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    NOVEL DELIVERY OF HYDROXY CARBOXYLIC ACIDS
    45.
    发明申请
    NOVEL DELIVERY OF HYDROXY CARBOXYLIC ACIDS 审中-公开
    羟基羧酸的新发行

    公开(公告)号：WO9945933A9

    公开(公告)日：1999-11-18

    申请号：PCT/US9905200

    申请日：1999-03-10

    Applicant: PCR

    Inventor： LEGROW GARY E ,  TERRY W LEONARD JR

    IPC: A61K8/55 ,  A01N55/00 ,  A61K6/00 ,  A61K8/00 ,  A61K8/06 ,  A61K8/58 ,  A61K8/89 ,  A61K8/891 ,  A61K31/695 ,  A61K31/74 ,  A61P17/00 ,  A61P43/00 ,  A61Q19/00 ,  A61Q19/08

    CPC classification number: A61Q19/00 ,  A61K8/585 ,  A61K2800/75 ,  A61Q19/08

    Abstract: The present invention provides greater than 99 % pure bis(triorganosilyl)hydroxycarboxylates of the general formulae: R3SiO-CHR -COO-SiR3 and R3SiO-CHR -R COO-SiR3 wherein each R is independently a monovalent straight or branched chain alkyl or alkenyl group having from 1 to about 6 carbon atoms, or an aryl group, R may be hydrogen, a monovalent straight or branched chain alkyl group having from 1 to about 18 carbon atoms, or an aryl group, and R is a divalent straight or branched chain alkyl group having from 1 to about 18 carbon atoms, an aryl group, or a straight or branched chain alkaryl group having from 7 to about 18 carbon atoms; a process for producing the bis(trimethylsilyl)-hydroxycarboxylates comprising the trimethylsilylation with hexamethyldisilazane of the corresponding hydroxy carboxylic acids; cosmetic formulation comprising the greater than 99 % pure bis(trimethylsilyl)hydroxycarboxylates dissolved in aprotic media; and a method of delivering hydroxycarbxylic acids to the epidermis without apparent irritation or inflammation of the epidermis or stratum corneum.

    Abstract translation: 本发明提供了通式如下的大于99％的纯双（三有机甲硅烷基）羟基羧酸盐：R3SiO-CHR 1 -COO-SiR 3和R 3 SiO-CHR 1 -R COO-SiR 3，其中每个R独立地为 具有1至约6个碳原子的一价直链或支链烷基或烯基或芳基，R 1可以是氢，具有1至约18个碳原子的一价直链或支链烷基，或 芳基，R 2为具有1至约18个碳原子的二价直链或支链烷基，芳基或具有7至约18个碳原子的直链或支链烷芳基; 包括与相应的羟基羧酸的六甲基二硅氮烷的三甲基甲硅烷基化的双（三甲基甲硅烷基） - 羟基羧酸盐的方法; 包含溶解在非质子介质中的大于99％的纯双（三甲基甲硅烷基）羟基羧酸盐的化妆品制剂; 以及将羟基甲酸递送到表皮而没有表皮或角质层的明显刺激或炎症的方法。

    SYSTEM FOR AND METHOD OF CHANGING TEMPERATURES OF SUBSTANCES
    48.
    发明专利
    SYSTEM FOR AND METHOD OF CHANGING TEMPERATURES OF SUBSTANCES 未知

    公开(公告)号：SG195143A1

    公开(公告)日：2013-12-30

    申请号：SG2013087036

    申请日：2011-05-24

    Applicant: INGENY PCR B V

    Inventor： DE VOS GERT

    Abstract: Temperature control device for controlling a temperature of a substance to obtain a first temperature (T1) and to change to a second temperature (T2). The system has a first heating block (27(1)) and a second heating block (29(1) and a heating device (47). The heating device (47) heats the first heating block (27(1)) to the first temperature (T1) and heats the second heating block (29(1)) to the second temperature (T2). The temperature control device has a first material (27(2)) opposing the first heating block ((27(1)) such as to define a first space between them arranged to receive the substance and to define a first temperature zone (27(3)) having substantially the first temperature (T1). The temperature control device has a second material (29(2)) opposing the second heating block ((27(1)) such as to define a second space between them arranged to receive the substance and define a second temperature zone (29(3)) having substantially the second temperature (T2), the first and second spaces being arranged such that the substance can be moved from the first temperature zone ((27(3)) to the second temperature zone ((29(3)).

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