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    METHOD OF TREATING PERIPHERAL ARTERIAL DISEASE
    41.
    发明专利
    METHOD OF TREATING PERIPHERAL ARTERIAL DISEASE 未知

    公开(公告)号：CA2722620A1

    公开(公告)日：2009-10-01

    申请号：CA2722620

    申请日：2009-03-24

    Applicant: ORTHOLOGIC CORP ,  TEXAS A & M UNIV SYS

    Inventor： CARNEY DARRELL H ,  OLSZEWSKA-PAZDRAK BARBARA ,  FOSSUM THERESA W

    IPC: A61K38/04 ,  A61K38/16 ,  A61P9/10

    Abstract: An agonist of a non-proteolytically activated thrombin receptor can be used in a method for treating peripheral arterial disease. The agonist can be a thrombin peptide derivative. In some embodiments, the peripheral arterial disease is characterized by intermittent claudication. The thrombin peptide derivatives to be used in the methods can have amino acid sequences similar to a region of thrombin. Usually, the thrombin peptide derivatives are 12-23 amino acid residues in length. In some cases, the thrombin peptide derivatives are dimers, and in particular, dimers that result from formation of a disulfide bond between two cysteine residues of peptide monomers.

    46.
    发明专利
    未知

    公开(公告)号：DE69332700T2

    公开(公告)日：2003-10-16

    申请号：DE69332700

    申请日：1993-11-08

    Applicant: ORTHOLOGIC CORP

    Inventor： KAUFMAN JONATHAN J ,  CHIABRERA ALESSANDRO

    IPC: A61M11/08 ,  A61B8/00 ,  A61B8/08 ,  A61B17/56 ,  A61H23/02 ,  A61J7/04 ,  A61M15/00 ,  A61M16/00 ,  A61N7/00 ,  G01N29/30 ,  G01N29/34

    Abstract: Non-invasive therapeutic treatment and/or quantitative evaluation of bone tissue are performed in vivo, by subjecting bone to an ultrasonic acoustic signal pulse of finite duration, and involving a composite sine-wave signal consisting of plural discrete frequencies that are spaced in the ultrasonic region to approximately 2 MHz; the excitation signal is repeated substantially in the range 1 to 1000 Hz. In a quantitative evaluation, the composite sine-wave signal is supplied to one of two transducers on opposite sides of the bone, and the signal received by the other transducer is processed (a) to sequentially average the most recently received given number of successive signals to obtain an averaged per-pulse signal and (b) to produce a Fourier transform of the averaged per-pulse bone-transmitted signal. In a separate operation not involving the bone, the same transducers are subjected to the same excitation, reception and processing, wherein the transducers are exposed to a medium of known acoustic properties and path length, all to the end of producing a reference Fourier transform which is processed with the Fourier transform of the bone-transmitted signal, to yield an evaluation or measurement. In a therapeutic treatment, the transducer supplied by the composite sine-wave signal is thus supplied for a period or periods of time, and with a magnitude, as may be prescribed by the physician for a given patient.

    47.
    发明专利
    未知

    公开(公告)号：DE69332700D1

    公开(公告)日：2003-03-27

    申请号：DE69332700

    申请日：1993-11-08

    Applicant: ORTHOLOGIC CORP

    Inventor： KAUFMAN JONATHAN J ,  CHIABRERA ALESSANDRO

    IPC: A61M11/08 ,  A61B8/00 ,  A61B8/08 ,  A61B17/56 ,  A61H23/02 ,  A61J7/04 ,  A61M15/00 ,  A61M16/00 ,  A61N7/00 ,  G01N29/30 ,  G01N29/34

    Abstract: Non-invasive therapeutic treatment and/or quantitative evaluation of bone tissue are performed in vivo, by subjecting bone to an ultrasonic acoustic signal pulse of finite duration, and involving a composite sine-wave signal consisting of plural discrete frequencies that are spaced in the ultrasonic region to approximately 2 MHz; the excitation signal is repeated substantially in the range 1 to 1000 Hz. In a quantitative evaluation, the composite sine-wave signal is supplied to one of two transducers on opposite sides of the bone, and the signal received by the other transducer is processed (a) to sequentially average the most recently received given number of successive signals to obtain an averaged per-pulse signal and (b) to produce a Fourier transform of the averaged per-pulse bone-transmitted signal. In a separate operation not involving the bone, the same transducers are subjected to the same excitation, reception and processing, wherein the transducers are exposed to a medium of known acoustic properties and path length, all to the end of producing a reference Fourier transform which is processed with the Fourier transform of the bone-transmitted signal, to yield an evaluation or measurement. In a therapeutic treatment, the transducer supplied by the composite sine-wave signal is thus supplied for a period or periods of time, and with a magnitude, as may be prescribed by the physician for a given patient.

    48.
    发明专利
    未知

    公开(公告)号：DE69610326T2

    公开(公告)日：2001-02-22

    申请号：DE69610326

    申请日：1996-11-14

    Applicant: ORTHOLOGIC CORP

    Inventor： SARINGER H ,  CULHANE J

    IPC: A61H1/02

    Abstract: The present invention provides continuous passive motion (CPM) devices for joints. An ankle CPM device includes a lower leg support attached at its lower end to a semi-circular track. An actuator slides along the track and can be locked in any desired position on the track. A shaft is pivotally connected at one end thereof to the actuator and a shoe is attached at the other end thereof. When the actuator is positioned at the bottom of the track the ankle joint of the patient undergoes inversion/eversion motion. When the motor housing is rotated 90 DEG and positioned near the top of the track plantar/dorsi flexion movement is obtained. A combination of both types of joint movement are obtained for the actuator in intermediate positions. A wrist CPM device includes a brace for the forearm attached to a semi-circular track on which an actuator is mounted. A hand grip is mounted on a semi-circular bracket and a shaft extends between the actuator and a coupling slidably mounted on the semi-circular bracket. With the actuator positioned below the forearm, when the actuator pivots the shaft the wrist joint undergoes ulnar/radial deviation movement and when the motor is rotated 90 DEG and positioned at the side of the arm extension/flexion movement of the wrist joint is obtained. Positioning the actuator in intermediate positions produces wrist movement which is a combination of extension/flexion and ulnar/radial deviation of the wrist joint.

    49.
    发明专利
    未知

    公开(公告)号：DE69119865T2

    公开(公告)日：1996-10-02

    申请号：DE69119865

    申请日：1991-10-16

    Applicant: ORTHOLOGIC CORP

    Inventor： LAMOND DONALD R ,  HEINZELMAN BERT

    IPC: A61N2/00 ,  A61B19/00 ,  A61G13/12 ,  A61N2/02

    Abstract: A medical treatment device (20) is disclosed which includes a medical treatment element (36,38) and resilient securing members (32,34) which adjust or deform to conform to the particular dimensions of that part of the patient's anatomy which is to be treated. The resilient securing members (32, 34) move or deform outwardly away from the patient (22) as the device is applied to conform to the size of the patient and ensure that the patient is centered within the treatment device. The medical treatment elements (36,38) are thus accurately positioned with respect to the patient (22). This is particularly important in treatments involving the application of magnetic fields to the patient (22). In addition, the disclosed medical device (20) is relatively comfortable and can be worn by a patient (22) for a relatively long period of time. The invention also extends to the method of applying the medical treatment device (20) to the patient (22).

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