-
31.发明授权公开(公告)号：US10059968B2
公开(公告)日：2018-08-28
申请号：US15314227
申请日：2015-05-28
Applicant: Reliance Industries Limited
Inventor： Gautam Das , Santanu Dasgupta , Venkatesh Prasad , Vinodhkumar Vijayakumar , Pranali Deore , Kannadasan Kaliyamoorthy , Sujata Kumari
CPC classification number: C12P7/6463 , C11C3/00 , C12N1/12 , C12N9/1007 , C12N9/1029 , C12N15/102 , C12N15/65 , C12N15/74 , C12P7/00 , C12R1/01 , C12Y201/01037 , C12Y203/01031
Abstract: The present disclosure relates to a method for increasing lipid content in microorganisms. The method comprises decreasing the expression of molecules involved in the protein synthesis to decrease protein synthesis and thereby increase lipid synthesis in the microorganisms. The present disclosure also provides a modified microorganism having increased lipid content.
-
公开(公告)号：US20180239878A1
公开(公告)日：2018-08-23
申请号：US15895057
申请日：2018-02-13
Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
Inventor： Vern L. Schramm , Quan Du , Zhen Wang
CPC classification number: G16C20/50 , C12N9/1007 , C12Q1/48 , C12Y201/01037 , G16C20/10
Abstract: Methods and systems for obtaining inhibitors of human DNA methyltransferase 1 (DNMT1) are disclosed where the methods involve designing compounds that resemble the DNMT1 transition state.
-
公开(公告)号：US20170268008A1
公开(公告)日：2017-09-21
申请号：US15529399
申请日：2015-11-24
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Ahmed Khalil , Sanford Markowitz
IPC: C12N15/113 , C12Q1/68
CPC classification number: C12N15/1137 , A61K31/7088 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N2310/10 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/20 , C12N2320/11 , C12Q1/6886 , C12Q2600/154 , C12Q2600/158 , C12Q2600/178 , C12Y201/01037 , G01N33/50 , G01N33/574
Abstract: A method for treating cancer in a subject in need thereof includes administering to cancer cells of the subject an agent effective to modulate the level of DNMT1-associated RNA and/or the interaction of DNMT1-associated RNA and DNMT1 in the cancer cells of the subject. Embodiments described herein relate to RNAs (e.g., IncRNAs) associated with DNA methyltransferase 1 (DNMTI-associated RNA) in human cancer cells, methods and compositions of modulating the levels of DNMTI-associated RNA and/or the interaction of DNMT1-associated RNA and DNMT1 in cancer cells of the subject to treat cancer cells or a subject in need thereof, and/or methods of measuring the expression profile of DNMT1 associated RNA to determine whether the subject has cancer or an increased risk of cancer and/or the efficacy of a therapeutic regimen agent.
-
公开(公告)号：US20170032079A1
公开(公告)日：2017-02-02
申请号：US15259311
申请日：2016-09-08
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Sarel FLEISHMAN , Adi Goldenzweig , Dan S. Tawfik
CPC classification number: G16B15/00 , C12N9/1007 , C12N9/16 , C12N9/18 , C12Y201/01037 , C12Y301/01007 , C12Y301/08001 , G16B15/20 , G16B30/00 , G16B35/00 , G16C20/10 , G16C20/60
Abstract: A method for designing and selecting a protein having a stabilized structure compared to a corresponding wild type protein, and proteins having at least six amino acid substitutions with respect to a corresponding wild type protein, designed for improved thermal stability, improved specific activity and/or improved expression levels, are provided herein.
Abstract translation: 与相应的野生型蛋白质相比，设计和选择具有稳定结构的蛋白质的方法，以及相对于相应野生型蛋白质具有至少6个氨基酸取代的蛋白质，其设计用于改善热稳定性，改善的比活性和/或 改善的表达水平。
-
公开(公告)号：US08962333B2
公开(公告)日：2015-02-24
申请号：US13439069
申请日：2012-04-04
Applicant: Janet Westpheling , DaeHwan Chung , Jennifer Huddleston , Joel A. Farkas
Inventor： Janet Westpheling , DaeHwan Chung , Jennifer Huddleston , Joel A. Farkas
CPC classification number: C12N9/22 , C12N9/1007 , C12P19/34 , C12Y201/01037 , C12Y301/21004
Abstract: The present invention relates to the discovery of a novel restriction/modification system in Caldicellulosiruptor bescii. The discovered restriction enzyme is a HaeIII-like restriction enzyme that possesses a thermophilic activity profile. The restriction/modification system also includes a methyltransferase, M.CbeI, that methylates at least one cytosine residue in the CbeI recognition sequence to m4C. Thus, the invention provides, in various aspects, isolated CbeI or M.CbeI polypeptides, or biologically active fragments thereof; isolated polynucleotides that encode the CbeI or M.CbeI polypeptides or biologically active fragments thereof, including expression vectors that include such polynucleotide sequences; methods of digesting DNA using a CbeI polypeptide; methods of treating a DNA molecule using a M.CbeI polypeptide; and methods of transforming a Caldicellulosiruptor cell.
Abstract translation: 本发明涉及在Caldicellulosiruptor bescii中发现新的限制/修饰系统。 所发现的限制酶是具有嗜热活性分布的HaeIII样限制酶。 限制/修饰系统还包括甲基转移酶M.CbeI，其将CbeI识别序列中的至少一个胞嘧啶残基甲基化为m4C。 因此，本发明在各个方面提供了分离的CbeI或M.CbeI多肽或其生物活性片段; 编码CbeI或M.CbeI多肽或其生物活性片段的分离的多核苷酸，包括包括这种多核苷酸序列的表达载体; 使用CbeI多肽消化DNA的方法; 使用M.CbeI多肽处理DNA分子的方法; 和转化Caldicellulosiruptor细胞的方法。
-
Patent Agency Ranking36.发明申请METHOD FOR INCREASING LIPID CONTENT IN MICROORGANISMS AND MODIFIED MICROORGANISMS THEREFROM 审中-公开增加微生物中脂质含量的方法及其改性微生物
公开(公告)号：WO2015181765A1
公开(公告)日：2015-12-03
申请号：PCT/IB2015/054011
申请日：2015-05-28
Applicant: RELIANCE INDUSTRIES LIMITED
Inventor： DAS, Gautam , DASGUPTA, Santanu , PRASAD, Venkatesh , VIJAYAKUMAR, Vinodhkumar , DEORE, Pranali , KALIYAMOORTHY, Kannadasan , KUMARI, Sujata
CPC classification number: C12P7/6463 , C11C3/00 , C12N1/12 , C12N9/1007 , C12N9/1029 , C12N15/102 , C12N15/65 , C12N15/74 , C12P7/00 , C12R1/01 , C12Y201/01037 , C12Y203/01031
Abstract: The present disclosure relates to a method for increasing lipid content in microorganisms. The method comprises decreasing the expression of molecules involved in the protein synthesis to decrease protein synthesis and thereby increase lipid synthesis in the microorganisms. The present disclosure also provides a modified microorganism having increased lipid content.
Abstract translation: 本发明涉及增加微生物中脂质含量的方法。 该方法包括降低参与蛋白质合成的分子的表达以减少蛋白质合成，从而增加微生物中的脂质合成。 本公开还提供了具有增加的脂质含量的经修饰的微生物。
-
37.发明申请OLIGONUCLEOTIDE INHIBITORS OF DNA METHYLTRANSFERASES AND THEIR USE IN TREATING DISEASES 审中-公开DNA甲基衍生物的寡核苷酸抑制剂及其在治疗疾病中的应用
公开(公告)号：WO2014011573A3
公开(公告)日：2015-04-09
申请号：PCT/US2013049624
申请日：2013-07-09
Applicant: METHEOR THERAPEUTICS CORP , SLEDZIEWSKI ANDREW Z , DEVOS THEODORE , KOLE RYSZARD
Inventor： SLEDZIEWSKI ANDREW Z , DEVOS THEODORE , KOLE RYSZARD
IPC: A61K48/00
CPC classification number: C12N15/1137 , C12N2310/13 , C12N2310/33 , C12N2310/3341 , C12N2310/531 , C12Y201/01037
Abstract: Modified oligonucleotides comprising CpG sites, wherein the cytosine is replaced by cytosine analogs are provided as well as methods of making the oligonucleotides and their use in inhibiting DNA Methyltransferase, inhibiting or reversing methylation of genes and in treating cancer, tumorigenesis and hyper-proliferative disorders.
Abstract translation: 提供了包含CpG位点的修饰的寡核苷酸，其中胞嘧啶被胞嘧啶类似物替代，以及制备寡核苷酸及其在抑制DNA甲基转移酶中的用途，抑制或逆转基因甲基化和治疗癌症，肿瘤发生和高增殖性疾病的方法。
-
公开(公告)号：WO2012142480A1
公开(公告)日：2012-10-18
申请号：PCT/US2012/033617
申请日：2012-04-13
Applicant: BETH ISRAEL DEACONESS MEDICAL CENTER, INC. , DIRUSCIO, Annalisa , EBRALIDZE, Alexander, K. , TENEN, Daniel, G. , LEONE, Giuseppe , UNIVERSITA CATTOLICA DEL SACRO CUORE
Inventor： DIRUSCIO, Annalisa , EBRALIDZE, Alexander, K. , TENEN, Daniel, G. , LEONE, Giuseppe
CPC classification number: C12N15/113 , C12N15/1137 , C12N15/635 , C12N2310/113 , C12N2310/13 , C12N2310/333 , C12N2310/334 , C12N2320/31 , C12Y201/01037 , C12N2310/14 , C12N2310/531
Abstract: The present invention relates to chimeric RNA oligonucleotides that are single-stranded oligonucleotides. These compounds are capable of targeting particular genes and reducing DNA methyltransferase activity. Accordingly, these compounds are particularly useful in the treatment of disease associated with aberrant DNA methyltransferase activity, such as cancer or a genetic disorder.
Abstract translation: 本发明涉及作为单链寡核苷酸的嵌合RNA寡核苷酸。 这些化合物能够靶向特定基因并降低DNA甲基转移酶活性。 因此，这些化合物特别可用于治疗与异常DNA甲基转移酶活性相关的疾病，例如癌症或遗传性疾病。
-
公开(公告)号：EP4441074A2
公开(公告)日：2024-10-09
申请号：EP22854318.7
申请日：2022-12-02
Inventor： LIU, David R. , CAHILL, Thomas J. III , DESOUZA, Philip , RAGURAM, Aditya , BANSKOTA, Samagya , AN, Meirui
IPC: C07K14/005 , C12N7/00 , C07K14/47 , C12N9/22 , C12N15/10 , C12N15/113 , C12N15/62 , C12N15/86
CPC classification number: C07K14/005 , C12N15/86 , C12N2740/1304520130101 , C12N2740/1302220130101 , C12N2740/1302320130101 , C12N9/22 , C12N15/102 , C12N15/1137 , C07K2319/09520130101 , C07K2319/03320130101 , C07K2319/5020130101 , C07K2319/73520130101 , C07K2319/0920130101 , C07K14/4713 , C12Y201/01037 , C12N2310/2020170501 , C12N15/113 , C12N15/1138
-
公开(公告)号：EP4395811A1
公开(公告)日：2024-07-10
申请号：EP22793616.8
申请日：2022-08-26
Applicant: Aditxt, Inc.
Inventor： PALIZA-CARRE, Marco , SHABAHANG, Shahrokh , CHEN, Ge
IPC: A61K39/00 , C12N9/10 , C12N15/117
CPC classification number: C12N9/1007 , C12Y201/01037
-
-
-
-
-
-
-
-
-
Search Results
90
records
(took 0.027 seconds)
