公开(公告)号：US20150101365A1

公开(公告)日：2015-04-16

申请号：US14286306

申请日：2014-05-23

Applicant: Master Dynamic Limited

Inventor： Koon Chung HUI ,  Wing Chi TANG ,  Ho CHING

IPC: G09F3/00 ,  G01J1/08 ,  G02B5/18 ,  G09F23/00 ,  A44C17/00

CPC classification number: G09F3/00 ,  A44C17/00 ,  B23K26/0006 ,  B23K26/355 ,  B23K2103/50 ,  B41M5/24 ,  G01J1/08 ,  G01N21/87 ,  G02B5/1842 ,  G02B5/1857 ,  G02B5/1861 ,  G09F23/00

Abstract: An identifiable mark on a portion of a polished facet of a surface of an article and being identifiable by an optical magnifying viewing device, said identifiable mark comprising a nano-structure formed by a two-dimensional or a three-dimensional lattice of a plurality of discrete nanometer sized recessed or protruded entities, wherein said entities are arranged within a predefined region of said polished facet in a predetermined arrangement in relation to each other and such that an outer interface surface between the facet of the article and air is formed and an inner interface surface between the facet of the article and air is formed. Said predetermined arrangement of said entities is non-uniform and non-periodic arrangement, and wherein said entities are sized and shaped so as to cause optical scattering upon reflection of incident light and the distance from the inner interface surface to the outer interface surface is greater than the amplitude of the non-marked portion of said polished face. Upon reflection of incident light having one or more predetermined wavelengths by said lattice at a predetermined angle of incidence to said lattice, interference due to scattering of light from said lattice is induced such that said reflected light has a variation in intensity providing one or more local maxima of one or more wavelengths. Said mark is identifiable by way of an optical magnifying viewing device inclined at a requisite viewing angle such that a local maxima is detected.

Abstract translation: 在物品表面的抛光小面的一部分上的可识别的标记并且可由光学放大观察装置识别，所述可识别标记包括由多个或多个的二维或三维网格形成的纳米结构 离散的纳米尺寸的凹入或突出的实体，其中所述实体以相对于彼此的预定布置布置在所述抛光小面的预定区域内，并且使得形成制品的小面与空气之间的外部界面表面， 形成制品的小面与空气之间的界面。 所述实体的所述预定布置是不均匀和非周期性布置，并且其中所述实体的尺寸和形状被设计成在入射光反射时引起光学散射，并且从内部界面表面到外部界面表面的距离更大 比所述抛光面的未标记部分的幅度大。 通过所述格子以预定的入射角对所述格子反射具有一个或多个预定波长的入射光，由于来自所述晶格的光的散射引起的干涉被引起，使得所述反射光具有提供一个或多个局部 一个或多个波长的最大值。 所述标记可通过以必要的视角倾斜的光学放大观察装置来识别，从而检测到局部最大值。

公开(公告)号：US20220031863A1

公开(公告)日：2022-02-03

申请号：US17299568

申请日：2019-12-03

Applicant: MASTER DYNAMIC LIMITED

Inventor： Ka Wing CHENG ,  Koon Chung HUI ,  Ching Tom KONG

IPC: A61K47/69 ,  A61K47/64

Abstract: A conjugate (110) comprising a nanoparticle (210) for delivery of a drug to a treatment site in the body of a subject; a drug molecule (220) releasably linked to said nanoparticle (210), wherein said drug molecule (220) has a therapeutic effect at the treatment site in the body of the subject; and a disease targeting molecule (230) releasably linked to said nanoparticle (210); wherein upon said conjugate (110) being adjacent diseased tissue (240) of a subject, said disease targeting molecule (230) retains the conjugate (110) adjacent said diseased tissue (240); said drug molecule (220) is released from said nanoparticle (110) so as to provide a therapeutic effect to said diseased tissue (240); and said disease targeting molecule (230) is subsequently released from said nanoparticle (210) such that retention of the nanoparticle (210) is released, and such that the nanoparticle (210) is dispersible from said diseased tissue (240).

公开(公告)号：US20210268123A1

公开(公告)日：2021-09-02

申请号：US17254685

申请日：2019-06-21

Applicant: MASTER DYNAMIC LIMITED

Inventor： Ka Wing CHENG ,  Wing Chi TANG ,  Koon Chung HUI

IPC: A61K47/69 ,  A61K31/436 ,  A61K9/00 ,  A61K41/00

Abstract: A conjugate comprising at least one calcineurin phosphatase inhibitor and a nanodiamond.

公开(公告)号：US09903049B2

公开(公告)日：2018-02-27

申请号：US15045159

申请日：2016-02-16

Applicant: Master Dynamic Limited

Inventor： Ho Ching ,  Pui Hang Ko

IPC: G04B17/22 ,  C30B29/06 ,  G04B17/06 ,  C30B33/12 ,  G04B1/14

CPC classification number: C30B29/06 ,  C30B33/12 ,  G04B1/145 ,  G04B17/066 ,  G04B17/227

Abstract: A torque-restoring element for an oscillator for a mechanical timepiece and having an oscillator frequency, said torque restoring element comprising a spiral spring body having a number N turnings with an inner terminal end for engagement with a rotational inertial element via a collet, and an outer terminal for engagement with a stationary cock element, and having a width, a height and a total arc length; wherein the spiral spring body includes a core formed from mono-crystalline silicon wafer oriented along the crystallographic axis ; and wherein the spiral spring body includes at least one peripheral coating of a material having a thermal elastic constant different from that of the core of the spiral spring body so as to maintain the oscillator frequency an oscillator including the torque-restoring element substantially insensitive to variations of ambient temperature.

公开(公告)号：US20170182838A1

公开(公告)日：2017-06-29

申请号：US15304843

申请日：2015-04-16

Applicant: Master Dynamic Limited

Inventor： Yingnan WANG ,  Ching Tom KONG

IPC: B44C1/22 ,  H01J37/32 ,  G03F7/00

CPC classification number: B44C1/227 ,  B28D5/00 ,  G03F7/00 ,  G03F7/0002 ,  H01J37/321 ,  H01J37/32192 ,  H01J2237/334

Abstract: A method of forming a non-optically detectable identifiable mark at an outer surface of an article formed from a solid state material, said method including the steps of forming a plurality of recesses within a predetermined region of a photoresist 5 applied to an outer surface of an article formed from a solid state material, wherein said plurality of recesses is formed by two-photon absorption lithography and wherein said one or more recesses extend at least partially through the photoresist and from an outer surface of the photoresist and towards said outer surface of the article 10 formed from a solid state material; and applying an etching process such that at least a portion of the outer surface of said article is exposed and etched so as to form a plurality of etched portions extending into said article from the outer surface of the article and corresponding to said plurality of recesses; wherein said predetermined region of said photoresist defines an identifiable mark to be applied to the outer 15 surface of said article; wherein said plurality of etched portions forms the nonoptically identifiable mark on the outer surface of said article; and wherein the maximum width of the etched portions of is less than 200 nm such that the identifiable mark is non-optically detectable in the visible light spectrum.

公开(公告)号：US09658598B2

公开(公告)日：2017-05-23

申请号：US13944554

申请日：2013-07-17

Applicant: Master Dynamic Limited

Inventor： Ho Ching

IPC: G04B17/06

CPC classification number: G04B17/066 ,  G04B17/06 ,  Y10T29/49581

Abstract: A method of increasing concentricity in use of a spiral hairspring mechanical timepiece; the hairspring having an inner terminal end portion for engagement with a collet, an outer terminal end portion for engagement with a stud, a first limb portion extending from the inner terminal end portion towards the outer terminal end portion, and a stiffening portion positioned at the outer turn of the hairspring and having a cross-sectional second moment of area different to that of the first limb portion such that bending stiffness of the stiffening portion has a greater bending stiffness than the single limb portion. The method includes modifying cross-sectional second moments of an area of the first limb portion and the stiffening portion by minimizing a cost function throughout the amplitude of the rotation of hairspring in use, the cost function being correlated to the net concentricity of the hairspring.

公开(公告)号：WO2022041222A1

公开(公告)日：2022-03-03

申请号：PCT/CN2020/112608

申请日：2020-08-31

Applicant: TOP TEAM TECHNOLOGY DEVELOPMENT LIMITED ,  MASTER DYNAMIC LIMITED

Inventor： YANG, Zhouwang ,  SONG, Yanzhi

IPC: G06K9/62 ,  G06K9/34 ,  G06N3/04 ,  G06N3/08

Abstract: Process for classification status of acquired image from subject according to pre-determined classification status, wherein the process comprising the steps of (i) dividing a acquired image from a subject into a plurality of instances; (ii) converting said acquired image to a graph according to the spatial relationship between the plurality of instances of step (i); (iii) extracting initial feature representations from the plurality of instances; (iv) inputting said graph acquired in step (ii) and said initial feature representations acquired in step (iii) into a pre-trained graph convolutional network, for transforming the instances into low-dimensional embeddings, wherein the pre-trained graph convolutional network has been pre-trained utilising one or more training data input sets, wherein said data inputs include a plurality of training images each of which is labeled according to a predetermined classification status; (v) computing a weighting vector for each instance utilising the graph of step (ii) and the low-dimensional embeddings of step (iv) by a graph attention mechanism which integrates the spatial relationship of the plurality of instances into the attention mechanism; (vi) calculating a weighting sum of the plurality of instances based on said lower-dimensional embeddings acquired in step (iv) and the and the weighting vector for each instance of step (v); wherein the weighting sum of the plurality of instances is converted into a class score indicating the classification status of the acquired image.

公开(公告)号：WO2021209048A1

公开(公告)日：2021-10-21

申请号：PCT/CN2021/087858

申请日：2021-04-16

Applicant: MASTER DYNAMIC LIMITED

Inventor： YIU, Yau Chuen ,  HUI, Koon Chung ,  MOK, Yan Yan

IPC: G01N23/046 ,  G01N23/20

Abstract: A system (300) for providing a three-dimensional computer tomography image of a gemstone, the system (300) comprising an X-ray source (330) for providing an X-ray towards a gemstone (320); an X-ray detector system for detecting X-rays transmitted through or diffracted by the gemstone (320). The X-ray detector system surrounds the gemstone (320) and detects a three-dimensional multi-angle X-ray diffraction pattern from the gemstone (320) upon rotation of the gemstone (320) within the X-ray field, and provides an output signal therefrom, wherein the output signal provides for invasive three-dimension multiangle X-ray diffraction reconstructed computed tomography from the three-dimension multiangle X-ray diffraction pattern.

公开(公告)号：WO2020030191A1

公开(公告)日：2020-02-13

申请号：PCT/CN2019/100255

申请日：2019-08-12

Applicant: MASTER DYNAMIC LIMITED

Inventor： CHENG, Chia-Liang

IPC: A61K47/69 ,  A61P35/00 ,  A61K31/704 ,  A61K31/519

Abstract: A conjugate comprising (a) a nanodiamond; (b) human serum albumin (HSA) adhered on the surface of nanodiamond by physical adsorption; and (c) a drug molecule chemically linked to said human serum albumin, wherein said drug molecule has a therapeutic effect.

公开(公告)号：WO2019242707A1

公开(公告)日：2019-12-26

申请号：PCT/CN2019/092175

申请日：2019-06-21

Applicant: MASTER DYNAMIC LIMITED

Inventor： CHENG, Ka Wing ,  HUI, Koon Chung ,  KONG, Ching Tom

IPC: G01N21/64 ,  G01N33/50 ,  A61K49/00

Abstract: A method of distinguishing cancerous cells and healthy cells of a subject from each other comprises the steps: (i) contacting a region of tissue of a subject suspected of including at least some cancer cells with a plurality of nanodiamonds, wherein the plurality of nanodiamonds comprise a first plurality of conjugates, wherein the conjugates of the first plurality of conjugates consist of first nanodiamonds and one or more cancer cell targeting agents, wherein the first nanodiamonds have a first type of colour center, and a second plurality of conjugates, wherein the conjugates of the second plurality of conjugates consist of second nanodiamonds and one or more healthy cell targeting agents, wherein the second nanodiamonds have a second type of colour center; and (ii) applying light of a first wavelength so as to excite the first type of colour center and applying light of a second wavelength so as to excite the second type of colour center, wherein upon contacting the region of tissue with the plurality of nanodiamonds, cancer cells are adhered to the first plurality of conjugates, and healthy cells are adhered to the second plurality of conjugates; wherein upon applying light to the region of tissue, the colour centers of the nanodiamonds of the first plurality of conjugates adhered to cancer cells emit fluorescence at a first wavelength, and the colour centers of the nanodiamonds of the second plurality of conjugates adhered to healthy cells emit fluorescence at a second wavelength; and wherein the colour contrast between the two wavelengths and the positions of respective conjugates delineate the area of cancer cells and the area of healthy cells from each other.