公开(公告)号：WO2007015259A2

公开(公告)日：2007-02-08

申请号：PCT/IN2005/000326

申请日：2005-09-27

Applicant: AVRA LABORATORIES PVT. LTD. ,  RAO, Ramakrishna ,  ALLA, Venkata, Rama, Rao

Inventor： ALLA, Venkata, Rama, Rao

IPC: C07C209/36 ,  C07C201/08 ,  C07C205/45

CPC classification number: C07C221/00 ,  C07C29/40 ,  C07C45/305 ,  C07C201/08 ,  C07C201/12 ,  C07C205/45 ,  C07D491/22 ,  C07C225/22 ,  C07C33/483 ,  C07C33/46 ,  C07C49/807

Abstract: The present invention discloses a process for efficient production of 2-amino-5- hydroxypropiophenone corresponding to the AB ring part of camptothecin (CPT) skelton, which is a key intermediate useful for the total synthesis of camptothecin analogs including 7-Ethyl-10-hydroxy camptothecin and novel intermediates thereof.

Abstract translation: 本发明公开了一种有效生产对应于喜树碱（CPT）skelton的AB环部分的2-氨基-5-羟基苯丙酮的方法，其是用于全合成喜树碱类似物的关键中间体，包括7-乙基-10- 羟基喜树碱及其新型中间体。

公开(公告)号：WO2005005342A3

公开(公告)日：2006-05-04

申请号：PCT/US2004012425

申请日：2004-04-21

Applicant: BAE SYSTEMS ORDNANCE SYSTEMS I ,  KYLER KEITH S ,  WILSON ANDREW R ,  TEAGUE CURTIS

Inventor： KYLER KEITH S ,  WILSON ANDREW R ,  TEAGUE CURTIS

IPC: C07C205/06 ,  C06B20060101 ,  D03D23/00

CPC classification number: C07C201/08 ,  C07C205/06

Abstract: A process for preparing trinitrololuene (TNT) in which toluene is treated with nitric acid having a concentration of about 90% to about 99%, and preferably about 98% to about 99%, by weight at a temperature of less than about 60°C, and preferably less than 30°C, to produce high purity dinitrotoluene. The resulting dinitrotoluene is then treated with nitric acid having a concentration of about 98% to about 99% by weight and trifluoromethane sulfuric acid to produce high purity TNT.

Abstract translation: 一种制备三硝基甲苯（TNT）的方法，其中在低于约60℃的温度下，用浓度为约90％至约99％，优选约98％至约99％的硝酸处理甲苯 ，优选小于30℃，以产生高纯度二硝基甲苯。 然后用浓度为约98％至约99％重量的硝酸和三氟甲烷硫酸处理所得的二硝基甲苯以产生高纯度的TNT。

公开(公告)号：WO2003062187A1

公开(公告)日：2003-07-31

申请号：PCT/JP2003/000660

申请日：2003-01-24

Applicant: 旭硝子株式会社 ,  清水 環

Inventor： 清水 環

IPC: C07C201/08

CPC classification number: C07J75/00 ,  C07C201/08 ,  C07J73/00 ,  C07C205/11

Abstract: A process by which 2,5-bis(trifluoromethyl)nitrobenzene can be produced from an industrially easily available material in high yield through a small number of steps under mild reaction conditions using an easily handleable substance with which the reaction operation is easy. 1,4-Bis(trifluoromethyl)benzene is nitrated with nitric acid in a solvent comprising as an essential ingredient an acid selected between sulfuric acid having a sulfuric acid concentration of 91 to 100 wt.% and fuming sulfuric acid having a sulfur trioxide concentration higher than 0 wt.% and not higher than 20 wt.%.

Abstract translation: 通过使用易于处理的物质（反应操作容易），在温和的反应条件下，通过少量的步骤，可以从工业上容易获得的材料以高产率制备2,5-双（三氟甲基）硝基苯的方法。 将1,4-双（三氟甲基）苯在硝酸中在含有选自硫酸浓度为91〜100重量％的硫酸和三氧化硫浓度较高的发烟硫酸作为主要成分的溶剂中硝化 0重量％以上20重量％以下。

公开(公告)号：WO0230865A2

公开(公告)日：2002-04-18

申请号：PCT/GB0104436

申请日：2001-10-05

Applicant: UNIV BELFAST ,  EARLE MARTYN JOHN ,  KATDARE SUHAS PRABHAKAR

Inventor： EARLE MARTYN JOHN ,  KATDARE SUHAS PRABHAKAR

IPC: C07B43/02 ,  C07B61/00 ,  C07C201/08 ,  C07C205/06 ,  C07C205/12 ,  C07C205/37 ,  C07C205/38

CPC classification number: C07C201/08 ,  C07C205/06 ,  C07C205/12 ,  C07C205/37

Abstract: A process for the nitration of an aromatic compound, wherein the aromatic compound is admixed with a nitrating agent in the presence of an ionic liquid is described. The method for the nitration of aromatic compounds in (e.g. neutral) ionic liquids has advantages over conventional nitrations, such as the only by-product being water, the ionic liquid not being consumed and the nitrating agent being relatively inexpensive.

Abstract translation: 描述了在离子液体存在下将芳族化合物与硝化剂混合的芳族化合物的硝化方法。 在（例如中性）离子液体中硝化芳族化合物的方法具有优于常规硝化的优点，例如仅有副产物是水，离子液体不被消耗，硝化剂相对便宜。

公开(公告)号：WO01064333A2

公开(公告)日：2001-09-07

申请号：PCT/US2001/006698

申请日：2001-03-01

IPC: B01F3/08 ,  B01F5/06 ,  B01F13/10 ,  B01J14/00 ,  B01J19/00 ,  B01J19/24 ,  C07C201/08 ,  C07C205/06

CPC classification number: B01J19/243 ,  B01F3/08 ,  B01F5/0682 ,  B01F5/0688 ,  B01F13/1013 ,  B01F2013/1091 ,  B01J14/00 ,  B01J19/006 ,  B01J19/2415 ,  B01J2219/00094 ,  B01J2219/00166 ,  B01J2219/00184 ,  B01J2219/00768 ,  C07C201/08 ,  Y10S210/05 ,  C07C205/06

Abstract: A tubular reactor (1) characterized by having short static mixing elements (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) separated by coalescing zones (20, 21, 22, 23, 24, 25, 26, 27) is used to conduct multiphase liquid/liquid reactions. Small droplets of one of the phases are dispersed into the other phase by the static mixing elements (1, 2, 3, 4, 5, 6, 7, 8, 9, 10). These droplets coalesce and at least partially phase separate as the mixture passes through the subsequent coalescing zone. The tubular reactor is particularly suitable for nitrating organic compounds while forming low levels of improperly nitrated by-products and low levels of nitrophenolics.

Abstract translation: 一种管状反应器（1），其特征在于具有由聚结区（20,21,22,23,24,25）分离的短静态混合元件（1,2,3,4,5,6,7,8,9,10） ，26,27）用于进行多相液/液反应。 一个相的小液滴通过静态混合元件（1,2,3,4,5,6,7,8,9,10）分散到另一相中。 当混合物通过随后的聚结区时，这些液滴聚结并且至少部分相分离。 管状反应器特别适用于硝化有机化合物，同时形成低水平的不适当硝化的副产物和低水平的硝基苯酚。

公开(公告)号：WO01046130A1

公开(公告)日：2001-06-28

申请号：PCT/GB2000/004731

申请日：2000-12-11

IPC: C07B61/00 ,  C07C51/215 ,  C07C51/48 ,  C07C65/21 ,  C07C201/08 ,  C07C205/59 ,  C07C303/40 ,  C07C303/44 ,  C07C311/51

CPC classification number: C07C201/08 ,  C07C303/40 ,  C07C311/51 ,  C07C205/59

Abstract: A process for producing fomesafen from acifluorfen comprises the steps of (a) converting acifluorfen to its acid chloride, (b) coupling the acid chloride so formed with methanesulphonamide to form crude fomesafen and (c) purifying the crude fomesafen, characterised in that each of the steps is carried out in a single common solvent, which is preferably a chloroalkane. Preferably the steps are telescoped together so that there is no isolation of the product for any step until fomesafen is obtained.

Abstract translation: 从氟锁草醚生产福莫斯芬的方法包括以下步骤：（a）将氟锁草醚转化为其酰氯，（b）将形成的酰氯与甲磺酰胺偶联形成粗制呋喃酮，（c）纯化粗制物，其特征在于， 该步骤在单一的普通溶剂中进行，其优选为氯代烷烃。 优选地，这些步骤被伸缩在一起，使得在获得fomesafen之前，没有任何步骤的产品被隔离。

公开(公告)号：WO1996002493A1

公开(公告)日：1996-02-01

申请号：PCT/FR1995000941

申请日：1995-07-12

Applicant: RHONE-POULENC CHIMIE ,  CROCHEMORE, Michel ,  GUIDOT, Gilbert

Inventor： RHONE-POULENC CHIMIE

IPC: C07C211/52

CPC classification number: C07C201/08 ,  C07C209/365 ,  C07C231/02 ,  C07C231/12 ,  C07C233/15 ,  C07C205/12 ,  C07C211/52

Abstract: A method useful for the synthesis of a meta-substituted nitrogen derivative, comprising the step of deaminating an ortho- and/or para-substituted nitroaniline of the aniline function. The method is useful for organic synthesis.

Abstract translation: 用于合成间位取代的氮衍生物的方法，包括使苯胺官能团的邻位和/或对位取代的硝基苯胺脱氨的步骤。 该方法对于有机合成是有用的。

公开(公告)号：WO1995019222A1

公开(公告)日：1995-07-20

申请号：PCT/US1995000012

申请日：1995-01-10

Applicant: E.I. DU PONT DE NEMOURS AND COMPANY

Inventor： E.I. DU PONT DE NEMOURS AND COMPANY ,  HARMER, Mark, Andrew

IPC: B01J31/10

CPC classification number: C07C5/2562 ,  B01J21/08 ,  B01J31/10 ,  B01J31/165 ,  B01J31/4007 ,  B01J35/10 ,  B01J35/1019 ,  B01J35/1023 ,  B01J35/1042 ,  B01J35/1047 ,  B01J35/1057 ,  B01J35/1061 ,  B01J2231/10 ,  B01J2231/4205 ,  B01J2231/52 ,  B01J2231/54 ,  C07C2/02 ,  C07C5/2266 ,  C07C41/30 ,  C07C45/46 ,  C07C67/04 ,  C07C201/08 ,  C07C2521/06 ,  C07C2521/08 ,  C07C2523/10 ,  C07C2523/26 ,  C07C2523/28 ,  C07C2523/745 ,  C07C2531/08 ,  C07C2531/20 ,  C07C2531/26 ,  C07C2531/34 ,  C07C2601/14 ,  Y02P20/584 ,  C07C11/02 ,  C07C49/784 ,  C07C69/013 ,  C07C69/14 ,  C07C205/06 ,  C07C43/275

Abstract: Porous microcomposites have been prepared from "NAFION3" ion-exchange polymer and metal oxides such as silica using the sol-gel process. Such microcomposites possess high surface area and exhibit extremely high catalytic activity.

Abstract translation: 使用溶胶 - 凝胶法从“NAFION3”离子交换聚合物和金属氧化物如二氧化硅制备多孔微复合材料。 这样的微复合材料具有高的表面积并且表现出极高的催化活性。

公开(公告)号：WO1992002485A1

公开(公告)日：1992-02-20

申请号：PCT/ES1991000049

申请日：1991-07-29

Applicant: ERCROS S.A. ,  SAINZ DIAZ, Claro, Ignacio ,  SANTA-OLALLA GADEA, Jesús

Inventor： ERCROS S.A.

IPC: C07C201/16

CPC classification number: C07C201/08 ,  C07C201/12 ,  C07C205/44 ,  C07C205/57 ,  C07C205/58 ,  C07C205/59

Abstract: Method for obtaining 2-nitrobenzaldehide derivatives and nitrobenzoïc acid derivatives having the formula (Ia) (III) respectively, wherein R is H, C1-4 alkyl, C1-4 alkoxy or halogen. The method is comprised of selectively oxidizing a mixture of nitrobenzaldehide derivatives (I) with an aqueous solution of an oxidizing agent (II) wherein X is halogen, M is an alkaline or alkaline-earth metal and n is 1 or 2. Through said oxidation, 3-nitrobenzaldehide derivatives essentially are oxidized. 2-nitrobenzaldehide derivatives (Ia) not oxidized may be removed through the use of a water-unmiscible solvent and the nitrobenzoïc acid derivatives (III) may be precipitated in the aqueous phase by pH regulation. In a preferred mode of execution, 2-nitrobenzaldehide is of pharmaceutical interest as coronary dilator and 3-nitrobenzoïc acid is of interest in the industry of dyes and in medicine as synthesis intermediary.

公开(公告)号：WO1990007480A1

公开(公告)日：1990-07-12

申请号：PCT/US1990000054

申请日：1990-01-03

Applicant: CATALYTICA, INC.

Inventor： CATALYTICA, INC. ,  KING, David, L. ,  COOPER, Michael, D. ,  USHIBA, Ken, K. ,  SANDERSON, William, A.

IPC: C07C05/22

CPC classification number: C07H3/02 ,  C07C2/26 ,  C07C2/58 ,  C07C37/08 ,  C07C37/14 ,  C07C37/20 ,  C07C41/09 ,  C07C45/455 ,  C07C45/46 ,  C07C45/49 ,  C07C45/53 ,  C07C45/72 ,  C07C45/74 ,  C07C51/14 ,  C07C201/08 ,  C07C407/00 ,  C07C409/24 ,  C07C409/26 ,  C07C2531/025 ,  C07C2531/10 ,  C07C2531/26 ,  C07C2531/38 ,  C07F9/3808 ,  Y02P20/52 ,  C07C205/06 ,  C07C39/04 ,  C07C43/043 ,  C07C43/06 ,  C07C39/06 ,  C07C39/16

Abstract: The present invention provides a process for the conversion of a reactant into a reaction product in the presence of a solid acid catalyst comprising one or more fluorine atoms, sulfo radicals and phosphono radicals, each such radical being bonded to the same or different carbon atom, with the proviso that at least one sulfo radical and at least one phosphono radical are bonded to such carbon atoms through the sulfur atom and the phosphorus atom, respectively. These compounds are preferably non-polymeric, i.e. they have a molecular weight of about 5000 or less. The above acid catalysts may be reacted with a tetravalent metal, e.g. Zr, to provide a solid acid catalyst.

Abstract translation: 本发明提供了在包含一个或多个氟原子，磺基和膦酰基的固体酸催化剂存在下将反应物转化成反应产物的方法，每个这样的基团键合到相同或不同的碳原子上， 条件是至少一个磺基和至少一个膦酰基分别通过硫原子和磷原子键合到这些碳原子上。 这些化合物优选是非聚合的，即其分子量为约5000或更小。 上述酸催化剂可以与四价金属反应，例如 Zr，以提供固体酸催化剂。