公开(公告)号：US20170029389A1

公开(公告)日：2017-02-02

申请号：US15105985

申请日：2014-12-18

Applicant: KYOTO UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  KAGOSHIMA UNIVERSITY

Inventor： Masatoshi HAGIWARA ,  Masayasu TOYOMOTO ,  Takamitsu HOSOYA ,  Suguru YOSHIDA ,  Takashi KURIHARA

IPC: C07D277/64

CPC classification number: C07D277/64

Abstract: Provided is a pain-related compound, a pain-related pharmaceutical composition, and use of the same. Provided in one or more embodiments is a compound represented by Formula (I), a prodrug of the same, or a pharmaceutically permissible salt of any of the same.

Abstract translation: 提供疼痛相关化合物，疼痛相关药物组合物及其用途。 在一个或多个实施方案中提供由式（I）表示的化合物，其前体药物或其药学上可允许的盐。

公开(公告)号：US20150343088A1

公开(公告)日：2015-12-03

申请号：US14654951

申请日：2013-12-19

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Takami MATSUYAMA ,  Taku NAGAI ,  Kazuhisa HASUI ,  Sonshin TAKAO

IPC: A61K47/48 ,  C07K16/30 ,  C07K16/46

CPC classification number: A61K47/48676 ,  A61K38/164 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/30 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2319/55

Abstract: The object of the present invention is to provide an antibody capable of immunologically and specifically binding to a folate receptor α and a folate receptor β. Specifically, the present invention relates to an antibody or a fragment thereof, in which the amino acid sequences of CDRH1, CDRH2, and CDRH3 of a heavy chain variable region (VH) are SEQ ID NOs: 2, 4, and 6, respectively, and the amino acid sequences of CDRL1, CDRL2, and CDRL3 of a light chain variable region (VL) are SEQ ID NOs: 10, 12, and 14, respectively.

Abstract translation: 本发明的目的是提供能够免疫和特异性结合叶酸受体α和叶酸受体bgr的抗体。 具体地，本发明涉及其中重链可变区（VH）的CDRH1，CDRH2和CDRH3的氨基酸序列分别为SEQ ID NO：2,4和6的抗体或其片段， 轻链可变区（VL）的CDRL1，CDRL2和CDRL3的氨基酸序列分别为SEQ ID NO：10,12和14。

公开(公告)号：US20150313659A1

公开(公告)日：2015-11-05

申请号：US14650280

申请日：2013-12-09

Applicant: KAGOSHIMA UNIVERSITY ,  MARUYAMA IRONWORKS CO., LTD.

Inventor： Shouichi MIYAWAKI ,  Takakazu YAGI ,  Hiroshi TOMONARI ,  Yuichi KIMURA ,  Yasuo OSAKO ,  Satoshi MARUYAMA

IPC: A61B17/86

CPC classification number: A61B17/8695 ,  A61B17/0642 ,  A61B17/8605 ,  A61B2017/0641 ,  A61B2017/8655 ,  A61C7/00 ,  A61C7/22 ,  A61C8/00 ,  A61C8/0096 ,  F16B35/048 ,  F16B39/282

Abstract: A fastening force auxiliary device (1) includes a seat part (10) in which a hole (11) allowing a screw part (3) of a miniscrew (2) to be inserted through is formed and which receives a head part (5) of the miniscrew (2). Further, the fastening force auxiliary device (1) has three spiked portions (13) extending from a periphery of the seat part (10) in a driving direction of the miniscrew (2). The spiked portions (13) extend so as to spread outward from the periphery of the seat part (10) and so as to gradually taper off. When the miniscrew (2) is implanted and fixed in a jaw bone or the like in an oral cavity, it is screwed into the jaw bone or the like while the screw part (3) is inserted through the hole (11) of the fastening force auxiliary device (1). Consequently, a flange (7) is received by the seat part (10) and tips of the spiked portions (13) come into pressure contact with a surface of the jaw bone or the like by being pressed by the flange portion (7). Consequently, it is possible to greatly reduce the failure of the miniscrew (2).

Abstract translation: 一种紧固力辅助装置（1）包括座部（10），其中形成有允许将迷你螺丝钉（2）的螺钉部分（3）插入穿过的孔（11），并容纳头部（5） 的迷你（2）。 此外，紧固力辅助装置（1）具有从座部（10）的周边沿着迷你盘（2）的驱动方向延伸的三个加标部（13）。 加标部（13）从座部（10）的周边向外侧延伸，逐渐变细。 当将迷你盘（2）植入并固定在口腔中的颚骨等中时，螺钉部分（3）通过紧固件的孔（11）插入颚骨等中， 强制辅助装置（1）。 因此，由座部（10）容纳凸缘（7），通过被凸缘部（7）按压，加标部（13）的顶端与颚骨等的表面压力接触。 因此，可以大大减少miniscrew（2）的故障。

公开(公告)号：US20150279057A1

公开(公告)日：2015-10-01

申请号：US14428924

申请日：2013-09-19

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Sakuichi Ohtsuka ,  Shoko Hira ,  Ken Kihara

IPC: G06T11/00

CPC classification number: G06T11/001 ,  H04N1/6075 ,  H04N9/643 ,  H04N9/77

Abstract: An image processing apparatus (100) is formed including: color image acquisition means (222) for acquiring a color image of an object, which is expressed by a luminance signal, a first color difference signal that is a color difference signal of a color pair that is easy to be identified by a dichromat and a second difference signal that is a color difference signal of a color pair that is difficult to be identified by the dichromat; color difference signal processing means (223) for performing mixing reprocessing that mixes a component of the second color difference signal with a component of the first color difference signal, for each pixel data of the color image; and display control means (230) for performing control to display the color image processed by the color difference signal processing means (223) on a display unit (109) as a color image subjected to color conversion. By this means, it is possible to provide a mechanism in which a dichromat can understand the hue of an object without learning.

Abstract translation: 一种图像处理装置（100），包括：彩色图像获取装置（222），用于获取由亮度信号表示的对象的彩色图像，作为彩色对的色差信号的第一色差信号 这是易于通过重铬酸盐识别的第二差异信号和作为难以被二色色识别的颜色对的色差信号的第二差分信号; 色差信号处理装置（223），用于对彩色图像的每个像素数据执行混合再处理，其将第二色差信号的分量与第一色差信号的分量混合; 以及显示控制装置（230），用于进行控制，以在作为进行颜色转换的彩色图像的显示单元（109）上显示由色差信号处理装置（223）处理的彩色图像。 通过这种方式，可以提供一种机制，其中二色性可以在不学习的情况下理解物体的色调。

公开(公告)号：US20130295689A1

公开(公告)日：2013-11-07

申请号：US13916274

申请日：2013-06-12

Applicant: Kagoshima University ,  SYSMEX CORPORATION

Inventor： Hiroyuki KABATA ,  Hideki TAKAHASHI ,  Rena TSURUOKA ,  Ikuro MARUYAMA

IPC: G01N33/74 ,  G01N33/86 ,  G01N33/68

CPC classification number: G01N33/74 ,  G01N21/82 ,  G01N33/536 ,  G01N33/6827 ,  G01N33/6872 ,  G01N33/86

Abstract: The present invention provides a method for detection of a basic peptide by mixing a sample suspected to contain the basic peptide and a reagent containing denatured albumin and detecting turbidness due to a complex of the basic peptide and denatured albumin.

Abstract translation: 本发明提供一种通过混合疑似含有碱性肽的样品和含有变性白蛋白的试剂并检测由于碱性肽和变性白蛋白的复合物而引起的混浊的检测碱性肽的方法。

公开(公告)号：US12280099B2

公开(公告)日：2025-04-22

申请号：US17438178

申请日：2020-03-13

Applicant: TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE ,  KAGOSHIMA UNIVERSITY ,  NAGASAKI UNIVERSITY

Inventor： Michinori Kohara ,  Fumihiko Yasui ,  Daisuke Yamane ,  Kyoko Kohara ,  Kouichi Morita ,  Yasuhiro Yasutomi ,  Koji Ishii

IPC: A61K39/12 ,  A61P31/14 ,  C12N15/113 ,  A61K39/00

Abstract: The present invention provides a recombinant Vaccinia virus as a dengue virus vaccine that can be used as a therapeutic or prophylactic agent in the clinic. This recombinant Vaccinia virus is characterized by including: all or part of a cDNA that encodes a non-structural protein from a dengue virus; and an expression promoter.

公开(公告)号：US20250059509A1

公开(公告)日：2025-02-20

申请号：US18723725

申请日：2022-12-22

Applicant: Kagoshima University

Inventor： Hiromitsu HARA ,  Shin-ei MATSUMOTO ,  Kenji TOYONAGA

IPC: C12N5/0786

Abstract: A method of producing macrophages includes a culture step of culturing hematopoietic progenitor cells in the presence of a TREM2 signal activator.

公开(公告)号：US20240124577A1

公开(公告)日：2024-04-18

申请号：US18363113

申请日：2023-08-01

Applicant: Kyowa Kirin Co., Ltd. ,  KAGOSHIMA UNIVERSITY

Inventor： Nobuaki Takahashi ,  Ryosuke NAKANO ,  Sayaka MAEDA ,  Yuji ITO

IPC: C07K16/28 ,  A61K47/10 ,  A61K47/36 ,  C12N5/12 ,  G01N33/563

CPC classification number: C07K16/2803 ,  A61K47/10 ,  A61K47/36 ,  C12N5/12 ,  G01N33/563 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565

Abstract: The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.

公开(公告)号：US11701440B2

公开(公告)日：2023-07-18

申请号：US17047859

申请日：2019-04-15

Applicant: NIHON MEDI-PHYSICS CO., LTD. ,  National University Corporation Kagoshima University ,  National University Corporation Chiba University

Inventor： Shota Komoto ,  Yu Ogawa ,  Yoshinari Shoyama ,  Tadashi Hatano ,  Yuji Ito ,  Yasushi Arano ,  Hiroyuki Suzuki ,  Tomoya Uehara

IPC: A61K47/68 ,  A61K51/10 ,  C07K5/065 ,  C07K5/087 ,  A61K51/04 ,  A61K51/08 ,  C07D257/02 ,  C07K7/08 ,  C07K16/32

CPC classification number: A61K51/1093 ,  A61K47/6887 ,  A61K47/6889 ,  A61K51/0482 ,  A61K51/088 ,  A61K51/1096 ,  C07D257/02 ,  C07K5/06078 ,  C07K5/0812 ,  C07K7/08 ,  C07K16/32 ,  C07K2317/21

Abstract: Described is a labeling technique which can facilitate the metabolism in the liver after administration to patients without the reduction in the antibody function, thereby reducing accumulation of radionuclides in an organ such as the liver, and a modified antibody containing an IgG antibody and an IgG-binding peptide bound to the IgG antibody. The IgG-binding peptide has an amino acid sequence consisting of 13 to 17 amino acid residues, such as GPDCAYH(Xaa1)GELVWCTFH (SEQ ID NO: 2) wherein Xaa1 represents a lysine residue, a cysteine residue, an aspartic acid residue, a glutamic acid residue, 2-aminosuberic acid, or diaminopropionic acid, and a compound represented by the following formula (II-1) is linked at a position of the lysine residue via a modification linker to the N terminus of the IgG-binding peptide.

公开(公告)号：US20230210967A1

公开(公告)日：2023-07-06

申请号：US17996866

申请日：2021-04-21

Applicant: BRIGHTPATH BIOTHERAPEUTICS CO., LTD. ,  KAGOSHIMA UNIVERSITY

Inventor： Yukie SASAKURA ,  Norihiro NAKAMURA ,  Yuji MISHIMA ,  Noriko MATSUMOTO ,  Fumiko ISODA ,  Yuji ITO

IPC: A61K39/00 ,  A61K39/12 ,  A61K47/64 ,  A61K47/68 ,  A61P35/00

CPC classification number: A61K39/0011 ,  A61K39/12 ,  A61K47/64 ,  A61K47/68 ,  A61P35/00 ,  A61K2039/505 ,  A61K2039/5154

Abstract: A peptide vaccine complexed so that the peptide vaccine can be delivered specifically to the surface of specific immune cells and a method for delivering a peptide vaccine specifically to the surface of specific immune cells. The peptide vaccine is combined with an IgG binding peptide capable of binding to an IgG that is an agonist against molecules on the surface of specific immune cells such as dendritic cells.