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公开(公告)号：US10125176B2
公开(公告)日：2018-11-13
申请号：US14902484
申请日：2014-07-03
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： Elisabeth Lindner , Helena Cowley , Aaron Cowley , Maria Akerman
IPC: C12N9/00 , C07K14/195 , A61K38/16 , C12N9/04 , C12N9/06 , C12N9/02 , C12N9/10 , C12N9/14 , C12N9/88 , A61K35/74 , A61K38/00
Abstract: The present invention relates to a secretagogue compound derived from oxalate degrading bacteria, for use in the treatment of an oxalate related disease and/or oxalate related imbalance in a subject, wherein the administration of the secretagogue results in a reduction of urinary oxalate and/or plasma oxalate in the subject. The invention further relates to a pharmaceutical composition comprising such a secretagogue compound, a method for treating a subject suffering from an oxalate related disease, and to a method for preparing a secretagogue.
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公开(公告)号：US09833499B2
公开(公告)日：2017-12-05
申请号：US14569077
申请日：2014-12-12
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： Harmeet Sidhu , Aaron Blake Cowley , Carl-Gustaf Golander , Qingshan Li
IPC: A61K38/00 , A61K38/54 , A61K38/44 , C12N9/88 , C12N9/10 , C12N9/06 , C07H21/04 , A61K38/51 , A61K9/16
CPC classification number: A61K38/51 , A61K9/1635 , A61K9/1682 , C12N9/88 , C12Y401/01002
Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, and methods for the purification and isolation of recombinant oxalate reducing enzyme proteins. The invention provides methods and compositions for the delivery of oxalate-reducing enzymes in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions.
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公开(公告)号：US20160137701A1
公开(公告)日：2016-05-19
申请号：US14902484
申请日：2014-07-03
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： Elisabeth LINDNER , Helena COWLEY , Aaron COWLEY
CPC classification number: C07K14/195 , A61K35/74 , A61K38/00 , A61K38/164 , C12N9/0006 , C12N9/0016 , C12N9/0051 , C12N9/1014 , C12N9/1085 , C12N9/14 , C12N9/88 , C12Y101/0106 , C12Y104/01016 , C12Y108/01 , C12Y201/02001 , C12Y205/01006 , C12Y205/01009 , C12Y205/01047 , C12Y303/01001 , C12Y402/01003
Abstract: The present invention relates to a secretagogue compound derived from oxalate degrading bacteria, for use in the treatment of an oxalate related disease and/or oxalate related imbalance in a subject, wherein the administration of the secretagogue results in a reduction of urinary oxalate and/or plasma oxalate in the subject. The invention further relates to a pharmaceutical composition comprising such a secretagogue compound, a method for treating a subject suffering from an oxalate related disease, and to a method for preparing a secretagogue.
Abstract translation: 本发明涉及一种衍生自草酸降解细菌的促分泌素化合物，用于治疗受试者中草酸盐相关疾病和/或草酸盐相关不平衡，其中所述促分泌素的施用导致尿草酸盐和/或 受试者血浆草酸盐。 本发明还涉及包含这种促分泌素化合物的药物组合物，用于治疗患有草酸盐相关疾病的受试者的方法和用于制备促分泌素的方法。
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44.发明申请PURIFICATION AND ISOLATION OF RECOMBINANT OXALATE DEGRADING ENZYMES AND SPRAY-DRIED PARTICLES CONTAINING OXALATE DEGRADING ENZYMES 审中-公开重组氧化降解酶和含有氧化物降解酶的喷雾干燥颗粒的纯化和分离公开(公告)号：US20150224180A1
公开(公告)日：2015-08-13
申请号：US14569077
申请日：2014-12-12
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： HARMEET SIDHU , AARON BLAKE COWLEY , CARL-GUSTAF GOLANDER , QINGSHAN LI
CPC classification number: A61K38/51 , A61K9/1635 , A61K9/1682 , C12N9/88 , C12Y401/01002
Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, and methods for the purification and isolation of recombinant oxalate reducing enzyme proteins. The invention provides methods and compositions for the delivery of oxalate-reducing enzymes in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions.
Abstract translation: 本发明包括用于还原人中草酸盐的方法和组合物，以及用于纯化和分离重组草酸盐还原酶蛋白质的方法。 本发明提供了用于在颗粒组合物中递送草酸盐还原酶的方法和组合物。 本发明的组合物适用于治疗或预防草酸盐相关病症的方法。
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公开(公告)号：US20150125538A1
公开(公告)日：2015-05-07
申请号：US14524361
申请日：2014-10-27
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： Qingshan Li , Harmeet Sidhu
CPC classification number: A61K9/1652 , A61K9/5036 , A61K9/5073 , A61K9/5089 , A61K9/5115 , A61K9/5161 , A61K9/5192 , A61K38/44 , A61K38/45 , A61K38/488 , A61K38/51 , A61K47/36 , C12Y102/03004 , C12Y208/03016 , C12Y304/23002 , C12Y401/01002 , C12Y401/01008 , A61K2300/00
Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans. For example, the invention provides methods and compositions for the delivery of one or more oxalate-reducing enzymes embedded in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions including, but not limited to, hyperoxaluria, absorptive hyperoxaluria, enteric hyperoxaluria, primary hyperoxaluria, idiopathic calcium oxalate kidney stone disease (urolithiasis), vulvodynia, oxalosis associated with end-stage renal disease, cardiac conductance disorders, inflammatory bowel disease, Crohn's disease, ulcerative colitis, and patients who have undergone gastrointestinal surgery and bariatric surgery (surgery for obesity), and/or who have undergone antibiotic treatment.
Abstract translation: 本发明包括用于还原人类中草酸盐的方法和组合物。 例如，本发明提供了用于递送一种或多种包含在颗粒组合物中的草酸盐还原酶的方法和组合物。 本发明的组合物适用于治疗或预防草酸盐相关病症的方法，包括但不限于高氧尿症，吸收性高氧尿症，肠高氧尿症，原发性高过氧化尿症，特发性草酸钙肾结石病（尿路结石），外阴，草酸病 与终末期肾脏疾病，心脏电导障碍，炎症性肠病，克罗恩病，溃疡性结肠炎以及经历胃肠外科手术和减肥手术（肥胖手术）的患者和/或已进行抗生素治疗的患者相关。
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Patent Agency Ranking
公开(公告)号：CY1120782T1
公开(公告)日：2019-12-11
申请号：CY181101090
申请日：2018-10-23
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： SIDHU HARMEET
Abstract: Ηπαρούσαεφεύρεσηαφοράμίαφαρμακευτικήσύνθεσηπουπεριλαμβάνειέναή περισσότεραένζυμαπουαποικοδομούνοξαλικά, όπουτοέναή περισσότεραένζυμαείναιπαγιδευμένασεμίατρισδιάστατηδικτυωτήδομήκατασκευασμένηαπόπολυμερήπουέχουνμεγέθηπόρωνταοποίαεπιτρέπουνταυποστρώματαενζύμουναδιεισδύουνμέσωτηςδομήςτουδικτυωτούώστεναφθάσουνσταένζυμα.
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公开(公告)号：PL2803366T3
公开(公告)日：2018-12-31
申请号：PL14180734
申请日：2005-06-15
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： SIDHU HARMEET
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公开(公告)号：LT2803366T
公开(公告)日：2018-12-27
申请号：LT14180734
申请日：2005-06-15
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： SIDHU HARMEET
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公开(公告)号：ES2692148T3
公开(公告)日：2018-11-30
申请号：ES14180734
申请日：2005-06-15
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： SIDHU HARMEET
Abstract: Una composición farmacéutica que comprende oxalato descarboxilasa, para usar en el tratamiento terapéutico de una afección relacionada con el oxalato reduciendo la concentración de oxalato en un ser humano, en donde la composición se administra más de una vez al día de forma continua cada día durante un periodo de meses o años y en donde dicha afección relacionada con el oxalato se selecciona del grupo que consiste en hiperoxaluria, hiperoxaluria primaria, enfermedad idiopática de cálculos renales por oxalato de calcio (urolitiasis) y hiperoxaluria entérica.
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公开(公告)号：DK2270138T3
公开(公告)日：2018-06-25
申请号：DK09164430
申请日：2009-07-02
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： COWLEY AARON BLAKE , GÖLANDER CARL-GUSTAF , LI QINGSHAN , SIDHU HARMEET
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