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Patent Agency Ranking
公开(公告)号：JPH10212292A
公开(公告)日：1998-08-11
申请号：JP20846997
申请日：1997-07-17
Applicant: PCR
Inventor： LEGROW GARY E , LATHAM III WILLIAM I
Abstract: PROBLEM TO BE SOLVED: To obtain a high-purity branched phenyl sesquioxane and to provide a method for preparing the compound. SOLUTION: This high-purity, neutral, colorless and odorless branched phenylsesquioxane liquid is shown by the formula Me3 SiO-(Me3 SiOPhSiO)x -SiMe3 (in the formula, Me is methyl; Ph is phenyl; (x) is 1 to 6) and substantially does not contain an alkoxysilane, chlorosilane, silanol functional substance, hexamethyldisiloxane and a free organic and/or inorganic compound.
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公开(公告)号：WO9945933A9
公开(公告)日：1999-11-18
申请号：PCT/US9905200
申请日：1999-03-10
Applicant: PCR
Inventor： LEGROW GARY E , TERRY W LEONARD JR
IPC: A61K8/55 , A01N55/00 , A61K6/00 , A61K8/00 , A61K8/06 , A61K8/58 , A61K8/89 , A61K8/891 , A61K31/695 , A61K31/74 , A61P17/00 , A61P43/00 , A61Q19/00 , A61Q19/08
CPC classification number: A61Q19/00 , A61K8/585 , A61K2800/75 , A61Q19/08
Abstract: The present invention provides greater than 99 % pure bis(triorganosilyl)hydroxycarboxylates of the general formulae: R3SiO-CHR -COO-SiR3 and R3SiO-CHR -R COO-SiR3 wherein each R is independently a monovalent straight or branched chain alkyl or alkenyl group having from 1 to about 6 carbon atoms, or an aryl group, R may be hydrogen, a monovalent straight or branched chain alkyl group having from 1 to about 18 carbon atoms, or an aryl group, and R is a divalent straight or branched chain alkyl group having from 1 to about 18 carbon atoms, an aryl group, or a straight or branched chain alkaryl group having from 7 to about 18 carbon atoms; a process for producing the bis(trimethylsilyl)-hydroxycarboxylates comprising the trimethylsilylation with hexamethyldisilazane of the corresponding hydroxy carboxylic acids; cosmetic formulation comprising the greater than 99 % pure bis(trimethylsilyl)hydroxycarboxylates dissolved in aprotic media; and a method of delivering hydroxycarbxylic acids to the epidermis without apparent irritation or inflammation of the epidermis or stratum corneum.
Abstract translation: 本发明提供了通式如下的大于99％的纯双（三有机甲硅烷基）羟基羧酸盐：R3SiO-CHR 1 -COO-SiR 3和R 3 SiO-CHR 1 -R COO-SiR 3，其中每个R独立地为 具有1至约6个碳原子的一价直链或支链烷基或烯基或芳基，R 1可以是氢，具有1至约18个碳原子的一价直链或支链烷基，或 芳基，R 2为具有1至约18个碳原子的二价直链或支链烷基，芳基或具有7至约18个碳原子的直链或支链烷芳基; 包括与相应的羟基羧酸的六甲基二硅氮烷的三甲基甲硅烷基化的双（三甲基甲硅烷基） - 羟基羧酸盐的方法; 包含溶解在非质子介质中的大于99％的纯双（三甲基甲硅烷基）羟基羧酸盐的化妆品制剂; 以及将羟基甲酸递送到表皮而没有表皮或角质层的明显刺激或炎症的方法。
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公开(公告)号：AU3075299A
公开(公告)日：1999-09-27
申请号：AU3075299
申请日：1999-03-10
Applicant: PCR
Inventor： LEGROW GARY E , TERRY W LEONARD JR
IPC: A61K8/55 , A01N55/00 , A61K6/00 , A61K8/00 , A61K8/06 , A61K8/58 , A61K8/89 , A61K8/891 , A61K31/695 , A61K31/74 , A61P17/00 , A61P43/00 , A61Q19/00 , A61Q19/08
Abstract: The present invention provides greater than 99% pure bis(triorganosilyl)hydroxycarboxylates of the general formulae: R3SiO-CHR1-COO-SiR3 R3SiO-CHR1-R2COO-SiR3wherein each R is independently a monovalent straight or branched chain alkyl or alkenyl group having from 1 to about 6 carbon atoms, or an aryl group, R1 may be hydrogen, a monovalent straight or branched chain alkyl group having from 1 to about 18 carbon atoms, or an aryl group, and R2 is a divalent straight or branched chain alkyl group having from 1 to about 18 carbon atoms, an aryl group, or a straight or branched chain alkaryl group having from 7 to about 18 carbon atoms; a process for producing the bis(trimethylsilyl)hydroxycarboxylates comprising the trimethylsilylation with hexamethyldisilazane of the corresponding hydroxy carboxylic acids; cosmetic formulation comprising the greater than 99% pure bis(trimethylsilyl)hydroxycarboxylates dissolved in aprotic media; and a method of delivering hydroxycarboxylic acids to the epidermis without apparent irritation or inflammation of the epidermis or stratum corneum.
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