公开(公告)号：US20150343088A1

公开(公告)日：2015-12-03

申请号：US14654951

申请日：2013-12-19

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Takami MATSUYAMA ,  Taku NAGAI ,  Kazuhisa HASUI ,  Sonshin TAKAO

IPC: A61K47/48 ,  C07K16/30 ,  C07K16/46

CPC classification number: A61K47/48676 ,  A61K38/164 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/30 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2319/55

Abstract: The object of the present invention is to provide an antibody capable of immunologically and specifically binding to a folate receptor α and a folate receptor β. Specifically, the present invention relates to an antibody or a fragment thereof, in which the amino acid sequences of CDRH1, CDRH2, and CDRH3 of a heavy chain variable region (VH) are SEQ ID NOs: 2, 4, and 6, respectively, and the amino acid sequences of CDRL1, CDRL2, and CDRL3 of a light chain variable region (VL) are SEQ ID NOs: 10, 12, and 14, respectively.

Abstract translation: 本发明的目的是提供能够免疫和特异性结合叶酸受体α和叶酸受体bgr的抗体。 具体地，本发明涉及其中重链可变区（VH）的CDRH1，CDRH2和CDRH3的氨基酸序列分别为SEQ ID NO：2,4和6的抗体或其片段， 轻链可变区（VL）的CDRL1，CDRL2和CDRL3的氨基酸序列分别为SEQ ID NO：10,12和14。