公开(公告)号：WO1994028913A1

公开(公告)日：1994-12-22

申请号：PCT/US1994006317

申请日：1994-06-02

Applicant: MARTEK BIOSCIENCES CORPORATION

Inventor： MARTEK BIOSCIENCES CORPORATION ,  KYLE, David, John

IPC: A61K37/00

CPC classification number: C12P7/6472 ,  A23L33/115 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/20 ,  A61K31/23 ,  A61K31/232 ,  A61K36/066 ,  A61K2300/00 ,  A23V2250/1868 ,  A23V2250/1862

Abstract: A method of treating a neurological disorder comprises administering to a person affected from such a disorder a microbial oil comprising DHA, a microbial oil comprising ARA or a combination of DHA and ARA oils in an amount sufficient to elevate the levels of circulating DHA and/or ARA in the person's blood to at least normal levels.

Abstract translation: 一种治疗神经障碍的方法包括向患有这种病症的人施用包含DHA的微生物油，包含ARA或DHA和ARA油的组合的微生物油，其量足以提高循环DHA和/或 ARA在人的血液中至少达到正常水平。

公开(公告)号：WO2011127163A1

公开(公告)日：2011-10-13

申请号：PCT/US2011/031410

申请日：2011-04-06

Applicant: MARTEK BIOSCIENCES CORPORATION ,  MAI, Jimbin ,  NEEDHAM, Micah ,  SU, Gang ,  WANG-NOLAN, Wei ,  HSU, Chia-Ping, Charles

Inventor： MAI, Jimbin ,  NEEDHAM, Micah ,  SU, Gang ,  WANG-NOLAN, Wei ,  HSU, Chia-Ping, Charles

IPC: A61K9/66

CPC classification number: A61K9/107 ,  A61K9/0095 ,  A61K9/19 ,  A61K31/20

Abstract: The present invention relates to thermally, stable oil-in-water emulsions comprising an oil comprising a polyunsaturated fatty acid, water, an emulsifier, and a water-soluble stabilizer, and processes for preparing the thermally stable oil-in-water emulsions. The thermally stable oil-in-water emulsions remain flowable at a temperature of -40 °C, and are free from a variation in particle size after 9 months in storage at a temperature of -40 °C to -15°C.

Abstract translation: 本发明涉及包含多不饱和脂肪酸，水，乳化剂和水溶性稳定剂的油的热稳定的水包油乳液，以及制备热稳定性水包油乳液的方法。 热稳定的水包油乳液在-40℃的温度下保持可流动，并且在-40℃至-15℃的温度下储存9个月后没有粒度变化。

公开(公告)号：WO2011112913A1

公开(公告)日：2011-09-15

申请号：PCT/US2011/028068

申请日：2011-03-11

Applicant: MARTEK BIOSCIENCES CORPORATION ,  ZIMMER, John, Paul ,  BUTT, Christopher, Michael

Inventor： ZIMMER, John, Paul ,  BUTT, Christopher, Michael

IPC: A01N43/04 ,  A61K31/70

CPC classification number: A61K31/7012 ,  A23L33/10 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/70 ,  A23V2200/322 ,  A23V2250/5438

Abstract: The invention provides methods and compositions for improving fetal and child health and development through nutritional supplementation with, for example, sialic acid. Sialic acid can be provided to a female before, during and/or after pregnancy to improve the health and development of a fetus and/or child. The sialic acid can be in a variety of forms in the supplements.

Abstract translation: 本发明提供了通过例如唾液酸的营养补充来改善胎儿和儿童健康和发育的方法和组合物。 在妊娠之前，之中和/或之后，可以向女性提供唾液酸以改善胎儿和/或儿童的健康和发育。 唾液酸可以是各种形式的补品。

公开(公告)号：WO2011109438A1

公开(公告)日：2011-09-09

申请号：PCT/US2011/026748

申请日：2011-03-01

Applicant: MARTEK BIOSCIENCES CORPORATION ,  SEIKAGAKU CORPORATION ,  DOHERTY, Daniel H. ,  WEAVER, Craig A. ,  MIYAMOTO, Kentaro ,  MINAMISAWA, Toshikazu

Inventor： DOHERTY, Daniel H. ,  WEAVER, Craig A. ,  MIYAMOTO, Kentaro ,  MINAMISAWA, Toshikazu

IPC: C12P19/04

CPC classification number: C12N15/63 ,  C07K14/245 ,  C07K16/1232 ,  C08B37/0069 ,  C08L5/08 ,  C12N15/52 ,  C12N15/70 ,  C12N15/74 ,  C12P19/04 ,  C12P19/26

Abstract: The invention relates to the field of recombinant DNA technology for the production of chondroitin, including the production of chondroitin sulfate via a combination of recombinant bacterial fermentation and post-fermentation sulfation.

Abstract translation: 本发明涉及用于生产软骨素的重组DNA技术领域，包括通过重组细菌发酵和后发酵硫酸化的组合生产硫酸软骨素。

公开(公告)号：WO2011097273A1

公开(公告)日：2011-08-11

申请号：PCT/US2011/023434

申请日：2011-02-02

Applicant: MARTEK BIOSCIENCES CORPORATION ,  HOFFMAN, James ,  KURATKO, Connye ,  NELSON, Edward, B. ,  RYAN, Alan ,  SALEM, Norman

Inventor： HOFFMAN, James ,  KURATKO, Connye ,  NELSON, Edward, B. ,  RYAN, Alan ,  SALEM, Norman

IPC: A01N37/00 ,  A61K31/20

CPC classification number: A61K31/202 ,  A61K31/198 ,  A61K36/06 ,  A61K36/07 ,  A61K36/48 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention is related to methods and compositions for treating non-alcoholic fatty liver disease (NAFLD), and methods of enhancing liver health and/or liver function, in a subject in need thereof, the methods comprising administering to the subject about 200 mg to about 12 g of docosahexaenoic acid (DHA) substantially free of eicosapentaenoic acid (EPA), and an effective amount of N-acetyl L-cysteine (NAC).

Abstract translation: 本发明涉及用于治疗非酒精性脂肪肝疾病（NAFLD）的方法和组合物，以及在有需要的受试者中增强肝健康和/或肝功能的方法，所述方法包括向受试者施用约200mg 至约12g基本不含二十碳五烯酸（EPA）的二十二碳六烯酸（DHA）和有效量的N-乙酰基L-半胱氨酸（NAC）。

公开(公告)号：WO2011090493A1

公开(公告)日：2011-07-28

申请号：PCT/US2010/028175

申请日：2010-03-22

Applicant: MARTEK BIOSCIENCES CORPORATION ,  APT, Kirk, E. ,  BEHRENS, Paul, Warren ,  HANSEN, Jon, Milton ,  PFEIFER III, Joseph, W. ,  STAHL, Tracey, Lynn ,  ZIRKLE, Ross

Inventor： APT, Kirk, E. ,  BEHRENS, Paul, Warren ,  HANSEN, Jon, Milton ,  PFEIFER III, Joseph, W. ,  STAHL, Tracey, Lynn ,  ZIRKLE, Ross

IPC: C12P19/34 ,  C12N1/14 ,  C12R1/89

CPC classification number: A23K20/158 ,  A23C9/1528 ,  A23D9/00 ,  A23D9/007 ,  A23K10/12 ,  A23K50/00 ,  A23K50/40 ,  A23K50/80 ,  A23L2/52 ,  A23L33/115 ,  A23L33/40 ,  A23V2002/00 ,  A61K8/361 ,  A61K31/201 ,  A61K31/202 ,  A61K35/68 ,  A61K2800/10 ,  A61Q19/00 ,  C11B1/10 ,  C11B3/04 ,  C12P7/6427 ,  C12P7/6472 ,  C12R1/89 ,  C12R1/90

Abstract: The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils.

Abstract translation: 本发明涉及分离的微生物以及其菌株和突变体，生物质，微生物油，组合物和培养物; 生产微生物油，生物质和突变体的方法; 以及使用分离的微生物，生物质和微生物油的方法。

公开(公告)号：WO2011082189A1

公开(公告)日：2011-07-07

申请号：PCT/US2010/062274

申请日：2010-12-28

Applicant: MARTEK BIOSCIENCES CORPORATION ,  APT, Kirk E.

Inventor： APT, Kirk E.

IPC: C12N15/45 ,  A61K39/17

CPC classification number: C12Y302/01018 ,  C12N7/00 ,  C12N9/2402 ,  C12N15/8257 ,  C12N2760/18151 ,  C12N2760/18651

Abstract: The present invention is directed to recombinant microalgal cells and their use production of heterologous hemagglutinin-neuraminidase (HN) polypeptides, as well compositions and uses thereof.

Abstract translation: 本发明涉及重组微藻细胞及其产生异源血凝素 - 神经氨酸酶（HN）多肽，以及其组合物和用途。

公开(公告)号：WO2011053892A1

公开(公告)日：2011-05-05

申请号：PCT/US2010/054901

申请日：2010-10-31

Applicant: MARTEK BIOSCIENCES CORPORATION ,  RAMAN, Krishna ,  TARWADE, Vinod ,  SALEM, Norman, Jr.

Inventor： RAMAN, Krishna ,  TARWADE, Vinod ,  SALEM, Norman, Jr.

IPC: C07C57/00

CPC classification number: C07C67/31 ,  C07C29/103 ,  C07C51/09 ,  C07C51/16 ,  C07C67/08 ,  C07C67/327 ,  C07C67/343 ,  C07D309/12 ,  C07C33/02 ,  C07C57/03 ,  C07C69/587 ,  C07C69/732

Abstract: The invention provides methods of synthesizing omega-3 and omega-6 very long chain polyunsaturated fatty acids (VLC- PUFAs, C28-C42:4,5 and 6), analogs and derivatives thereof, pharmaceutical compositions containing these isolated VLC-PUFA compounds and therapeutic uses therefor.

Abstract translation: 本发明提供了合成ω-3和ω-6非常长链多不饱和脂肪酸（VLC-PUFA，C28-C42：4,5和6）的类似物和衍生物的方法，含有这些分离的VLC-PUFA化合物的药物组合物和 治疗用途。

公开(公告)号：WO2010107415A1

公开(公告)日：2010-09-23

申请号：PCT/US2009/001720

申请日：2009-03-19

Applicant: MARTEK BIOSCIENCES CORPORATION ,  APT, Kirk, E. ,  PFEIFER, Joseph, W., III ,  HANSEN, Jon, Milton ,  BEHRENS, Paul, Warren ,  ZIRKLE, Ross ,  STAHL, Tracey, Lynn

Inventor： APT, Kirk, E. ,  PFEIFER, Joseph, W., III ,  HANSEN, Jon, Milton ,  BEHRENS, Paul, Warren ,  ZIRKLE, Ross ,  STAHL, Tracey, Lynn

IPC: C12N15/82

CPC classification number: C12R1/89 ,  C12N1/12 ,  C12P7/6427 ,  C12P7/6472

Abstract: The present invention is directed to isolated thraustochytrid microorganisms as well as strains and mutants thereof. The invention is further directed to biomasses, microbial oils, compositions, cultures, methods of producing microbial oils, and methods of using the isolated thraustochytrids, biomasses, and microbial oils.

Abstract translation: 本发明涉及分离的破釜状菌属微生物以及其菌株和突变体。 本发明进一步涉及生物质，微生物油，组合物，培养物，生产微生物油的方法，以及使用分离的破釜蛇疮，生物质和微生物油的方法。

公开(公告)号：WO2008025034A2

公开(公告)日：2008-02-28

申请号：PCT/US2007/076900

申请日：2007-08-27

Applicant: MARTEK BIOSCIENCES CORPORATION ,  SUBRAMANIAN, Srinivasan ,  CONNOLLY, Brian ,  CRANDELL, Michelle ,  ABRIL, Jesus Ruben

Inventor： SUBRAMANIAN, Srinivasan ,  CONNOLLY, Brian ,  CRANDELL, Michelle ,  ABRIL, Jesus Ruben

CPC classification number: A23L33/175 ,  A23L7/135 ,  A23L27/72 ,  A23L33/12 ,  A23L33/15 ,  A23L33/16 ,  A23P10/30 ,  A23P20/10

Abstract: Coated food products fortified with a polyunsaturated fatty acid, including sweetened food products, and methods for their preparation are provided.

Abstract translation: 提供了用多不饱和脂肪酸强化的包衣食品，包括甜食品，及其制备方法。