. The implantable microneedle includes a coating layer for covering at least one part of the surface of a tip part of the microneedle. When exposed to moisture, the coating layer can be separated from the tip part of the microneedle and thus be implanted.
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公开(公告)号：US11938308B2
公开(公告)日：2024-03-26
申请号：US16959620
申请日：2019-01-17
Applicant: SNVIA CO., LTD.
Inventor： Seung Yun Yang , Sang-Gu Yim , Young Jun Hwang
CPC classification number: A61M5/3286 , B81B1/008 , B81C1/00111 , A61M2207/00 , B81B2201/055 , B81B2203/0361 , B81C2201/0197
Abstract: The present invention provides an implantable microneedle and a manufacturing method therefor. An implantable microneedle according to the present invention comprises a coating layer for covering at least one part of the surface of a tip part of the microneedle. When exposed to moisture, the coating layer can be separated from the tip part of the microneedle and thus be implanted.
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公开(公告)号：US20230248953A1
公开(公告)日：2023-08-10
申请号：US18135775
申请日：2023-04-18
Applicant: Kinneret Rand
Inventor： Kinneret Rand
IPC: A61M37/00
CPC classification number: A61M37/0015 , A61M2037/0053 , B81B2201/055 , B81B2201/057 , B33Y80/00
Abstract: An object of the present invention is to provide an anti-adhesive/anti-clogging and/or color marked/tinted micro-capillary tube (microtube), microneedle, or micropipette. Typically, the color/tint will be selected such that the tip of the microneedle or micropipette is in contrast (e.g., visually) to the biological material. The tint/color may be selected to contrast the stained biological material. In some aspects, the color mark comprises nanoparticles that are modified by adding a non-adhesive coating/material that minimizes protein adhesion/adsorption. The microtubes and/or micropipettes may be treated with an anti-clogging reagent and an anti-adhesive reagent to prevent or reduce clogging and adhesion of the micropipette or microneedle to biological materials. The microtubes and/or micropipettes may be formed using additive printing processes and additive manufacturing techniques or from micropipette and microneedle pullers.
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公开(公告)号：US20180355297A1
公开(公告)日：2018-12-13
申请号：US16066724
申请日：2017-01-03
Inventor： Jürgen KOSEL , Mincho Nikolaev KAVALDZHIEV , Jose Efrain PEREZ
CPC classification number: C12M1/26 , A61B5/685 , A61B10/0045 , A61B10/0233 , A61B2010/0225 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B81B1/008 , B81B2201/055 , B81C1/00111 , B82Y5/00 , C12M23/20
Abstract: Nanoneedles and nanoneedle arrays and methods of making nanoneedles are provided. The methods can include multilayer fabrication methods using a negative photoresist and/or a positive photoresist. The nanoneedle arrays include one or more nanoneedles attached to a surface of a substrate. The nanoneedle can have both a proximal opening and a distal opening, and an inner passageway connecting the proximal opening and the distal opening. The nanoneedle can have a functional coating. The nanoneedle can include iron, cobalt, nickel, gold, and oxides and alloys thereof. The nanoneedle arrays can be used for the administration and/or the extraction of agents from individual cells. In one or more aspects, the nanoneedles can be magnetic nanoneedles. An oscillating magnetic field applied to a magnetic nanoneedle can induce one or both of heating and vibration of the magnetic nanoneedle. The heating and/or vibration can cause a magnetic nanoneedle to penetrate the wall of a cell.
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