公开(公告)号：EP3394579A1

公开(公告)日：2018-10-31

申请号：EP16823462.3

申请日：2016-12-20

Applicant: Verily Life Sciences LLC

Inventor： WU, Cheng-Hsun ,  ACOSTA, Victor, Marcel ,  PEIKON, lan ,  LEBEL, Paul ,  SCHWARTZ, Jerrod, Joseph

IPC: G01J3/02 ,  G01J3/18 ,  G02B21/36 ,  G02B5/18 ,  G02B26/08 ,  G01N21/64

CPC classification number: G01N21/6458 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/08 ,  G01J3/14 ,  G01J3/18 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/4406 ,  G01J2003/1213 ,  G01J2003/2826 ,  G01N21/6408 ,  G01N21/6428 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2201/0633 ,  G01N2201/0675 ,  G02B5/1828 ,  G02B21/16 ,  G02B21/361 ,  G02B21/367 ,  G02B26/0808 ,  G02B26/0833 ,  G02F1/29 ,  G02F2201/34 ,  G02F2203/12 ,  G06T7/90 ,  G06T2207/10004 ,  G06T2207/10056

Abstract: Methods are provided to identify spatially and spectrally multiplexed probes in a biological environment. Such probes are identified by the ordering and color of fluorophores of the probes. The devices and methods provided facilitate determination of the locations and colors of such fluorophores, such that a probe can be identified. In some embodiments, probes are identified by applying light from a target environment to a spatial light modulator that can be used to control the direction and magnitude of chromatic dispersion of the detected light; multiple images of the target, corresponding to multiple different spatial light modulator settings, can be deconvolved and used to determine the colors and locations of fluorophores. In some embodiments, light from a region of the target can be simultaneously imaged spatially and spectrally. Correlations between the spatial and spectral images over time can be used to determine the color of fluorophores in the target.

公开(公告)号：EP3019912A1

公开(公告)日：2016-05-18

申请号：EP14738372.3

申请日：2014-07-09

Applicant: Danmarks Tekniske Universitet

Inventor： TIDEMAND-LICHTENBERG, Peter ,  DAM, Jeppe Seidelin ,  PEDERSEN, Christian

IPC: G02F1/35 ,  G01J3/26 ,  G01J3/28 ,  G01J3/443 ,  G01J3/08

CPC classification number: G01J3/0297 ,  G01J3/0294 ,  G01J3/08 ,  G01J3/26 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/443 ,  G01J2003/1291

Abstract: A multi-channel infrared spectrometer for detecting an infrared spectrum of light received from an object. The spectrometer comprises a wavelength converter system comprising a nonlinear material and having an input side and an output side. The wavelength converter system comprises at least a first up-conversion channel and a second up-conversion channel, and is arranged such that light traversing the wavelength converter system at different angles in the nonlinear material is imaged into different positions in an image plane. The first up- conversion channel is configurable for phase-matching infrared light in a first input wavelength range incident on the first side and light in a first output wavelength range output on the second side, and correspondingly, the second up-conversion channel is configurable for phase-matching infrared light in a second input wavelength range incident on the first side into light in a second output wavelength range output on the second side. The spectrometer further comprises a demultiplexer configured for demultiplexing light in the first up-conversion channel and light in the second up-conversion channel. The demultiplexer is located on the first side or the second side of the wavelength converter system. Finally, the spectrometer comprises a spatially resolved detector arranged in the image plane to detect light in the first output wavelength range and second output wavelength range output of the wavelength converter system.

公开(公告)号：EP2811286A1

公开(公告)日：2014-12-10

申请号：EP14170185.4

申请日：2014-05-28

Applicant: SICK AG

Inventor： Disch, Rolf ,  Ortwein, Pascal ,  Brüchig, Florian

IPC: G01N21/35 ,  G01J3/427 ,  G01N21/31 ,  G01N21/33

CPC classification number: G01N21/3151 ,  G01J3/08 ,  G01J3/10 ,  G01J3/42 ,  G01J3/427 ,  G01N21/33 ,  G01N21/3504 ,  G01N2021/3155 ,  G01N2021/317 ,  G01N2021/3513

Abstract: Die Erfindung betrifft ein zweikanaliges Messgerät zur Bestimmung von Gaskonzentrationen. Dies umfasst:
- eine erste und eine zweite Lichtquelle, die Licht unterschiedlicher Wellenlängenbereiche in eine Messstrecke senden,
- eine Empfangsanordnung, die das Licht der Lichtquellen empfängt,
- eine Choppervorrichtung, die zwei für einen der Wellenlängenbereiche hoch reflektierende Spiegel und zwei auf gleichem Teilkreis zwischen den Spiegeln liegende Durchbrüche aufweist, zum wechselweise Durchlassen bzw. Umlenken des Lichts der Lichtquellen, um das Licht auf den selben optischen Weg in die Messstrecke zu bringen
- und mit einer Auswerteeinheit zur Auswertung der Empfangssignale und Bestimmung einer Gaskonzentration daraus,
- wobei die Empfangsanordnung einen ersten und einen zweiten Empfänger aufweist,
- wobei der erste Empfänger der ersten Lichtquelle und der zweite Empfänger der zweiten Lichtquelle zugeordnet ist zum Empfang des Lichts entsprechender Wellenlänge
- und wobei die Choppervorrichtung auch Teil der Empfangsanordnung ist und die Choppervorrichtung das Licht nach Durchlaufen der Messstrecke durch Umlenken bzw. Durchlassen von demselben optischen Weg trennt und dem entsprechenden Empfänger zuordnet.
Erfindungsgemäß ist die Choppervorrichtung als ein einziges Chopperrad ausgebildet und die Spiegel sind als Sektoren des Chopperrads ausgebildet, so dass die Spiegelflächen senkrecht zur Rotationsachse des Chopperrades liegen.

Abstract translation: 本发明涉及一种用于测量气体浓度的双通道仪器。 这包括： - 第一和发射不同波长范围的光在测量路径，第二光源 - 其接收的光源的光的接收设备， - 一个斩波器装置中的两个高反射之间的波长中的一个上相同的节圆的范围镜和两个 具有躺在突破用于交替地传输或偏转的光源的光，以便使光在测量部分中的相同的光路的镜子 - 和与评估单元，用于将接收到的信号进行评估，并且确定它们的气体浓度， - 其中，所述接收装置包括 第一和第二接收器， - 其中所述第一光源的所述第一接收器和与第二光源，用于接收对应的波长的光相关联的第二接收器 - 并且其中，所述斩波器装置也接收装置和斩波器装置中，所述锂的一部分 CHT通过测量路径传递通过偏转或相同的光路通过后分离，并分配到相应的接收方。 根据本发明，斩波器装置被形成为单个斩光轮和镜形成为斩光轮的扇区，从而使反射镜表面是垂直于所述斩光轮的旋转轴线。

公开(公告)号：EP2703794A4

公开(公告)日：2014-10-08

申请号：EP12776102

申请日：2012-04-05

Applicant: KONICA MINOLTA INC

Inventor： TERAOKA YOSHITAKA ,  TSURUTANI KATSUTOSHI ,  YAMANOI YUTA

IPC: G01J3/02 ,  G01J3/08 ,  G01J3/50 ,  G01N21/25 ,  G01N21/47 ,  G01N21/57

CPC classification number: G01J3/50 ,  G01J3/0218 ,  G01J3/0272 ,  G01J3/08 ,  G01J3/504 ,  G01N21/251 ,  G01N21/255 ,  G01N2021/4711 ,  G01N2021/4735 ,  G01N2021/575 ,  G01N2201/0221 ,  G01N2201/061 ,  G01N2201/08

Abstract: A multi-angle colorimeter (100) employs a multi-angle mode and a symmetrical arrangement mode in an optical arrangement. Light detection on both sides of the symmetrical arrangement is performed by a single photodetector unit (41). The photodetector unit (41) is used on both sides, and thus, the device becomes simpler, without any impact on individual difference in characteristics of multiple photodetector units. Conversely, elements for illumination can be used on both sides. Also in a case where multiple photodetector units are used, the size and cost of the device can be reduced with the use of a photodetector unit having a relatively low wavelength resolution as a photodetector unit to be used on one side. This enables to reduce an attitude error due to relative tilting of a measurement surface while reducing the size and cost of the device.

公开(公告)号：EP2463643A1

公开(公告)日：2012-06-13

申请号：EP10806508.7

申请日：2010-08-05

Applicant: Universal Bio Research Co., Ltd.

Inventor： TAJIMA, Hideji

IPC: G01N21/64 ,  G01N21/78

CPC classification number: G01N21/6452 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/024 ,  G01J3/0291 ,  G01J3/08 ,  G01J3/10 ,  G01J3/32 ,  G01J3/4406 ,  G01J2003/1213 ,  G01N21/253 ,  G01N35/028 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833 ,  G02B6/4298

Abstract: Disclosed is a highly reliable optical fiber measurement device and measurement method having a simple and compact structure. The device includes a planar liquid holder having a plurality of liquid holding portions arranged along a flat face; a plurality of light receiving optical fibers for transmitting fluorescence generated in the liquid holding portions; a plurality of light emitting optical fibers for transmitting excitation light into the liquid holding portions; a measurement head capable of being positioned in the each liquid holding portion while supporting a plurality of measurement ends having a bundle of one light receiving end of the light receiving optical fibers and one light emitting end of light emitting optical fibers; a light reception selecting element that, by sequentially selecting one by one from plural the light receiving optical fibers and sequentially selecting one by one from plural kinds of wavelength or wavelength bands, sequentially guides the light of the selected wavelength or wavelength band of the fluorescence received by the selected light receiving optical fibers to one photoelectric element; and a photoelectric element for sequentially conducting photoelectric conversion on the guided fluorescence.

Abstract translation: 公开了一种高度可靠的光纤测量装置和具有简单紧凑结构的测量方法。 该装置包括具有沿着平坦表面布置的多个液体保持部分的平面液体保持器; 多个用于透射在液体保持部分中产生的荧光的光接收光纤; 用于将激发光发射到液体保持部分中的多个发光光纤; 测量头，其能够定位在每个液体保持部分中，同时支撑具有光接收光纤的一个光接收端的束和发光光纤的一个发光端的多个测量端; 光接收选择元件，通过从多个光接收光纤中逐一选择并从多种波长或波长带顺序地选择一个，顺序地引导所接收的荧光的所选波长或波长带的光 通过所选择的光接收光纤到一个光电元件; 以及用于在引导荧光上顺序导电光电转换的光电元件。

公开(公告)号：EP2092296A2

公开(公告)日：2009-08-26

申请号：EP07869277.9

申请日：2007-12-14

Applicant: Asd, Inc.

Inventor： CURTISS, Brian ,  GOETZ, Alexander F. H. ,  FELDMAN, Leonid G. ,  CIUPAK, Thomas ,  FAUS, Robert J.

IPC: G01N21/00 ,  G01J3/00

CPC classification number: G01N21/278 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0232 ,  G01J3/0256 ,  G01J3/0262 ,  G01J3/0291 ,  G01J3/08 ,  G01J3/42 ,  G01N21/255 ,  G01N21/55 ,  G01N2021/8411 ,  G01N2201/0636 ,  G01N2201/064

Abstract: A system and method for optical spectroscopic measurements is described. One embodiment includes a measurement head for optical spectroscopic measurements, the measurement head comprising an illumination source configured to illuminate a sample, a collection optic configured to view the sample, and an internal reference, wherein the internal reference can be illuminated by the illumination source and viewed by the collection optic.

公开(公告)号：EP2078187A2

公开(公告)日：2009-07-15

申请号：EP07863751.9

申请日：2007-11-01

Applicant: University of South Carolina

Inventor： MYRICK, Michael L. ,  FREESE, Robert P. ,  PERKINS, David L. ,  TEAGUE, Terrell ,  SOLTMANN, William

IPC: G01N21/00

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/08 ,  G01J3/42 ,  G01J2003/1213 ,  G01N2201/128 ,  G01N2201/1293

Abstract: The present subject matter relates to methods of high-speed analysis of product samples. Light is directed to a portion of a product under analysis and reflected from or transmitted through the product toward an optical detector. Signals for the detector are compared with reference signals based on a portion of the illuminating light passing through a reference element to determine characteristics of the product under analysis. The products under analysis may be stationary, moved by an inspection point by conveyor or other means, or may be contained within a container, the container including a window portion through which the product illuminating light may pass.

公开(公告)号：EP1754032B1

公开(公告)日：2008-05-07

申请号：EP05766803.0

申请日：2005-06-02

Applicant: Gesellschaft zur Förderung angewandter Optik, Optoelektronik, Quantenelektronik und Spektroskopie e.V. ,  Gesellschaft zur Förderung der Analytischen Wissenschaft e.V.

Inventor： BECKER-ROSS, Helmut ,  FLOREK, Stefan ,  WESEMANN, Günter ,  OKRUSS, Michael

IPC: G01J3/18

CPC classification number: G01J3/1809 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0232 ,  G01J3/0237 ,  G01J3/0286 ,  G01J3/0294 ,  G01J3/08 ,  G01J3/12 ,  G01J3/2803

Abstract: The invention relates to a spectrometer arrangement (10) comprising a spectrometer (14) for producing a spectrum of a first wavelength range of radiation from a radiation source on a detector (42). Said arrangement also comprises: an Echelle grating (36) for the spectral decomposition of the radiation penetrating the spectrometer arrangement (10) in a main dispersion direction (46); a dispersing element (34) for separating the degrees by means of spectral decomposition of the radiation in a transversal dispersion direction (48) which forms an angle with the main dispersion direction of the Echelle grating (36), in such a way that a two-dimensional spectrum (50) can be produced with a plurality of separated degrees (52); an imaging optical element (24, 38) for imaging the radiation penetrating through an inlet gap (20) into the spectrometer arrangement (10), in an image plane (40); and a surface detector (42) comprising a two-dimensional arrangement of a plurality of detector elements in the image plane (40). The inventive arrangement is characterised in that another spectrometer (12) comprising at least one other dispersing element (64) and another imaging optical element (60, 66) is provided in order to produce a spectrum (68) of a second wavelength range of radiation, which is different from the first wavelength range, from a radiation source on the same detector (42). The spectra can be spatially or temporally separated on the detector.

公开(公告)号：EP1211827A2

公开(公告)日：2002-06-05

申请号：EP01128247.2

申请日：2001-11-28

Applicant: Axsun Technologies, Inc.

Inventor： Flanders, Dale C.

IPC: H04B10/17 ,  H04B10/08 ,  H04J14/02

CPC classification number: G01J3/08

Abstract: An optical spectrum analyzer includes an integrated beam switch array (136). As a result, a single spectrum detector (138) can be amortized across multiple optical links with pigtails (110) transmitting the optical signals from separate optical links. The switch array (136) provides one of the optical signals as an input signal to the optical spectrum detector (138).

Abstract translation: 光谱分析仪包括在集成光束开关阵列（136）。 其结果是，一个单一的频谱检测（138）可以在多个光学链路摊销的辫子（110）发送从单独的光学链路的光信号。 开关阵列（136）提供的光信号作为输入到信号到光频谱检测（138）中的一个。

公开(公告)号：EP1166089A1

公开(公告)日：2002-01-02

申请号：EP99965784.4

申请日：1999-11-10

Applicant: The Government of the United States represented by the Administrator of the National Aeronautics and Space Administration-NASA

Inventor： SACHSE, Glen

IPC: G01N21/35 ,  G01J3/08

CPC classification number: G01J3/08 ,  G01N21/314 ,  G01N21/3518

Abstract: A system and method are provided for detecting one or more substances. An optical path switch divides sample path radiation into a time of alternating first and second polarized components. The first polarized components are transmitted along a first optical path and the second polarized components along a second optical path. A first gasless optical filter train filters the first polarized components to isolate at least a first wavelength band thereby generating first filtered radiation. A second gasless optical filter train filters the second polarized components to isolate at least a second wavelength band thereby generating second filter radiation. Spectral absorption of a substance of interest is different at the first wavelength band as compared to the second wavelength band. A beam combiner combines the first and the second filtered radiation to form a combined beam of radiation. A detector is disposed to monitor magnitude of at least a portion of the combined beam alternately at the first wavelength band and the second wavelength band as an indication of the concentration of the substance in the sample path.