公开(公告)号：US08471221B2

公开(公告)日：2013-06-25

申请号：US12680964

申请日：2008-10-01

Applicant: Thomas Hennig

Inventor： Thomas Hennig

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  A61B5/0088 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/024 ,  G01J3/10 ,  G01J3/4406 ,  G01J3/508 ,  G01J2003/1213 ,  G01N21/645 ,  G01N2021/6421 ,  G01N2021/6484

Abstract: The invention relates to a device for measuring fluorescent radiation emitted by biological substances, comprising a light source, a capturing unit, an evaluation unit, at least one emission fiber, and at least one detection fiber. Said emission fiber guides excitation radiation to the biological substrate and the detection fiber receives fluorescent radiation and guides it to the evaluation unit. The capturing unit comprises a semiconductor sensor arrangement that detects fluorescent radiation emitted by the biological substance in wave length areas that are separate from each other, are arranged. Data sets of at least two different reference measurements on at least two different biological substances are stored and compared to the measured measurement values to the stored data sets and issues a result relating to the pathological attacks of the examined biological substances and/or relating to the type of examined, biological substances.

Abstract translation: 本发明涉及一种用于测量由生物物质发射的荧光辐射的装置，包括光源，捕获单元，评估单元，至少一种发射光纤和至少一种检测光纤。 所述发射光纤将激发辐射引导到生物衬底，并且检测光纤接收荧光辐射并将其引导到评估单元。 捕获单元包括在彼此分离的波长区域中检测由生物物质发射的荧光辐射的半导体传感器装置。 存储至少两种不同生物物质的至少两种不同参考测量值的数据集，并将其与所测量的测量值进行比较以存储数据集，并发布与所检查的生物物质的病理攻击相关的结果和/或与 检查类型，生物物质。

公开(公告)号：US08442363B2

公开(公告)日：2013-05-14

申请号：US12786751

申请日：2010-05-25

Applicant: Sascha Hallstein ,  Donald A. Ice

Inventor： Sascha Hallstein ,  Donald A. Ice

IPC: G02B6/26

CPC classification number: G02B6/26 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0229 ,  G01J3/024 ,  G01J3/04 ,  G02B6/0076 ,  G02B6/10 ,  G02B27/0994

Abstract: An apparatus consisting of stacked slab waveguides whose outputs are vertically staggered is disclosed. At the input to the stacked waveguides, the entrances to each slab lie in approximately the same vertical plane. A spot which is imaged onto the input will be transformed approximately to a set of staggered rectangles at the output, without substantial loss in brightness, which staggered rectangles can serve as a convenient input to a spectroscopic apparatus. A slit mask can be added to spatially filter the outputs so as to present the desired transverse width in the plane of the spectroscopic apparatus parallel to its dispersion.

Abstract translation: 公开了一种由输出垂直交错的堆叠平板波导组成的装置。 在堆叠波导的输入端，每个板的入口处于大致相同的垂直平面。 成像在输入上的点将在输出处大致变换成一组交错的矩形，而不会明显地损失亮度，这种交错矩形可以作为分光装置的方便的输入。 可以添加狭缝掩模以对输出进行空间过滤，以在分光装置的平面中呈现与其分散体平行的期望的横向宽度。

公开(公告)号：US08384045B2

公开(公告)日：2013-02-26

申请号：US12829070

申请日：2010-07-01

Applicant: Koji Takasaki ,  Katsuhiro Seo ,  Mitsuru Toishi ,  Shinji Yamada ,  Atsushi Fukumoto ,  Gary Durack

Inventor： Koji Takasaki ,  Katsuhiro Seo ,  Mitsuru Toishi ,  Shinji Yamada ,  Atsushi Fukumoto ,  Gary Durack

IPC: G01N21/64

CPC classification number: G01N15/1434 ,  G01J3/024 ,  G01J3/1256 ,  G01N15/1459 ,  G01N21/53 ,  G01N21/645 ,  G02B6/14 ,  G02B6/32 ,  G02B6/4215

Abstract: A minute particle analyzing device includes: a light source; a first condenser lens for condensing light from the light source to a first end of a multimode optical fiber; a second condenser lens for condensing the light emerging from a second end of the multimode optical fiber to a minute particle; and a detector for detecting light generated from the minute particle by the application of the light from the light source.

Abstract translation: 微粒分析装置包括：光源; 用于将来自光源的光聚焦到多模光纤的第一端的第一聚光透镜; 第二聚光透镜，用于将从多模光纤的第二端出射的光聚焦到微小颗粒; 以及检测器，用于通过施加来自光源的光来检测由微粒产生的光。

公开(公告)号：US20130016348A1

公开(公告)日：2013-01-17

申请号：US13183346

申请日：2011-07-14

Applicant: Damian W. ASHMEAD ,  Francis J. DECK

Inventor： Damian W. ASHMEAD ,  Francis J. DECK

IPC: G01N21/01

CPC classification number: G01J3/024 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/42 ,  G01N21/3151 ,  G01N2021/035 ,  G01N2021/3181

Abstract: An optical device is provided that includes a converging lens device, a transmitting optical fiber, a sample holder, and a receiving optical fiber. The converging lens device focuses light onto the transmitting optical fiber, which receives the focused light through an entrance face and transmits the light from an exit face, through a sample, and onto the receiving optical fiber. The sample holder holds the sample for analysis. The receiving optical fiber receives the light through an entrance face of the receiving optical fiber after transmission through the sample. The converging lens device is positioned to focus the light onto the entrance face of the transmitting optical fiber such that a half-angle of the angular distribution of the focused light that reaches the entrance face of the transmitting optical fiber is selected to underfill an entrance aperture of the entrance face of the receiving optical fiber in both a spatial dimension and an angular dimension.

Abstract translation: 提供一种光学装置，其包括会聚透镜装置，发射光纤，样本保持器和接收光纤。 会聚透镜装置将光聚焦到发射光纤上，发射光纤通过入射面接收聚焦光，并将光从出射面透过样品，并传输到接收光纤上。 样品架持有样品进行分析。 接收光纤在通过样品传输后通过接收光纤的入射面接收光。 会聚透镜装置被定位成将光聚焦到发射光纤的入射面上，使得到达发射光纤的入射面的聚焦光的角分布的半角被选择为向下填充入射孔 在空间尺寸和角度尺寸上的接收光纤的入射面。

公开(公告)号：US08351044B2

公开(公告)日：2013-01-08

申请号：US12729628

申请日：2010-03-23

Applicant: Shinya Matsumoto ,  Koki Morishita ,  Motohiro Mitamura

Inventor： Shinya Matsumoto ,  Koki Morishita ,  Motohiro Mitamura

IPC: G01J3/45

CPC classification number: G01J3/26 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/024 ,  G01J3/027 ,  G01J3/2823 ,  G01J3/36 ,  G01J2003/1213 ,  G01J2003/2866

Abstract: A spectral imaging apparatus includes: a spectral transmittance variable element having a spectral transmittance characteristics such that a transmittance periodically varies with wavelength and being capable of changing the variation period, for converting light from an object under observation into light having a plurality of peak wavelengths; a light extracting device for extracting, from the light having a plurality of peak wavelengths, light for imaging that contains a peak wavelength proximate to a predetermined command wavelength designated by a user and light for calibration that contains a peak wavelength other than the peak wavelength proximate to the command wavelength; an image sensor for capturing an image of the object under observation formed of the light for imaging; a detector for detecting, from the light for calibration, the peak wavelength other than the peak wavelength proximate to the command wavelength; and a control unit including, an operation processing section that calculates the peak wavelength that is proximate to the command wavelength and is contained in the light for imaging, from the peak wavelength that is other than the peak wavelength proximate to the command wavelength, is contained in the light for calibration and is detected by the detector, calculates an amount of shift between the peak wavelength proximate to the command wavelength as calculated and the command wavelength, and determines an amount of adjustment of the variation period on a basis of the amount of shift, and a drive processing section that drives the spectral transmittance variable element for changing the variation period.

Abstract translation: 一种光谱成像装置包括：具有分光透射率特性的光谱透射率可变元件，使得透射率周期性地随波长变化并且能够改变变化周期，用于将来自被观察物体的光转换成具有多个峰值波长的光; 一种光提取装置，用于从具有多个峰值波长的光中提取含有接近用户指定的预定指令波长的峰值波长的成像用光和用于校准的光，其包含峰值波长以外的峰值波长 指令波长; 用于捕获由用于成像的光形成的观察对象的图像的图像传感器; 用于从用于校准的光检测除了接近命令波长的峰值波长之外的峰值波长的检测器; 以及控制单元，包括：操作处理部，其从除了与命令波长相邻的峰值波长以外的峰值波长包含计算接近指令波长并且被包含在用于成像的光中的峰值波长的运算处理部， 在用于校准的光并由检测器检测的光中，计算接近所计算的命令波长的峰值波长与指令波长之间的偏移量，并且基于指示波长的量来确定变化周期的调整量 以及驱动处理部分，其驱动用于改变变化周期的光谱透射率可变元件。

公开(公告)号：US20120212737A1

公开(公告)日：2012-08-23

申请号：US13033146

申请日：2011-02-23

Applicant: Lovell E. Comstock, II ,  Jeffrey J. Santman ,  Richard L. Wiggins

Inventor： Lovell E. Comstock, II ,  Jeffrey J. Santman ,  Richard L. Wiggins

IPC: G01J3/28

CPC classification number: G01J3/2823 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/024 ,  G01J3/0262 ,  G01J3/0297

Abstract: A hyperspectral imaging system and a method are described herein for using an array of optical homogenizing elements to reduce spectral noise in an image of a real-world scene. In one embodiment, the hyperspectral imaging system and method use the array of optical homogenizing elements for homogenizing a spatial, an angular, and a polarization distribution of light from different elements within the real-world scene before it is measured by a spectrometer.

Abstract translation: 本文中描述了使用光学均匀化元件阵列以减少真实世界场景的图像中的光谱噪声的高光谱成像系统和方法。 在一个实施例中，高光谱成像系统和方法使用光学均匀化元件阵列，用于在通过光谱仪测量之前使来自真实世界场景中的不同元件的光的空间，角度和偏振分布均匀化。

公开(公告)号：US08248588B2

公开(公告)日：2012-08-21

申请号：US13087753

申请日：2011-04-15

Applicant: Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang

Inventor： Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang

IPC: G01N21/25

CPC classification number: G01N21/552 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/4535 ,  G01N2021/3595

Abstract: We disclose apparatus that includes: (a) an enclosure including an aperture; (b) a prism mounted in the enclosure so that a surface of the prism is exposed through the aperture; (c) an optical assembly contained within the enclosure, the optical assembly including a radiation source and a radiation detector, the source being configured to direct radiation towards the prism and the detector being configured to detect radiation from the source reflected from the exposed surface of the prism; and (d) an electronic processor contained within the enclosure, the electronic processor being in communication with the detector. The apparatus can be configured so that, during operation, the electronic processor determines information about a sample placed in contact with the exposed surface of the prism based on radiation reflected from the exposed prism surface while it is in contact with the sample.

Abstract translation: 我们公开了包括以下设备：（a）包括孔的外壳; （b）安装在外壳中的棱镜，使得棱镜的表面通过该孔露出; （c）包含在所述外壳内的光学组件，所述光学组件包括辐射源和辐射探测器，所述源被配置成将辐射引向所述棱镜，并且所述检测器被配置为检测来自所述源的反射的源的辐射， 棱镜; 以及（d）包含在所述外壳内的电子处理器，所述电子处理器与所述检测器通信。 该装置可以被配置为使得在操作期间，电子处理器在与样品接触的同时基于从暴露的棱镜表面反射的辐射来确定关于与棱镜的暴露表面接触的样品的信息。

公开(公告)号：US20120170026A1

公开(公告)日：2012-07-05

申请号：US13416771

申请日：2012-03-09

Applicant: Stephen K. Wilcken

Inventor： Stephen K. Wilcken

IPC: G01J3/46 ,  G02B6/00 ,  G01N21/49

CPC classification number: G01J3/4412 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/0262 ,  G01J3/027 ,  G01J3/0272 ,  G01N21/3563 ,  G01N21/474 ,  G01N21/8422

Abstract: Fiber optic probe scatterometers for spectroscopy measurements are disclosed. An example device includes an optically transparent illumination tube, an opaque tube, an inner surface of the opaque tube being adjacent an outer surface of the illumination tube and the illumination tube being disposed within the opaque tube, and an optical fiber disposed within and spaced a first distance from the illumination tube, wherein the opaque tube is to be coupled to a spectrometer and an illumination source to provide a light signal along the illumination tube and to collect a scattered light signal via the optical fiber for the spectrometer.

Abstract translation: 公开了用于光谱测量的光纤探针散射仪。 示例性装置包括光学透明的照明管，不透明管，不透明管的内表面邻近照明管的外表面，并且照明管设置在不透明管内，以及光纤， 与照明管的第一距离，其中不透明管将耦合到光谱仪和照明源，以沿着照明管提供光信号，并且经由用于光谱仪的光纤收集散射光信号。

公开(公告)号：US20120038915A1

公开(公告)日：2012-02-16

申请号：US13049110

申请日：2011-03-16

Applicant: Yasuo TSUCHIDA ,  Hirofumi Kawazumi ,  Kazuyoshi Arikata ,  Akihiro Tsuchida ,  Toshiaki Oinuma

Inventor： Yasuo TSUCHIDA ,  Hirofumi Kawazumi ,  Kazuyoshi Arikata ,  Akihiro Tsuchida ,  Toshiaki Oinuma

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0221 ,  G01J3/024 ,  G01J3/44

Abstract: An apparatus for receiving Raman scattering signals, includes an optic light-collection system for collecting Raman scattering lights having scattered from an object when excitation laser beams are irradiated thereto, a spectroscope including a diffraction grating, for separating the Raman scattering lights into its spectral components, and an optical path converter including at least one optical waveguide for converting lights having been collected by the optic light-collection system into slit-shaped lights in compliance with an orientation of the diffraction grating.

Abstract translation: 一种用于接收拉曼散射信号的装置，包括：当激发激光束被照射时，收集从物体散射的拉曼散射光的光学收集系统，包括衍射光栅的分光镜，用于将拉曼散射光分离成其光谱分量 以及光路转换器，其包括至少一个用于将由光学收集系统收集的光转换成符合衍射光栅的取向的狭缝状光的光波导。

公开(公告)号：US20110309247A1

公开(公告)日：2011-12-22

申请号：US13087753

申请日：2011-04-15

Applicant: Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang

Inventor： Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang

IPC: G01J5/02

CPC classification number: G01N21/552 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/4535 ,  G01N2021/3595

Abstract: We disclose apparatus that includes: (a) an enclosure including an aperture; (b) a prism mounted in the enclosure so that a surface of the prism is exposed through the aperture; (c) an optical assembly contained within the enclosure, the optical assembly including a radiation source and a radiation detector, the source being configured to direct radiation towards the prism and the detector being configured to detect radiation from the source reflected from the exposed surface of the prism; and (d) an electronic processor contained within the enclosure, the electronic processor being in communication with the detector. The apparatus can be configured so that, during operation, the electronic processor determines information about a sample placed in contact with the exposed surface of the prism based on radiation reflected from the exposed prism surface while it is in contact with the sample.

Abstract translation: 我们公开了包括以下设备：（a）包括孔的外壳; （b）安装在外壳中的棱镜，使得棱镜的表面通过该孔露出; （c）包含在所述外壳内的光学组件，所述光学组件包括辐射源和辐射探测器，所述源被配置成将辐射引向所述棱镜，并且所述检测器被配置为检测来自所述源的反射的来自所述源的辐射， 棱镜; 以及（d）包含在所述外壳内的电子处理器，所述电子处理器与所述检测器通信。 该装置可以被配置为使得在操作期间，电子处理器在与样品接触的同时基于从暴露的棱镜表面反射的辐射来确定关于与棱镜的暴露表面接触的样品的信息。