公开(公告)号：US20140367568A1

公开(公告)日：2014-12-18

申请号：US14358809

申请日：2011-11-28

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Hyun Sik Kim ,  Seung Young Kim ,  Mo Yang

IPC: H01J49/00 ,  H01J49/42

CPC classification number: H01J49/08 ,  H01J27/028 ,  H01J43/04 ,  H01J43/246 ,  H01J49/0045 ,  H01J49/0054 ,  H01J49/10 ,  H01J49/147 ,  H01J49/38 ,  H01J49/426

Abstract: The present invention relates to an anion generating and electron capture dissociation apparatus using cold electrons, which uses an MCP electron multiplier plate for generating an electron beam for ionization within an ion trap of a Fourier transform ion cyclotron resonance mass spectroscope, injects ultraviolet photons emitted from an ultraviolet diode across the entire surface of the MCP electron multiplier plate, uses an electron focusing lens to focus and inject an electron beam into the trap, and generates an ECD reaction by coupling electrons to molecules having multiple positive charges using a low energy electron beam emitting apparatus for the negative ionization of neutral molecules in the ion trap. The anion generating and electron capturing and analyzing apparatus of the present invention, which uses cold electrons and is configured of a cold electron generating module which generates a large number of cold electrons from ultraviolet photons emitted into a mass spectroscope in a high vacuum state, comprises a plurality of ultraviolet diodes emitting ultraviolet photons in the mass spectroscope, an MCP electron multiplier plate inducing and amplifying an initial electron emission of ultraviolet photons from the ultraviolet diodes, and generating a high capacity electron beam from a back plate, an electron focusing lens for focusing the electron beam amplified through the MCP electron multiplier plate, and a grid for adjusting the energy and current of electrons.

Abstract translation: 本发明涉及一种使用冷电子的阴离子产生和电子捕获离解装置，其使用MCP电子倍增器板在傅里叶变换离子回旋共振质谱仪的离子阱内产生用于离子化的电子束，注入从 跨越MCP电子倍增器板的整个表面的紫外线二极管使用电子聚焦透镜将电子束聚焦并注入陷阱，并通过使用低能电子束将电子耦合到具有多个正电荷的分子来产生ECD反应 用于离子阱中的中性分子的负电离的发射装置。 本发明的阴离子产生和电子捕获和分析装置，其使用冷电子并且由在高真空状态下发射到质谱仪中的紫外光子产生大量冷电子的冷电子发生模块构成，包括 在质谱仪中发射紫外光子的多个紫外线二极管，MCP电子倍增器板，其从紫外二极管感应并放大紫外光子的初始电子发射，并从背板产生高容量电子束;电子聚焦透镜， 聚焦通过MCP电子倍增器板放大的电子束，以及用于调节电子的能量和电流的栅格。

公开(公告)号：US20140339423A1

公开(公告)日：2014-11-20

申请号：US14125436

申请日：2011-12-16

Applicant: Seung Yong Kim ,  Mo Yang ,  Hyun Sik Kim

Inventor： Seung Yong Kim ,  Mo Yang ,  Hyun Sik Kim

IPC: H01J49/16

CPC classification number: H01J49/161 ,  H01J49/0022 ,  H01J49/08 ,  H01J49/424 ,  Y10T29/49826

Abstract: The present invention relates to an ultraviolet diode and an atomic mass analysis ionization source collecting device using an MCP. In the manufacturing of a portable atomic mass analyzer, an object of the present invention is to use an MCP electron multiplier plate, whereby ultraviolet photons emitted from an ultraviolet diode are irradiated on a front surface plate of the MCP electron multiplier plate to induce primary electrons, an amplified electron beam is collected from the electrons, and an electron beam is generated at a low temperature and low power and having a discharge time that is accurately controlled. The atomic mass analysis ionization source collecting device using an ultraviolet diode and an MCP according to the present invention comprises: an ultraviolet diode emitting ultraviolet rays by means of supplied power; an MCP electron multiplier plate inducing and amplifying primary electron discharge from ultraviolet photons from the ultraviolet diode, and collecting a large amount of electron beams from an MCP reverse surface plate; an electron condenser lens condensing the electron beam amplified through the MCP electron multiplier plate; an ion trap atomic mass separator ionizing gas sample molecules by means of an electron beam injected through the electron condenser lens; and an ion detector performing detection of ions separated from the ion trap atomic mass separator, by means of an atomic mass spectrum.

Abstract translation: 本发明涉及使用MCP的紫外二极管和原子质量分析电离源收集装置。 在便携式原子质量分析仪的制造中，本发明的目的是使用MCP电子倍增器板，其中从紫外二极管发射的紫外光子照射在MCP电子倍增器板的前表面板上以诱导一次电子 从电子收集放大的电子束，并且在低温和低功率下产生电子束，并且具有被精确控制的放电时间。 根据本发明的使用紫外二极管和MCP的原子质量分析电离源收集装置包括：通过供电的电源发射紫外线的紫外二极管; MCP电子倍增器板从紫外二极管的紫外光子中诱发和放大一次电子放电，并从MCP反面板收集大量的电子束; 电子聚光透镜，聚合通过MCP电子倍增器板放大的电子束; 离子阱原子质量分离器通过通过电子聚光透镜注入的电子束离子化气体样品分子; 以及离子检测器，其通过原子质谱进行离子阱原子质量分离器分离的离子的检测。

公开(公告)号：US08410433B2

公开(公告)日：2013-04-02

申请号：US13205925

申请日：2011-08-09

Applicant: Martin Wuest ,  Wolfram Knapp

Inventor： Martin Wuest ,  Wolfram Knapp

IPC: H01J49/26 ,  G21K5/04

CPC classification number: H01J49/08 ,  H01J49/147 ,  H01J49/16

Abstract: A cathode configuration for emission of electrons has a reaction zone connected to an entrance opening for the supply of neutral particles. The opening communicates with the cathode configuration for the ionization of the neutral particles and an ion extraction system communicates with the reaction zone. Ions from the extraction system are sent to a detection system and a mechanism for the evacuation of the mass spectrometer arrangement. The cathode configuration includes a field emission cathode with an emitter surface, wherein at a short distance from this emitter surface, an extraction grid is disposed for the extraction of electrons, which grid substantially covers the emitter surface. The emitter surface encompasses herein at least partially a hollow volume such that a tubular structure is formed.

Abstract translation: 用于发射电子的阴极结构具有连接到用于供应中性粒子的入口的反应区。 开口与阴极结构连通，用于中性粒子的电离，离子提取系统与反应区连通。 来自提取系统的离子被发送到检测系统和用于疏散质谱仪装置的机构。 阴极配置包括具有发射极表面的场致发射阴极，其中在离该发射体表面短的距离处，设置用于提取电子的提取栅格，栅格基本上覆盖发射器表面。 发射器表面在此包括至少部分为中空体积，从而形成管状结构。

公开(公告)号：US20090200459A1

公开(公告)日：2009-08-13

申请号：US12349957

申请日：2009-01-07

Applicant: Klaus Zimmer

Inventor： Klaus Zimmer

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/147 ,  H01J49/08

Abstract: In an analytical spectrometer in which accelerated electrons are used to ionize analytes, a non-radioactive electron source uses a gas discharge to generate the electrons. The gas discharge is located in a substantially hermetic source chamber and the free electrons in the plasma of the gas discharge are accelerated in an electric acceleration region towards a partition wall which separates the source chamber from a reaction chamber. The partition wall is permeable to the accelerated electrons but impermeable to gas in the source chamber so that the electrons penetrate the partition wall into the reaction chamber and generate primary ions that chemically ionize the analytes.

Abstract translation: 在使用加速电子电离分析物的分析光谱仪中，非放射性电子源使用气体放电来产生电子。 气体放电位于基本密封的源室中，并且气体放电的等离子体中的自由电子在电加速区域中朝向将源室与反应室分离的分隔壁加速。 分隔壁对加速的电子是可渗透的，但是对于源室中的气体不可渗透，使得电子穿过分隔壁进入反应室并产生化学电离分析物的初级离子。

公开(公告)号：US20030015658A1

公开(公告)日：2003-01-23

申请号：US10245656

申请日：2002-09-16

Inventor： Thomas E. Felter

IPC: H01J049/42 ,  H01J049/04

CPC classification number: H01J49/147 ,  H01J1/3042 ,  H01J49/08 ,  H01J49/4215 ,  H01J2201/30407

Abstract: An improved quadrupole mass spectrometer is described. The improvement lies in the substitution of the conventional hot filament electron source with a cold cathode field emitter array which in turn allows operating a small QMS at much high internal pressures then are currently achievable. By eliminating of the hot filament such problems as thermally nullcrackingnull delicate analyte molecules, outgassing a nullhotnull filament, high power requirements, filament contamination by outgas species, and spurious em fields are avoid all together. In addition, the ability of produce FEAs using well-known and well developed photolithographic techniques, permits building a QMS having multiple redundancies of the ionization source at very low additional cost.

Abstract translation: 描述了改进的四极质谱仪。 改进之处在于用冷阴极场发射体阵列代替传统的热丝电子源，该冷阴极场发射器阵列又允许在很高的内部压力下操作小的QMS，然后目前是可实现的。 通过消除热丝，诸如热“裂解”精细的分析物分子，排除“热”丝，高功率需求，排气物质的细丝污染和杂散电场等问题都避免在一起。 此外，使用已知和发展良好的光刻技术制造FEA的能力允许以非常低的附加成本构建具有多个电离源冗余的QMS。

公开(公告)号：US06239549B1

公开(公告)日：2001-05-29

申请号：US09004911

申请日：1998-01-09

Applicant: Bruce Laprade

Inventor： Bruce Laprade

IPC: H01J4318

CPC classification number: H01J49/08 ,  H01J1/32 ,  H01J43/04 ,  H01J43/246

Abstract: An electron multiplier with a source for spontaneously generating electrons is used as an electron source for an ionization source in a mass spectrometer or the like. The electron multiplier can be a microchannel plate, in which case it produces a wide electron beam. The microchannel plate can be acid-leached to provide a surface for spontaneous generation of electrons, or the first strike surface can be coated with an alkali-containing material. The electron source can be tuned by providing an electrode for rejecting electrons having too high an energy and a grid for rejecting electrons having too low an energy.

Abstract translation: 在质谱仪等中使用具有用于自发生成电子的源的电子倍增器作为电离源的电子源。 电子倍增器可以是微通道板，在这种情况下，它产生宽电子束。 微通道板可以被酸浸以提供用于自发生成电子的表面，或者可以用含碱材料涂覆第一冲击表面。 可以通过提供用于排斥具有太高能量的电子的电极和用于排斥具有太低能量的电子的栅极来调节电子源。

公开(公告)号：US5852295A

公开(公告)日：1998-12-22

申请号：US838431

申请日：1997-04-07

Applicant: Enio Frota Da Silveira ,  Kevin Bernard Ray ,  Emile Alfred Schweikert ,  Melvin Andrew Park

Inventor： Enio Frota Da Silveira ,  Kevin Bernard Ray ,  Emile Alfred Schweikert ,  Melvin Andrew Park

IPC: H01J49/02 ,  H01J49/14 ,  H01J49/40 ,  H01J49/00

CPC classification number: H01J49/147 ,  H01J49/08 ,  H01J49/40

Abstract: A mass spectrometer 20 includes an electron multiplier 30 for producing an electron avalanche 58 directed toward an ionization region 38. A sample 40 enters the ionization region 38 through a sample inlet 68. In the ionization region 38 the electron avalanche 58 collides with the sample 40 and produces ions 60. A start detector 56 detects the electron avalanche 58 and provides a start signal. The ions 60 exit the ionization region 38 and enter a flight region 26. The ions 60 flow through the flight region 26 and interact with a stop detector 42. The stop detector 42 generates a stop signal in response to being activated. A low pressure enclosure 22 encloses at least the electron multiplier 30 and the ionization region 38. The start and stop signals are supplied to an analysis system for determining the mass of the sample using time-of-flight mass spectrometry.

Abstract translation: 质谱仪20包括用于产生朝向电离区域38的电子雪崩58的电子倍增器30.样品40通过样品入口68进入电离区域38.在电离区域38中，电子雪崩58与样品40碰撞 并产生离子60.启动检测器56检测电子雪崩58并提供启动信号。 离子60离开电离区域38并进入飞行区域26.离子60流过飞行区域26并与停止检测器42相互作用。停止检测器42响应于被激活而产生停止信号。 低压外壳22至少包围电子倍增器30和电离区38.启动和停止信号被提供给用于使用飞行时间质谱法确定样品质量的分析系统。

公开(公告)号：WO2016174545A1

公开(公告)日：2016-11-03

申请号：PCT/IB2016/052226

申请日：2016-04-20

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： HAGER, James Walter

IPC: H01J49/42 ,  H01J49/08 ,  H01J49/36

CPC classification number: H01J49/38 ,  H01J49/08 ,  H01J49/4205

Abstract: A quadrupole is filled with ions and the ions are cooled by applying a pressure and gas flow within the quadrupole. Ions are trapped in the quadrupole by applying a DC voltage and an RF voltage to quadrupole rods of the quadrupole, one or more DC voltages to a plurality of auxiliary electrodes of the quadrupole, and a DC voltage and an RF voltage to an exit lens at the end of the quadrupole. The ions are coherently oscillated after the filling and cooling by applying a coherent excitation between at least two rods of the quadrupole rods. The coherently oscillating ions are axially ejected through the exit lens and to a destructive detector for detection by changing one or more voltages of the one or more DC voltages of the plurality of auxiliary electrodes and changing the DC voltage of the exit lens.

Abstract translation: 四极杆填充有离子，并通过在四极杆内施加压力和气流来冷却离子。 通过向四极杆的四极杆施加直流电压和RF电压，将一个或多个直流电压施加到四极杆的多个辅助电极，并将直流电压和射频电压施加到出射透镜 四极杆的末端。 通过在四极棒的至少两个杆之间施加相干激发，在填充和冷却之后离子相干地振荡。 通过改变多个辅助电极中的一个或多个直流电压的一个或多个电压并改变出射透镜的直流电压，相干振荡离子通过出射透镜轴向地弹出并通过一个破坏性检测器进行检测。

公开(公告)号：WO2013081195A1

公开(公告)日：2013-06-06

申请号：PCT/KR2011/009105

申请日：2011-11-28

Applicant: 한국기초과학지원연구원 ,  김현식 ,  김승용 ,  양모

Inventor： 김현식 ,  김승용 ,  양모

IPC: H01J49/26 ,  H01J49/10 ,  G01N27/62

CPC classification number: H01J49/08 ,  H01J27/028 ,  H01J43/04 ,  H01J43/246 ,  H01J49/0045 ,  H01J49/0054 ,  H01J49/10 ,  H01J49/147 ,  H01J49/38 ,  H01J49/426

Abstract: 본 발명은 냉전자를 이용한 음이온 발생과 전자포획 분해장치에 관한 것으로, 푸리에변환 이온싸이클로트론공명 질량분석기의 이온트랩 내에서 이온화를 위한 전자빔 발생을 하기 위하여 MCP전자증배판을 사용하되, 자외선다이오드에서 방출하는 자외선 광자를 MCP 전자증배판 전면에 주사하여 증폭된 전자빔을 획득하고, 전자집속렌즈를 이용하여 트랩내로 전자빔을 집속하여 주입하고, 이온트랩 내에서 중성분자의 음이온화를 목적으로 하는 저에너지 전자빔 방출 장치와 다중양전하를 띈 분자에 전자를 결합시켜 ECD 반응 생성하게 한다. 본 발명은 고진공 상태의 질량분석기 내부에 조사된 자외선광자로부터 많은 수의 냉전자를 발생하는 냉전자발생모듈로 구성된 냉전자를 이용한 음이온 발생과 전자포획 분해장치에 있어서, 질량분석기 내에 자외선 광자를 방출하는 다수의 자외선다이오드; 자외선다이오드로부터 자외선 광자들의 초기 전자방출을 유도 및 증폭하여 후면판에서 대량의 전자빔을 발생시키는 MCP 전자증배판; MCP 전자증배판을 통해 증폭된 전자빔을 집적하는 전자집적렌즈; 전자의 에너지와 전류를 조정하는 그리드;를 포함하여 이루어진다.

Abstract translation: 本发明涉及使用冷电子的阴离子产生和电子俘获解离装置，其使用MCP电子倍增器板在傅里叶变换离子回旋共振质谱仪的离子阱内产生用于电离的电子束，注入从 跨越MCP电子倍增器板的整个表面的紫外线二极管使用电子聚焦透镜将电子束聚焦并注入陷阱，并通过使用低能电子束将电子耦合到具有多个正电荷的分子来产生ECD反应 用于离子阱中的中性分子的负电离的发射装置。 本发明的阴离子产生和电子捕获和分析装置，其使用冷电子并且由在高真空状态下发射到质谱仪中的紫外光子产生大量冷电子的冷电子发生模块构成，包括 ：在质谱仪中发射紫外光子的多个紫外二极管; 诱导和放大来自紫外二极管的紫外光子的初始电子发射并从背板产生高容量电子束的MCP电子倍增器板; 用于聚焦通过MCP电子倍增器板放大的电子束的电子聚焦透镜; 以及用于调节电子的能量和电流的栅格。

公开(公告)号：WO2012080352A1

公开(公告)日：2012-06-21

申请号：PCT/EP2011/072790

申请日：2011-12-14

Applicant: THERMO FISHER SCIENTIFIC (BREMEN) GMBH ,  MAKAROV, Alexander Alekseevich

Inventor： MAKAROV, Alexander Alekseevich

IPC: H01J49/42

CPC classification number: H01J49/282 ,  H01J49/027 ,  H01J49/08 ,  H01J49/38 ,  H01J49/4245

Abstract: Mass analysers and methods of ion detection for a mass analyser are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.

Abstract translation: 提供了用于质量分析仪的质量分析仪和离子检测方法。 静电场发生器提供静电场，使离子包沿着一个方向振荡。 在比离子振荡的周期短的持续时间内检测脉冲瞬态信号，或使用具有明显小于离子谐波运动的跨度的宽度的脉冲检测电极。 还检测到谐波瞬态信号。 然后基于脉冲瞬态信号和谐波瞬态信号来识别关于质荷比的离子强度。