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    11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene citrate salt
    35.
    发明授权
    11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene citrate salt 有权
    11-（2-吡咯烷-1-基 - 乙氧基）-14,19-二氧杂-5,7,26-三氮杂 - 四环[19.3.1.1（2,6）.1（8,12）]十七酸-1（ 25），2（26），3,5,8,10,12（27），16,21,23-十氢化柠檬酸盐

    公开(公告)号：US08980873B2

    公开(公告)日：2015-03-17

    申请号：US13133297

    申请日：2009-12-09

    Applicant: Brian Dymock ,  Cheng H. Lee ,  Anthony D. William

    Inventor： Brian Dymock ,  Cheng H. Lee ,  Anthony D. William

    IPC: C07D498/04 ,  C07D201/10

    CPC classification number: C07D498/08 ,  C07B2200/13 ,  C07C55/22 ,  C07D201/10 ,  C07D498/04

    Abstract: The present invention relates to certain salts of a 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (Compound I) which have been found to have improved properties. In particular the present invention relates to the citrate salt of this compound. The invention also relates to pharmaceutical compositions containing the citrate salt and methods of use of the citrate salt in the treatment of certain medical conditions.

    Abstract translation: 本发明涉及11-（2-吡咯烷-1-基 - 乙氧基）-14,19-二氧杂-5,7,26-三氮杂 - 四环[19.3.1.1（2,6）.1（ 8,12）]，已被发现具有改善的性能的十七酸-1（25），2（26），3,5,8,10,12（27），16,21,23-十氢烯（化合物I）。 特别地，本发明涉及该化合物的柠檬酸盐。 本发明还涉及含有柠檬酸盐的药物组合物和柠檬酸盐在使用某些医疗条件下的使用方法。

    Method for production of hydroxylammonium phosphate in the synthesis of caprolactam
    36.
    发明授权
    Method for production of hydroxylammonium phosphate in the synthesis of caprolactam 失效
    己内酰胺合成中磷酸羟铵的生产方法

    公开(公告)号：US06333411B1

    公开(公告)日：2001-12-25

    申请号：US09221211

    申请日：1998-12-24

    Applicant: Diego Fernandez Echegaray ,  Antonio Augusto M. Velloso ,  Matthew Lincoln Wagner

    Inventor： Diego Fernandez Echegaray ,  Antonio Augusto M. Velloso ,  Matthew Lincoln Wagner

    IPC: C07D20104

    CPC classification number: C07D201/06 ,  C07D201/10

    Abstract: A method for production of caprolactam. The method involves: (a) reacting air with ammonia gas in an ammonia conversion zone to produce nitric oxide; (b) oxidizing at least a portion of the nitric oxide to nitrogen dioxide to produce an NOx-rich process gas stream; (c) reactively absorbing the NOx-rich gas stream with phosphoric acid containing solution in an absorption zone to form nitrate ions; (d) contacting the nitrate ions with air in a degassing zone to produce a nitrate-rich aqueous process stream; (e) reducing the nitrate-rich aqueous stream with hydrogen in the presence of phosphoric acid to produce hydroxylammonium phosphate; (f) oximating the hydroxylammonium phosphate with cyclohexanone to produce cyclohexanone oxime; and (g) converting the cyclohexanone oxime to caprolactam. According to the invention, supplemental oxygen is added downstream of the ammonia conversion zone to increase the quantity and rate of formation of nitrogen dioxide in the NOx-rich process gas stream.

    Abstract translation: 一种生产己内酰胺的方法。 该方法包括：（a）在氨转化区中使空气与氨气反应以产生一氧化氮;（b）将至少一部分一氧化氮氧化成二氧化氮以产生富含NO x的工艺气流;（c） 在吸收区中用含磷酸溶液反应性吸收富含NO x的气流，形成硝酸根离子;（d）使硝酸根离子与脱气区的空气接触，产生富含硝酸盐的含水工艺流;（e） 富含硝酸盐的含水流在磷酸存在下用氢气生成磷酸羟铵;（f）用环己酮肟化磷酸羟铵以制备环己酮肟; 并且（g）将环己酮肟转化为己内酰胺。根据本发明，在氨转化区的下游添加补充氧以增加富氮过程气流中二氧化氮的形成量和速率。

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